clomipramine has been researched along with Phobic Disorders in 49 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Phobic Disorders: Anxiety disorders in which the essential feature is persistent and irrational fear of a specific object, activity, or situation that the individual feels compelled to avoid. The individual recognizes the fear as excessive or unreasonable.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the effects of long-term treatment with citalopram or clomipramine on subjective phobic symptoms in patients with panic disorder." | 9.09 | Citalopram controls phobic symptoms in patients with panic disorder: randomized controlled trial. ( Koponen, H; Lehto, H; Leinonen, E; Lepola, U; Turtonen, J; Wade, A, 2000) |
| "Seventeen outpatients with panic anxiety and agoraphobia were treated with a low, flexible dose of clomipramine in an 8-week open trial." | 9.06 | Panic attacks and agoraphobia: low dose clomipramine treatment. ( Codner, S; Cohen, L; Gladic, D; Gloger, S; Grunhaus, L; O'Ryan, F, 1989) |
| "A multi-centre, double-blind trial was carried out in general practice to compare the effectiveness and tolerability of clomipramine and diazepam in patients with agoraphobia or social phobia." | 9.05 | Clomipramine and diazepam in the treatment of agoraphobia and social phobia in general practice. ( Allsopp, LF; Cooper, GL; Poole, PH, 1984) |
| "Clomipramine was effective and well-tolerated in controlling signs of obsessive-compulsive disorder and/or separation anxiety and/or noise phobia in 16 of 24 assessable cases, when used in combination with behaviour modification, and improvement in clinical signs was noted in 5 others." | 7.71 | Use of clomipramine in treatment of obsessive-compulsive disorder, separation anxiety and noise phobia in dogs: a preliminary, clinical study. ( Lindeman, MJ; Seksel, K, 2001) |
| "In a large, open, multicentre trial, conducted in general practice, 765 patients suffering from agoraphobia or social phobias were treated with clomipramine (Anafranil, Geigy Pharmaceuticals)." | 7.65 | A large open multicentre trial of clomipramine (Anafranil) in the management of phobic disorders. ( Beaumont, G, 1977) |
| "To examine the effects of long-term treatment with citalopram or clomipramine on subjective phobic symptoms in patients with panic disorder." | 5.09 | Citalopram controls phobic symptoms in patients with panic disorder: randomized controlled trial. ( Koponen, H; Lehto, H; Leinonen, E; Lepola, U; Turtonen, J; Wade, A, 2000) |
| "Seventeen outpatients with panic anxiety and agoraphobia were treated with a low, flexible dose of clomipramine in an 8-week open trial." | 5.06 | Panic attacks and agoraphobia: low dose clomipramine treatment. ( Codner, S; Cohen, L; Gladic, D; Gloger, S; Grunhaus, L; O'Ryan, F, 1989) |
| "The efficacy of clomipramine hydrochloride in the treatment of agoraphobia was investigated in an eight-week placebo-controlled double-blind study." | 5.06 | Clomipramine treatment of agoraphobic women. An eight-week controlled trial. ( Johnston, DG; Troyer, IE; Whitsett, SF, 1988) |
| "A multi-centre, double-blind trial was carried out in general practice to compare the effectiveness and tolerability of clomipramine and diazepam in patients with agoraphobia or social phobia." | 5.05 | Clomipramine and diazepam in the treatment of agoraphobia and social phobia in general practice. ( Allsopp, LF; Cooper, GL; Poole, PH, 1984) |
| "The subject of dosage of clomipramine (Anafranil) in depression and in obsessional and phobic disorders is discussed." | 4.75 | Practical considerations on the use of clomipramine (Anafranil) in general practice: an updated review. ( Beaumont, G, 1977) |
