clomipramine has been researched along with Pregnancy in 50 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Excerpt | Relevance | Reference |
---|---|---|
"Clomipramine is one of the drugs for depression during pregnancy; however, pharmacokinetic data of clomipramine and its active metabolite desmethylclomipramine in this vulnerable period are lacking." | 7.81 | Pharmacokinetics of clomipramine during pregnancy. ( de Jong-van de Berg, LT; Proost, JH; Smit, JP; Ter Horst, PG; Vries, MT; Wilffert, B, 2015) |
"The case is described of a neonate who suffered from withdrawal symptoms within 24 hours after birth as a result of the use of clomipramine by the mother during pregnancy." | 7.68 | [Neonatal withdrawal symptoms following the use of clomipramine during pregnancy]. ( Boringa, JB; de Jong, GM; Touw, DJ, 1992) |
"The subject of dosage of clomipramine (Anafranil) in depression and in obsessional and phobic disorders is discussed." | 4.75 | Practical considerations on the use of clomipramine (Anafranil) in general practice: an updated review. ( Beaumont, G, 1977) |
"Clomipramine is one of the drugs for depression during pregnancy; however, pharmacokinetic data of clomipramine and its active metabolite desmethylclomipramine in this vulnerable period are lacking." | 3.81 | Pharmacokinetics of clomipramine during pregnancy. ( de Jong-van de Berg, LT; Proost, JH; Smit, JP; Ter Horst, PG; Vries, MT; Wilffert, B, 2015) |
" We examined whether the administration of clomipramine, a serotonin reuptake inhibitor, to neonatal mice could result in depression-related behavioral alterations in adult mice." | 3.79 | Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice. ( Ahn, HS; Baik, JH; Kim, JW; Yoon, BJ, 2013) |
" In previous studies on rats, we found that neonatal treatment with clomipramine (CLI) during postnatal days 8--21 (P8-21) produced behavioral and physiological abnormalities in adult rats that resembled the abnormalities found in human endogenous depression." | 3.71 | The critical window of brain development from susceptive to insusceptive. Effects of clomipramine neonatal treatment on sexual behavior. ( Feng, P; Ma, Y; Vogel, GW, 2001) |
"The case is described of a neonate who suffered from withdrawal symptoms within 24 hours after birth as a result of the use of clomipramine by the mother during pregnancy." | 3.68 | [Neonatal withdrawal symptoms following the use of clomipramine during pregnancy]. ( Boringa, JB; de Jong, GM; Touw, DJ, 1992) |
"Clomipramine was injected at 40 mg/kg and 80 mg/kg to the second and third groups, respectively." | 1.39 | The role of clomipramine in potentiating the teratogenic effects of caffeine in pregnant rats: a histopathological study. ( Bakhtiarian, A; Giorgi, M; Nabavi, SM; Nikoui, V; Ostadhadi, S; Takzare, N, 2013) |
"The observed withdrawal symptoms were too short a period of sleep after feeding (6), poor feeding (3), mild to severe tremors (6), hyperactive Moro reflex (3) and respiratory rate >60 breaths min(-1)." | 1.38 | Clomipramine concentration and withdrawal symptoms in 10 neonates. ( De Jong-van den Berg, LT; den Boon, J; Jansman, FG; Smit, JP; ter Horst, PG; van der Linde, S; van Lingen, RA; Wilffert, B, 2012) |
