clomipramine has been researched along with Neuroleptic Malignant Syndrome in 5 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "During treatment with clomipramine and haloperidol, a 54-year-old depressed woman exhibited a typical neuroleptic malignant syndrome (NMS)." | 3.67 | Central dopaminergic and noradrenergic receptor blockade in a patient with neuroleptic malignant syndrome. ( Ansseau, M; Dresse, AE; Franck, G; Kupfer, DJ; Poncelet, PF; Reynolds, CF; Reznik, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haddow, AM | 1 |
| Harris, D | 1 |
| Wilson, M | 1 |
| Logie, H | 1 |
| Isbister, GK | 1 |
| Buckley, NA | 1 |
| Verhoeven, WM | 1 |
| Noten, JB | 1 |
| Tuinier, S | 1 |
| van Schendel, FM | 1 |
| Ansseau, M | 1 |
| Reynolds, CF | 1 |
| Kupfer, DJ | 1 |
| Poncelet, PF | 1 |
| Franck, G | 1 |
| Dresse, AE | 1 |
| Reznik, M | 1 |
| Gotouda, H | 1 |
| Nagao, M | 1 |
| Mizukami, K | 1 |
| Takatori, T | 1 |
5 other studies available for clomipramine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Clomipramine induced neuroleptic malignant syndrome and pyrexia of unknown origin.
Topics: Antidepressive Agents, Tricyclic; Clomipramine; Dementia; Fever of Unknown Origin; Humans; Male; Mid | 2004 |
Clomipramine and neuroleptic malignant syndrome: literature on adverse reactions to psychotropic drugs continues to confuse.
Topics: Antidepressive Agents, Tricyclic; Clomipramine; Neuroleptic Malignant Syndrome; Selective Serotonin | 2005 |
[The serotonin syndrome; a misdiagnosed complication of antidepressive agents].
Topics: Adult; Akathisia, Drug-Induced; Antidepressive Agents; Clomipramine; Delirium; Diagnosis, Differenti | 1995 |
Central dopaminergic and noradrenergic receptor blockade in a patient with neuroleptic malignant syndrome.
Topics: Clomipramine; Female; Haloperidol; Humans; Middle Aged; Neuroleptic Malignant Syndrome; Receptors, A | 1986 |
[A case report of death from neuroleptic malignant syndrome].
Topics: Adult; Cause of Death; Clomipramine; Haloperidol; Humans; Male; Neuroleptic Malignant Syndrome | 1988 |