Page last updated: 2024-10-25

clonazepam and Aggression

clonazepam has been researched along with Aggression in 15 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.

Research Excerpts

ExcerptRelevanceReference
"Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums."3.72Brief report: clonazepam behavioral side effects with an individual with mental retardation. ( Hanzel, TE; Harder, SR; Kalachnik, JE; Sevenich, R, 2003)
" Adjunctive treatment with clonazepam resulted in the cessation of the seizures and of persistent, violent hallucinations."3.67Antiaggressive effect of adjunctive clonazepam in schizophrenia associated with seizure disorder. ( Keats, MM; Mukherjee, S, 1988)
"Clonazepam was offered as the first-line treatment (starting dose: 0."1.43A prospective, naturalistic follow-up study of treatment outcomes with clonazepam in rapid eye movement sleep behavior disorder. ( Chan, JW; Ho, CK; Lam, SP; Lam, VK; Li, SX; Liu, Y; Wing, YK; Yu, MW; Zhang, J; Zhou, J, 2016)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19907 (46.67)18.7374
1990's3 (20.00)18.2507
2000's3 (20.00)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Reddy, MSS1
Achary, U1
Harbishettar, V1
Sivakumar, PT1
Varghese, M1
Li, SX1
Lam, SP1
Zhang, J1
Yu, MW1
Chan, JW1
Liu, Y1
Lam, VK1
Ho, CK1
Zhou, J1
Wing, YK1
Kalachnik, JE1
Hanzel, TE1
Sevenich, R1
Harder, SR1
Coffey, B1
Fantini, ML1
Corona, A1
Clerici, S1
Ferini-Strambi, L1
Rehm, WF1
Beglinger, R1
Becker, M1
Hamza, B1
Heizmann, P1
Schulze, J1
Auta, J1
Romeo, E1
Kozikowski, A1
Ma, D1
Costa, E1
Guidotti, A1
Miachon, S1
Cespuglio, R1
Barfod, S1
Wendelboe, J1
Krsiak, M1
Sulcova, A1
Rodgers, RJ1
Randall, JI1
Smeraski, PJ1
Keats, MM1
Mukherjee, S1
Binder, RL1
Edwards, VE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Redictive Risk Factors of Conversion Into Idiopathic RBD. Italian Study [FAttori di Rischio PREdittivi di Conversione Nell'RBD Idiopatico. STudio ItalianO[NCT05262543]300 participants (Anticipated)Observational2020-05-25Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

15 other studies available for clonazepam and Aggression

ArticleYear
Paradoxical reaction to benzodiazepines in elderly - Case series.
    Asian journal of psychiatry, 2018, Volume: 35

    Topics: Aged; Aggression; Benzodiazepines; Clonazepam; GABA Modulators; Humans; Lorazepam; Male; Psychomotor

2018
A prospective, naturalistic follow-up study of treatment outcomes with clonazepam in rapid eye movement sleep behavior disorder.
    Sleep medicine, 2016, Volume: 21

    Topics: Aged; Aggression; Clonazepam; Dreams; Female; Follow-Up Studies; GABA Modulators; Humans; Male; Poly

2016
Brief report: clonazepam behavioral side effects with an individual with mental retardation.
    Journal of autism and developmental disorders, 2003, Volume: 33, Issue:3

    Topics: Aggression; Anticonvulsants; Clonazepam; Humans; Intellectual Disability; Male; Mental Disorders; Mi

2003
Clinical case presentation: therapeutic challenges in adolescent-onset bipolar disorder.
    Journal of child and adolescent psychopharmacology, 2003,Winter, Volume: 13, Issue:4

    Topics: Adolescent; Aggression; Anti-Anxiety Agents; Antimanic Agents; Antipsychotic Agents; Bipolar Disorde

2003
Aggressive dream content without daytime aggressiveness in REM sleep behavior disorder.
    Neurology, 2005, Oct-11, Volume: 65, Issue:7

    Topics: Aged; Aggression; Brain Stem; Circadian Rhythm; Clonazepam; Dreams; Female; GABA Modulators; Humans;

2005
[Use of benzodiazepines in swine].
    Berliner und Munchener tierarztliche Wochenschrift, 1982, Apr-15, Volume: 95, Issue:8

    Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Chemical Phenomena; Chemistry; Clonazepam

1982
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2

    Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal;

1993
Prevention of ACTH- and adrenalectomy-induced muricidal behavior: by benzodiazepinic ligands.
    Peptides, 1997, Volume: 18, Issue:2

    Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aggression; Animals; Benzodiazepinones; Clonazepam; Flum

1997
[Severe psychiatric side effects of clonazepam treatment. 2 cases].
    Ugeskrift for laeger, 1977, Oct-10, Volume: 139, Issue:41

    Topics: Adolescent; Aggression; Akathisia, Drug-Induced; Benzodiazepinones; Child, Preschool; Clonazepam; Fe

1977
Differential effects of six structurally related benzodiazepines on some ethological measures of timidity, aggression and locomotion in mice.
    Psychopharmacology, 1990, Volume: 101, Issue:3

    Topics: Aggression; Alprazolam; Animals; Anti-Anxiety Agents; Behavior, Animal; Clonazepam; Lorazepam; Male;

1990
Blockade of non-opioid analgesia in intruder mice by selective neuronal and non-neuronal benzodiazepine recognition site ligands.
    Psychopharmacology, 1988, Volume: 96, Issue:1

    Topics: Aggression; Analgesia; Animals; Benzodiazepinones; Clonazepam; Convulsants; Isoquinolines; Ligands;

1988
Clonazepam treatment of multi-infarct dementia.
    Journal of geriatric psychiatry and neurology, 1988, Volume: 1, Issue:1

    Topics: Aged; Aggression; Clonazepam; Dementia, Multi-Infarct; Drug Therapy, Combination; Humans; Male; Psyc

1988
Antiaggressive effect of adjunctive clonazepam in schizophrenia associated with seizure disorder.
    The Journal of clinical psychiatry, 1988, Volume: 49, Issue:3

    Topics: Adult; Aggression; Clonazepam; Drug Therapy, Combination; Electroconvulsive Therapy; Epilepsy, Tempo

1988
Three case reports of behavioral disinhibition with clonazepam.
    General hospital psychiatry, 1987, Volume: 9, Issue:2

    Topics: Adult; Aggression; Bipolar Disorder; Clonazepam; Humans; Inhibition, Psychological; Male

1987
Side effects of clonazepam therapy.
    Proceedings of the Australian Association of Neurologists, 1974, Volume: 11

    Topics: Adolescent; Adult; Aggression; Ataxia; Benzodiazepinones; Clonazepam; Drug Interactions; Epilepsy; E

1974