clomipramine has been researched along with Osteoporosis in 1 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "CLP promoted OC formation and bone resorption and expression of OC-associated genes." | 5.46 | Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid. ( Boyce, BF; Li, J; Li, X; Pei, L; Sun, W; Wang, M; Wang, Z; Xing, L; Zhang, H, 2017) |
| "CLP promoted OC formation and bone resorption and expression of OC-associated genes." | 1.46 | Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid. ( Boyce, BF; Li, J; Li, X; Pei, L; Sun, W; Wang, M; Wang, Z; Xing, L; Zhang, H, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Sun, W | 1 |
| Li, J | 1 |
| Wang, M | 1 |
| Zhang, H | 1 |
| Pei, L | 1 |
| Boyce, BF | 1 |
| Wang, Z | 1 |
| Xing, L | 1 |
1 other study available for clomipramine and Osteoporosis
| Article | Year |
|---|---|
Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid.
Topics: Animals; Bone Marrow Cells; Bone Resorption; Cell Count; Clomipramine; Diphosphonates; Imidazoles; M | 2017 |