Page last updated: 2024-10-25

clonazepam and Anxiety

clonazepam has been researched along with Anxiety in 33 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"Low-dose cotherapy of fluoxetine with clonazepam was safe and accelerated response over 21 days of treatment, decreasing anxiety and sleep disturbance as symptoms and partially suppressed them as SSRI side-effects; it also modestly reduced core symptoms of low mood and loss of interest."9.09Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression. ( Glaudin, V; Londborg, PD; Painter, JR; Smith, WT, 2000)
" Clonazepam, a commonly prescribed benzodiazepine, has been increasingly used as a countermeasure to cocaine side-effects, including sleep reduction and anxiety."7.96Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats. ( Andersen, ML; Dokkedal-Silva, V; Galduróz, JCF; Tufik, S, 2020)
"Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment."6.67Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992)
"Low-dose cotherapy of fluoxetine with clonazepam was safe and accelerated response over 21 days of treatment, decreasing anxiety and sleep disturbance as symptoms and partially suppressed them as SSRI side-effects; it also modestly reduced core symptoms of low mood and loss of interest."5.09Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression. ( Glaudin, V; Londborg, PD; Painter, JR; Smith, WT, 2000)
" Clonazepam, a commonly prescribed benzodiazepine, has been increasingly used as a countermeasure to cocaine side-effects, including sleep reduction and anxiety."3.96Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats. ( Andersen, ML; Dokkedal-Silva, V; Galduróz, JCF; Tufik, S, 2020)
" The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), the Hamilton rating scales for Depression (HAM-D) and Anxiety (HAM-A) were performed at baseline (time 0), after 2 months of topical clonazepam (time 1) and after 6 months of benzodiazepine and antidepressant drugs (time 2)."3.88Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. ( Adamo, D; Aria, M; Fortuna, G; Mignogna, MD; Pecoraro, G, 2018)
" The dual and complementary mechanisms of action of etifoxine (directly on the GABA A receptor and indirectly via the neuroactive steroids) may represent a therapeutic benefit in the treatment of various anxiety disorders with abnormal production of neuroactive steroids."3.74Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes. ( Gillardin, JM; Heulard, I; Verleye, M, 2008)
"The tolerability of clonazepam in geropsychiatric inpatients was examined in patients with and without a diagnosis of dementia."3.69Tolerability of clonazepam in demented and non-demented geropsychiatric patients. ( Calkin, PA; Kunik, ME; Molinari, V; Orengo, CA; Workman, R, 1997)
"Four patients with panic disorder whose panic attacks responded to benzodiazepine treatment but who suffered persistent anxiety improved after addition of buspirone."3.67Adjunctive buspirone in benzodiazepine treatment of four patients with panic disorder. ( Gastfriend, DR; Rosenbaum, JF, 1989)
"Add-on effect of Shirodhara reduced the daytime sleepiness."2.77Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled study. ( Chandrashekar, CR; Kutty, BM; Lavekar, GS; Prabha, TN; Sudhakar, D; Tubaki, BR, 2012)
"Anxious depression, defined as major depressive disorder (MDD) accompanied by high levels of anxiety, seems to be both common and difficult to treat, with antidepressant monotherapy often yielding modest results."2.75Fluoxetine-clonazepam cotherapy for anxious depression: an exploratory, post-hoc analysis of a randomized, double blind study. ( Ameral, VE; Baer, L; Brintz, C; Clain, A; Fava, M; Glaudin, V; Londborg, PD; Painter, JR; Papakostas, GI; Smith, WT, 2010)
"Cotherapy was effective in reducing insomnia but not anxiety or core symptoms (low mood, suicidality, reduced interest)."2.70Is extended clonazepam cotherapy of fluoxetine effective for outpatients with major depression? ( Glaudin, V; Londborg, PD; Painter, JR; Smith, WT, 2002)
"Clonazepam and placebo were administered in a double-blind pilot study to 75 outpatients with social phobia."2.67Treatment of social phobia with clonazepam and placebo. ( Davidson, JR; Ford, SM; Krishnan, R; Potts, N; Richichi, E; Smith, R; Wilson, WH, 1993)
"Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment."2.67Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992)
"Clonazepam (0."1.62Oxytetracycline induces anxiety-like behavior in adult zebrafish. ( Altenhofen, S; Bonan, CD; Fritsch, PM; Gusso, D; Rübensam, G, 2021)
"Burning Mouth Syndrome (BMS) is a chronic pain condition characterized by persistent intraoral burning without related objective findings and unknown etiology that affects elderly females mostly."1.46Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbiities, treatment and outcome. ( Deligianni, CI; Ljubisavljevic, S; Mitsikostas, DD, 2017)
"Clonazepam was used as the standard drug."1.35Anxiolytic-like effect of Sonchus oleraceus L. in mice. ( Cardoso Vilela, F; Giusti-Paiva, A; Soncini, R, 2009)
"Clonazepam treatment in a dose 1-2 mg/day brought about a significant stabilization of blood pressure in 82."1.31[Labile hypertension in elderly: clinical features, autonomic regulation of circulation, approaches to treatment]. ( Dmitriev, KV; Fedorova, VI; Nedostup, AV, 2000)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19903 (9.09)18.7374
1990's5 (15.15)18.2507
2000's9 (27.27)29.6817
2010's11 (33.33)24.3611
2020's5 (15.15)2.80

