clomipramine has been researched along with Sleep Wake Disorders in 15 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to establish if there are differences in the 24-hour melatonin secretion profile between patients with major depression (before, and after treatment with clomipramine) compared to those in healthy subjects." | 7.71 | Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment. ( Karasek, M; Rabe-Jablonska, J; Szymanska, A, 2001) |
| "The aim of the study was to establish if there are differences in the 24-hour melatonin secretion profile between patients with major depression (before, and after treatment with clomipramine) compared to those in healthy subjects." | 3.71 | Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment. ( Karasek, M; Rabe-Jablonska, J; Szymanska, A, 2001) |
| "Clomipramine was prescribed to three patients who all reported immediate relief of symptoms." | 1.28 | The exploding head syndrome: polysomnographic recordings and therapeutic suggestions. ( Sachs, C; Svanborg, E, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lagus, M | 2 |
| Gass, N | 2 |
| Saharinen, J | 2 |
| Saarela, J | 1 |
| Porkka-Heiskanen, T | 2 |
| Paunio, T | 2 |
| McDowell, AL | 1 |
| Strohl, KP | 1 |
| Feng, P | 1 |
| Savelyev, S | 1 |
| Mavanji, V | 1 |
| Datta, S | 1 |
| Leckman, JF | 1 |
| Gillin, JC | 1 |
| Sitaram, N | 1 |
| Duncan, W | 1 |
| Wyatt, RJ | 1 |
| Follenius, M | 1 |
| Spiegel, K | 1 |
| Gronfier, C | 1 |
| Saini, J | 1 |
| Brandenberger, G | 1 |
| Nofzinger, EA | 1 |
| Reynolds, CF | 1 |
| Szymanska, A | 1 |
| Rabe-Jablonska, J | 1 |
| Karasek, M | 1 |
| Kaplan, R | 1 |
| Beersma, DG | 1 |
| van den Hoofdakker, RH | 1 |
| Smeyatsky, N | 1 |
| Baldwin, D | 1 |
| Botros, W | 1 |
| Gura, R | 1 |
| Kurian, T | 1 |
| Lambert, MT | 1 |
| Patel, AG | 1 |
| Steinert, J | 1 |
| Priest, RG | 1 |
| Sachs, C | 1 |
| Svanborg, E | 1 |
| Vogel, G | 1 |
| Neill, D | 1 |
| Kors, D | 1 |
| Hagler, M | 1 |
| Wurthmann, C | 1 |
| Hartung, HP | 1 |
| Dengler, W | 1 |
| Gerhardt, P | 1 |
| Myers, BA | 1 |
| Klerman, GL | 1 |
| Hartmann, E | 1 |
1 review available for clomipramine and Sleep Wake Disorders
| Article | Year |
|---|---|
The treatment of sleep disorders.
Topics: Adult; Amphetamines; Analgesics; Benzodiazepines; Child; Clomipramine; Diet, Reducing; Electroenceph | 1992 |
1 trial available for clomipramine and Sleep Wake Disorders
| Article | Year |
|---|---|
Clomipramine-induced sleep disturbance does not impair its prolactin-releasing action.
Topics: Administration, Oral; Adult; Circadian Rhythm; Clomipramine; Dose-Response Relationship, Drug; Human | 1994 |
13 other studies available for clomipramine and Sleep Wake Disorders
| Article | Year |
|---|---|
Gene expression patterns in a rodent model for depression.
Topics: Animals; Clomipramine; Depressive Disorder; Disease Models, Animal; Female; Gene Expression; Male; O | 2010 |
Sleep-related epilepsy in a Long-Evans hooded rat model of depression.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Dise | 2012 |
Inter-tissue networks between the basal forebrain, hippocampus, and prefrontal cortex in a model for depression caused by disturbed sleep.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Disease Model | 2012 |
Sleep-wake effects of yohimbine and atropine in rats with a clomipramine-based model of depression.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Aggression; Animals; Animals, Newborn; Antidepressive Agen | 2002 |
Intravenous chlorimipramine affects REM cycle in patients with excessive daytime sleepiness and control subjects.
Topics: Adult; Clomipramine; Electroencephalography; Female; Humans; Injections, Intravenous; Male; Sleep Wa | 1980 |
REM sleep behavior disorder.
Topics: Adult; Clomipramine; Female; Humans; Obsessive-Compulsive Disorder; Panic Disorder; Sleep Wake Disor | 1994 |
Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment.
Topics: Adult; Affect; Antidepressive Agents; Circadian Rhythm; Clomipramine; Depression; Female; Humans; Ma | 2001 |
The perils of fragmented sleep.
Topics: Adult; Clomipramine; Female; Humans; Nasal Obstruction; Panic Disorder; Sleep Wake Disorders | 1992 |
Can non-REM sleep be depressogenic?
Topics: Antidepressive Agents, Tricyclic; Benzodiazepines; Clomipramine; Depressive Disorder; Electroencepha | 1992 |
The exploding head syndrome: polysomnographic recordings and therapeutic suggestions.
Topics: Adult; Aged; Arousal; Auditory Perception; Cerebral Cortex; Clomipramine; Electroencephalography; Fe | 1991 |
REM sleep abnormalities in a new animal model of endogenous depression.
Topics: Animals; Clomipramine; Depressive Disorder; Disease Models, Animal; Male; Rats; Rats, Inbred Strains | 1990 |
[Kleine-Levin syndrome. The provocation of manic symptoms by an antidepressant and a therapeutic trial of carbamazepine].
Topics: Adolescent; Bipolar Disorder; Carbamazepine; Clomipramine; Disorders of Excessive Somnolence; Drug E | 1989 |
Nocturnal cataclysms with myoclonus: a new side effect of clomipramine.
Topics: Clomipramine; Depressive Disorder; Female; Humans; Middle Aged; Myoclonus; Sleep Wake Disorders | 1986 |