clonazepam has been researched along with Anxiety in 33 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Low-dose cotherapy of fluoxetine with clonazepam was safe and accelerated response over 21 days of treatment, decreasing anxiety and sleep disturbance as symptoms and partially suppressed them as SSRI side-effects; it also modestly reduced core symptoms of low mood and loss of interest." | 9.09 | Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression. ( Glaudin, V; Londborg, PD; Painter, JR; Smith, WT, 2000) |
| " Clonazepam, a commonly prescribed benzodiazepine, has been increasingly used as a countermeasure to cocaine side-effects, including sleep reduction and anxiety." | 7.96 | Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats. ( Andersen, ML; Dokkedal-Silva, V; Galduróz, JCF; Tufik, S, 2020) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 6.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| "Low-dose cotherapy of fluoxetine with clonazepam was safe and accelerated response over 21 days of treatment, decreasing anxiety and sleep disturbance as symptoms and partially suppressed them as SSRI side-effects; it also modestly reduced core symptoms of low mood and loss of interest." | 5.09 | Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression. ( Glaudin, V; Londborg, PD; Painter, JR; Smith, WT, 2000) |
| " Clonazepam, a commonly prescribed benzodiazepine, has been increasingly used as a countermeasure to cocaine side-effects, including sleep reduction and anxiety." | 3.96 | Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats. ( Andersen, ML; Dokkedal-Silva, V; Galduróz, JCF; Tufik, S, 2020) |
| " The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), the Hamilton rating scales for Depression (HAM-D) and Anxiety (HAM-A) were performed at baseline (time 0), after 2 months of topical clonazepam (time 1) and after 6 months of benzodiazepine and antidepressant drugs (time 2)." | 3.88 | Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. ( Adamo, D; Aria, M; Fortuna, G; Mignogna, MD; Pecoraro, G, 2018) |
| " The dual and complementary mechanisms of action of etifoxine (directly on the GABA A receptor and indirectly via the neuroactive steroids) may represent a therapeutic benefit in the treatment of various anxiety disorders with abnormal production of neuroactive steroids." | 3.74 | Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes. ( Gillardin, JM; Heulard, I; Verleye, M, 2008) |
| "The tolerability of clonazepam in geropsychiatric inpatients was examined in patients with and without a diagnosis of dementia." | 3.69 | Tolerability of clonazepam in demented and non-demented geropsychiatric patients. ( Calkin, PA; Kunik, ME; Molinari, V; Orengo, CA; Workman, R, 1997) |
| "Four patients with panic disorder whose panic attacks responded to benzodiazepine treatment but who suffered persistent anxiety improved after addition of buspirone." | 3.67 | Adjunctive buspirone in benzodiazepine treatment of four patients with panic disorder. ( Gastfriend, DR; Rosenbaum, JF, 1989) |
| "Add-on effect of Shirodhara reduced the daytime sleepiness." | 2.77 | Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled study. ( Chandrashekar, CR; Kutty, BM; Lavekar, GS; Prabha, TN; Sudhakar, D; Tubaki, BR, 2012) |