| "Clomipramine was effective and well-tolerated in controlling signs of obsessive-compulsive disorder and/or separation anxiety and/or noise phobia in 16 of 24 assessable cases, when used in combination with behaviour modification, and improvement in clinical signs was noted in 5 others." | 3.71 | Use of clomipramine in treatment of obsessive-compulsive disorder, separation anxiety and noise phobia in dogs: a preliminary, clinical study. ( Lindeman, MJ; Seksel, K, 2001) |
| "In a large, open, multicentre trial, conducted in general practice, 765 patients suffering from agoraphobia or social phobias were treated with clomipramine (Anafranil, Geigy Pharmaceuticals)." | 3.65 | A large open multicentre trial of clomipramine (Anafranil) in the management of phobic disorders. ( Beaumont, G, 1977) |
| "The author describes his experience in treating phobic disorders with both parenteral and oral clomipramine." | 3.65 | Clinical experience in the treatment of phobic disorders. ( Marshall, WK, 1977) |
| "A multicentre clinical trial of clomipramine in the treatment of obsessional and phobic disorders in general practice is described." | 3.65 | An investigation into the use of anafranil in phobic and obsessional disorders. ( Waxman, D, 1975) |
| "Alprazolam was given at a dosage of 0." | 2.71 | Use of clomipramine, alprazolam, and behavior modification for treatment of storm phobia in dogs. ( Crowell-Davis, SL; Curtis, TM; Parthasarathy, V; Seibert, LM; Sung, W, 2003) |
| "1." | 2.67 | Early response with clomipramine in obsessive compulsive disorder--a placebo controlled study. ( Fineberg, N; Montgomery, DB; Montgomery, SA, 1990) |
| " Patients were allocated at random to receive clomipramine 75 mg once daily as either the sustained-release or conventional formulation for 11 weeks following a 1-week dosage build-up period." | 2.66 | Efficacy and tolerability of sustained-release clomipramine (Anafranil SR) in the treatment of phobias: a comparison with the conventional formulation of clomipramine (Anafranil). ( Allsopp, LF; Brodie, NH; Deering, RB; Huitson, A, 1985) |
| "Patients were assessed for phobias, obsessions, general psychiatric symptoms and side-effects and each was rated on a special symptom inventory at 0, 2, 4 and 6 weeks of treatment." | 2.64 | A clinical trial of clomipramine and diazepam in the treatment of phobic and obsessional illness. ( Waxman, D, 1977) |
| "Sertraline was first developed and approved for the treatment of depression." | 1.31 | Sertraline in the treatment of anxiety disorders. ( Hirschfeld, RM, 2000) |
| "Good results have been obtained in the treatment of depression, and obsessive/compulsive/phobic states, and mixed patients." | 1.26 | Clinical experience in the treatment of obsessional states (2). ( Rack, PH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (77.55) | 18.7374 |
| 1990's | 6 (12.24) | 18.2507 |
| 2000's | 5 (10.20) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crowell-Davis, SL | 1 |
| Seibert, LM | 1 |
| Sung, W | 1 |
| Parthasarathy, V | 1 |
| Curtis, TM | 1 |
| Stein, DJ | 1 |
| Vythilingum, B | 1 |
| Mavissakalian, M | 1 |
| Telch, MJ | 1 |
| Tearnan, BH | 1 |
| Taylor, CB | 1 |
| Cobb, J | 1 |
| Marks, I | 1 |
| Ananth, J | 3 |
| Allsopp, LF | 2 |
| Cooper, GL | 1 |
| Poole, PH | 1 |
| Berney, T | 1 |
| Kolvin, I | 1 |
| Bhate, SR | 1 |
| Garside, RF | 1 |
| Jeans, J | 1 |
| Kay, B | 1 |
| Scarth, L | 1 |
| Cassano, GB | 1 |
| Castrogiovanni, P | 1 |
| Mauri, M | 1 |
| Rutigliano, G | 1 |
| Pirro, R | 1 |
| Cerone, G | 1 |
| Nielsen, NP | 1 |
| Reitano, S | 1 |
| Guidotti, N | 1 |
| Bedarida, D | 1 |
| Marchetti, FP | 1 |
| Catalano, A | 1 |
| Benecchi, MV | 1 |
| Amabile, G | 1 |
| Zanasi, M | 1 |
| Pugliese, L | 1 |
| Rocco, ML | 1 |
| Balestrieri, A | 1 |
| Tansella, M | 1 |
| Burti, L | 1 |
| Pariante, F | 1 |
| Pecknold, JC | 2 |
| McClure, DJ | 1 |
| Appeltauer, L | 1 |
| Allan, T | 1 |
| Wrzesinski, L | 1 |
