clomipramine has been researched along with Sex Disorders in 25 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-six patients with obsessive-compulsive disorder undergoing a double-blind controlled study of clomipramine and placebo were interviewed to assess changes in sexual function." | 9.06 | Anorgasmia from clomipramine in obsessive-compulsive disorder. A controlled trial. ( Lelliott, PT; Marks, IM; Monteiro, WO; Noshirvani, HF, 1987) |
| "In this study, 12 fully remitted panic disorder patients, complaining of severe clomipramine-induced ejaculatory delay, were randomly assigned to either bethanecol chloride tablets (20 mg, as needed) or placebo in a randomized, double-blind, placebo-controlled, two-period crossover study." | 5.11 | Bethanecol chloride for treatment of clomipramine-induced orgasmic dysfunction in males. ( Bernik, M; Nunes, PV; Vieira, AH, 2004) |
| "Differences between the side effect profiles of clomipramine (CMI) and the selective serotonin reuptake inhibitors may be important factors in both treatment outcome and patient selection in obsessive-compulsive disorder (OCD)." | 5.09 | Side effects as predictors of drug response in obsessive-compulsive disorder. ( Ackerman, DL; Bystritsky, A; Greenland, S, 1999) |
| "Forty-six patients with obsessive-compulsive disorder undergoing a double-blind controlled study of clomipramine and placebo were interviewed to assess changes in sexual function." | 5.06 | Anorgasmia from clomipramine in obsessive-compulsive disorder. A controlled trial. ( Lelliott, PT; Marks, IM; Monteiro, WO; Noshirvani, HF, 1987) |
| "Paroxetine was superior to the pause-squeeze technique in terms of efficacy (P < 0." | 2.70 | Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation. ( Abdel-Hamid, IA; El Gilany, AH; El Naggar, EA, 2001) |
| "Treatment with sertraline was nearly as effective and had a lower incidence of side effects." | 2.69 | Efficacy and safety of fluoxetine, sertraline and clomipramine in patients with premature ejaculation: a double-blind, placebo controlled study. ( Kim, SC; Seo, KK, 1998) |
| " Among studies that provided comprehensive adverse event data, safety and tolerability observations in men with PE were generally similar to those observed in other populations; however, with the exception of dapoxetine, known SSRI-class effects (e." | 2.47 | Oral agents for the treatment of premature ejaculation: review of efficacy and safety in the context of the recent International Society for Sexual Medicine criteria for lifelong premature ejaculation. ( McMahon, CG; Porst, H, 2011) |
| "There was a dose-response effect on ejaculatory latency with increasing levels of clomipramine; 30 mg increased the latency from 25 s to 220 s, a clinically significant increase." | 1.31 | Effective daily treatment with clomipramine in men with premature ejaculation when 25 mg (as required) is ineffective. ( De Gouveia Brazao, CA; Koos Slob, A; Rowland, DL, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (28.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 11 (44.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yildirim, EA | 1 |
| Hacioglu Yildirim, M | 1 |
| Carpar, E | 1 |
| Sarac, I | 1 |
| Zargooshi, J | 1 |
| Birowo, P | 1 |
| Uckert, S | 1 |
| Kedia, GT | 1 |
| Scheller, F | 1 |
| Meyer, M | 1 |
| Taher, A | 1 |
| Rahardjo, D | 1 |
| Jonas, U | 1 |
| Kuczyk, MA | 1 |
| McMahon, CG | 2 |
| Porst, H | 1 |
| Waldinger, MD | 2 |
| Zwinderman, AH | 2 |
| Schweitzer, DH | 2 |
| Olivier, B | 2 |
| Rowland, DL | 2 |
| Tai, WL | 1 |
| Brummett, K | 1 |
| Slob, AK | 1 |
| Bernik, M | 1 |
| Vieira, AH | 1 |
| Nunes, PV | 1 |
| Schuster, TG | 1 |
| Gurkan, L | 1 |
| Oommen, M | 1 |
| Hellstrom, WJ | 1 |
| Mercado, MG | 1 |
| Kimmer, SL | 1 |
| Holman, JR | 1 |
| Wanserski, G | 1 |
| Lo, V | 1 |
| Klug, B | 1 |
| Harrison, W | 1 |
| Stewart, J | 1 |
| McGrath, PJ | 1 |
| Quitkin, F | 1 |
| Goodman, RE | 1 |
| Evanoff, A | 1 |
| Newton, WP | 1 |
| Kim, SC | 1 |
| Seo, KK | 1 |
| Hsieh, JT | 1 |
| Chang, HC | 1 |
| Law, HS | 1 |
| Hsieh, CH | 1 |
| Cheng, JT | 1 |
| Ackerman, DL | 1 |
| Greenland, S | 1 |
| Bystritsky, A | 1 |
| Samali, R | 1 |
| De Gouveia Brazao, CA | 1 |
| Koos Slob, A | 1 |
| Abdel-Hamid, IA | 1 |
| El Naggar, EA | 1 |
| El Gilany, AH | 1 |
| Beaumont, G | 1 |
| Monteiro, WO | 1 |
| Noshirvani, HF | 1 |
| Marks, IM | 1 |
| Lelliott, PT | 1 |
| Murphy, M | 1 |
| Riley, AJ | 1 |
| Riley, EJ | 1 |
5 reviews available for clomipramine and Sex Disorders
| Article | Year |
|---|---|
Oral agents for the treatment of premature ejaculation: review of efficacy and safety in the context of the recent International Society for Sexual Medicine criteria for lifelong premature ejaculation.
Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Benzylamines; Clomipramine; Drug Ther | 2011 |
Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Dose-Response Relationship, Drug; Double-Blin | 2004 |
Premature ejaculation.
Topics: Adrenergic alpha-Antagonists; Antidepressive Agents, Tricyclic; Clomipramine; Diagnosis, Differentia | 2006 |
Premature ejaculation: current and future treatments.
Topics: Anesthetics, Local; Behavior Therapy; Clomipramine; Ejaculation; Humans; Lidocaine; Male; Prilocaine | 2008 |
Pharmacological treatment of premature ejaculation.
Topics: Antidepressive Agents, Tricyclic; Clomipramine; Ejaculation; Fluoxetine; Humans; Male; Paroxetine; R | 1999 |
7 trials available for clomipramine and Sex Disorders
| Article | Year |
|---|---|
Predicting responsiveness to the treatment of rapid ejaculation with 25 mg clomipramine as needed.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Double-Blind Method; Ejaculation; Erectile Dy | 2004 |
Bethanecol chloride for treatment of clomipramine-induced orgasmic dysfunction in males.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Bethanechol; Clomipramine; Cross-Over Stu | 2004 |
An assessment of clomipramine (Anafranil) in the treatment of premature ejaculation.
Topics: Adult; Clomipramine; Double-Blind Method; Ejaculation; Female; Follow-Up Studies; Humans; Male; Midd | 1980 |
Efficacy and safety of fluoxetine, sertraline and clomipramine in patients with premature ejaculation: a double-blind, placebo controlled study.
Topics: 1-Naphthylamine; Adult; Antidepressive Agents, Tricyclic; Clomipramine; Double-Blind Method; Ejacula | 1998 |
Side effects as predictors of drug response in obsessive-compulsive disorder.
Topics: Adolescent; Adult; Anxiety; Clomipramine; Dose-Response Relationship, Drug; Ejaculation; Female; Flu | 1999 |
Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation.
Topics: Adult; Antidepressive Agents; Clomipramine; Double-Blind Method; Ejaculation; Humans; Male; Middle A | 2001 |
Anorgasmia from clomipramine in obsessive-compulsive disorder. A controlled trial.
Topics: Clinical Trials as Topic; Clomipramine; Humans; Obsessive-Compulsive Disorder; Orgasm; Random Alloca | 1987 |
13 other studies available for clomipramine and Sex Disorders
| Article | Year |
|---|---|
Clomipramine trial for treatment-resistant persistent genital arousal disorder: a case series.
Topics: Adult; Aged; Clomipramine; Combined Modality Therapy; Female; Humans; Middle Aged; Psychotherapy; Se | 2017 |
Male sexual dysfunction in unconsummated marriage: long-term outcome in 417 patients.
Topics: Adolescent; Adult; Aged; Clomipramine; Erectile Dysfunction; Female; Fluoxetine; Follow-Up Studies; | 2008 |
Evaluating the role of the serotoninergic system in the control of human seminal vesicle smooth muscle-an in vitro approach.
Topics: Adrenergic alpha-Agonists; Aged; Clomipramine; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, D | 2009 |
The majority of men with lifelong premature ejaculation prefer daily drug treatment: an observation study in a consecutive group of Dutch men.
Topics: Adult; Benzylamines; Clomipramine; Cohort Studies; Coitus; Dose-Response Relationship, Drug; Ejacula | 2007 |
Clinical inquiries. What's the best drug treatment for premature ejaculation?
Topics: Anesthetics, Local; Antidepressive Agents; Clomipramine; Ejaculation; Fluoxetine; Humans; Lidocaine; | 2008 |
Clomipramine in premature ejaculation.
Topics: Adult; Clomipramine; Ejaculation; Female; Humans; Male; Obsessive-Compulsive Disorder; Sexual Dysfun | 1984 |
Unusual side effects of clomipramine associated with yawning.
Topics: Clomipramine; Ejaculation; Female; Humans; Male; Reflex, Abnormal; Sexual Dysfunction, Physiological | 1984 |
Treatment of premature ejaculation.
Topics: 1-Naphthylamine; Adult; Clomipramine; Ejaculation; Fluoxetine; Humans; Male; Patient Satisfaction; R | 1998 |
In vivo evaluation of serotonergic agents and alpha-adrenergic blockers on premature ejaculation by inhibiting the seminal vesicle pressure response to electrical nerve stimulation.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Clomipramine; Dose-Response Rel | 1998 |
Effective daily treatment with clomipramine in men with premature ejaculation when 25 mg (as required) is ineffective.
Topics: Adult; Aged; Clomipramine; Ejaculation; Humans; Male; Middle Aged; Patient Satisfaction; Reaction Ti | 2001 |
Sexual side-effects of clomipramine (Anafranil).
Topics: Adult; Clomipramine; Coitus; Depression; Dibenzazepines; Female; Humans; Male; Orgasm; Sexual Behavi | 1977 |
Down-regulation of post-synaptic serotonin receptors as a mechanism for clomipramine-induced anorgasmia.
Topics: Animals; Clomipramine; Male; Orgasm; Rats; Receptors, Serotonin; Sexual Dysfunction, Physiological | 1987 |
Cyproheptadine and antidepressant-induced anorgasmia.
Topics: Adult; Clomipramine; Cyproheptadine; Depressive Disorder; Female; Humans; Imipramine; Sexual Dysfunc | 1986 |