Page last updated: 2024-10-25

clomipramine and Pregnancy

clomipramine has been researched along with Pregnancy in 50 studies

Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Clomipramine is one of the drugs for depression during pregnancy; however, pharmacokinetic data of clomipramine and its active metabolite desmethylclomipramine in this vulnerable period are lacking."7.81Pharmacokinetics of clomipramine during pregnancy. ( de Jong-van de Berg, LT; Proost, JH; Smit, JP; Ter Horst, PG; Vries, MT; Wilffert, B, 2015)
"The case is described of a neonate who suffered from withdrawal symptoms within 24 hours after birth as a result of the use of clomipramine by the mother during pregnancy."7.68[Neonatal withdrawal symptoms following the use of clomipramine during pregnancy]. ( Boringa, JB; de Jong, GM; Touw, DJ, 1992)
"The subject of dosage of clomipramine (Anafranil) in depression and in obsessional and phobic disorders is discussed."4.75Practical considerations on the use of clomipramine (Anafranil) in general practice: an updated review. ( Beaumont, G, 1977)
"Clomipramine is one of the drugs for depression during pregnancy; however, pharmacokinetic data of clomipramine and its active metabolite desmethylclomipramine in this vulnerable period are lacking."3.81Pharmacokinetics of clomipramine during pregnancy. ( de Jong-van de Berg, LT; Proost, JH; Smit, JP; Ter Horst, PG; Vries, MT; Wilffert, B, 2015)
" We examined whether the administration of clomipramine, a serotonin reuptake inhibitor, to neonatal mice could result in depression-related behavioral alterations in adult mice."3.79Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice. ( Ahn, HS; Baik, JH; Kim, JW; Yoon, BJ, 2013)
" In previous studies on rats, we found that neonatal treatment with clomipramine (CLI) during postnatal days 8--21 (P8-21) produced behavioral and physiological abnormalities in adult rats that resembled the abnormalities found in human endogenous depression."3.71The critical window of brain development from susceptive to insusceptive. Effects of clomipramine neonatal treatment on sexual behavior. ( Feng, P; Ma, Y; Vogel, GW, 2001)
"The case is described of a neonate who suffered from withdrawal symptoms within 24 hours after birth as a result of the use of clomipramine by the mother during pregnancy."3.68[Neonatal withdrawal symptoms following the use of clomipramine during pregnancy]. ( Boringa, JB; de Jong, GM; Touw, DJ, 1992)
"Clomipramine was injected at 40 mg/kg and 80 mg/kg to the second and third groups, respectively."1.39The role of clomipramine in potentiating the teratogenic effects of caffeine in pregnant rats: a histopathological study. ( Bakhtiarian, A; Giorgi, M; Nabavi, SM; Nikoui, V; Ostadhadi, S; Takzare, N, 2013)
"The observed withdrawal symptoms were too short a period of sleep after feeding (6), poor feeding (3), mild to severe tremors (6), hyperactive Moro reflex (3) and respiratory rate >60 breaths min(-1)."1.38Clomipramine concentration and withdrawal symptoms in 10 neonates. ( De Jong-van den Berg, LT; den Boon, J; Jansman, FG; Smit, JP; ter Horst, PG; van der Linde, S; van Lingen, RA; Wilffert, B, 2012)
"Tricyclic antidepressants (TCAs) are the non-selective amine re-uptake inhibitors, well absorbed from small intestine, cross the blood-brain barrier, distributed in the brain, and are bound to glutathione S-transferase-π (GST-π)."1.37The inhibition characteristics of human placental glutathione S-transferase-π by tricyclic antidepressants: amitriptyline and clomipramine. ( Dalmizrak, O; Kulaksiz-Erkmen, G; Ozer, N, 2011)
" These effects were similar to the effects induced for subchronic and chronic administration of the antidepressant fluoxetine (5 mg/kg sc), a selective serotonin re-uptake inhibitor."1.33Antidepressant effects of nicotine and fluoxetine in an animal model of depression induced by neonatal treatment with clomipramine. ( Bonilla-Jaime, H; Vázquez-Palacios, G; Velázquez-Moctezuma, J, 2005)
"Treatment with fluoxetine reversed these changes, as in SC rats."1.32Alterations in voiding frequency and cystometry in the clomipramine induced model of endogenous depression and reversal with fluoxetine. ( Dean-McKinney, T; Klausner, AP; Lee, KS; Na, YG; Steers, WD; Tuttle, JB, 2003)
" The only significant difference in sexual behavior between those males whose mothers received CLI during pregnancy compared to males from untreated mothers was an increase in the number of intromissions in the highest dosage group."1.31Chronic oral administration of clomipramine decreases sexual behavior in the male Syrian hamster (Mesocricetus auratus). ( Boscarino, BT; Parfitt, DB, 2002)
"Four clomipramine-treated breastfeeding mother-infant pairs were assessed for serum concentrations of clomipramine, N-desmethylclomipramine, and corresponding 8-hydroxymetabolites."1.29Serum clomipramine and metabolite levels in four nursing mother-infant pairs. ( Foglia, JP; Perel, JM; Wisner, KL, 1995)
"Clomipramine is a chlorinated tricyclic antidepressant commonly used in the treatment of depression (1)."1.28Toxic neonatal effects following maternal clomipramine therapy. ( Katz, EZ; Koren, G; Pastuszak, A; Schimmell, MS; Shaag, Y, 1991)
"5 mg/kg/day, revealed a similar profile to that seen after chronic administration of benzodiazepines in the adult."1.27Prenatal treatment with clomipramine: effects on the behaviour of male and female adolescent rats. ( File, SE; Tucker, JC, 1984)
" The third patient manipulated dosage times to diminish the orgastic problem."1.26Sexual dysfunction and clomipramine. ( Einarson, TR; Quirk, KC, 1982)

