clomipramine has been researched along with Substance Withdrawal Syndrome in 37 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the need for maintenance drug therapy in patients with obsessive-compulsive disorder, the authors assessed 21 patients with obsessive-compulsive disorder who manifested sustained improvement during 5 to 27 months of clomipramine treatment and who agreed to participate in a double-blind discontinuation study." | 9.06 | Return of symptoms after discontinuation of clomipramine in patients with obsessive-compulsive disorder. ( Murphy, DL; Pato, MT; Zohar, J; Zohar-Kadouch, R, 1988) |
| "To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen." | 7.71 | Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine. ( Dewan, V; Zerjav-Lacombe, S, 2001) |
| "Clinical examinations, questionnaires, and 24- or 36-hour polygraphic recordings were performed on 21 adult patients with the narcolepsy syndrome to investigate the short- and long-term effects of clomipramine HCL." | 7.65 | Evaluation of short-term and long-term treatment of the narcolepsy syndrome with clomipramine hydrochloride. ( Carskadon, M; Dement, W; Guilleminault, C; Raynal, D; Takahashi, S, 1976) |
| "To evaluate the need for maintenance drug therapy in patients with obsessive-compulsive disorder, the authors assessed 21 patients with obsessive-compulsive disorder who manifested sustained improvement during 5 to 27 months of clomipramine treatment and who agreed to participate in a double-blind discontinuation study." | 5.06 | Return of symptoms after discontinuation of clomipramine in patients with obsessive-compulsive disorder. ( Murphy, DL; Pato, MT; Zohar, J; Zohar-Kadouch, R, 1988) |
| "To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen." | 3.71 | Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine. ( Dewan, V; Zerjav-Lacombe, S, 2001) |
| "Fluvoxamine 25-200 mg daily and clomipramine 25-200 mg daily were given for separate three week periods to 18 subjects with narcolepsy and cataplexy." | 3.66 | Fluvoxamine and clomipramine in the treatment of cataplexy. ( Parkes, JD; Schachter, M, 1980) |
| "Clinical examinations, questionnaires, and 24- or 36-hour polygraphic recordings were performed on 21 adult patients with the narcolepsy syndrome to investigate the short- and long-term effects of clomipramine HCL." | 3.65 | Evaluation of short-term and long-term treatment of the narcolepsy syndrome with clomipramine hydrochloride. ( Carskadon, M; Dement, W; Guilleminault, C; Raynal, D; Takahashi, S, 1976) |
| "Alternatively, tricyclic antidepressant withdrawal symptoms often respond to anticholinergics, such as atropine or benztropine mesylate." | 2.40 | Antidepressant withdrawal reactions. ( Wolfe, RM, 1997) |
| "The observed withdrawal symptoms were too short a period of sleep after feeding (6), poor feeding (3), mild to severe tremors (6), hyperactive Moro reflex (3) and respiratory rate >60 breaths min(-1)." | 1.38 | Clomipramine concentration and withdrawal symptoms in 10 neonates. ( De Jong-van den Berg, LT; den Boon, J; Jansman, FG; Smit, JP; ter Horst, PG; van der Linde, S; van Lingen, RA; Wilffert, B, 2012) |
| "Clomipramine was increased to 60 mg/day, and her symptoms subsided." | 1.35 | Symptoms of delusion: the effects of discontinuation of low-dose venlafaxine. ( Kodaka, F; Koga, M; Miyata, H; Nakayama, K, 2009) |