"Tricyclic antidepressants (TCAs) are the non-selective amine re-uptake inhibitors, well absorbed from small intestine, cross the blood-brain barrier, distributed in the brain, and are bound to glutathione S-transferase-π (GST-π)." | 1.37 | The inhibition characteristics of human placental glutathione S-transferase-π by tricyclic antidepressants: amitriptyline and clomipramine. ( Dalmizrak, O; Kulaksiz-Erkmen, G; Ozer, N, 2011) |
" These effects were similar to the effects induced for subchronic and chronic administration of the antidepressant fluoxetine (5 mg/kg sc), a selective serotonin re-uptake inhibitor." | 1.33 | Antidepressant effects of nicotine and fluoxetine in an animal model of depression induced by neonatal treatment with clomipramine. ( Bonilla-Jaime, H; Vázquez-Palacios, G; Velázquez-Moctezuma, J, 2005) |
"Treatment with fluoxetine reversed these changes, as in SC rats." | 1.32 | Alterations in voiding frequency and cystometry in the clomipramine induced model of endogenous depression and reversal with fluoxetine. ( Dean-McKinney, T; Klausner, AP; Lee, KS; Na, YG; Steers, WD; Tuttle, JB, 2003) |
" The only significant difference in sexual behavior between those males whose mothers received CLI during pregnancy compared to males from untreated mothers was an increase in the number of intromissions in the highest dosage group." | 1.31 | Chronic oral administration of clomipramine decreases sexual behavior in the male Syrian hamster (Mesocricetus auratus). ( Boscarino, BT; Parfitt, DB, 2002) |
"Four clomipramine-treated breastfeeding mother-infant pairs were assessed for serum concentrations of clomipramine, N-desmethylclomipramine, and corresponding 8-hydroxymetabolites." | 1.29 | Serum clomipramine and metabolite levels in four nursing mother-infant pairs. ( Foglia, JP; Perel, JM; Wisner, KL, 1995) |
"Clomipramine is a chlorinated tricyclic antidepressant commonly used in the treatment of depression (1)." | 1.28 | Toxic neonatal effects following maternal clomipramine therapy. ( Katz, EZ; Koren, G; Pastuszak, A; Schimmell, MS; Shaag, Y, 1991) |
"5 mg/kg/day, revealed a similar profile to that seen after chronic administration of benzodiazepines in the adult." | 1.27 | Prenatal treatment with clomipramine: effects on the behaviour of male and female adolescent rats. ( File, SE; Tucker, JC, 1984) |
" The third patient manipulated dosage times to diminish the orgastic problem." | 1.26 | Sexual dysfunction and clomipramine. ( Einarson, TR; Quirk, KC, 1982) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 18 (36.00) | 18.7374 |
1990's | 13 (26.00) | 18.2507 |
2000's | 10 (20.00) | 29.6817 |
2010's | 7 (14.00) | 24.3611 |
2020's | 2 (4.00) | 2.80 |
Authors | Studies |
---|---|
Leutritz, AL | 1 |
van Braam, L | 1 |
Preis, K | 1 |
Gehrmann, A | 1 |
Scherf-Clavel, M | 1 |
Fiedler, K | 1 |
Unterecker, S | 1 |
Kittel-Schneider, S | 1 |
Chakraborty, S | 1 |
Tripathi, SJ | 1 |
Raju, TR | 1 |
Shankaranarayana Rao, BS | 1 |
Molina-Jiménez, T | 1 |
Limón-Morales, O | 1 |
Bonilla-Jaime, H | 3 |
Nikoui, V | 1 |
Ostadhadi, S | 1 |
Takzare, N | 1 |
Nabavi, SM | 1 |
Giorgi, M | 1 |
Bakhtiarian, A | 1 |
Ter Horst, PG | 2 |
Proost, JH | 1 |
Smit, JP | 2 |
Vries, MT | 1 |
de Jong-van de Berg, LT | 1 |
Wilffert, B | 2 |
Fukushima, N | 1 |
Nanao, K | 1 |
Fukushima, H | 1 |
Namera, A | 1 |
Miura, M | 1 |
Dalmizrak, O | 1 |
Kulaksiz-Erkmen, G | 1 |
Ozer, N | 1 |
van der Linde, S | 1 |
den Boon, J | 1 |
van Lingen, RA | 1 |
Jansman, FG | 1 |
De Jong-van den Berg, LT | 1 |
Kim, JW | 1 |
Ahn, HS | 1 |