Authors

AuthorsStudies
Rossella, I1
Alessandro, V1
Naman, R1
Gary, K1
Hervé, SY1
Piwowarczyk-Nowak, A1
Pałasz, A1
Bogus, K1
Krzystanek, M1
Błaszczyk, I1
Worthington, JJ1
Grajoszek, A1
Dokkedal-Silva, V1
Galduróz, JCF1
Tufik, S1
Andersen, ML1
Lohiya, N2
Karve, S1
Agarkhedkar, S1
Gusso, D1
Altenhofen, S1
Fritsch, PM1
Rübensam, G1
Bonan, CD1
Mitsikostas, DD1
Ljubisavljevic, S1
Deligianni, CI1
Kar, SK1
Shahi, MK1
Roy, P1
Adamo, D1
Mignogna, MD1
Pecoraro, G1
Aria, M1
Fortuna, G1
Doron, R1
Sever, A1
Handelsman, A1
Toledano, R1
Franko, M1
Hirshler, Y1
Shamir, A1
Burstein, O1
Rehavi, M1
Walden, J1
Pobbe, RL1
Lopes, MA1
Vasconcelos, AT1
Yamashita, PS1
de Bortoli, VC1
Zangrossi, H1
Ramirez, K1
Niraula, A1
Sheridan, JF1
Gunter, BW1
Jones, SA1
Paul, IA1
Platt, DM1
Rowlett, JK1
Cardoso Vilela, F1
Soncini, R1
Giusti-Paiva, A1
Papakostas, GI1
Clain, A1
Ameral, VE1
Baer, L1
Brintz, C1
Smith, WT3
Londborg, PD3
Glaudin, V3
Painter, JR3
Fava, M1
Barker, KE1
Batstone, MD1
Savage, NW1
Tubaki, BR1
Chandrashekar, CR1
Sudhakar, D1
Prabha, TN1
Lavekar, GS1
Kutty, BM1
Han, S1
Tai, C1
Westenbroek, RE1
Yu, FH1
Cheah, CS1
Potter, GB1
Rubenstein, JL1
Scheuer, T1
de la Iglesia, HO1
Catterall, WA1
Sattar, SP1
Gastfriend, DR2
Lerner, AG1
Gelkopf, M1
Skladman, I1
Rudinski, D1
Nachshon, H1
Bleich, A1
Verleye, M1
Heulard, I1
Gillardin, JM1
Davidson, JR1
Potts, N1
Richichi, E1
Krishnan, R1
Ford, SM1
Smith, R1
Wilson, WH1
Jenck, F1
Martin, JR1
Moreau, JL1
Fish, DE1
Neff, R1
Benedek, D1
Calkin, PA1
Kunik, ME1
Orengo, CA1
Molinari, V1
Workman, R1
Nedostup, AV1
Fedorova, VI1
Dmitriev, KV1
Weizman, R1
Paz, L1
Peter, Y1
Toren, P1
Pick, CG1
Hewlett, WA1
Vinogradov, S1
Agras, WS1
Rosenbaum, JF1
Manchon, M1
Kopp, N1
Bobillier, P1
Miachon, S1
Beaudry, P1
Fontaine, R1
Chouinard, G1
Annable, L1

