clomipramine has been researched along with Muscle Rigidity in 2 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Muscle Rigidity: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spasms are increased by Chlorimipramine which may by used as a provocative test in uncertain cases." | 1.26 | [The stiff-man syndrome. A case report with regard to clinical, electromyographical and pharmacological signs (author's transl)]. ( Heckl, R; Stöhr, M, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meinck, HM | 1 |
| Ricker, K | 1 |
| Conrad, B | 1 |
| Stöhr, M | 1 |
| Heckl, R | 1 |
2 other studies available for clomipramine and Muscle Rigidity
| Article | Year |
|---|---|
The stiff-man syndrome: new pathophysiological aspects from abnormal exteroceptive reflexes and the response to clomipramine, clonidine, and tizanidine.
Topics: Adult; Brain Stem; Clomipramine; Clonidine; Diazepam; Electromyography; Female; Humans; Muscle Rigid | 1984 |
[The stiff-man syndrome. A case report with regard to clinical, electromyographical and pharmacological signs (author's transl)].
Topics: Aged; Baclofen; Clomipramine; Clonazepam; Female; Humans; Muscle Rigidity; Muscles; Reaction Time; S | 1977 |