clonazepam has been researched along with Alloxan Diabetes in 7 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is known that oxidative stress occurs in peripheral blood in an experimental animal model of diabetes and depression, and acute treatment with insulin and clonazepam (CNZ) has a protective effect on oxidative stress in this model." | 7.79 | The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression. ( Barros, HM; Mescka, CP; Moreira, JC; Nin, MS; Pasquali, MA; Schnorr, CE; Tortato, C; Vargas, CR; Wayhs, CA, 2013) |
| " There is a well recognized association between depression and diabetes, once prevalence of depression in diabetic patients is higher than in general population, and clonazepam is being used to treat this complication." | 3.79 | Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior. ( Barros, HM; Guerreiro, G; Manfredini, V; Mescka, CP; Nin, MS; Ribas, GS; Vanzin, CS; Vargas, CR; Wayhs, CA, 2013) |
| "It is known that oxidative stress occurs in peripheral blood in an experimental animal model of diabetes and depression, and acute treatment with insulin and clonazepam (CNZ) has a protective effect on oxidative stress in this model." | 3.79 | The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression. ( Barros, HM; Mescka, CP; Moreira, JC; Nin, MS; Pasquali, MA; Schnorr, CE; Tortato, C; Vargas, CR; Wayhs, CA, 2013) |
| "Clonazepam was administered 24, 5 and 1 h before test." | 1.34 | Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect. ( Barden, AT; Barros, HM; Barschak, AG; da Silva Haeser, A; Deon, M; Gomez, R; Landgraff, S; Schmitt, GO; Sitta, A; Vargas, CR, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wayhs, CA | 4 |
| Mescka, CP | 3 |
| Vanzin, CS | 2 |
| Ribas, GS | 2 |
| Guerreiro, G | 2 |
| Nin, MS | 4 |
| Manfredini, V | 2 |
| Barros, HM | 7 |
| Vargas, CR | 5 |
| Moraes, TB | 1 |
| Jacques, CE | 1 |
| Rosa, AP | 1 |
| Ferri, MK | 1 |
| Dutra-Filho, CS | 1 |
| Sitta, A | 2 |
| Deon, M | 2 |
| Biancini, GB | 1 |
| Tortato, C | 1 |
| Pasquali, MA | 1 |
| Schnorr, CE | 1 |
| Moreira, JC | 1 |
| Gomez, R | 3 |
| da Silva Haeser, A | 1 |
| Barschak, AG | 1 |
| Barden, AT | 1 |
| Schmitt, GO | 1 |
| Landgraff, S | 1 |
7 other studies available for clonazepam and Alloxan Diabetes
| Article | Year |
|---|---|
Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior.
Topics: Animals; Behavior, Animal; Brain; Clonazepam; Depression; Diabetes Mellitus, Experimental; DNA Damag | 2013 |
Diabetic encephalopathy-related depression: experimental evidence that insulin and clonazepam restore antioxidant status in rat brain.
Topics: Animals; Anticonvulsants; Antioxidants; Brain Diseases; Cerebral Cortex; Clonazepam; Corpus Striatum | 2014 |
Effects of insulin and clonazepam on DNA damage in diabetic rats submitted to the forced swimming test.
Topics: Animals; Clonazepam; Comet Assay; Diabetes Mellitus, Experimental; DNA Damage; Drug Therapy, Combina | 2010 |
The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression.
Topics: Animals; Catalase; Clonazepam; Depression; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2013 |
Clonazepam increases in vivo striatal extracellular glucose in diabetic rats after glucose overload.
Topics: Animals; Blood Glucose; Clonazepam; Diabetes Mellitus, Experimental; Extracellular Space; GABA Modul | 2003 |
Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect.
Topics: Analysis of Variance; Animals; Behavior, Animal; Catalase; Clonazepam; Depression; Diabetes Mellitus | 2007 |
Ethopharmacology of the antidepressant effect of clonazepam in diabetic rats.
Topics: Animals; Antidepressive Agents; Blood Glucose; Brain; Clonazepam; Depression; Diabetes Mellitus, Exp | 2000 |