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-199018 (36.00)18.7374
1990's13 (26.00)18.2507
2000's10 (20.00)29.6817
2010's7 (14.00)24.3611
2020's2 (4.00)2.80

Authors

AuthorsStudies
Leutritz, AL1
van Braam, L1
Preis, K1
Gehrmann, A1
Scherf-Clavel, M1
Fiedler, K1
Unterecker, S1
Kittel-Schneider, S1
Chakraborty, S1
Tripathi, SJ1
Raju, TR1
Shankaranarayana Rao, BS1
Molina-Jiménez, T1
Limón-Morales, O1
Bonilla-Jaime, H3
Nikoui, V1
Ostadhadi, S1
Takzare, N1
Nabavi, SM1
Giorgi, M1
Bakhtiarian, A1
Ter Horst, PG2
Proost, JH1
Smit, JP2
Vries, MT1
de Jong-van de Berg, LT1
Wilffert, B2
Fukushima, N1
Nanao, K1
Fukushima, H1
Namera, A1
Miura, M1
Dalmizrak, O1
Kulaksiz-Erkmen, G1
Ozer, N1
van der Linde, S1
den Boon, J1
van Lingen, RA1
Jansman, FG1
De Jong-van den Berg, LT1
Kim, JW1
Ahn, HS1
Baik, JH1
Yoon, BJ1
Retana-Marquez, S1
Vazquez-Palacios, G2
Velázquez-Moctezuma, J2
Lee, KS1
Na, YG1
Dean-McKinney, T1
Klausner, AP1
Tuttle, JB1
Steers, WD1
Wu, CC1
Chen, JY1
Tao, PL1
Chen, YA1
Yeh, GC1
Maciag, D1
Simpson, KL1
Coppinger, D1
Lu, Y1
Wang, Y1
Lin, RC1
Paul, IA1
Loughhead, AM1
Stowe, ZN1
Newport, DJ1
Ritchie, JC1
DeVane, CL1
Owens, MJ1
Källén, B1
Otterblad Olausson, P1
Vulink, NC1
Denys, D1
Bus, L1
Westenberg, HG1
Rodríguez Echandía, EL2
Broitman, ST2
File, SE2
Tucker, JC2
Larsen, T1
Verder, H1
Christensen, JK1
Cowe, L1
Lloyd, DJ1
Dawling, S1
Vaghi, M1
Curatolo, L1
Algeri, S1
Brunello, N1
Mennini, T1
Morasca, L1
Salmona, AL1
Mella, L1
Locati, M1
Dolfini, E1
Elkins, R1
Rapoport, JL1
Lipsky, A1
Ostergaard, GZ2
Pedersen, SE1
Quirk, KC1
Einarson, TR1
Pedersen, S1
Wisner, KL1
Perel, JM1
Foglia, JP1
Bromiker, R1
Kaplan, M1
Hilakivi-Clarke, L1
Wright, A1
Lippman, ME1
Vogel, G2
Hagler, M2
Hennessey, A1
Richard, C1
Lidén, K1
Gustaf Ellström, K1
Dwyer, SM1
Rosenwasser, AM1
Bloem, BR1
Lammers, GJ1
Roofthooft, DW1
De Beaufort, AJ1
Brouwer, OF1
Feng, P1
Ma, Y1
Vogel, GW1
Boscarino, BT1
Parfitt, DB1
Beaumont, G1
Donoso, AO1
Musa, AB1
Smith, CS1
Romero, G1
Toscano, E1
Montero, D2
De Felipe, MC2
Del Rio, J3
Boringa, JB1
de Jong, GM1
Touw, DJ1
Schimmell, MS1
Katz, EZ1
Shaag, Y1
Pastuszak, A1
Koren, G1
