clomipramine has been researched along with Gelineau Syndrome in 33 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clomipramine is known to suppress REM sleep, and this property may be of value in treating certain features of narcolepsy." | 7.66 | The use of clomipramine as an REM sleep suppressant in narcolepsy. ( Chen, CN, 1980) |
| "Clinical examinations, questionnaires, and 24- or 36-hour polygraphic recordings were performed on 21 adult patients with the narcolepsy syndrome to investigate the short- and long-term effects of clomipramine HCL." | 7.65 | Evaluation of short-term and long-term treatment of the narcolepsy syndrome with clomipramine hydrochloride. ( Carskadon, M; Dement, W; Guilleminault, C; Raynal, D; Takahashi, S, 1976) |
| "Fluvoxamine 25-200 mg daily and clomipramine 25-200 mg daily were given for separate three week periods to 18 subjects with narcolepsy and cataplexy." | 3.66 | Fluvoxamine and clomipramine in the treatment of cataplexy. ( Parkes, JD; Schachter, M, 1980) |
| "Clomipramine is known to suppress REM sleep, and this property may be of value in treating certain features of narcolepsy." | 3.66 | The use of clomipramine as an REM sleep suppressant in narcolepsy. ( Chen, CN, 1980) |
| "Clinical examinations, questionnaires, and 24- or 36-hour polygraphic recordings were performed on 21 adult patients with the narcolepsy syndrome to investigate the short- and long-term effects of clomipramine HCL." | 3.65 | Evaluation of short-term and long-term treatment of the narcolepsy syndrome with clomipramine hydrochloride. ( Carskadon, M; Dement, W; Guilleminault, C; Raynal, D; Takahashi, S, 1976) |
| "Narcolepsy is an emblematic, unique disease within sleep disorders that is characterised by excessive daytime sleepiness, cataplexy and other abnormal manifestations of REM sleep." | 2.48 | [Diagnostic and therapeutic update in narcolepsy]. ( Santamaria-Cano, J, 2012) |
| "Narcolepsy is a disorder of the central nervous system, the main symptoms of which are excessive daytime sleepiness (EDS) and cataplexy (an abrupt and reversible decrease in or loss of muscle tone, affecting the limbs or trunk or both, elicited by emotional stimuli)." | 2.44 | Antidepressant drugs for narcolepsy. ( Candelise, L; D'Alessandro, R; Vignatelli, L, 2008) |
| "Narcolepsy is a disorder of the central nervous system, the main symptoms of which are excessive daytime sleepiness (EDS) and cataplexy (an abrupt and reversible decrease in or loss of muscle tone, affecting the limbs and/or trunk, elicited by emotional stimuli)." | 2.43 | Antidepressant drugs for narcolepsy. ( Candelise, L; D'Alessandro, R; Vignatelli, L, 2005) |
| "Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness and cataplexy." | 2.43 | Molecular genetics and treatment of narcolepsy. ( Dauvilliers, Y; Tafti, M, 2006) |
| "Narcolepsy was diagnosed in the 32-year-old man." | 2.41 | [Unwanted napping]. ( van Duijn, H; Wouda, EJ, 2001) |
| "Narcolepsy is a disorder of sleep with uncontrolled sleepiness and cataplexy." | 2.40 | [Narcolepsy]. ( Shimizu, T, 1998) |
| "Cataplexy is by far the most predictive feature of narcolepsy." | 1.40 | Status cataplecticus as initial presentation of late onset narcolepsy. ( Panda, S, 2014) |
| "Saudi patients with narcolepsy have the same clinical presentation as reported in the Western literature." | 1.33 | Narcolepsy in Saudi Arabia. Demographic and clinical perspective of an under-recognized disorder. ( Alenezi, AM; BaHammam, AS, 2006) |