| "Anxious depression, defined as major depressive disorder (MDD) accompanied by high levels of anxiety, seems to be both common and difficult to treat, with antidepressant monotherapy often yielding modest results." | 2.75 | Fluoxetine-clonazepam cotherapy for anxious depression: an exploratory, post-hoc analysis of a randomized, double blind study. ( Ameral, VE; Baer, L; Brintz, C; Clain, A; Fava, M; Glaudin, V; Londborg, PD; Painter, JR; Papakostas, GI; Smith, WT, 2010) |
| "Cotherapy was effective in reducing insomnia but not anxiety or core symptoms (low mood, suicidality, reduced interest)." | 2.70 | Is extended clonazepam cotherapy of fluoxetine effective for outpatients with major depression? ( Glaudin, V; Londborg, PD; Painter, JR; Smith, WT, 2002) |
| "Clonazepam and placebo were administered in a double-blind pilot study to 75 outpatients with social phobia." | 2.67 | Treatment of social phobia with clonazepam and placebo. ( Davidson, JR; Ford, SM; Krishnan, R; Potts, N; Richichi, E; Smith, R; Wilson, WH, 1993) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 2.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| "Clonazepam (0." | 1.62 | Oxytetracycline induces anxiety-like behavior in adult zebrafish. ( Altenhofen, S; Bonan, CD; Fritsch, PM; Gusso, D; Rübensam, G, 2021) |
| "Burning Mouth Syndrome (BMS) is a chronic pain condition characterized by persistent intraoral burning without related objective findings and unknown etiology that affects elderly females mostly." | 1.46 | Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbiities, treatment and outcome. ( Deligianni, CI; Ljubisavljevic, S; Mitsikostas, DD, 2017) |
| "Clonazepam was used as the standard drug." | 1.35 | Anxiolytic-like effect of Sonchus oleraceus L. in mice. ( Cardoso Vilela, F; Giusti-Paiva, A; Soncini, R, 2009) |
| "Clonazepam treatment in a dose 1-2 mg/day brought about a significant stabilization of blood pressure in 82." | 1.31 | [Labile hypertension in elderly: clinical features, autonomic regulation of circulation, approaches to treatment]. ( Dmitriev, KV; Fedorova, VI; Nedostup, AV, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.09) | 18.7374 |
| 1990's | 5 (15.15) | 18.2507 |
| 2000's | 9 (27.27) | 29.6817 |
| 2010's | 11 (33.33) | 24.3611 |
| 2020's | 5 (15.15) | 2.80 |
| Authors | Studies |
|---|---|
| Rossella, I | 1 |
| Alessandro, V | 1 |
| Naman, R | 1 |
| Gary, K | 1 |
| Hervé, SY | 1 |
| Piwowarczyk-Nowak, A | 1 |
| Pałasz, A | 1 |
| Bogus, K | 1 |
| Krzystanek, M | 1 |
| Błaszczyk, I | 1 |
| Worthington, JJ | 1 |
| Grajoszek, A | 1 |
| Dokkedal-Silva, V | 1 |
| Galduróz, JCF | 1 |
| Tufik, S | 1 |
| Andersen, ML | 1 |
| Lohiya, N | 2 |
| Karve, S | 1 |
| Agarkhedkar, S | 1 |
| Gusso, D | 1 |
| Altenhofen, S | 1 |
| Fritsch, PM | 1 |
| Rübensam, G | 1 |
| Bonan, CD | 1 |
| Mitsikostas, DD | 1 |
| Ljubisavljevic, S | 1 |
| Deligianni, CI | 1 |
| Kar, SK | 1 |
| Shahi, MK | 1 |
| Roy, P | 1 |
| Adamo, D | 1 |
| Mignogna, MD | 1 |
| Pecoraro, G | 1 |
| Aria, M | 1 |
| Fortuna, G | 1 |
| Doron, R | 1 |
| Sever, A | 1 |
| Handelsman, A | 1 |
| Toledano, R | 1 |
| Franko, M | 1 |
| Hirshler, Y | 1 |
| Shamir, A | 1 |
| Burstein, O | 1 |
| Rehavi, M | 1 |
| Walden, J | 1 |
| Pobbe, RL | 1 |
| Lopes, MA | 1 |
| Vasconcelos, AT | 1 |
| Yamashita, PS | 1 |
| de Bortoli, VC | 1 |
| Zangrossi, H | 1 |
| Ramirez, K | 1 |
| Niraula, A | 1 |
| Sheridan, JF | 1 |
| Gunter, BW | 1 |
| Jones, SA | 1 |
| Paul, IA | 1 |
| Platt, DM | 1 |
| Rowlett, JK | 1 |
| Cardoso Vilela, F | 1 |
| Soncini, R | 1 |
| Giusti-Paiva, A | 1 |
| Papakostas, GI | 1 |
| Clain, A | 1 |
| Ameral, VE | 1 |
| Baer, L | 1 |
| Brintz, C | 1 |
| Smith, WT | 3 |
| Londborg, PD | 3 |
| Glaudin, V | 3 |
