clomipramine has been researched along with Inadequate Sleep in 31 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study patients with a major depressive disorder were first subjected to total sleep deprivation (TSD) and then treated with clomipramine." | 7.68 | The effects of total sleep deprivation and subsequent treatment with clomipramine on depressive symptoms and sleep electroencephalography in patients with a major depressive disorder. ( Berger, M; Riemann, D, 1990) |
| "In the present study patients with a major depressive disorder were first subjected to total sleep deprivation (TSD) and then treated with clomipramine." | 3.68 | The effects of total sleep deprivation and subsequent treatment with clomipramine on depressive symptoms and sleep electroencephalography in patients with a major depressive disorder. ( Berger, M; Riemann, D, 1990) |
| "Improvement in depression after total sleep deprivation (TSD) is, as a rule, followed by relapse after subsequent ad libitum sleep." | 2.67 | Total and partial sleep deprivation in clomipramine-treated endogenous depressives. ( Beersma, D; Elsenga, S; Van den Hoofdakker, RH, 1990) |
| "A negative response to sleep deprivation, an increase in MAO activity as a result of sleep deprivation, the appearance of signs of fatigue (vigilance index) in the EEG after the first infusion as well as obvious autonomic symptoms before the start of treatment are indicative of a response to maprotiline." | 2.66 | Biological predictors of success of antidepressant drug therapy. ( Fähndrich, E, 1987) |
| "In a previous study it was shown that in endogenous depression repeated sleep deprivation (SD) during clomipramine treatment resulted in rapid improvement after each SD." | 2.65 | Maintenance of therapeutic effects of total sleep deprivation by limitation of subsequent sleep. A pilot study. ( van Bemmel, AL; van den Hoofdakker, RH, 1981) |
| "In the sleep deprivation/chlorimipramine group a quick and long-lasting remission of depressive symptoms could be demonstrated." | 2.64 | [Combined sleep deprivation/chlorimipramine therapy of endogenous depression (author's transl)]. ( Amelung, U; Loosen, PT; Merkel, U, 1976) |
| "Twenty-four hours of total sleep deprivation produced changes in firing rate comparable to 10 days of clomipramine treatment." | 1.29 | Sleep deprivation is a less potent agent than clomipramine in increasing firing rate in lateral septal neurons in the rat. ( Alcalá-Herrera, V; Contreras, CM; Marván, ML, 1993) |
| "3." | 1.29 | The combination of several antidepressants is not synergistic on the firing of lateral septal neurons in the rat. ( Beltrán, D; Contreras, CM; Molina-Hernández, M; Saavedra, M, 1995) |
| "These effects of sleep deprivation were to a large extent similar to those of sleep deprivation under drug free conditions." | 1.28 | Effect of clomipramine on sleep and EEG power spectra in the diurnal rodent Eutamias sibiricus. ( Beersma, DG; Daan, S; Dijk, DJ; Strijkstra, A; Van den Hoofdakker, RH, 1991) |
| "Total sleep deprivation (TSD) in depressive patients is known to produce sudden changes in mood, but the factors involved in these mood changes are poorly understood." | 1.28 | Observed behavior as a predictor of the response to sleep deprivation in depressed patients. ( Beersma, DG; Bouhuys, AL; van den Hoofdakker, RH, 1989) |
| "The reaction to sleep deprivation (SD) and the changes in MAO activity resulting from sleep deprivation were tested on 60 depressive patients as predictors for antidepressant drug treatment." | 1.27 | [When do I give which antidepressant in the individual case?]. ( Fähndrich, E, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (61.29) | 18.7374 |
| 1990's | 10 (32.26) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kundermann, B | 1 |
| Strate, P | 1 |
| Hemmeter-Spernal, J | 1 |
| Huber, MT | 1 |
| Krieg, JC | 1 |
| Lautenbacher, S | 1 |
| Fähndrich, E | 4 |
