clomipramine has been researched along with Seizures in 20 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a puzzling case of a 25-year-old depressive man suffering from seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration." | 7.70 | A puzzling case of seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration. ( Ohmori, O; Shinkai, T; Terao, T, 1999) |
| "An epileptic patient well controlled on valproic acid (VPA) developed a prolonged episode of status epilepticus 12 days after initiation of 75 mg of clomipramine (CMI) to treat depression." | 7.69 | Status epilepticus associated with the combination of valproic acid and clomipramine. ( DeToledo, JC; Haddad, H; Ramsay, RE, 1997) |
| "A 0." | 6.38 | Clomipramine for obsessive-compulsive disorder. ( Feinberg, M, 1991) |
| "A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a." | 5.31 | Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine. ( Dubisar, BM; Farrar, CD; Khan, R; Stoner, SC, 2002) |
| "We present a puzzling case of a 25-year-old depressive man suffering from seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration." | 3.70 | A puzzling case of seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration. ( Ohmori, O; Shinkai, T; Terao, T, 1999) |
| "An epileptic patient well controlled on valproic acid (VPA) developed a prolonged episode of status epilepticus 12 days after initiation of 75 mg of clomipramine (CMI) to treat depression." | 3.69 | Status epilepticus associated with the combination of valproic acid and clomipramine. ( DeToledo, JC; Haddad, H; Ramsay, RE, 1997) |
| "A 0." | 2.38 | Clomipramine for obsessive-compulsive disorder. ( Feinberg, M, 1991) |
| "A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a." | 1.31 | Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine. ( Dubisar, BM; Farrar, CD; Khan, R; Stoner, SC, 2002) |
| "Serotonin syndrome is the result of the drug interaction that enhances serotonergic tone in the central nervous system." | 1.30 | Serotonin syndrome presenting with migrainelike stroke. ( Molaie, M, 1997) |
| "Fengabine (SL 79." | 1.27 | Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. ( Bartholini, G; Depoortere, H; Lloyd, KG; Sanger, D; Zivkovic, B, 1987) |
| "The effects of the chronic administration of antidepressants on threshold electroconvulsive (ECS) seizures were evaluated in rats." | 1.27 | Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats. ( Peterson, SL; St Mary, JS; Trzeciakowski, JP, 1985) |
| " In the present study we determined the time-course and dose-response effects of 6-MeO-THbetaC for blockade of AGS." | 1.26 | Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THbetaC) on audiogenic seizures in DBA/2J mice. ( Buckholtz, NS; Sparks, DL, 1980) |
| "Generalised seizures were seen 15-30 min after imipramine or chlorimipramine (20 mg/kg), and these two drugs showed no difference in their epileptogenicity." | 1.26 | Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms. ( Anlezark, G; Meldrum, B; Trimble, M, 1977) |
| "could increase the risk of seizures." | 1.26 | [Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents]. ( Escande, M; Gayral, L; Golberger, E; Jarrige, A; Kulik, J, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (60.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dubisar, BM | 1 |
| Stoner, SC | 1 |
| Khan, R | 1 |
| Farrar, CD | 1 |
| Flechter, S | 1 |
| Rabey, JM | 1 |
| Regev, I | 1 |
| Borenstein, N | 1 |
| Vardi, J | 1 |
| Larsen, T | 1 |
| Verder, H | 1 |
| Christensen, JK | 1 |
| Sparks, DL | 1 |
| Buckholtz, NS | 1 |
| Cowe, L | 1 |
| Lloyd, DJ | 1 |
| Dawling, S | 1 |
| Sternbach, H | 1 |
| Ambrosini, PJ | 1 |
| Bianchi, MD | 1 |
| Rabinovich, H | 1 |
| Elia, J | 1 |
| DeToledo, JC | 1 |
| Haddad, H | 1 |
| Ramsay, RE | 1 |
| Molaie, M | 1 |
| Terao, T | 1 |
| Ohmori, O | 1 |
| Shinkai, T | 1 |
| Deshauer, D | 1 |
| Albuquerque, J | 1 |
| Alda, M | 1 |
| Grof, P | 1 |
| Trimble, M | 1 |
| Anlezark, G | 2 |
| Meldrum, B | 1 |
| Koella, WP | 1 |
| Glatt, A | 1 |
| Klebs, K | 1 |
| Dürst, T | 1 |
| Robinson, ML | 1 |
| Escande, M | 1 |
| Gayral, L | 1 |
| Golberger, E | 1 |
| Jarrige, A | 1 |
| Kulik, J | 1 |
| Trimble, MR | 1 |
| Meldrum, BS | 1 |
| Feinberg, M | 1 |
| Lloyd, KG | 1 |
| Zivkovic, B | 1 |
| Sanger, D | 1 |
| Depoortere, H | 1 |
| Bartholini, G | 1 |
| Rasmussen, BK | 1 |
| Peterson, SL | 1 |
| Trzeciakowski, JP | 1 |
| St Mary, JS | 1 |
2 reviews available for clomipramine and Seizures
| Article | Year |
|---|---|
Antidepressant treatments in children and adolescents: II. Anxiety, physical, and behavioral disorders.
