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clomipramine and Seizures

clomipramine has been researched along with Seizures in 20 studies

Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"We present a puzzling case of a 25-year-old depressive man suffering from seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration."7.70A puzzling case of seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration. ( Ohmori, O; Shinkai, T; Terao, T, 1999)
"An epileptic patient well controlled on valproic acid (VPA) developed a prolonged episode of status epilepticus 12 days after initiation of 75 mg of clomipramine (CMI) to treat depression."7.69Status epilepticus associated with the combination of valproic acid and clomipramine. ( DeToledo, JC; Haddad, H; Ramsay, RE, 1997)
"A 0."6.38Clomipramine for obsessive-compulsive disorder. ( Feinberg, M, 1991)
"A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a."5.31Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine. ( Dubisar, BM; Farrar, CD; Khan, R; Stoner, SC, 2002)
"We present a puzzling case of a 25-year-old depressive man suffering from seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration."3.70A puzzling case of seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration. ( Ohmori, O; Shinkai, T; Terao, T, 1999)
"An epileptic patient well controlled on valproic acid (VPA) developed a prolonged episode of status epilepticus 12 days after initiation of 75 mg of clomipramine (CMI) to treat depression."3.69Status epilepticus associated with the combination of valproic acid and clomipramine. ( DeToledo, JC; Haddad, H; Ramsay, RE, 1997)
"A 0."2.38Clomipramine for obsessive-compulsive disorder. ( Feinberg, M, 1991)
"A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a."1.31Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine. ( Dubisar, BM; Farrar, CD; Khan, R; Stoner, SC, 2002)
"Serotonin syndrome is the result of the drug interaction that enhances serotonergic tone in the central nervous system."1.30Serotonin syndrome presenting with migrainelike stroke. ( Molaie, M, 1997)
"Fengabine (SL 79."1.27Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. ( Bartholini, G; Depoortere, H; Lloyd, KG; Sanger, D; Zivkovic, B, 1987)
"The effects of the chronic administration of antidepressants on threshold electroconvulsive (ECS) seizures were evaluated in rats."1.27Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats. ( Peterson, SL; St Mary, JS; Trzeciakowski, JP, 1985)
" In the present study we determined the time-course and dose-response effects of 6-MeO-THbetaC for blockade of AGS."1.26Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THbetaC) on audiogenic seizures in DBA/2J mice. ( Buckholtz, NS; Sparks, DL, 1980)
"Generalised seizures were seen 15-30 min after imipramine or chlorimipramine (20 mg/kg), and these two drugs showed no difference in their epileptogenicity."1.26Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms. ( Anlezark, G; Meldrum, B; Trimble, M, 1977)
"could increase the risk of seizures."1.26[Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents]. ( Escande, M; Gayral, L; Golberger, E; Jarrige, A; Kulik, J, 1976)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199012 (60.00)18.7374
1990's6 (30.00)18.2507
2000's2 (10.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dubisar, BM1
Stoner, SC1
Khan, R1
Farrar, CD1
Flechter, S1
Rabey, JM1
Regev, I1
Borenstein, N1
Vardi, J1
Larsen, T1
Verder, H1
Christensen, JK1
Sparks, DL1
Buckholtz, NS1
Cowe, L1
Lloyd, DJ1
Dawling, S1
Sternbach, H1
Ambrosini, PJ1
Bianchi, MD1
Rabinovich, H1
Elia, J1
DeToledo, JC1
Haddad, H1
Ramsay, RE1
Molaie, M1
Terao, T1
Ohmori, O1
Shinkai, T1
Deshauer, D1
Albuquerque, J1
Alda, M1
Grof, P1
Trimble, M1
Anlezark, G2
Meldrum, B1
Koella, WP1
Glatt, A1
Klebs, K1
Dürst, T1
Robinson, ML1
Escande, M1
Gayral, L1
Golberger, E1
Jarrige, A1
Kulik, J1
Trimble, MR1
Meldrum, BS1
Feinberg, M1
Lloyd, KG1
Zivkovic, B1
Sanger, D1
Depoortere, H1
Bartholini, G1
Rasmussen, BK1
Peterson, SL1
Trzeciakowski, JP1
St Mary, JS1

Reviews

2 reviews available for clomipramine and Seizures

ArticleYear
Antidepressant treatments in children and adolescents: II. Anxiety, physical, and behavioral disorders.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1993, Volume: 32, Issue:3