Singh, S1
Gulati, S1
Narang, A1
Bhakoo, ON1
Whitaker-Azmitia, PM1
Molino, LJ1
Caruso, J1
Shemer, AV1
De Ceballos, ML1
Benedi, A1
Urdin, C1
Hartley, P1
Neill, D1
Kors, D1
Fóscolo, MR1
Gonzalez, A1
Zucconi, GG1
Belia, S1
Menichini, E1
Castigli, E1
Giuditta, A1
Hilakivi, L1

Reviews

3 reviews available for clomipramine and Pregnancy

ArticleYear
Obsessive-compulsive disorder of childhood and adolescence. A neurobiological viewpoint.
    Journal of the American Academy of Child Psychiatry, 1980,Summer, Volume: 19, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Clomipramine; Diseases in Twins; Encephalitis; Female; Frontal

1980
Practical considerations on the use of clomipramine (Anafranil) in general practice: an updated review.
    The Journal of international medical research, 1977, Volume: 5, Issue:1 Suppl

    Topics: Clomipramine; Depression; Dibenzazepines; Drug Interactions; Female; Humans; Male; Phobic Disorders;

1977
Effect of perinatal exposure to therapeutic doses of chlorimipramine on grooming behavior in the adult rat.
    Annals of the New York Academy of Sciences, 1988, Volume: 525

    Topics: Aging; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Clomipramine; Female; Grooming;

1988

Other Studies

47 other studies available for clomipramine and Pregnancy

ArticleYear
Psychotropic medication in pregnancy and lactation and early development of exposed children.
    British journal of clinical pharmacology, 2023, Volume: 89, Issue:2

    Topics: Child; Clomipramine; Female; Humans; Infant, Newborn; Lactation; Pregnancy; Pregnancy Complications;

2023
Brain stimulation rewarding experience attenuates neonatal clomipramine-induced adulthood anxiety by reversal of pathological changes in the amygdala.
    Progress in neuro-psychopharmacology & biological psychiatry, 2020, 12-20, Volume: 103

    Topics: Amygdala; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Anxiety; Biogenic Monoamines;

2020
Early postnatal treatment with clomipramine induces female sexual behavior and estrous cycle impairment.
    Pharmacology, biochemistry, and behavior, 2018, Volume: 166