Topics: Adolescent; Antidepressive Agents; Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; | 1993 |
Clomipramine for obsessive-compulsive disorder.
Topics: Clinical Trials as Topic; Clomipramine; Humans; Incidence; Obsessive-Compulsive Disorder; Seizures | 1991 |
18 other studies available for clomipramine and Seizures
| Article | Year |
|---|---|
Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.
Topics: Adult; Asperger Syndrome; Basal Ganglia Diseases; Clomipramine; Humans; Interferon beta-1a; Interfer | 2002 |
Convulsive attacks due to antidepressant drug overdoses: case reports and discussion.
Topics: Adult; Antidepressive Agents; Cerebral Cortex; Clomipramine; Dibenzazepines; Electroencephalography; | 1983 |
[Neonatal seizures in maternal clomipramine treatment. Cyclic antidepressives and pregnancy].
Topics: Adult; Clomipramine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Seizures | 1984 |
Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THbetaC) on audiogenic seizures in DBA/2J mice.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Benzofurans; Carbolines; Citalopram; Clomipramin | 1980 |
Neonatal convulsions caused by withdrawal from maternal clomipramine.
Topics: Adult; Clomipramine; Depressive Disorder; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases | 1982 |
Fluoxetine-clomipramine interaction.
Topics: Adult; Clomipramine; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Fem | 1995 |
Status epilepticus associated with the combination of valproic acid and clomipramine.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Female; | 1997 |
Serotonin syndrome presenting with migrainelike stroke.
Topics: Adult; Brain Ischemia; Cerebrovascular Circulation; Cerebrovascular Disorders; Clomipramine; Confusi | 1997 |
A puzzling case of seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Hallucinations; Humans; | 1999 |
Seizures caused by possible interaction between olanzapine and clomipramine.
Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepines; Clomipramine; Drug I | 2000 |
Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Electroencephal | 1977 |
Epileptic phenomena induced in the cat by the antidepressants maprotiline, imipramine, clomipramine, and amitriptyline.
Topics: Amitriptyline; Animals; Anthracenes; Cats; Cerebral Cortex; Clomipramine; Electroencephalography; Ev | 1979 |
Epileptic fit after clomipramine.
Topics: Aged; Clomipramine; Dibenzazepines; Female; Humans; Seizures; Substance Withdrawal Syndrome | 1978 |
[Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents].
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Electroencephalography; | 1976 |
Effect of nomifensine on brain amines and epilepsy in photosensitive baboons.
Topics: Amines; Animals; Brain Chemistry; Clomipramine; Dose-Response Relationship, Drug; Imipramine; Isoqui | 1977 |
Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Bicuculline; Chlorophenols; Cl | 1987 |
[Seizure occurring during treatment with antidepressive agents].
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Female; Humans; Male; Maprotiline; Middle Age | 1987 |
Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats.
Topics: Amoxapine; Animals; Antidepressive Agents; Clomipramine; Convulsants; Desipramine; Electric Stimulat | 1985 |