| "A boy with autistic disorder and severe mental retardation developed severe dyskinesias, including objective akathisia (probable) and tics, a month after discontinuation of at least two years of treatment with drugs block dopamine receptors." | 1.30 | Dyskinesias subside off all medication in a boy with autistic disorder and severe mental retardation. ( Ahmad, R; Ahn, SC; Aisemberg, P; Barnett, JY; Brasić, JR; Kaplan, D; Mendonça, Mde F; Nadrich, RH, 1997) |
| "We studied reported withdrawal symptoms in a retrospective chart review of 352 patients treated in an outpatient clinic with the nonselective serotonin reuptake inhibitor clomipramine or with one of the selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine, or sertraline." | 1.29 | Serotonin reuptake inhibitor withdrawal. ( Bell, CJ; Coupland, NJ; Potokar, JP, 1996) |
| "2 patients with withdrawal symptoms following discontinuation of clomipramine are presented." | 1.28 | [Withdrawal reactions after clomipramine]. ( Aizenberg, D; Hermesh, H; Weizman, A; Zemishlany, Z, 1992) |
| " A tapering schedule was carried out during a 12-day stay in the hospital in which the diazepam dosage was reduced by a fixed quantity every day, corresponding to about ten percent of the initial dosage." | 1.28 | Panic attacks and major depression after discontinuation of long-term diazepam abuse. ( Magni, G; Schifano, F, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (54.05) | 18.7374 |
| 1990's | 9 (24.32) | 18.2507 |
| 2000's | 6 (16.22) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fullam, S | 1 |
| Scott, A | 1 |
| Garvey, JF | 1 |
| Koga, M | 1 |
| Kodaka, F | 1 |
| Miyata, H | 1 |
| Nakayama, K | 1 |
| ter Horst, PG | 1 |
| van der Linde, S | 1 |
| Smit, JP | 1 |
| den Boon, J | 1 |
| van Lingen, RA | 1 |
| Jansman, FG | 1 |
| De Jong-van den Berg, LT | 1 |
| Wilffert, B | 1 |
| Wu, CC | 1 |
| Chen, JY | 1 |
| Tao, PL | 1 |
| Chen, YA | 1 |
| Yeh, GC | 1 |
| Marchesi, C | 1 |
| Tonna, M | 1 |
| Maggini, C | 1 |
| Taylor, DA | 4 |
| Fennessy, MR | 4 |
| Telch, MJ | 1 |
| Tearnan, BH | 1 |
| Taylor, CB | 1 |
| Verberne, AJ | 2 |
| Schachter, M | 1 |
| Parkes, JD | 1 |
| Cowe, L | 1 |
| Lloyd, DJ | 1 |
| Dawling, S | 1 |
| Borg, V | 1 |
| Lee, RL | 1 |
| Spencer, PS | 1 |
| Stolz, JF | 1 |
| Marsden, CA | 1 |
| Serfaty, MA | 1 |
| McCluskey, S | 1 |
| Eccleston, D | 1 |
| Bromiker, R | 1 |
| Kaplan, M | 1 |
| Coupland, NJ | 1 |
| Bell, CJ | 1 |
| Potokar, JP | 1 |
| Wolfe, RM | 1 |
| Brasić, JR | 1 |
| Barnett, JY | 1 |
| Aisemberg, P | 1 |
| Ahn, SC | 1 |
| Nadrich, RH | 1 |
| Kaplan, D | 1 |
| Ahmad, R | 1 |
| Mendonça, Mde F | 1 |
| Benazzi, F | 1 |
| Voirol, P | 1 |
| Rubin, C | 1 |
| Bryois, C | 1 |
| Kosel, M | 1 |
| Buclin, T | 1 |
| Baumann, P | 1 |
| Bloem, BR | 1 |
| Lammers, GJ | 1 |
| Roofthooft, DW | 1 |
| De Beaufort, AJ | 1 |
| Brouwer, OF | 1 |
| Zerjav-Lacombe, S | 1 |
| Dewan, V | 1 |
| Duggal, HS | 1 |
| Dutta, S | 1 |
| Sinha, VK | 1 |
| Isbister, GK | 1 |
| Dawson, A | 1 |
| Whyte, IM | 1 |
| Whtye, IM | 1 |
| Musa, AB | 1 |
| Smith, CS | 1 |
| Robinson, ML | 1 |
| Kraft, TB | 1 |
| Guilleminault, C | 1 |
| Raynal, D | 1 |
| Takahashi, S | 1 |
| Carskadon, M | 1 |
| Dement, W | 1 |
| Zemishlany, Z | 1 |
| Aizenberg, D | 1 |
| Hermesh, H | 1 |
| Weizman, A | 1 |
| Van Sweden, B | 1 |
| Schifano, F | 1 |
| Magni, G | 1 |
| Diamond, BI | 1 |
| Borison, RL | 1 |
| Katz, R | 1 |
| DeVeaugh-Geiss, J | 1 |
| Pato, MT | 1 |
| Zohar-Kadouch, R | 1 |
| Zohar, J | 1 |
| Murphy, DL | 1 |
| Morstyn, R | 1 |
| Jouvent, R | 1 |
| Baruch, P | 1 |
| Simon, P | 1 |
2 reviews available for clomipramine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Antidepressant medication in the treatment of agoraphobia: a critical review.