    Topics: Adolescent; Antidepressive Agents; Anxiety Disorders; Attention Deficit Disorder with Hyperactivity;

1993
Clomipramine for obsessive-compulsive disorder.
    American family physician, 1991, Volume: 43, Issue:5

    Topics: Clinical Trials as Topic; Clomipramine; Humans; Incidence; Obsessive-Compulsive Disorder; Seizures

1991

Other Studies

18 other studies available for clomipramine and Seizures

ArticleYear
Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.
    Pharmacotherapy, 2002, Volume: 22, Issue:11

    Topics: Adult; Asperger Syndrome; Basal Ganglia Diseases; Clomipramine; Humans; Interferon beta-1a; Interfer

2002
Convulsive attacks due to antidepressant drug overdoses: case reports and discussion.
    General hospital psychiatry, 1983, Volume: 5, Issue:3

    Topics: Adult; Antidepressive Agents; Cerebral Cortex; Clomipramine; Dibenzazepines; Electroencephalography;

1983
[Neonatal seizures in maternal clomipramine treatment. Cyclic antidepressives and pregnancy].
    Ugeskrift for laeger, 1984, Jul-02, Volume: 146, Issue:27

    Topics: Adult; Clomipramine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Seizures

1984
Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THbetaC) on audiogenic seizures in DBA/2J mice.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:1

    Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Benzofurans; Carbolines; Citalopram; Clomipramin

1980
Neonatal convulsions caused by withdrawal from maternal clomipramine.
    British medical journal (Clinical research ed.), 1982, Jun-19, Volume: 284, Issue:6332

    Topics: Adult; Clomipramine; Depressive Disorder; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases

1982
Fluoxetine-clomipramine interaction.
    The Journal of clinical psychiatry, 1995, Volume: 56, Issue:4

    Topics: Adult; Clomipramine; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Fem

1995
Status epilepticus associated with the combination of valproic acid and clomipramine.
    Therapeutic drug monitoring, 1997, Volume: 19, Issue:1

    Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Female;

1997
Serotonin syndrome presenting with migrainelike stroke.
    Headache, 1997, Volume: 37, Issue:8

    Topics: Adult; Brain Ischemia; Cerebrovascular Circulation; Cerebrovascular Disorders; Clomipramine; Confusi

1997
A puzzling case of seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration.
    Acta psychiatrica Scandinavica, 1999, Volume: 99, Issue:5

    Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Hallucinations; Humans;

1999
Seizures caused by possible interaction between olanzapine and clomipramine.
    Journal of clinical psychopharmacology, 2000, Volume: 20, Issue:2

    Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepines; Clomipramine; Drug I

2000
Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms.
    Psychopharmacology, 1977, Jan-31, Volume: 51, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Electroencephal

1977
Epileptic phenomena induced in the cat by the antidepressants maprotiline, imipramine, clomipramine, and amitriptyline.
    Biological psychiatry, 1979, Volume: 14, Issue:3

    Topics: Amitriptyline; Animals; Anthracenes; Cats; Cerebral Cortex; Clomipramine; Electroencephalography; Ev

1979
Epileptic fit after clomipramine.
    The British journal of psychiatry : the journal of mental science, 1978, Volume: 132

    Topics: Aged; Clomipramine; Dibenzazepines; Female; Humans; Seizures; Substance Withdrawal Syndrome

1978
[Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents].
    L'Encephale, 1976, Volume: 2, Issue:2

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Electroencephalography;

1976
Effect of nomifensine on brain amines and epilepsy in photosensitive baboons.
    British journal of clinical pharmacology, 1977, Volume: 4Suppl 2

    Topics: Amines; Animals; Brain Chemistry; Clomipramine; Dose-Response Relationship, Drug; Imipramine; Isoqui

1977
Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Bicuculline; Chlorophenols; Cl

1987
[Seizure occurring during treatment with antidepressive agents].
    Ugeskrift for laeger, 1987, Nov-23, Volume: 149, Issue:48

    Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Female; Humans; Male; Maprotiline; Middle Age

1987
Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats.
    Neuropharmacology, 1985, Volume: 24, Issue:10

    Topics: Amoxapine; Animals; Antidepressive Agents; Clomipramine; Convulsants; Desipramine; Electric Stimulat

1985