Trials

8 trials available for clonazepam and Anxiety

ArticleYear
Fluoxetine-clonazepam cotherapy for anxious depression: an exploratory, post-hoc analysis of a randomized, double blind study.
    International clinical psychopharmacology, 2010, Volume: 25, Issue:1

    Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Clonazepam; Depressive Disorder, Major;

2010
Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled study.
    Journal of alternative and complementary medicine (New York, N.Y.), 2012, Volume: 18, Issue:6

    Topics: Adult; Anxiety; Anxiety Disorders; Bacopa; Biological Products; Clonazepam; Depression; Disorders of

2012
Is extended clonazepam cotherapy of fluoxetine effective for outpatients with major depression?
    Journal of affective disorders, 2002, Volume: 70, Issue:3

    Topics: Administration, Oral; Adult; Antidepressive Agents, Second-Generation; Anxiety; Clonazepam; Depressi

2002
Clonazepam treatment of lysergic acid diethylamide-induced hallucinogen persisting perception disorder with anxiety features.
    International clinical psychopharmacology, 2003, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Anxiety; Clonazepam; Drug Administration Schedule; Female; GABA Modulators; Hallu

2003
Treatment of social phobia with clonazepam and placebo.
    Journal of clinical psychopharmacology, 1993, Volume: 13, Issue:6

    Topics: Adult; Anxiety; Clonazepam; Double-Blind Method; Female; Humans; Male; Phobic Disorders; Pilot Proje

1993
Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression.
    Journal of affective disorders, 2000, Volume: 61, Issue:1-2

    Topics: Adult; Aged; Anxiety; Clonazepam; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug

2000
Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder.
    Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:6

    Topics: Adult; Analysis of Variance; Anxiety; Clomipramine; Clonazepam; Clonidine; Depression; Double-Blind

1992
An open clinical trial of clonazepam in the treatment of patients with recurrent panic attacks.
    Progress in neuro-psychopharmacology & biological psychiatry, 1985, Volume: 9, Issue:5-6

    Topics: Adult; Anxiety; Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Fear; Female; Humans; Male;

1985

Other Studies

25 other studies available for clonazepam and Anxiety

ArticleYear
Topical clonazepam for burning mouth syndrome: Is it efficacious in patients with anxiety or depression?
    Journal of oral rehabilitation, 2022, Volume: 49, Issue:1

    Topics: Anxiety; Burning Mouth Syndrome; Clonazepam; Depression; Humans; Retrospective Studies

2022
Modulatory effect of long-term treatment with escitalopram and clonazepam on the expression of anxiety-related neuropeptides: neuromedin U, neuropeptide S and their receptors in the rat brain.
    Molecular biology reports, 2022, Volume: 49, Issue:9

    Topics: Animals; Anxiety; Brain; Clonazepam; Escitalopram; GABA Modulators; Male; Neuropeptides; Rats; Rats,

2022
Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 197

    Topics: Animals; Anxiety; Behavior, Animal; Clonazepam; Cocaine; Corticosterone; Exploratory Behavior; Male;

2020
A Tale of COVID-19: Beyond Physical Ailment.
    Indian pediatrics, 2021, 02-15, Volume: 58, Issue:2

    Topics: Anxiety; Anxiety Disorders; Child; Clonazepam; Cognitive Behavioral Therapy; COVID-19; Diagnosis, Di

2021
Oxytetracycline induces anxiety-like behavior in adult zebrafish.
    Toxicology and applied pharmacology, 2021, 09-01, Volume: 426

    Topics: Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Anxiety; Aquaculture; Behavior, Animal; Clonaze

2021
Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbiities, treatment and outcome.
    The journal of headache and pain, 2017, Volume: 18, Issue:1

    Topics: Aged; Anticonvulsants; Anxiety; Burning Mouth Syndrome; Chronic Disease; Chronic Pain; Clonazepam; C

2017
Understanding the anxiety phenomenology in psychotic prodrome: A case report.
    Asian journal of psychiatry, 2017, Volume: 28

    Topics: Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Biguanides; Clonazepam; Drug Therapy, Combinatio

2017
Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study.
    The Journal of dermatological treatment, 2018, Volume: 29, Issue:6

