clomipramine has been researched along with Glioma in 5 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of chronic treatment with antidepressants, verapamil, or lithium on serotonin (5-HT)-induced Ca2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy." | 7.69 | Chronic treatment with antidepressants, verapamil, or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells. ( Kagaya, A; Uchitomi, Y; Yamaji, T; Yamawaki, S; Yokota, N, 1997) |
| "The effects of chronic treatment with antidepressants, verapamil, or lithium on serotonin (5-HT)-induced Ca2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy." | 3.69 | Chronic treatment with antidepressants, verapamil, or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells. ( Kagaya, A; Uchitomi, Y; Yamaji, T; Yamawaki, S; Yokota, N, 1997) |
| "Rat C6 glioma is a chemo-resistant experimental brain tumor that is difficult to treat with various drug combinations." | 1.35 | Potentiation of cytotoxicity by combination of imatinib and chlorimipramine in glioma. ( Aktas, E; Bilir, A; Bonavida, B; Erguven, M; Oktem, G; Ozdemir, A; Uslu, A, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Daley, E | 1 |
| Wilkie, D | 1 |
| Loesch, A | 1 |
| Hargreaves, IP | 1 |
| Kendall, DA | 1 |
| Pilkington, GJ | 1 |
| Bates, TE | 1 |
| Bilir, A | 1 |
| Erguven, M | 1 |
| Oktem, G | 1 |
| Ozdemir, A | 1 |
| Uslu, A | 1 |
| Aktas, E | 1 |
| Bonavida, B | 1 |
| Yamaji, T | 3 |
| Kagaya, A | 3 |
| Okamoto, Y | 2 |
| Hayashi, T | 2 |
| Nagaoka, I | 1 |
| Motohashi, N | 2 |
| Yamawaki, S | 3 |
| Uchitomi, Y | 1 |
| Yokota, N | 1 |
5 other studies available for clomipramine and Glioma
| Article | Year |
|---|---|
Chlorimipramine: a novel anticancer agent with a mitochondrial target.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Respiration; Cell Size; Cell Survival; Clomipr | 2005 |
Potentiation of cytotoxicity by combination of imatinib and chlorimipramine in glioma.
Topics: Animals; Annexin A5; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Bromodeoxyuridine; | 2008 |
Intracellular calcium concentration in C6BU-1 rat glioma cells: a single cell study using fluorescence microscopy/video imaging system.
Topics: Animals; Antidepressive Agents; Calcium; Cell Line; Clomipramine; Glioma; Microscopy, Fluorescence; | 1993 |
Effects of clomipramine and verapamil on 5-HT-induced intracellular calcium changes in individual C6 rat glioma cells.
Topics: Animals; Calcium; Clomipramine; Dose-Response Relationship, Drug; Glioma; Rats; Serotonin; Time Fact | 1996 |
Chronic treatment with antidepressants, verapamil, or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells.
Topics: Animals; Antidepressive Agents; Calcium; Calcium Channel Blockers; Citalopram; Clomipramine; Drug In | 1997 |