| Painter, JR | 3 |
| Fava, M | 1 |
| Barker, KE | 1 |
| Batstone, MD | 1 |
| Savage, NW | 1 |
| Tubaki, BR | 1 |
| Chandrashekar, CR | 1 |
| Sudhakar, D | 1 |
| Prabha, TN | 1 |
| Lavekar, GS | 1 |
| Kutty, BM | 1 |
| Han, S | 1 |
| Tai, C | 1 |
| Westenbroek, RE | 1 |
| Yu, FH | 1 |
| Cheah, CS | 1 |
| Potter, GB | 1 |
| Rubenstein, JL | 1 |
| Scheuer, T | 1 |
| de la Iglesia, HO | 1 |
| Catterall, WA | 1 |
| Sattar, SP | 1 |
| Gastfriend, DR | 2 |
| Lerner, AG | 1 |
| Gelkopf, M | 1 |
| Skladman, I | 1 |
| Rudinski, D | 1 |
| Nachshon, H | 1 |
| Bleich, A | 1 |
| Verleye, M | 1 |
| Heulard, I | 1 |
| Gillardin, JM | 1 |
| Davidson, JR | 1 |
| Potts, N | 1 |
| Richichi, E | 1 |
| Krishnan, R | 1 |
| Ford, SM | 1 |
| Smith, R | 1 |
| Wilson, WH | 1 |
| Jenck, F | 1 |
| Martin, JR | 1 |
| Moreau, JL | 1 |
| Fish, DE | 1 |
| Neff, R | 1 |
| Benedek, D | 1 |
| Calkin, PA | 1 |
| Kunik, ME | 1 |
| Orengo, CA | 1 |
| Molinari, V | 1 |
| Workman, R | 1 |
| Nedostup, AV | 1 |
| Fedorova, VI | 1 |
| Dmitriev, KV | 1 |
| Weizman, R | 1 |
| Paz, L | 1 |
| Peter, Y | 1 |
| Toren, P | 1 |
| Pick, CG | 1 |
| Hewlett, WA | 1 |
| Vinogradov, S | 1 |
| Agras, WS | 1 |
| Rosenbaum, JF | 1 |
| Manchon, M | 1 |
| Kopp, N | 1 |
| Bobillier, P | 1 |
| Miachon, S | 1 |
| Beaudry, P | 1 |
| Fontaine, R | 1 |
| Chouinard, G | 1 |
| Annable, L | 1 |
8 trials available for clonazepam and Anxiety
| Article | Year |
|---|---|
Fluoxetine-clonazepam cotherapy for anxious depression: an exploratory, post-hoc analysis of a randomized, double blind study.
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Clonazepam; Depressive Disorder, Major; | 2010 |
Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled study.
Topics: Adult; Anxiety; Anxiety Disorders; Bacopa; Biological Products; Clonazepam; Depression; Disorders of | 2012 |
Is extended clonazepam cotherapy of fluoxetine effective for outpatients with major depression?
Topics: Administration, Oral; Adult; Antidepressive Agents, Second-Generation; Anxiety; Clonazepam; Depressi | 2002 |
Clonazepam treatment of lysergic acid diethylamide-induced hallucinogen persisting perception disorder with anxiety features.
Topics: Adolescent; Adult; Anxiety; Clonazepam; Drug Administration Schedule; Female; GABA Modulators; Hallu | 2003 |
Treatment of social phobia with clonazepam and placebo.
Topics: Adult; Anxiety; Clonazepam; Double-Blind Method; Female; Humans; Male; Phobic Disorders; Pilot Proje | 1993 |
Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression.
Topics: Adult; Aged; Anxiety; Clonazepam; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug | 2000 |
Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder.
Topics: Adult; Analysis of Variance; Anxiety; Clomipramine; Clonazepam; Clonidine; Depression; Double-Blind | 1992 |
An open clinical trial of clonazepam in the treatment of patients with recurrent panic attacks.
Topics: Adult; Anxiety; Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Fear; Female; Humans; Male; | 1985 |
25 other studies available for clonazepam and Anxiety
| Article | Year |
|---|---|
Topical clonazepam for burning mouth syndrome: Is it efficacious in patients with anxiety or depression?
Topics: Anxiety; Burning Mouth Syndrome; Clonazepam; Depression; Humans; Retrospective Studies | 2022 |
Modulatory effect of long-term treatment with escitalopram and clonazepam on the expression of anxiety-related neuropeptides: neuromedin U, neuropeptide S and their receptors in the rat brain.