    Topics: Aged; Aged, 80 and over; Antidepressive Agents; Anxiety; Benzodiazepines; Burning Mouth Syndrome; Cl

2018
GABA
    Journal of molecular neuroscience : MN, 2018, Volume: 65, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Clonazepam; Male; Maze Learning; Mice; Mice, Inbred C5

2018
Fear.
    Family medicine, 2019, Volume: 51, Issue:3

    Topics: Anticonvulsants; Anxiety; Clonazepam; Depression; Family Practice; Fear; Female; Fluoxetine; Humans;

2019
Influence of procedural variables on rat inhibitory avoidance and escape behaviors generated by the elevated T-maze.
    Behavioural brain research, 2014, Oct-15, Volume: 273

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Clonazepam; Diazepam; Escape Reaction; Ha

2014
GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations.
    Brain, behavior, and immunity, 2016, Volume: 51

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bone Marrow; Brain; CD11b Antigen; Clonazep

2016
Benzodiazepine and neuroactive steroid combinations in rats: anxiolytic-like and discriminative stimulus effects.
    Psychopharmacology, 2016, Volume: 233, Issue:17

    Topics: Anesthetics; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Clonazepam; Discrimination Lea

2016
Anxiolytic-like effect of Sonchus oleraceus L. in mice.
    Journal of ethnopharmacology, 2009, Jul-15, Volume: 124, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Clonazepam; Male; Maze Learning; Mice; Mice, Inbred BALB C; M

2009
Comparison of treatment modalities in burning mouth syndrome.
    Australian dental journal, 2009, Volume: 54, Issue:4

    Topics: Anxiety; Burning Mouth Syndrome; Chi-Square Distribution; Clonazepam; Depression; Diazepam; Female;

2009
Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.
    Nature, 2012, Sep-20, Volume: 489, Issue:7416

    Topics: Animals; Anxiety; Autistic Disorder; Clonazepam; Epilepsies, Myoclonic; GABA Modulators; GABAergic N

2012
Visual inspection of medications in preventing unexplained relapses.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:10

    Topics: Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Aspirin; Benzodiazepines; Cetirizine; Clonazepam

2002
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
    Psychopharmacology, 2008, Volume: 197, Issue:4

    Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convul

2008
Behavioral effects of CCKB receptor ligands in a validated simulation of panic anxiety in rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1996, Volume: 6, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Caffeine; Clonazepam; Dose-Response Relati

1996
Clonazepam induced delirium in Bosnia.
    Military medicine, 1997, Volume: 162, Issue:2

    Topics: Adult; Anxiety; Bosnia and Herzegovina; Clonazepam; Delirium; Female; GABA Modulators; Humans; Milit

1997
Tolerability of clonazepam in demented and non-demented geropsychiatric patients.
    International journal of geriatric psychiatry, 1997, Volume: 12, Issue:7

    Topics: Aged; Anticonvulsants; Anxiety; Clonazepam; Dementia; Geriatric Psychiatry; Humans; Male; Memory; Mi

1997
[Labile hypertension in elderly: clinical features, autonomic regulation of circulation, approaches to treatment].
    Klinicheskaia meditsina, 2000, Volume: 78, Issue:7

    Topics: Aged; Aged, 80 and over; Anxiety; Autonomic Nervous System; Blood Pressure; Circadian Rhythm; Clonaz

2000
Behavioral effects of agents active at the gamma-aminobutyric acid receptor complex in the staircase paradigm.
    Brain research, 2001, May-18, Volume: 901, Issue:1-2

    Topics: Acetates; Adjuvants, Immunologic; Amines; Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compound

2001
Adjunctive buspirone in benzodiazepine treatment of four patients with panic disorder.
    The American journal of psychiatry, 1989, Volume: 146, Issue:7

    Topics: Adult; Alprazolam; Anti-Anxiety Agents; Anxiety; Buspirone; Clonazepam; Diazepam; Drug Combinations;

1989
Autoradiographic and quantitative study of benzodiazepine-binding sites in human hippocampus.
    Neuroscience letters, 1985, Nov-20, Volume: 62, Issue:1

    Topics: Adolescent; Adult; Aged; Anxiety; Autoradiography; Benzodiazepines; Binding Sites; Binding, Competit

1985