Baik, JH | 1 |
Yoon, BJ | 1 |
Retana-Marquez, S | 1 |
Vazquez-Palacios, G | 2 |
Velázquez-Moctezuma, J | 2 |
Lee, KS | 1 |
Na, YG | 1 |
Dean-McKinney, T | 1 |
Klausner, AP | 1 |
Tuttle, JB | 1 |
Steers, WD | 1 |
Wu, CC | 1 |
Chen, JY | 1 |
Tao, PL | 1 |
Chen, YA | 1 |
Yeh, GC | 1 |
Maciag, D | 1 |
Simpson, KL | 1 |
Coppinger, D | 1 |
Lu, Y | 1 |
Wang, Y | 1 |
Lin, RC | 1 |
Paul, IA | 1 |
Loughhead, AM | 1 |
Stowe, ZN | 1 |
Newport, DJ | 1 |
Ritchie, JC | 1 |
DeVane, CL | 1 |
Owens, MJ | 1 |
Källén, B | 1 |
Otterblad Olausson, P | 1 |
Vulink, NC | 1 |
Denys, D | 1 |
Bus, L | 1 |
Westenberg, HG | 1 |
Rodríguez Echandía, EL | 2 |
Broitman, ST | 2 |
File, SE | 2 |
Tucker, JC | 2 |
Larsen, T | 1 |
Verder, H | 1 |
Christensen, JK | 1 |
Cowe, L | 1 |
Lloyd, DJ | 1 |
Dawling, S | 1 |
Vaghi, M | 1 |
Curatolo, L | 1 |
Algeri, S | 1 |
Brunello, N | 1 |
Mennini, T | 1 |
Morasca, L | 1 |
Salmona, AL | 1 |
Mella, L | 1 |
Locati, M | 1 |
Dolfini, E | 1 |
Elkins, R | 1 |
Rapoport, JL | 1 |
Lipsky, A | 1 |
Ostergaard, GZ | 2 |
Pedersen, SE | 1 |
Quirk, KC | 1 |
Einarson, TR | 1 |
Pedersen, S | 1 |
Wisner, KL | 1 |
Perel, JM | 1 |
Foglia, JP | 1 |
Bromiker, R | 1 |
Kaplan, M | 1 |
Hilakivi-Clarke, L | 1 |
Wright, A | 1 |
Lippman, ME | 1 |
Vogel, G | 2 |
Hagler, M | 2 |
Hennessey, A | 1 |
Richard, C | 1 |
Lidén, K | 1 |
Gustaf Ellström, K | 1 |
Dwyer, SM | 1 |
Rosenwasser, AM | 1 |
Bloem, BR | 1 |
Lammers, GJ | 1 |
Roofthooft, DW | 1 |
De Beaufort, AJ | 1 |
Brouwer, OF | 1 |
Feng, P | 1 |
Ma, Y | 1 |
Vogel, GW | 1 |
Boscarino, BT | 1 |
Parfitt, DB | 1 |
Beaumont, G | 1 |
Donoso, AO | 1 |
Musa, AB | 1 |
Smith, CS | 1 |
Romero, G | 1 |
Toscano, E | 1 |
Montero, D | 2 |
De Felipe, MC | 2 |
Del Rio, J | 3 |
Boringa, JB | 1 |
de Jong, GM | 1 |
Touw, DJ | 1 |
Schimmell, MS | 1 |
Katz, EZ | 1 |
Shaag, Y | 1 |
Pastuszak, A | 1 |
Koren, G | 1 |
Singh, S | 1 |
Gulati, S | 1 |
Narang, A | 1 |
Bhakoo, ON | 1 |
Whitaker-Azmitia, PM | 1 |
Molino, LJ | 1 |
Caruso, J | 1 |
Shemer, AV | 1 |
De Ceballos, ML | 1 |
Benedi, A | 1 |
Urdin, C | 1 |
Hartley, P | 1 |
Neill, D | 1 |
Kors, D | 1 |
Fóscolo, MR | 1 |
Gonzalez, A | 1 |
Zucconi, GG | 1 |
Belia, S | 1 |
Menichini, E | 1 |
Castigli, E | 1 |
Giuditta, A | 1 |
Hilakivi, L | 1 |
3 reviews available for clomipramine and Pregnancy
Article | Year |
---|---|
Obsessive-compulsive disorder of childhood and adolescence. A neurobiological viewpoint.
Topics: Adolescent; Child; Child, Preschool; Clomipramine; Diseases in Twins; Encephalitis; Female; Frontal | 1980 |
Practical considerations on the use of clomipramine (Anafranil) in general practice: an updated review.
Topics: Clomipramine; Depression; Dibenzazepines; Drug Interactions; Female; Humans; Male; Phobic Disorders; | 1977 |
Effect of perinatal exposure to therapeutic doses of chlorimipramine on grooming behavior in the adult rat.
Topics: Aging; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Clomipramine; Female; Grooming; | 1988 |
47 other studies available for clomipramine and Pregnancy
Article | Year |
---|---|
Psychotropic medication in pregnancy and lactation and early development of exposed children.
Topics: Child; Clomipramine; Female; Humans; Infant, Newborn; Lactation; Pregnancy; Pregnancy Complications; | 2023 |
Brain stimulation rewarding experience attenuates neonatal clomipramine-induced adulthood anxiety by reversal of pathological changes in the amygdala.