Topics: Agoraphobia; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior Therapy; Clomipramine | 1983 |
Antidepressant withdrawal reactions.
Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clomipramine; Cyclohe | 1997 |
4 trials available for clomipramine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
[Clinical trial of Tegretol and Anafranil/Sinequan in alcohol abstinence symptoms].
Topics: Alcoholism; Carbamazepine; Clinical Trials as Topic; Clomipramine; Depression; Double-Blind Method; | 1980 |
Pharmacokinetic consequences of a citalopram treatment discontinuation.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Citalopram; Clomipramine; Female; | 1999 |
Rebound withdrawal reactions due to clomipramine.
Topics: Adult; Aged; Clomipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Obsessive-Compuls | 1989 |
Return of symptoms after discontinuation of clomipramine in patients with obsessive-compulsive disorder.
Topics: Adult; Clinical Trials as Topic; Clomipramine; Combined Modality Therapy; Double-Blind Method; Femal | 1988 |
31 other studies available for clomipramine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Status Cataplecticus Following Abrupt Withdrawal of Clomipramine
Topics: Adult; Cataplexy; Clomipramine; Humans; Male; Narcolepsy; Orexins; Selective Serotonin Reuptake Inhi | 2019 |
Symptoms of delusion: the effects of discontinuation of low-dose venlafaxine.
Topics: Adult; Clomipramine; Cyclohexanols; Delusions; Depressive Disorder, Major; Dose-Response Relationshi | 2009 |
Clomipramine concentration and withdrawal symptoms in 10 neonates.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Female; Half-Life; Human | 2012 |
Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine.
Topics: Animals; Animals, Newborn; Behavior, Animal; Citalopram; Clomipramine; Female; Fluoxetine; Maternal- | 2005 |
Obsessive-compulsive disorder followed by psychotic episode in long-term ecstasy misuse.
Topics: Adolescent; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Antipsychotic Agents; B | 2009 |
Time-course of the effects of chronic delta 9-tetrahydrocannabinol on behaviour, body temperature, brain amines and withdrawal-like behaviour in the rat.
Topics: Animals; Behavior, Animal; Biogenic Amines; Body Temperature; Brain Chemistry; Clomipramine; Dronabi | 1982 |
Withdrawal-like behaviour induced by inhibitors of biogenic amine reuptake in rats treated chronically with delta 9-tetrahydrocannabinol.
Topics: Animals; Biogenic Amines; Body Weight; Clomipramine; Dronabinol; Eating; Fluoxetine; Humans; Imipram | 1980 |
Attenuation of delta 9-tetrahydrocannabinol-induced withdrawal-like behaviour by delta 9-tetrahydrocannabinol.
Topics: Animals; Behavior, Animal; Clomipramine; Dronabinol; Humans; Male; Rats; Substance Withdrawal Syndro | 1981 |
Fluvoxamine and clomipramine in the treatment of cataplexy.
Topics: Adult; Aged; Cataplexy; Clomipramine; Dose-Response Relationship, Drug; Female; Fluvoxamine; Humans; | 1980 |
Neonatal convulsions caused by withdrawal from maternal clomipramine.
Topics: Adult; Clomipramine; Depressive Disorder; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases | 1982 |
Effect of tricyclic antidepressants on analgesic activity in laboratory animals.
