clomipramine has been researched along with Multiple Sclerosis in 2 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In mice with experimental autoimmune encephalomyelitis, a model of MS, clomipramine ameliorates clinical signs of acute and chronic phases." | 5.46 | Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic. ( Faissner, S; Fan, Y; Kaushik, DK; Koch, M; Metz, L; Mishra, M; Rauw, G; Silva, C; Wang, J; Yong, VW, 2017) |
| "A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a." | 5.31 | Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine. ( Dubisar, BM; Farrar, CD; Khan, R; Stoner, SC, 2002) |
| "In mice with experimental autoimmune encephalomyelitis, a model of MS, clomipramine ameliorates clinical signs of acute and chronic phases." | 1.46 | Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic. ( Faissner, S; Fan, Y; Kaushik, DK; Koch, M; Metz, L; Mishra, M; Rauw, G; Silva, C; Wang, J; Yong, VW, 2017) |
| "A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a." | 1.31 | Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine. ( Dubisar, BM; Farrar, CD; Khan, R; Stoner, SC, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Faissner, S | 1 |
| Mishra, M | 1 |
| Kaushik, DK | 1 |
| Wang, J | 1 |
| Fan, Y | 1 |
| Silva, C | 1 |
| Rauw, G | 1 |
| Metz, L | 1 |
| Koch, M | 1 |
| Yong, VW | 1 |
| Dubisar, BM | 1 |
| Stoner, SC | 1 |
| Khan, R | 1 |
| Farrar, CD | 1 |
2 other studies available for clomipramine and Multiple Sclerosis
| Article | Year |
|---|---|
Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic.
Topics: Animals; Axons; B-Lymphocytes; Blood-Brain Barrier; Cell Proliferation; Cells, Cultured; Clomipramin | 2017 |
Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.
Topics: Adult; Asperger Syndrome; Basal Ganglia Diseases; Clomipramine; Humans; Interferon beta-1a; Interfer | 2002 |