Topics: Amygdala; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Anxiety; Biogenic Monoamines; | 2020 |
Early postnatal treatment with clomipramine induces female sexual behavior and estrous cycle impairment.
Topics: Animals; Animals, Newborn; Clomipramine; Estrous Cycle; Female; Pregnancy; Rats; Rats, Wistar; Selec | 2018 |
The role of clomipramine in potentiating the teratogenic effects of caffeine in pregnant rats: a histopathological study.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Clomipramine; Dose-Response Relationship, Drug; Drug | 2013 |
Pharmacokinetics of clomipramine during pregnancy.
Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Clomipramine; Depression; Female; H | 2015 |
A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants.
Topics: Abnormalities, Drug-Induced; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Female; Hum | 2016 |
The inhibition characteristics of human placental glutathione S-transferase-π by tricyclic antidepressants: amitriptyline and clomipramine.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Dinitrochlorobenzene; Enzyme Assays; | 2011 |
Clomipramine concentration and withdrawal symptoms in 10 neonates.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Female; Half-Life; Human | 2012 |
Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice.
Topics: Animals; Animals, Newborn; Antidepressive Agents; Behavior, Animal; Clomipramine; Depression; Female | 2013 |
Corticosterone and testosterone levels after chronic stress in an animal model of depression.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Behavior, Animal; | 2003 |
Alterations in voiding frequency and cystometry in the clomipramine induced model of endogenous depression and reversal with fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Clomipramine; Depressive Disorder; Escape Reactio | 2003 |
Antidepressant effects of nicotine and fluoxetine in an animal model of depression induced by neonatal treatment with clomipramine.
Topics: Animals; Animals, Newborn; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepr | 2005 |
Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine.
Topics: Animals; Animals, Newborn; Behavior, Animal; Citalopram; Clomipramine; Female; Fluoxetine; Maternal- | 2005 |
Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry.
Topics: Animals; Animals, Newborn; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antigens, Nuclea | 2006 |
Placental passage of tricyclic antidepressants.
Topics: Antidepressive Agents, Tricyclic; Birth Weight; Clomipramine; Depressive Disorder, Major; Dose-Respo | 2006 |
Antidepressant drugs during pregnancy and infant congenital heart defect.
Topics: Abnormalities, Drug-Induced; Antidepressive Agents; Clomipramine; Female; Heart Defects, Congenital; | 2006 |
Female hormones affect symptom severity in obsessive-compulsive disorder.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Clomipramine; Contraceptives, Oral, Hormonal; De | 2006 |
Effect of prenatal and postnatal exposure to therapeutic doses of chlorimipramine on emotionality in the rat.
Topics: Animals; Animals, Newborn; Behavior, Animal; Clomipramine; Emotions; Environment; Female; Male; Preg | 1983 |
Prenatal treatment with clomipramine: effects on the behaviour of male and female adolescent rats.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Clomipramine; Female; Humans; Interpersonal Relations; Ma | 1984 |
[Neonatal seizures in maternal clomipramine treatment. Cyclic antidepressives and pregnancy].
Topics: Adult; Clomipramine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Seizures | 1984 |
Prenatal treatment with clomipramine has an anxiolytic profile in the adolescent rat.
Topics: Age Factors; Aggression; Animals; Anxiety; Behavior, Animal; Body Weight; Clomipramine; Environment; | 1983 |
Neonatal convulsions caused by withdrawal from maternal clomipramine.
Topics: Adult; Clomipramine; Depressive Disorder; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases | 1982 |
Studies on a neuronal-like transport system for serotonin in two cell lines.
Topics: Animals; Cell Line; Clomipramine; Female; Fluoxetine; Kinetics; Mice; Neurons; Pregnancy; Serotonin | 1982 |
Neonatal effects of maternal clomipramine treatment.
Topics: Acidosis, Respiratory; Clomipramine; Cyanosis; Depressive Disorder; Female; Humans; Infant, Newborn; | 1982 |
Sexual dysfunction and clomipramine.
Topics: Adult; Clomipramine; Depressive Disorder; Drug Administration Schedule; Ejaculation; Erectile Dysfun | 1982 |
[Neonatal complications caused by maternal clomipramine treatment].