Topics: Analgesia; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Drug Interactions; Drug Toleranc | 1980 |
Withdrawal from chronic treatment with metergoline, dl-propranolol and amitriptyline enhances serotonin receptor mediated behaviour in the rat.
Topics: Amitriptyline; Animals; Behavior, Animal; Clomipramine; Ergolines; Humans; Iprindole; Male; Metergol | 1982 |
Extreme suicidality following serotonin syndrome.
Topics: Adolescent; Antidepressive Agents; Clomipramine; Depressive Disorder; Dothiepin; Drug Administration | 1995 |
Apparent intrauterine fetal withdrawal from clomipramine hydrochloride.
Topics: Clomipramine; Female; Fetal Diseases; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Complicati | 1994 |
Serotonin reuptake inhibitor withdrawal.
Topics: 1-Naphthylamine; Adolescent; Adult; Age Factors; Clomipramine; Dizziness; Female; Fluvoxamine; Human | 1996 |
Dyskinesias subside off all medication in a boy with autistic disorder and severe mental retardation.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Autistic Disorder; Child; Clomipramine; Dopamine Anta | 1997 |
Fluoxetine for clomipramine withdrawal symptoms.
Topics: Adult; Clomipramine; Comorbidity; Depressive Disorder; Fluoxetine; Humans; Male; Panic Disorder; Sub | 1999 |
Clomipramine withdrawal in newborns.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Female; Humans; Infant, Newborn; Myoclonus; P | 1999 |
Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine.
Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Clomipramine; Clozapine; Humans; Male | 2001 |
Clomipramine discontinuation-emergent dystonia.
Topics: Acute Disease; Adult; Antidepressive Agents, Tricyclic; Clomipramine; Dystonic Disorders; Humans; Ma | 2001 |
Comment: serotonin syndrome and 5-HT2A antagonism.
Topics: Animals; Clomipramine; Clozapine; Humans; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Selecti | 2001 |
"Antagonist"-precipitated withdrawal in the rat after chronic delta9-tetrahydrocannabinol treatment.
Topics: Animals; Behavior, Animal; Body Temperature; Clomipramine; Dibenzazepines; Dronabinol; Feeding Behav | 1978 |
Neonatal effects of maternal clomipramine therapy.
Topics: Clomipramine; Dibenzazepines; Female; Humans; Hypothermia; Infant, Newborn; Infant, Newborn, Disease | 1979 |
Epileptic fit after clomipramine.
Topics: Aged; Clomipramine; Dibenzazepines; Female; Humans; Seizures; Substance Withdrawal Syndrome | 1978 |
[Severe withdrawal symptoms following use of clomipramine].
Topics: Clomipramine; Dibenzazepines; Female; Humans; Substance Withdrawal Syndrome | 1977 |
Evaluation of short-term and long-term treatment of the narcolepsy syndrome with clomipramine hydrochloride.
Topics: Adult; Cataplexy; Clomipramine; Dibenzazepines; Drug Evaluation; Female; Humans; Male; Methysergide; | 1976 |
[Withdrawal reactions after clomipramine].
Topics: Anxiety; Clomipramine; Fatigue; Female; Headache; Humans; Male; Middle Aged; Sleep Initiation and Ma | 1992 |
Rebound antidepressant cardiac arrhythmia.
Topics: Cardiac Complexes, Premature; Clomipramine; Depressive Disorder; Electrocardiography; Female; Humans | 1988 |
Panic attacks and major depression after discontinuation of long-term diazepam abuse.
Topics: Adult; Anxiety; Clomipramine; Depressive Disorder; Diazepam; Fear; Female; Humans; Panic; Substance | 1989 |
Clomipramine in obsessional disorders: a cautionary tale.
Topics: Adult; Clomipramine; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Humans; Ob | 1988 |
Manic episode after propranolol withdrawal.
Topics: Bipolar Disorder; Clomipramine; Depressive Disorder; Female; Humans; Middle Aged; Propranolol; Subst | 1986 |