| Pohl, R | 1 |
| Berchou, R | 1 |
| Rainey, JM | 1 |
| Stern, R | 1 |
| Gloger, S | 2 |
| Grunhaus, L | 2 |
| Birmacher, B | 1 |
| Troudart, T | 1 |
| Vila, G | 1 |
| Mouren-Simeoni, MC | 1 |
| Gangdev, PS | 1 |
| Leinonen, E | 1 |
| Lepola, U | 1 |
| Koponen, H | 1 |
| Turtonen, J | 1 |
| Wade, A | 1 |
| Lehto, H | 1 |
| Hirschfeld, RM | 1 |
| Seksel, K | 1 |
| Lindeman, MJ | 1 |
| Waxman, D | 3 |
| Beaumont, G | 2 |
| Amin, MM | 1 |
| Ban, TA | 1 |
| Klingner, A | 1 |
| Karabanow, O | 1 |
| Gringras, M | 1 |
| Wotton, LW | 1 |
| Bailey, RI | 2 |
| Marshall, WK | 2 |
| Rack, PH | 2 |
| Carey, MS | 1 |
| Hawkinson, R | 1 |
| Kornhaber, A | 1 |
| Wellish, CS | 1 |
| Escobar, JI | 1 |
| Landbloom, RP | 1 |
| Silva, FR | 1 |
| Wijewickrama, HS | 1 |
| Allen, JJ | 1 |
| Micev, V | 1 |
| Colgan, A | 1 |
| Wootton, LW | 1 |
| Kelly, D | 1 |
| Carrasco, JL | 1 |
| Hollander, E | 2 |
| Schneier, FR | 1 |
| Liebowitz, MR | 3 |
| de Haan, E | 1 |
| Hoogduin, CA | 1 |
| Austin, LS | 1 |
| Lydiard, RB | 1 |
| Fossey, MD | 1 |
| Zealberg, JJ | 1 |
| Laraia, MT | 1 |
| Ballenger, JC | 1 |
| Montgomery, SA | 1 |
| Montgomery, DB | 1 |
| Fineberg, N | 1 |
| Gladic, D | 1 |
| O'Ryan, F | 1 |
| Cohen, L | 1 |
| Codner, S | 1 |
| Fyer, AJ | 1 |
| Gorman, JM | 1 |
| Campeas, RB | 1 |
| Sandberg, DP | 1 |
| Papp, LA | 1 |
| Klein, DF | 1 |
| Versiani, M | 1 |
| Mundim, FD | 1 |
| Nardi, AE | 1 |
| Johnston, DG | 1 |
| Troyer, IE | 1 |
| Whitsett, SF | 1 |
| Huitson, A | 1 |
| Deering, RB | 1 |
| Brodie, NH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of Pre- and Post-Synaptic Dopamine Function in Developmental Stuttering Using 11C-Raclopride and Positron Emission Tomography[NCT00024960] | 12 participants (Actual) | Observational | 2001-10-03 | Completed | |||
| Clinical, Neurocognitive and Neuroimaging Variables Associated With Response to Treatment in Patients With OCD[NCT03993535] | Phase 4 | 250 participants (Actual) | Interventional | 2018-10-10 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for clomipramine and Phobic Disorders
| Article | Year |
|---|---|
Pharmacologic treatment of anxiety disorders.
Topics: Adrenergic beta-Antagonists; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Benzodia | 1982 |
Antidepressant medication in the treatment of agoraphobia: a critical review.
Topics: Agoraphobia; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior Therapy; Clomipramine | 1983 |
Behaviour therapy in phobic and obsessional disorders.
Topics: Agoraphobia; Arousal; Behavior Therapy; Clomipramine; Cognition; Combined Modality Therapy; Desensit | 1983 |
Are there anticompulsive or antiphobic drugs? Review of the evidence.
Topics: Adult; Antidepressive Agents; Child; Clomipramine; Depressive Disorder; Female; Humans; Male; Middle | 1983 |
Clomipramine in obsessive-compulsive disorder: a review.
Topics: Behavior Therapy; Clomipramine; Depression; Double-Blind Method; Humans; Obsessive Behavior; Obsessi | 1983 |
Practical considerations on the use of clomipramine (Anafranil) in general practice: an updated review.
Topics: Clomipramine; Depression; Dibenzazepines; Drug Interactions; Female; Humans; Male; Phobic Disorders; | 1977 |
Tricyclic therapy of the DSM-III anxiety disorders: a review with implications for further research.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Anxiety Disorders; Child; Clomipramine; Humans; Obsess | 1988 |
Clomipramine: an antiobsessive drug.
Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive D | 1986 |
17 trials available for clomipramine and Phobic Disorders
| Article | Year |
|---|---|
Use of clomipramine, alprazolam, and behavior modification for treatment of storm phobia in dogs.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Behavior Therapy; Behavi | 2003 |
Pharmacologic treatment of anxiety disorders.