    Topics: Animals; Animals, Newborn; Clomipramine; Estrous Cycle; Female; Pregnancy; Rats; Rats, Wistar; Selec

2018
The role of clomipramine in potentiating the teratogenic effects of caffeine in pregnant rats: a histopathological study.
    TheScientificWorldJournal, 2013, Volume: 2013

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Clomipramine; Dose-Response Relationship, Drug; Drug

2013
Pharmacokinetics of clomipramine during pregnancy.
    European journal of clinical pharmacology, 2015, Volume: 71, Issue:12

    Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Clomipramine; Depression; Female; H

2015
A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants.
    European journal of pediatrics, 2016, Volume: 175, Issue:8

    Topics: Abnormalities, Drug-Induced; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Female; Hum

2016
The inhibition characteristics of human placental glutathione S-transferase-π by tricyclic antidepressants: amitriptyline and clomipramine.
    Molecular and cellular biochemistry, 2011, Volume: 355, Issue:1-2

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Dinitrochlorobenzene; Enzyme Assays;

2011
Clomipramine concentration and withdrawal symptoms in 10 neonates.
    British journal of clinical pharmacology, 2012, Volume: 73, Issue:2

    Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Female; Half-Life; Human

2012
Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice.
    Journal of psychopharmacology (Oxford, England), 2013, Volume: 27, Issue:2

    Topics: Animals; Animals, Newborn; Antidepressive Agents; Behavior, Animal; Clomipramine; Depression; Female

2013
Corticosterone and testosterone levels after chronic stress in an animal model of depression.
    Neuropsychobiology, 2003, Volume: 48, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Behavior, Animal;

2003
Alterations in voiding frequency and cystometry in the clomipramine induced model of endogenous depression and reversal with fluoxetine.
    The Journal of urology, 2003, Volume: 170, Issue:5

    Topics: Animals; Antidepressive Agents, Second-Generation; Clomipramine; Depressive Disorder; Escape Reactio

2003
Antidepressant effects of nicotine and fluoxetine in an animal model of depression induced by neonatal treatment with clomipramine.
    Progress in neuro-psychopharmacology & biological psychiatry, 2005, Volume: 29, Issue:1

    Topics: Animals; Animals, Newborn; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepr

2005
Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine.
    European journal of pharmacology, 2005, Apr-04, Volume: 512, Issue:1

    Topics: Animals; Animals, Newborn; Behavior, Animal; Citalopram; Clomipramine; Female; Fluoxetine; Maternal-

2005
Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:1

    Topics: Animals; Animals, Newborn; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antigens, Nuclea

2006
Placental passage of tricyclic antidepressants.
    Biological psychiatry, 2006, Feb-01, Volume: 59, Issue:3

    Topics: Antidepressive Agents, Tricyclic; Birth Weight; Clomipramine; Depressive Disorder, Major; Dose-Respo

2006
Antidepressant drugs during pregnancy and infant congenital heart defect.
    Reproductive toxicology (Elmsford, N.Y.), 2006, Volume: 21, Issue:3

    Topics: Abnormalities, Drug-Induced; Antidepressive Agents; Clomipramine; Female; Heart Defects, Congenital;

2006
Female hormones affect symptom severity in obsessive-compulsive disorder.
    International clinical psychopharmacology, 2006, Volume: 21, Issue:3

    Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Clomipramine; Contraceptives, Oral, Hormonal; De

2006
Effect of prenatal and postnatal exposure to therapeutic doses of chlorimipramine on emotionality in the rat.
    Psychopharmacology, 1983, Volume: 79, Issue:2-3

    Topics: Animals; Animals, Newborn; Behavior, Animal; Clomipramine; Emotions; Environment; Female; Male; Preg

1983
Prenatal treatment with clomipramine: effects on the behaviour of male and female adolescent rats.
    Psychopharmacology, 1984, Volume: 82, Issue:3