| Mirmiran, M | 2 |
| Scholtens, J | 1 |
| van de Poll, NE | 2 |
| Uylings, HB | 2 |
| van der Gugten, J | 1 |
| Boer, GJ | 2 |
| Müller-Oerlinghausen, B | 1 |
| van Bemmel, AL | 1 |
| van den Hoofdakker, RH | 7 |
| Kitahama, K | 2 |
| Valatx, JL | 2 |
| Jouvet, M | 1 |
| Corner, MA | 1 |
| Bour, HL | 1 |
| van Oyen, HG | 1 |
| Asakura, W | 1 |
| Matsumoto, K | 1 |
| Ohta, H | 1 |
| Watanabe, H | 1 |
| Contreras, CM | 2 |
| Marván, ML | 1 |
| Alcalá-Herrera, V | 1 |
| Nagayama, H | 1 |
| Maudhuit, C | 1 |
| Hamon, M | 1 |
| Adrien, J | 1 |
| Beltrán, D | 1 |
| Saavedra, M | 1 |
| Molina-Hernández, M | 1 |
| Prathiba, J | 1 |
| Kumar, KB | 1 |
| Karanth, KS | 1 |
| Loosen, PT | 2 |
| Merkel, U | 2 |
| Amelung, U | 2 |
| Wirz-Justice, A | 2 |
| Pühringer, W | 2 |
| Hole, G | 2 |
| Beersma, DG | 3 |
| Dijk, DJ | 1 |
| Strijkstra, A | 1 |
| Daan, S | 1 |
| Achermann, P | 1 |
| Borbély, AA | 1 |
| Elsenga, S | 3 |
| Beersma, D | 1 |
| Riemann, D | 1 |
| Berger, M | 1 |
| Bouhuys, AL | 1 |
| Zucconi, GG | 1 |
| Belia, S | 1 |
| Menichini, E | 1 |
| Castigli, E | 1 |
| Giuditta, A | 1 |
| Hilakivi, L | 2 |
| Sinclair, JD | 1 |
1 review available for clomipramine and Inadequate Sleep
| Article | Year |
|---|---|
[Therapy of emotional disturbance by manipulation of the biological clocks].
Topics: Affective Symptoms; Antidepressive Agents; Circadian Rhythm; Clinical Trials as Topic; Clomipramine; | 1995 |
6 trials available for clomipramine and Inadequate Sleep
| Article | Year |
|---|---|
Mid-term effects of serial sleep deprivation therapy implemented in cognitive-behavioral treatment on the neuroendocrine response to clomipramine in patients with major depression.
Topics: Adult; Affect; Analysis of Variance; Antidepressive Agents, Tricyclic; Behavior Therapy; Clomipramin | 2009 |
Maintenance of therapeutic effects of total sleep deprivation by limitation of subsequent sleep. A pilot study.
Topics: Clinical Trials as Topic; Clomipramine; Depressive Disorder; Female; Humans; Male; Middle Aged; Pilo | 1981 |
Letter: Combined sleep deprivation and clomipramine in primary depression.
Topics: Adult; Clomipramine; Depression; Dibenzazepines; Humans; Middle Aged; Remission, Spontaneous; Sleep | 1976 |
[Combined sleep deprivation/chlorimipramine therapy of endogenous depression (author's transl)].
Topics: Adult; Clomipramine; Depression; Dibenzazepines; Humans; Middle Aged; Sleep Deprivation; Time Factor | 1976 |
Total and partial sleep deprivation in clomipramine-treated endogenous depressives.
Topics: Body Temperature Regulation; Clomipramine; Combined Modality Therapy; Depressive Disorder; Electroen | 1990 |
Biological predictors of success of antidepressant drug therapy.
Topics: Age Factors; Anthracenes; Circadian Rhythm; Clomipramine; Depressive Disorder; Drug Administration S | 1987 |
24 other studies available for clomipramine and Inadequate Sleep
| Article | Year |
|---|---|
[When do I give which antidepressant in the individual case?].
Topics: Anthracenes; Antidepressive Agents; Clomipramine; Depressive Disorder; Humans; Maprotiline; Monoamin | 1984 |
Effect of sleep deprivation as a predictor of treatment response to antidepressant medication.
Topics: Adult; Aged; Anthracenes; Clomipramine; Depressive Disorder; Female; Humans; Male; Maprotiline; Midd | 1983 |
Effects of experimental suppression of active (REM) sleep during early development upon adult brain and behavior in the rat.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain; Cell Differentiation; Clomipramine; Clonidine; | 1983 |
Monoamine oxidase activity in platelets before and after sleep deprivation as predictor for antidepressive drug response.
Topics: Antidepressive Agents; Blood Platelets; Clomipramine; Depressive Disorder; Female; Humans; Kinetics; | 1983 |
Paradoxical sleep deprivation and performance of an active avoidance task: impairment of c57BR mice and no effect in c57BL/6 mice.