Topics: Adrenergic beta-Antagonists; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Benzodia | 1982 |
Clomipramine and diazepam in the treatment of agoraphobia and social phobia in general practice.
Topics: Adolescent; Adult; Aged; Agoraphobia; Clinical Trials as Topic; Clomipramine; Diazepam; Double-Blind | 1984 |
School phobia: a therapeutic trial with clomipramine and short-term outcome.
Topics: Adolescent; Age Factors; Child; Clinical Trials as Topic; Clomipramine; Double-Blind Method; Female; | 1981 |
A multicenter controlled trial in phobic-obsessive psychoneurosis. The effect of chlorimipramine and of its combinations with haloperidol and diazepam.
Topics: Adult; Aged; Clinical Trials as Topic; Clomipramine; Diazepam; Dose-Response Relationship, Drug; Dou | 1981 |
Does tryptophan potentiate clomipramine in the treatment of agoraphobic and social phobic patients?
Topics: Adult; Agoraphobia; Clinical Trials as Topic; Clomipramine; Double-Blind Method; Drug Synergism; Dru | 1982 |
Citalopram controls phobic symptoms in patients with panic disorder: randomized controlled trial.
Topics: Adolescent; Adult; Aged; Citalopram; Clomipramine; Dose-Response Relationship, Drug; Female; Humans; | 2000 |
Clomipramine (Anafranil) and behaviour therapy in obsessive-compulsive and phobic disorders.
Topics: Adult; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Dibenzazepines; Double-Blind Method | 1977 |
Double-blind controlled study in phobias and obsessions.
Topics: Adult; Clinical Trials as Topic; Clomipramine; Dibenzazepines; Double-Blind Method; Female; Humans; | 1977 |
A clinical trial of clomipramine and diazepam in the treatment of phobic and obsessional illness.
Topics: Adolescent; Adult; Aged; Clomipramine; Diazepam; Dibenzazepines; Female; Humans; Male; Medical Histo | 1977 |
Treatment of phobic neurosis with clomipramine: a controlled clinical trial.
Topics: Adult; Clinical Trials as Topic; Clomipramine; Dibenzazepines; Drug Evaluation; Female; Humans; Male | 1976 |
Changes in obsessive/compulsive patients as measured by the Leyton Inventory before and after treatment with clomipramine.
Topics: Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Humans; Obsessive-Compulsive Dis | 1975 |
Early response with clomipramine in obsessive compulsive disorder--a placebo controlled study.
Topics: Adult; Clomipramine; Female; Humans; Male; Obsessive-Compulsive Disorder; Phobic Disorders; Placebos | 1990 |
Panic attacks and agoraphobia: low dose clomipramine treatment.
Topics: Adolescent; Adult; Agoraphobia; Anxiety Disorders; Clinical Trials as Topic; Clomipramine; Depressiv | 1989 |
Clomipramine treatment of agoraphobic women. An eight-week controlled trial.
Topics: Adult; Agoraphobia; Clinical Trials as Topic; Clomipramine; Double-Blind Method; Drug Administration | 1988 |
Clomipramine: an antiobsessive drug.
Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive D | 1986 |
Efficacy and tolerability of sustained-release clomipramine (Anafranil SR) in the treatment of phobias: a comparison with the conventional formulation of clomipramine (Anafranil).
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Clomipramine; Delayed-Action Preparations; Double | 1985 |
26 other studies available for clomipramine and Phobic Disorders
| Article | Year |
|---|---|
Social anxiety disorder: psychobiological and evolutionary underpinnings.
Topics: Amygdala; Cerebrovascular Circulation; Clomipramine; Diagnostic and Statistical Manual of Mental Dis | 2007 |
Tricyclic antidepressants and monoamine oxidase inhibitors in the treatment of agoraphobia.
Topics: Agoraphobia; Antidepressive Agents, Tricyclic; Clomipramine; Diazepam; Double-Blind Method; Humans; | 1982 |
Psychotropic drugs and behaviour therapy.
Topics: Adult; Behavior Therapy; Clomipramine; Diazepam; Female; Humans; Male; Middle Aged; Obsessive-Compul | 1981 |
Treatment of spontaneous panic attacks with chlomipramine.
Topics: Adult; Agoraphobia; Anxiety Disorders; Clomipramine; Female; Humans; Male; Middle Aged; Phobic Disor | 1981 |
[Panic attacks and panic disorders in the child].
