clonazepam has been researched along with Aging in 22 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 7.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "Both cortical and hippocampal EEG seizures was extremely poor in this model." | 5.29 | Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures. ( Mareś, P; Velísek, L, 1995) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 3.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| "Clonazepam treatment of RBD was completely or partially successful in 87% of the patients who used the drug." | 1.31 | Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. ( Boeve, BF; Olson, EJ; Silber, MH, 2000) |
| "Both cortical and hippocampal EEG seizures was extremely poor in this model." | 1.29 | Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures. ( Mareś, P; Velísek, L, 1995) |
| "Rotarod ataxia was quantitatively greater and of longer duration in aging animals." | 1.28 | Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals. ( Barnhill, JG; Gaver, A; Greenblatt, DJ; Harmatz, JS; Miller, LG; Shader, RI, 1990) |
| "[3H]muscimol was used for the labeling of GABA receptors and [3H]flunitrazepam for benzodiazepine receptors." | 1.26 | Ontogeny of high-affinity GABA and benzodiazepine receptors in the rat cerebellum: an autoradiographic study. ( Kuhar, MJ; Palacios, JM, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (40.91) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yasuda, K | 1 |
| Nomura, T | 1 |
| Inoue, Y | 1 |
| Nakashima, K | 1 |
| Palacios, JM | 1 |
| Kuhar, MJ | 1 |
| Komiskey, HL | 1 |
| MacFarlan, MF | 1 |
| Pacifici, GM | 1 |
| Taddeucci-Brunelli, G | 1 |
| Rane, A | 1 |
| Morselli, PL | 1 |
| Franco-Morselli, R | 1 |
| Oh, KS | 1 |
| Lee, CJ | 1 |
| Gibbs, JW | 2 |
| Coulter, DA | 2 |
| Kubová, H | 2 |
| Mares, P | 6 |
| Vorlícek, J | 1 |
| Velísek, L | 3 |
| Schroder, GB | 1 |
| Olson, EJ | 1 |
| Boeve, BF | 1 |
| Silber, MH | 1 |
| Perno, M | 1 |
| Hvidberg, EF | 1 |
| Dam, M | 1 |
| Stanková, L | 1 |
| Turski, W | 1 |
| Dziki, M | 1 |
| Parada, J | 1 |
| Kleinrok, Z | 1 |
| Cavalheiro, EA | 1 |
| Barnhill, JG | 1 |
| Greenblatt, DJ | 1 |
| Miller, LG | 1 |
| Gaver, A | 1 |
| Harmatz, JS | 1 |
| Shader, RI | 1 |
| Smith, D | 1 |
| Gallager, D | 1 |
| Sieghart, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism: a Prospective, Randomized, Double-blind and Placebo-controlled Trial[NCT02312908] | Phase 2 | 40 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for clonazepam and Aging
| Article | Year |
|---|---|
[Benzodiazepine (clonazepam, nitrazepam, diazepam)].
Topics: Aging; Anticonvulsants; Biomarkers; Chromatography, Gas; Chromatography, High Pressure Liquid; Clona | 2004 |
Clinical pharmacokinetics of antiepileptic drugs in adults.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; H | 1980 |
Burning mouth syndrome.
Topics: Aging; Anticonvulsants; Burning Mouth Syndrome; Clonazepam; Estrogen Replacement Therapy; Female; Hu | 2001 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
18 other studies available for clonazepam and Aging
| Article | Year |
|---|---|
Clinical characteristics of Restless legs syndrome in patients with Parkinson's disease.
Topics: Age of Onset; Aged; Aging; Anticonvulsants; Clonazepam; Dopamine; Dopamine Agonists; Dose-Response R | 2006 |
Ontogeny of high-affinity GABA and benzodiazepine receptors in the rat cerebellum: an autoradiographic study.
Topics: Aging; Animals; Autoradiography; Cerebellum; Clonazepam; Female; Flunitrazepam; gamma-Aminobutyric A | 1981 |
Effect on neuronal and non-neuronal benzodiazepine binding sites.
Topics: Aging; Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Cerebellum; Clonazepam; Frontal L | 1983 |
Clonazepam serum protein binding during development.
Topics: Adult; Aging; Benzodiazepinones; Blood Proteins; Child; Child, Preschool; Clonazepam; Female; Fetal | 1984 |
Postnatal development of GABAA receptor function in somatosensory thalamus and cortex: whole-cell voltage-clamp recordings in acutely isolated rat neurons.
Topics: Aging; Animals; Animals, Newborn; Cell Separation; Chlorides; Clonazepam; Electrophysiology; Neurons | 1995 |
Stable anticonvulsant action of benzodiazepines during development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Clonazepam; Electric Stimulation; Electroencephal | 1993 |
Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Electroencephalography; Epilepsy, Ton | 1995 |
GABAA receptor function in developing rat thalamic reticular neurons: whole cell recordings of GABA-mediated currents and modulation by clonazepam.
Topics: Aging; Analysis of Variance; Animals; Chloride Channels; Clonazepam; GABA Modulators; gamma-Aminobut | 1996 |
Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Aging; Anticonvulsants; Atrophy; Brain; Clonazepam; De | 2000 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Dru | 1992 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonaz | 1992 |
The action of clonazepam against seizures induced by N-methyl-D-aspartate in rats during ontogenesis.
Topics: Aging; Animals; Clonazepam; Epilepsy; Male; N-Methylaspartate; Rats; Rats, Inbred Strains | 1991 |
Sleep disorders and aging.
Topics: Aged; Aging; Clonazepam; Estrogens; Female; Humans; Sleep Wake Disorders | 1991 |
Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals.
Topics: Aging; Animals; Ataxia; Binding Sites; Brain; Chlorides; Clonazepam; Injections, Intraperitoneal; Ma | 1990 |
Potentiation of the anticonvulsant action of clonazepam by phenytoin could be demonstrated in adult as well as young rats.
Topics: Aging; Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Ph | 1989 |
GABA, benzodiazepine and serotonergic receptor development in the dorsal raphe nucleus: electrophysiological studies.
Topics: Action Potentials; Aging; Animals; Clonazepam; Electric Stimulation; gamma-Aminobutyric Acid; Raphe | 1987 |
Comparison of benzodiazepine receptors in cerebellum and inferior colliculus.
Topics: Aging; Animals; Animals, Newborn; Carbolines; Cell Membrane; Cerebellum; Clonazepam; Diazepam; Fluni | 1986 |
Influence of clonazepam on electrocorticographic changes induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Clonazepam; Electrodes, Implanted; Electroencephalography; Male; Pentylenetetrazole; | 1987 |