Topics: alpha-Methyltyrosine; Animals; Attention; Avoidance Learning; Clomipramine; Discrimination Learning; | 1981 |
Instrumental and pharmacological paradoxical sleep deprivation in mice: strain differences.
Topics: Animals; Clomipramine; Electrodes, Implanted; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; M | 1980 |
Does rapid-eye-movement sleep play a role in brain development?
Topics: Animals; Behavior, Animal; Body Weight; Brain; Clomipramine; Female; Male; Organ Size; Rats; Sleep D | 1980 |
REM sleep deprivation potentiates the effects of imipramine and desipramine but not that of clomipramine in the forced swimming test.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Behavior, Animal; Brain; Clomipramine; | 1993 |
Sleep deprivation is a less potent agent than clomipramine in increasing firing rate in lateral septal neurons in the rat.
Topics: Animals; Clomipramine; Male; Rats; Rats, Wistar; Septal Nuclei; Sleep Deprivation; Time Factors | 1993 |
Effects of chronic treatment with zimelidine and REM sleep deprivation on the regulation of raphe neuronal activity in a rat model of depression.
Topics: Animals; Citalopram; Clomipramine; Depression; Dose-Response Relationship, Drug; Electrophysiology; | 1996 |
The combination of several antidepressants is not synergistic on the firing of lateral septal neurons in the rat.
Topics: Animals; Antidepressive Agents; Clomipramine; Drug Synergism; Electroconvulsive Therapy; Male; Rats; | 1995 |
Effects of REM sleep deprivation on cholinergic receptor sensitivity and passive avoidance behavior in clomipramine model of depression.
Topics: Animals; Animals, Newborn; Avoidance Learning; Clomipramine; Depression; Male; Motor Activity; Musca | 2000 |
Sleep deprivation and clomipramine in endogenous depression.
Topics: Clomipramine; Depression; Dibenzazepines; Humans; Maprotiline; Sleep Deprivation | 1976 |
Response to sleep deprivation as a predictor of therapeutic results with antidepressant drugs.
Topics: Antidepressive Agents, Tricyclic; Clomipramine; Depression; Female; Humans; Imipramine; Male; Maprot | 1979 |
Can non-REM sleep be depressogenic?
Topics: Antidepressive Agents, Tricyclic; Benzodiazepines; Clomipramine; Depressive Disorder; Electroencepha | 1992 |
Effect of clomipramine on sleep and EEG power spectra in the diurnal rodent Eutamias sibiricus.
Topics: Animals; Arousal; Clomipramine; Electroencephalography; Male; Sciuridae; Sleep; Sleep Deprivation; S | 1991 |
Simulation of human sleep: ultradian dynamics of electroencephalographic slow-wave activity.
Topics: Acoustic Stimulation; Activity Cycles; Adult; Clomipramine; Electroencephalography; Humans; Male; Mo | 1990 |
The effects of total sleep deprivation and subsequent treatment with clomipramine on depressive symptoms and sleep electroencephalography in patients with a major depressive disorder.
Topics: Adolescent; Adult; Clomipramine; Depressive Disorder; Electroencephalography; Female; Humans; Male; | 1990 |
Observed behavior as a predictor of the response to sleep deprivation in depressed patients.
Topics: Adult; Arousal; Attention; Clomipramine; Depressive Disorder; Female; Humans; Male; Middle Aged; Mot | 1989 |
Body core temperature and depression during total sleep deprivation in depressives.
Topics: Body Temperature Regulation; Circadian Rhythm; Clomipramine; Combined Modality Therapy; Depressive D | 1988 |
Paradoxical sleep deprivation of the mother enhances DNA synthesis in fetal rat brain: autoradiographic and biochemical evidence.
Topics: Animals; Autoradiography; Brain; Cell Division; Clomipramine; DNA; Female; Fetus; Pregnancy; Rats; R | 1986 |
Adult alcohol consumption after pharmacological intervention in neonatal sleep.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Brain; Clomipramine; Electroencephalography; Electromyo | 1987 |
Response to total sleep deprivation and clomipramine in endogenous depression.
Topics: Adult; Aged; Bipolar Disorder; Circadian Rhythm; Clomipramine; Combined Modality Therapy; Depressive | 1987 |
Effect of neonatal clomipramine treatment on adult alcohol drinking in the AA and ANA rat lines.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Clomipramine; Drinking; Male; Mice; Rats; Rats, Inbred | 1986 |