Topics: Anxiety, Separation; Child; Clomipramine; Depressive Disorder; Dose-Response Relationship, Drug; Dru | 1993 |
Obsessive-compulsive disorder with unusual themes.
Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Clomipramine; Comorbidity; Humans; Male; Monoam | 1996 |
Sertraline in the treatment of anxiety disorders.
Topics: Adult; Clinical Trials as Topic; Clomipramine; Dose-Response Relationship, Drug; Drug Administration | 2000 |
Use of clomipramine in treatment of obsessive-compulsive disorder, separation anxiety and noise phobia in dogs: a preliminary, clinical study.
Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety, Separation; Behavior Therapy; Behavior, Animal; | 2001 |
The management of phobic disorders using clomipramine (Anafranil).
Topics: Behavior Therapy; Clomipramine; Dibenzazepines; Humans; Phobic Disorders; Relaxation Therapy | 1977 |
An uncontrolled trial of clomipramine (Anafranil) in the treatment of phobic and obsessional states in general practice.
Topics: Adult; Agoraphobia; Clomipramine; Dibenzazepines; Female; Humans; Male; Obsessive-Compulsive Disorde | 1977 |
A large open multicentre trial of clomipramine (Anafranil) in the management of phobic disorders.
Topics: Adolescent; Adult; Aged; Agoraphobia; Clomipramine; Dibenzazepines; Female; Humans; Male; Marriage; | 1977 |
The management of phobic disorders in general practice.
Topics: Clomipramine; Dibenzazepines; Humans; Phobic Disorders | 1977 |
Treatment of obsessive-compulsive neurosis with clomipramine (Anafranil).
Topics: Adult; Aged; Anxiety; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Middle Aged; O | 1977 |
Clinical experience in the treatment of phobic disorders.
Topics: Administration, Oral; Clomipramine; Dibenzazepines; Humans; Infusions, Parenteral; Phobic Disorders | 1977 |
Clinical experience in the treatment of obsessional states (2).
Topics: Clomipramine; Depression; Dibenzazepines; Humans; Obsessive-Compulsive Disorder; Phobic Disorders | 1977 |
The use of clomipramine in phobic patients. Preliminary research report.
Topics: Adolescent; Adult; Anxiety; Clomipramine; Depression; Dibenzazepines; Drug Evaluation; Drug Toleranc | 1975 |
Clomipramine in phobic and obsessional states: preliminary report.
Topics: Adult; Clomipramine; Dibenzazepines; Female; Humans; Male; Middle Aged; Obsessive-Compulsive Disorde | 1976 |
The role of intravenous clomipramine in the treatment of obsessional and phobic disorders.
Topics: Adult; Clomipramine; Dibenzazepines; Drug Evaluation; Female; Histrionic Personality Disorder; Human | 1975 |
A pilot study of anafranil in the treatment of phobic states.
Topics: Administration, Oral; Adult; Alcoholism; Blood Pressure; Clomipramine; Depression; Dibenzazepines; D | 1975 |
An investigation into the use of anafranil in phobic and obsessional disorders.
Topics: Administration, Oral; Adolescent; Adult; Aged; Clomipramine; Dibenzazepines; Drug Evaluation; Family | 1975 |
A preliminary report on the use of clomipramine in general practice.
Topics: Administration, Oral; Adult; Aged; Alcoholism; Clomipramine; Depression; Dibenzazepines; Family Prac | 1975 |
Physiological measurements in phobic and obsessional disorders.
Topics: Anxiety; Behavior Therapy; Blood Pressure; Cardiac Output; Chlordiazepoxide; Clomipramine; Diazepam; | 1975 |
Treatment outcome of obsessive compulsive disorder with comorbid social phobia.
Topics: Adult; Clomipramine; Comorbidity; Female; Fluoxetine; Fluvoxamine; Humans; Male; Middle Aged; Obsess | 1992 |
The treatment of children with obsessive-compulsive disorder.
Topics: Adolescent; Adolescent Behavior; Age Factors; Behavior Therapy; Child; Child Behavior; Clomipramine; | 1992 |
Panic and phobic disorders in patients with obsessive compulsive disorder.
Topics: Acute Disease; Adolescent; Adult; Aged; Anxiety Disorders; Clomipramine; Comorbidity; Female; Humans | 1990 |
Tranylcypromine in social phobia.
Topics: Adolescent; Adult; Anxiety; Bromazepam; Clomipramine; Female; Humans; Male; Middle Aged; Phobic Diso | 1988 |