    Topics: Aging; Animals; Anxiety; Behavior, Animal; Clomipramine; Female; Humans; Interpersonal Relations; Ma

1984
[Neonatal seizures in maternal clomipramine treatment. Cyclic antidepressives and pregnancy].
    Ugeskrift for laeger, 1984, Jul-02, Volume: 146, Issue:27

    Topics: Adult; Clomipramine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Seizures

1984
Prenatal treatment with clomipramine has an anxiolytic profile in the adolescent rat.
    Physiology & behavior, 1983, Volume: 31, Issue:1

    Topics: Age Factors; Aggression; Animals; Anxiety; Behavior, Animal; Body Weight; Clomipramine; Environment;

1983
Neonatal convulsions caused by withdrawal from maternal clomipramine.
    British medical journal (Clinical research ed.), 1982, Jun-19, Volume: 284, Issue:6332

    Topics: Adult; Clomipramine; Depressive Disorder; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases

1982
Studies on a neuronal-like transport system for serotonin in two cell lines.
    Pharmacological research communications, 1982, Volume: 14, Issue:9

    Topics: Animals; Cell Line; Clomipramine; Female; Fluoxetine; Kinetics; Mice; Neurons; Pregnancy; Serotonin

1982
Neonatal effects of maternal clomipramine treatment.
    Pediatrics, 1982, Volume: 69, Issue:2

    Topics: Acidosis, Respiratory; Clomipramine; Cyanosis; Depressive Disorder; Female; Humans; Infant, Newborn;

1982
Sexual dysfunction and clomipramine.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1982, Volume: 27, Issue:3

    Topics: Adult; Clomipramine; Depressive Disorder; Drug Administration Schedule; Ejaculation; Erectile Dysfun

1982
[Neonatal complications caused by maternal clomipramine treatment].
    Ugeskrift for laeger, 1981, Feb-09, Volume: 143, Issue:7

    Topics: Acidosis, Respiratory; Clomipramine; Cyanosis; Female; Humans; Infant, Newborn; Infant, Newborn, Dis

1981
Serum clomipramine and metabolite levels in four nursing mother-infant pairs.
    The Journal of clinical psychiatry, 1995, Volume: 56, Issue:1

    Topics: Adult; Breast Feeding; Clomipramine; Female; Half-Life; Humans; Infant; Infant, Newborn; Male; Obses

1995
Apparent intrauterine fetal withdrawal from clomipramine hydrochloride.
    JAMA, 1994, Dec-14, Volume: 272, Issue:22

    Topics: Clomipramine; Female; Fetal Diseases; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Complicati

1994
DMBA-induced mammary tumor growth in rats exhibiting increased or decreased ability to cope with stress due to early postnatal handling or antidepressant treatment.
    Physiology & behavior, 1993, Volume: 54, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adaptation, Psychological; Animals; Animals, Newborn; Arousal; Clo

1993
Dose-dependent decrements in adult male rat sexual behavior after neonatal clorimipramine treatment.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 54, Issue:3

    Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Clomipramine; Depression, Chemical; Dos

1996
[Warning on antidepressive agents during pregnancy. Even low doses can affect the infant].
    Lakartidningen, 1997, May-28, Volume: 94, Issue:22

    Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Female; Humans; Infant, Newborn; Neonatal Abs

1997
Neonatal clomipramine treatment, alcohol intake and circadian rhythms in rats.
    Psychopharmacology, 1998, Volume: 138, Issue:2

    Topics: Alcohol Drinking; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Circadian Rhythm; Clo

1998
Clomipramine withdrawal in newborns.
    Archives of disease in childhood. Fetal and neonatal edition, 1999, Volume: 81, Issue:1

    Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Female; Humans; Infant, Newborn; Myoclonus; P

1999
The critical window of brain development from susceptive to insusceptive. Effects of clomipramine neonatal treatment on sexual behavior.
    Brain research. Developmental brain research, 2001, Jul-23, Volume: 129, Issue:1

