clomipramine has been researched along with Muscle Contraction in 16 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clomipramine was the most potent drug for inhibition of elevation in intraluminal pressure of the rat vas deferens induced by electrical stimulation of the rat hypogastric nerve." | 1.31 | Inhibitory effect of serotonergic drugs on contractile response of the rat vas deferens to electrical nerve stimulation: in vivo study. ( Han, JH; Kim, SC; Lee, MY; Seo, KK, 2000) |
| "Clomipramine was about 100-fold more potent than sertraline, fluoxetine or paroxetine for inhibiting the norepinephrine induced contraction of human vasal muscle strips." | 1.31 | Comparison of peripheral inhibitory effects of clomipramine with selective serotonin re-uptake inhibitors on contraction of vas deferens: in vitro and in vivo studies. ( Kim, SC; Lee, MY; Seo, KK, 2001) |
| " A clearcut dosage schedule for in- and out-patients using imipramine (Tofranil) or chlorimipramine (Anafranil) and haloperidol (Haldol) is established." | 1.26 | [The treatment of chronic pain with psychotropic drugs]. ( Kocher, R, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Birowo, P | 1 |
| Uckert, S | 1 |
| Kedia, GT | 1 |
| Scheller, F | 1 |
| Meyer, M | 1 |
| Taher, A | 1 |
| Rahardjo, D | 1 |
| Jonas, U | 1 |
| Kuczyk, MA | 1 |
| Mousavizadeh, K | 1 |
| Ghafourifar, P | 1 |
| Sadeghi-Nejad, H | 1 |
| McLean, DL | 1 |
| Sillar, KT | 1 |
| Masuda, Y | 1 |
| Edo, T | 1 |
| Gonella, J | 1 |
| Martrette, JM | 1 |
| Hartmann, N | 1 |
| Westphal, A | 1 |
| Divry, M | 1 |
| Ocharan, ME | 1 |
| Asbun, J | 1 |
| Valencia, I | 1 |
| Castillo, C | 1 |
| Castillo, EF | 1 |
| Leroi, AM | 1 |
| Lalaude, O | 1 |
| Antonietti, M | 1 |
| Touchais, JY | 1 |
| Ducrotte, P | 1 |
| Menard, JF | 1 |
| Denis, P | 1 |
| Kim, SC | 2 |
| Seo, KK | 2 |
| Han, JH | 1 |
| Lee, MY | 2 |
| Delini-Stula, A | 1 |
| Radeke, E | 1 |
| Vassout, A | 1 |
| Kocher, R | 1 |
| Tseng, LF | 2 |
| Mtabaji, JP | 1 |
| Manku, MS | 1 |
| Horrobin, DF | 1 |
| Van Dorsser, W | 1 |
| Dresse, A | 1 |
16 other studies available for clomipramine and Muscle Contraction
| Article | Year |
|---|---|
Evaluating the role of the serotoninergic system in the control of human seminal vesicle smooth muscle-an in vitro approach.
Topics: Adrenergic alpha-Agonists; Aged; Clomipramine; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, D | 2009 |
Calcium channel blocking activity of thioridazine, clomipramine and fluoxetine in isolated rat vas deferens: a relative potency measurement study.
Topics: Animals; Antidepressive Agents; Calcium; Calcium Channel Blockers; Clomipramine; Dose-Response Relat | 2002 |
Divergent actions of serotonin receptor activation during fictive swimming in frog embryos.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Axons; Central Nervous System; C | 2004 |
Mechanisms involved in the contraction of intrahepatic portal vein branches by clomipramine and oxethazaine in isolated perfused rat livers.
Topics: Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Ethanolamines; Liver; M | 2005 |
The physiological role of peripheral serotoninergic neurones. A review.
Topics: Animals; Clomipramine; Electric Stimulation; Fenclonine; Muscle Contraction; Muscle, Smooth; Myenter | 1981 |
Effect of controllable stress on myosin heavy chain expression and muscle-specific protection by clomipramine.
Topics: Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Clomipramine; Female; Gene Expression | 1998 |
A study of the interactions of tricyclic antidepressants with alpha 1-adrenoceptor subtypes in rat aorta and caudal arteries.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Aorta, Thoracic; Arteries; Clomipramine; D | 1998 |
Prolonged stationary colonic motility recording in seven patients with severe constipation secondary to antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents; Anxiety Disorders; Cathartics; Cholinergic Antagonists; | 2000 |
Inhibitory effect of serotonergic drugs on contractile response of the rat vas deferens to electrical nerve stimulation: in vivo study.
Topics: Animals; Clomipramine; Electric Stimulation; Fluoxetine; Male; Muscle Contraction; Muscle, Smooth; P | 2000 |
Comparison of peripheral inhibitory effects of clomipramine with selective serotonin re-uptake inhibitors on contraction of vas deferens: in vitro and in vivo studies.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Dose-Response Relationship, Drug; Electric St | 2001 |
Some aspects of the psychopharmacological activity of maprotiline (Ludiomil): effects of single and repeated treatments.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Anthracenes; Behavior, Animal; Body Temperature; Clomip | 1978 |
[The treatment of chronic pain with psychotropic drugs].
Topics: Clomipramine; Haloperidol; Humans; Imipramine; Methotrimeprazine; Muscle Contraction; Pain; Psychotr | 1978 |
Blockade of para-methoxyamphetamine induced serotonin release by serotonin uptake inhibitors.
Topics: Amphetamines; Animals; Brain; Clomipramine; Desipramine; Fluoxetine; Hydroxyindoleacetic Acid; Male; | 1978 |
Hydroxytryptamine uptake inhibitors block para- methoxyamphetamine-induced 5-HT release.
Topics: Amphetamines; Animals; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Male | 1979 |
Actions of the tricyclic antidepressant clomipramine on responses to pressor agents. Interactions with prostaglandin E2.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Clomipramine; Dibenzazepines; Drug Synergism; Ileum; | 1977 |
[Comparative effects of various antidepressants on the response to noradrenaline of the deferent canal and the arterial pressure, and the response to 5-hydroxytryptamine of the rat uterus].
Topics: Amitriptyline; Animals; Antidepressive Agents; Blood Pressure; Carotid Arteries; Clomipramine; Diben | 1974 |