clomipramine has been researched along with Hypotension, Orthostatic in 11 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") of yohimbine in 12 patients with depression with clomipramine-induced orthostatic hypotension." | 9.06 | Effect of yohimbine on blood pressure in patients with depression and orthostatic hypotension induced by clomipramine. ( Bensimon, G; Diquet, B; Isnard, F; Lacomblez, L; Lecrubier, Y; Puech, AJ, 1989) |
| ") of yohimbine in 12 patients with depression with clomipramine-induced orthostatic hypotension." | 5.06 | Effect of yohimbine on blood pressure in patients with depression and orthostatic hypotension induced by clomipramine. ( Bensimon, G; Diquet, B; Isnard, F; Lacomblez, L; Lecrubier, Y; Puech, AJ, 1989) |
| "Following the observation that two patients with depression and essential orthostatic hypotension recovered from the latter affection after yohimbine administration, an open study was conducted to assess the activity of yohimbine in correcting orthostatic hypotension induced by tricyclic antidepressants." | 3.66 | [Treatment of orthostatic hypotension induced by tricyclic antidepressants with yohimbine (author's transl)]. ( Allilaire, JF; des Lauriers, A; Lecrubier, Y; Simon, P; Widlocher, D, 1980) |
| "From a clinical point of view, orthostatic hypotension is a significant side effect during antidepressant treatment, particularly in the case of tricyclic antidepressants (TCAs)." | 2.71 | Orthostatic side effects of clomipramine and moclobemide during treatment for depression. ( Stage, KB, 2005) |
| "Milnacipran is a new antidepressive drug, a combined noradrenaline/serotonin (NA/5-HT) reuptake inhibitor, which has been suggested to be as effective as and better tolerated than tricyclic antidepressants." | 2.68 | Long-term efficacy and safety of milnacipran compared to clomipramine in patients with major depression. ( Koponen, H; Leinonen, E; Lepola, U; Mehtonen, OP; Rimon, R, 1997) |
| "Orthostatic hypotension, the clinically most important side effect in treatment with tricyclic antidepressants, was investigated in a double-blind study with clomipramine and the selective serotonin reuptake inhibitor citalopram given for 5 weeks." | 2.66 | Orthostatic side effects of clomipramine and citalopram during treatment for depression. ( Christensen, P; Gram, LF; Kragh-Sørensen, P; Pedersen, OL; Thomsen, HY, 1985) |
| "Clomipramine used alone is an affective analgesic against organic pain due to a lesion of the peripheral nervous system, in particular post-herpetic pain." | 1.26 | [The treatment of organic pain of the peripheral nervous system using clomipramine. 30 cases (author's transl)]. ( Castaigne, P; Laplane, D; Morales, R, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stage, KB | 1 |
| Lecrubier, Y | 4 |
| Puech, AJ | 2 |
| Des Lauriers, A | 3 |
| Widlocher, D | 2 |
| Allilaire, JF | 2 |
| Simon, P | 1 |
| Schlingemann, RO | 1 |
| Smit, AA | 1 |
| Lunel, HF | 1 |
| Hijdra, A | 1 |
| Leinonen, E | 1 |
| Lepola, U | 1 |
| Koponen, H | 1 |
| Mehtonen, OP | 1 |
| Rimon, R | 1 |
| Castaigne, P | 1 |
| Laplane, D | 1 |
| Morales, R | 1 |
| Steru, L | 1 |
| Puech, A | 1 |
| Escobar, JI | 1 |
| Teeter, RR | 1 |
| Tuason, VB | 1 |
| Schiele, BC | 1 |
| Lacomblez, L | 1 |
| Bensimon, G | 1 |
| Isnard, F | 1 |
| Diquet, B | 1 |
| Christensen, P | 1 |
| Thomsen, HY | 1 |
| Pedersen, OL | 1 |
| Gram, LF | 1 |
| Kragh-Sørensen, P | 1 |
| Balant-Gorgia, AE | 1 |
| Balant, LP | 1 |
| Aapro, N | 1 |
| Garrone, GE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Depression - Can Vitamin D Alleviate Symptoms of Depression Not Cured by Antidepressants as Well as Alleviate Negative Skeletal Effects Caused by Antidepressants?[NCT01932931] | 71 participants (Actual) | Interventional | 2013-10-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for clomipramine and Hypotension, Orthostatic
| Article | Year |
|---|---|
Orthostatic side effects of clomipramine and moclobemide during treatment for depression.
Topics: Adult; Aged; Antidepressive Agents; Clomipramine; Depressive Disorder, Major; Drug Administration Sc | 2005 |
Favourable effects of yohimbine on clomipramine-induced orthostatic hypotension: a double-blind study.
Topics: Clinical Trials as Topic; Clomipramine; Double-Blind Method; Humans; Hypotension, Orthostatic; Yohim | 1981 |
Long-term efficacy and safety of milnacipran compared to clomipramine in patients with major depression.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Clomipramine; Cyclopropanes; Depressive Disorder; Do | 1997 |
Effect of yohimbine on blood pressure in patients with depression and orthostatic hypotension induced by clomipramine.
Topics: Adult; Blood Pressure; Clomipramine; Depression; Double-Blind Method; Female; Heart Rate; Humans; Hy | 1989 |
Orthostatic side effects of clomipramine and citalopram during treatment for depression.
Topics: Adult; Citalopram; Clomipramine; Depressive Disorder; Female; Humans; Hypotension, Orthostatic; Male | 1985 |
6 other studies available for clomipramine and Hypotension, Orthostatic
| Article | Year |
|---|---|
[Treatment of orthostatic hypotension induced by tricyclic antidepressants with yohimbine (author's transl)].
Topics: Blood Pressure; Clomipramine; Depression; Double-Blind Method; Humans; Hypotension, Orthostatic; Yoh | 1980 |
Amaurosis fugax on standing and angle-closure glaucoma with clomipramine.
Topics: Antidepressive Agents, Tricyclic; Blindness; Clomipramine; Depression; Female; Glaucoma, Angle-Closu | 1996 |
[The treatment of organic pain of the peripheral nervous system using clomipramine. 30 cases (author's transl)].
Topics: Adult; Aged; Clomipramine; Diazepam; Dibenzazepines; Drug Evaluation; Female; Fludrocortisone; Herpe | 1979 |
[Favorable effect of yohimbine hydrochloride on orthostatic hypotension induced by clomipramine].
Topics: Clomipramine; Humans; Hypotension, Orthostatic; Yohimbine | 1979 |
Intravenous chlorimipramine and depressive subtypes.
Topics: Adult; Aged; Bipolar Disorder; Blood Pressure; Clomipramine; Depression; Dibenzazepines; Drug Evalua | 1976 |
Treatment of major depressive disorder with melancholia.
Topics: Bromazepam; Clomipramine; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Fluraze | 1985 |