    Topics: Animals; Animals, Newborn; Brain; Clomipramine; Critical Period, Psychological; Depression; Disease

2001
Chronic oral administration of clomipramine decreases sexual behavior in the male Syrian hamster (Mesocricetus auratus).
    Physiology & behavior, 2002, Volume: 75, Issue:3

    Topics: Animals; Antidepressive Agents, Tricyclic; Clomipramine; Cricetinae; Depression, Chemical; Dose-Resp

2002
Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development.
    Psychopharmacology, 1978, Jan-31, Volume: 56, Issue:1

    Topics: Animals; Body Weight; Clomipramine; Dibenzazepines; Female; Growth; Imipramine; Maternal Behavior; M

1978
Neonatal effects of maternal clomipramine therapy.
    Archives of disease in childhood, 1979, Volume: 54, Issue:5

    Topics: Clomipramine; Dibenzazepines; Female; Humans; Hypothermia; Infant, Newborn; Infant, Newborn, Disease

1979
Effect of prenatal exposure to tianeptine on different neurotransmitter receptors and 5-HT-stimulated inositol phosphate formation in rat brain.
    Journal of neural transmission. General section, 1992, Volume: 90, Issue:2

    Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Female; Imipramine; Inositol Phospha

1992
[Neonatal withdrawal symptoms following the use of clomipramine during pregnancy].
    Nederlands tijdschrift voor geneeskunde, 1992, Jul-25, Volume: 136, Issue:30

    Topics: Adult; Clomipramine; Clonazepam; Depressive Disorder; Female; Humans; Infant, Newborn; Male; Neonata

1992
Toxic neonatal effects following maternal clomipramine therapy.
    Journal of toxicology. Clinical toxicology, 1991, Volume: 29, Issue:4

    Topics: Adult; Akathisia, Drug-Induced; Animals; Bottle Feeding; Breast Feeding; Clomipramine; Depressive Di

1991
Acute or chronic antidepressants do not modify [125I]cyanopindolol binding to 5-HT1B receptors in rat brain.
    European journal of pharmacology, 1991, Apr-24, Volume: 196, Issue:3

    Topics: Animals; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Brain; Clomipramine; Female; Iodine

1991
Non-narcotic withdrawal syndrome in a neonate due to maternal clomipramine therapy.
    Journal of paediatrics and child health, 1990, Volume: 26, Issue:2

    Topics: Clomipramine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Neonatal Abstinence Syndrome

1990
Serotonergic agents restore appropriate decision-making in neonatal rats displaying dopamine D1 receptor-mediated vacillatory behavior.
    European journal of pharmacology, 1990, May-16, Volume: 180, Issue:2-3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Behavior, Ani

1990
Prenatal exposure of rats to antidepressant drugs down-regulates beta-adrenoceptors and 5-HT2 receptors in cerebral cortex. Lack of correlation between 5-HT2 receptors and serotonin-mediated behaviour.
    Neuropharmacology, 1985, Volume: 24, Issue:10

    Topics: Animals; Antidepressive Agents; Cerebral Cortex; Clomipramine; Female; Iprindole; Mianserin; Nomifen

1985
Animal depression model by neonatal clomipramine: reduction of shock induced aggression.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:1

    Topics: Age Factors; Aggression; Animals; Animals, Newborn; Clomipramine; Depression; Disease Models, Animal

1988
Paradoxical sleep deprivation of the mother enhances DNA synthesis in fetal rat brain: autoradiographic and biochemical evidence.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1986, Volume: 4, Issue:2

    Topics: Animals; Autoradiography; Brain; Cell Division; Clomipramine; DNA; Female; Fetus; Pregnancy; Rats; R

1986
Adult alcohol consumption after pharmacological intervention in neonatal sleep.
    Acta physiologica Scandinavica. Supplementum, 1987, Volume: 562

    Topics: Alcohol Drinking; Animals; Behavior, Animal; Brain; Clomipramine; Electroencephalography; Electromyo

1987