clomipramine has been researched along with Lipidoses in 9 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| "Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types." | 1.36 | Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010) |
| "to drug-induced lipidosis." | 1.25 | Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs. ( Lüllmann-Rauch, R; Scheid, D, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lowe, R | 1 |
| Glen, RC | 1 |
| Mitchell, JB | 1 |
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Sgaragli, GP | 3 |
| Della Corte, L | 3 |
| Gremigni, D | 4 |
| Vannelli, G | 2 |
| Sgaragli, G | 1 |
| Mengazzini, I | 1 |
| Xia, Z | 1 |
| Appelkvist, EL | 1 |
| DePierre, JW | 1 |
| Nässberger, L | 1 |
| Lüllmann-Rauch, R | 2 |
| Scheid, D | 1 |
| Megazzini, I | 1 |
| Mobilio, R | 1 |
9 other studies available for clomipramine and Lipidoses
| Article | Year |
|---|---|
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio | 2010 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
Chlorimipramine-induced phospholipidosis: biochemical and pharmacokinetic observations in the rat.
Topics: Animals; Clomipramine; Kidney; Lipidoses; Liver; Lung; Male; Phospholipids; Rats; Rats, Inbred Strai | 1983 |
[Phospholipidosis of the rat lung following administrations of chlorimipramine].
Topics: Animals; Clomipramine; Lipidoses; Lung; Lung Diseases; Phospholipids; Rats | 1981 |
[Phospholipidosis induced by chlorimipramine in rat lung].
Topics: Animals; Clomipramine; Lipidoses; Lung; Male; Microscopy, Electron; Mitochondria; Phospholipids; Rat | 1980 |
Tricyclic antidepressant-induced lipidosis in human peripheral monocytes in vitro, as well as in a monocyte-derived cell line, as monitored by spectrofluorimetry and flow cytometry after staining with Nile red.
Topics: Antidepressive Agents, Tricyclic; Cell Line; Citalopram; Clomipramine; Flow Cytometry; Fluorescent D | 1997 |
Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chlorpromazine; Clomipramine; Dibenzocyclo | 1975 |
Chlorimipramine-induced phospholipidosis: biochemical and pharmacokinetic observations [proceedings].
Topics: Animals; Clomipramine; Kinetics; Lipidoses; Male; Phospholipids; Rats | 1979 |
Lipidosis-like ultrastructural alterations in rat lymph nodes after treatment with tricyclic antidepressants or neuroleptics.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chlorpromazine; Clomipramine; Dibenzocyclo | 1974 |