Topics: Acidosis, Respiratory; Clomipramine; Cyanosis; Female; Humans; Infant, Newborn; Infant, Newborn, Dis | 1981 |
Serum clomipramine and metabolite levels in four nursing mother-infant pairs.
Topics: Adult; Breast Feeding; Clomipramine; Female; Half-Life; Humans; Infant; Infant, Newborn; Male; Obses | 1995 |
Apparent intrauterine fetal withdrawal from clomipramine hydrochloride.
Topics: Clomipramine; Female; Fetal Diseases; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Complicati | 1994 |
DMBA-induced mammary tumor growth in rats exhibiting increased or decreased ability to cope with stress due to early postnatal handling or antidepressant treatment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adaptation, Psychological; Animals; Animals, Newborn; Arousal; Clo | 1993 |
Dose-dependent decrements in adult male rat sexual behavior after neonatal clorimipramine treatment.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Clomipramine; Depression, Chemical; Dos | 1996 |
[Warning on antidepressive agents during pregnancy. Even low doses can affect the infant].
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Female; Humans; Infant, Newborn; Neonatal Abs | 1997 |
Neonatal clomipramine treatment, alcohol intake and circadian rhythms in rats.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Circadian Rhythm; Clo | 1998 |
Clomipramine withdrawal in newborns.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Female; Humans; Infant, Newborn; Myoclonus; P | 1999 |
The critical window of brain development from susceptive to insusceptive. Effects of clomipramine neonatal treatment on sexual behavior.
Topics: Animals; Animals, Newborn; Brain; Clomipramine; Critical Period, Psychological; Depression; Disease | 2001 |
Chronic oral administration of clomipramine decreases sexual behavior in the male Syrian hamster (Mesocricetus auratus).
Topics: Animals; Antidepressive Agents, Tricyclic; Clomipramine; Cricetinae; Depression, Chemical; Dose-Resp | 2002 |
Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development.
Topics: Animals; Body Weight; Clomipramine; Dibenzazepines; Female; Growth; Imipramine; Maternal Behavior; M | 1978 |
Neonatal effects of maternal clomipramine therapy.
Topics: Clomipramine; Dibenzazepines; Female; Humans; Hypothermia; Infant, Newborn; Infant, Newborn, Disease | 1979 |
Effect of prenatal exposure to tianeptine on different neurotransmitter receptors and 5-HT-stimulated inositol phosphate formation in rat brain.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Female; Imipramine; Inositol Phospha | 1992 |
[Neonatal withdrawal symptoms following the use of clomipramine during pregnancy].
Topics: Adult; Clomipramine; Clonazepam; Depressive Disorder; Female; Humans; Infant, Newborn; Male; Neonata | 1992 |
Toxic neonatal effects following maternal clomipramine therapy.
Topics: Adult; Akathisia, Drug-Induced; Animals; Bottle Feeding; Breast Feeding; Clomipramine; Depressive Di | 1991 |
Acute or chronic antidepressants do not modify [125I]cyanopindolol binding to 5-HT1B receptors in rat brain.
Topics: Animals; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Brain; Clomipramine; Female; Iodine | 1991 |
Non-narcotic withdrawal syndrome in a neonate due to maternal clomipramine therapy.
Topics: Clomipramine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Neonatal Abstinence Syndrome | 1990 |
Serotonergic agents restore appropriate decision-making in neonatal rats displaying dopamine D1 receptor-mediated vacillatory behavior.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Behavior, Ani | 1990 |
Prenatal exposure of rats to antidepressant drugs down-regulates beta-adrenoceptors and 5-HT2 receptors in cerebral cortex. Lack of correlation between 5-HT2 receptors and serotonin-mediated behaviour.
Topics: Animals; Antidepressive Agents; Cerebral Cortex; Clomipramine; Female; Iprindole; Mianserin; Nomifen | 1985 |
Animal depression model by neonatal clomipramine: reduction of shock induced aggression.
Topics: Age Factors; Aggression; Animals; Animals, Newborn; Clomipramine; Depression; Disease Models, Animal | 1988 |
Paradoxical sleep deprivation of the mother enhances DNA synthesis in fetal rat brain: autoradiographic and biochemical evidence.
Topics: Animals; Autoradiography; Brain; Cell Division; Clomipramine; DNA; Female; Fetus; Pregnancy; Rats; R | 1986 |
Adult alcohol consumption after pharmacological intervention in neonatal sleep.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Brain; Clomipramine; Electroencephalography; Electromyo | 1987 |