clonazepam has been researched along with Acute Post-Traumatic Stress Disorder in 8 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Phase 1 was a 6-week lead-in with open-label sertraline flexibly dosed to 100 mg (or escitalopram equivalent) to prospectively define treatment refractoriness (lack of remission)." | 2.74 | Next-step strategies for panic disorder refractory to initial pharmacotherapy: a 3-phase randomized clinical trial. ( Hoge, EA; Lebeau, RT; Moshier, SJ; Otto, MW; Pollack, MH; Simon, NM; Thompson, EH; Worthington, JJ; Zalta, AK, 2009) |
| "Clonazepam therapy was largely ineffective in improving sleep disturbances, particularly nightmares, associated with combat-related PTSD." | 2.71 | Clonazepam for treatment of sleep disturbances associated with combat-related posttraumatic stress disorder. ( Bishop, MH; Cates, ME; Davis, LL; Lowe, JS; Woolley, TW, 2004) |
| "The primary outcome was change in total PTSD symptom severity." | 2.46 | Combined pharmacotherapy and psychological therapies for post traumatic stress disorder (PTSD). ( Garner, B; Hetrick, SE; Parslow, R; Purcell, R, 2010) |
| "One patient died of pulmonary edema and subsequent heart failure, but the rest of the patients recovered without any sequelae." | 1.34 | Hemoperfusion in the treatment of acute clozapine intoxication in China. ( Cai, ZJ; He, JL; Li, WB; Ungvari, GS; Xiang, YT, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Simon, NM | 1 |
| Otto, MW | 1 |
| Worthington, JJ | 1 |
| Hoge, EA | 1 |
| Thompson, EH | 1 |
| Lebeau, RT | 1 |
| Moshier, SJ | 1 |
| Zalta, AK | 1 |
| Pollack, MH | 1 |
| Hetrick, SE | 1 |
| Purcell, R | 1 |
| Garner, B | 1 |
| Parslow, R | 1 |
| Cates, ME | 1 |
| Bishop, MH | 1 |
| Davis, LL | 1 |
| Lowe, JS | 1 |
| Woolley, TW | 1 |
| Connor, KM | 1 |
| Vaishnavi, S | 1 |
| Davidson, JR | 1 |
| Sheehan, DV | 1 |
| Sheehan, KH | 1 |
| He, JL | 1 |
| Xiang, YT | 1 |
| Li, WB | 1 |
| Cai, ZJ | 1 |
| Ungvari, GS | 1 |
| Gelpin, E | 1 |
| Bonne, O | 1 |
| Peri, T | 1 |
| Brandes, D | 1 |
| Shalev, AY | 2 |
| Rogel-Fuchs, Y | 1 |
| Patterson, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment Refractory Panic Disorder[NCT00118417] | Phase 2/Phase 3 | 46 participants (Actual) | Interventional | 1999-03-31 | Completed | ||
| Early Pharmacological Intervention With Diazepam in the Emergency Room Setting to Prevent Posttraumatic Stress Disorder (PTSD).[NCT01221883] | Phase 4 | 40 participants (Anticipated) | Interventional | 2013-05-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
This measure is the change in points between baseline and endpoint scores on the Panic Disorder Severity Scale (PDSS). The PDSS is a 7-item scale with each item rated from 0 (none) to 4 (extreme), for a total score range of 0 to 28 points, and an established interrater reliability of 0.87. (NCT00118417)
Timeframe: Measured at baseline and after Phase 1 (6 weeks)
| Intervention | Points on a scale (Mean) |
|---|---|
| Moderate Sertraline Treatment | 4.3 |
This measure is the change in points between baseline and endpoint scores on the Panic Disorder Severity Scale (PDSS). The PDSS is a 7-item scale with each item rated from 0 (none) to 4 (extreme), for a total score range of 0 to 28 points, and an established interrater reliability of 0.87. (NCT00118417)
Timeframe: Measured after Phase 1 (Week 6) and Phase 2 (Week 12)
| Intervention | Points on a scale (Mean) |
|---|---|
| Increased Sertraline | 2.36 |
| Sertraline Plus Placebo | 2.31 |
This measure is the change in points between baseline and endpoint scores on the Panic Disorder Severity Scale (PDSS). The PDSS is a 7-item scale with each item rated from 0 (none) to 4 (extreme), for a total score range of 0 to 28 points, and an established interrater reliability of 0.87. (NCT00118417)
Timeframe: Measured after Phase 2 (Week 12) and Phase 3 (Week 24)
| Intervention | Points on a scale (Mean) |
|---|---|
| Medication Optimization | 3.78 |
| Augmented Cognitive Behavior Therapy | 2.9 |
1 review available for clonazepam and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Combined pharmacotherapy and psychological therapies for post traumatic stress disorder (PTSD).
Topics: Adolescent; Adult; Child; Child Abuse, Sexual; Clonazepam; Cognitive Behavioral Therapy; Combined Mo | 2010 |
3 trials available for clonazepam and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Next-step strategies for panic disorder refractory to initial pharmacotherapy: a 3-phase randomized clinical trial.
Topics: Adult; Anticonvulsants; Citalopram; Clonazepam; Cognitive Behavioral Therapy; Combined Modality Ther | 2009 |
Clonazepam for treatment of sleep disturbances associated with combat-related posttraumatic stress disorder.
Topics: Adult; Aged; Clonazepam; Combat Disorders; Cross-Over Studies; Dreams; Humans; Hypnotics and Sedativ | 2004 |
Treatment of recent trauma survivors with benzodiazepines: a prospective study.
Topics: Alprazolam; Anxiety Disorders; Arousal; Benzodiazepines; Clonazepam; Follow-Up Studies; Heart Rate; | 1996 |
4 other studies available for clonazepam and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Perceived stress in anxiety disorders and the general population: a study of the Sheehan stress vulnerability scale.
Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Clonazepam; Cross-Sectional Studies; Female; F | 2007 |
Hemoperfusion in the treatment of acute clozapine intoxication in China.
Topics: Acute Disease; Adult; Alprazolam; Antipsychotic Agents; China; Clonazepam; Clozapine; Depressive Dis | 2007 |
Auditory startle reflex in post-traumatic stress disorder patients treated with clonazepam.
Topics: Adult; Arousal; Auditory Perception; Clonazepam; Female; Habituation, Psychophysiologic; Humans; Mal | 1992 |
Withdrawal from alprazolam dependency using clonazepam: clinical observations.
Topics: Alprazolam; Ambulatory Care; Clonazepam; Hospitalization; Humans; Male; Middle Aged; Stress Disorder | 1990 |