Topics: Animals; Anxiety; Brain; Clonazepam; Escitalopram; GABA Modulators; Male; Neuropeptides; Rats; Rats, | 2022 |
Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats.
Topics: Animals; Anxiety; Behavior, Animal; Clonazepam; Cocaine; Corticosterone; Exploratory Behavior; Male; | 2020 |
A Tale of COVID-19: Beyond Physical Ailment.
Topics: Anxiety; Anxiety Disorders; Child; Clonazepam; Cognitive Behavioral Therapy; COVID-19; Diagnosis, Di | 2021 |
Oxytetracycline induces anxiety-like behavior in adult zebrafish.
Topics: Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Anxiety; Aquaculture; Behavior, Animal; Clonaze | 2021 |
Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbiities, treatment and outcome.
Topics: Aged; Anticonvulsants; Anxiety; Burning Mouth Syndrome; Chronic Disease; Chronic Pain; Clonazepam; C | 2017 |
Understanding the anxiety phenomenology in psychotic prodrome: A case report.
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Biguanides; Clonazepam; Drug Therapy, Combinatio | 2017 |
Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Anxiety; Benzodiazepines; Burning Mouth Syndrome; Cl | 2018 |
GABA
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Clonazepam; Male; Maze Learning; Mice; Mice, Inbred C5 | 2018 |
Fear.
Topics: Anticonvulsants; Anxiety; Clonazepam; Depression; Family Practice; Fear; Female; Fluoxetine; Humans; | 2019 |
Influence of procedural variables on rat inhibitory avoidance and escape behaviors generated by the elevated T-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Clonazepam; Diazepam; Escape Reaction; Ha | 2014 |
GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bone Marrow; Brain; CD11b Antigen; Clonazep | 2016 |
Benzodiazepine and neuroactive steroid combinations in rats: anxiolytic-like and discriminative stimulus effects.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Clonazepam; Discrimination Lea | 2016 |
Anxiolytic-like effect of Sonchus oleraceus L. in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Clonazepam; Male; Maze Learning; Mice; Mice, Inbred BALB C; M | 2009 |
Comparison of treatment modalities in burning mouth syndrome.
Topics: Anxiety; Burning Mouth Syndrome; Chi-Square Distribution; Clonazepam; Depression; Diazepam; Female; | 2009 |
Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.
Topics: Animals; Anxiety; Autistic Disorder; Clonazepam; Epilepsies, Myoclonic; GABA Modulators; GABAergic N | 2012 |
Visual inspection of medications in preventing unexplained relapses.
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Aspirin; Benzodiazepines; Cetirizine; Clonazepam | 2002 |
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convul | 2008 |
Behavioral effects of CCKB receptor ligands in a validated simulation of panic anxiety in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Caffeine; Clonazepam; Dose-Response Relati | 1996 |
Clonazepam induced delirium in Bosnia.
Topics: Adult; Anxiety; Bosnia and Herzegovina; Clonazepam; Delirium; Female; GABA Modulators; Humans; Milit | 1997 |
Tolerability of clonazepam in demented and non-demented geropsychiatric patients.
Topics: Aged; Anticonvulsants; Anxiety; Clonazepam; Dementia; Geriatric Psychiatry; Humans; Male; Memory; Mi | 1997 |
[Labile hypertension in elderly: clinical features, autonomic regulation of circulation, approaches to treatment].
Topics: Aged; Aged, 80 and over; Anxiety; Autonomic Nervous System; Blood Pressure; Circadian Rhythm; Clonaz | 2000 |
Behavioral effects of agents active at the gamma-aminobutyric acid receptor complex in the staircase paradigm.
Topics: Acetates; Adjuvants, Immunologic; Amines; Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compound | 2001 |
Adjunctive buspirone in benzodiazepine treatment of four patients with panic disorder.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Anxiety; Buspirone; Clonazepam; Diazepam; Drug Combinations; | 1989 |
Autoradiographic and quantitative study of benzodiazepine-binding sites in human hippocampus.
Topics: Adolescent; Adult; Aged; Anxiety; Autoradiography; Benzodiazepines; Binding Sites; Binding, Competit | 1985 |