| "Treatment with methylphenidate and clomipramine was effective; methylphenidate (30 mg/day) improved his wakefulness and alertness throughout the day, and clomipramine (20 mg/day) reduced the number of cataplexic episodes." | 1.31 | [Narcolepsy in a prepubertal boy]. ( Chang, S; Ishikawa, T; Mizuno, K; Tsukamoto, H, 2001) |
| "A case of narcolepsy with marked cataplexy is described in detail." | 1.26 | Severe hypermotility during sleep in treatment of cataplexy with clomipramine. ( Bental, E; Lavie, P; Sharf, B, 1979) |
| " Side effects were common and almost half these patients became tolerant, needing higher dosage to control symptoms." | 1.25 | Natural history, symptoms and treatment of the narcoleptic syndrome. ( Asselman, P; Baraitser, M; Marsden, CD; Parkes, JD, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (36.36) | 18.7374 |
| 1990's | 6 (18.18) | 18.2507 |
| 2000's | 9 (27.27) | 29.6817 |
| 2010's | 5 (15.15) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Ando, T | 1 |
| Wakai, M | 1 |
| Kanbayashi, T | 1 |
| Katsuno, M | 1 |
| Fullam, S | 1 |
| Scott, A | 1 |
| Garvey, JF | 1 |
| Meinen, CN | 1 |
| Smith, KM | 1 |
| Tillema, JM | 1 |
| Kotagal, S | 1 |
| Panda, S | 1 |
| Parkes, JD | 3 |
| Baraitser, M | 1 |
| Marsden, CD | 1 |
| Asselman, P | 1 |
| Tarrant, N | 1 |
| Cavanna, AE | 1 |
| Rickards, H | 1 |
| Santamaria-Cano, J | 1 |
| Willie, JT | 1 |
| Chemelli, RM | 1 |
| Sinton, CM | 1 |
| Tokita, S | 1 |
| Williams, SC | 1 |
| Kisanuki, YY | 1 |
| Marcus, JN | 1 |
| Lee, C | 1 |
| Elmquist, JK | 1 |
| Kohlmeier, KA | 1 |
| Leonard, CS | 1 |
| Richardson, JA | 1 |
| Hammer, RE | 1 |
| Yanagisawa, M | 1 |
| Vignatelli, L | 2 |
| D'Alessandro, R | 2 |
| Candelise, L | 2 |
| Dauvilliers, Y | 1 |
| Tafti, M | 1 |
| Quick, AD | 1 |
| Black, DN | 1 |
| Attarian, HP | 1 |
| BaHammam, AS | 1 |
| Alenezi, AM | 1 |
| Janeiro, M | 1 |
| Camblor, E | 1 |
| Fernández, R | 1 |
| Núñez, D | 1 |
| Hess, CW | 1 |
| Schachter, M | 1 |
| Schrader, H | 1 |
| Chen, CN | 1 |
| Clavelou, P | 1 |
| Tournilhac, M | 1 |
| Vidal, C | 1 |
| Georget, AM | 1 |
| Picard, L | 1 |
| Merienne, L | 1 |
| Parkes, D | 1 |
| Helbing-Zwanenburg, B | 1 |
| Kamphuisen, HA | 1 |
| Mourtazaev, MS | 1 |
| Shimizu, T | 1 |
| Tsukamoto, H | 1 |
| Ishikawa, T | 1 |
| Chang, S | 1 |
| Mizuno, K | 1 |
| Wouda, EJ | 1 |
| van Duijn, H | 1 |
| Bental, E | 1 |
| Lavie, P | 1 |
| Sharf, B | 1 |
| Montplaisir, J | 1 |
| Debono, AG | 1 |
| Jenner, P | 1 |
| Walters, J | 1 |
| Guilleminault, C | 1 |
| Raynal, D | 1 |
| Takahashi, S | 1 |
| Carskadon, M | 1 |
| Dement, W | 1 |
| Lange, KW | 1 |
| Egeler-Peerdeman, SM | 1 |
| Visscher, F | 1 |
| Taphoorn, MJ | 1 |
| Vespignani, H | 1 |
| Weber, M | 1 |
| Atlas, P | 1 |
| Barroche, G | 1 |
| Aguirre, M | 1 |
| Broughton, R | 1 |
| Stuss, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial[NCT02832336] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2016-10-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for clomipramine and Gelineau Syndrome
| Article | Year |
|---|---|
[Diagnostic and therapeutic update in narcolepsy].
Topics: Adolescent; Adult; Age of Onset; Animals; Autoimmune Diseases; Benzhydryl Compounds; Cataplexy; Chil | 2012 |
Antidepressant drugs for narcolepsy.
Topics: Antidepressive Agents; Cataplexy; Clomipramine; Fluvoxamine; Humans; Narcolepsy; Piperidines; Random | 2005 |
Molecular genetics and treatment of narcolepsy.
Topics: Animals; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Catechol O-Methyltransferase; Centr | 2006 |
Antidepressant drugs for narcolepsy.
Topics: Antidepressive Agents; Cataplexy; Clomipramine; Fluvoxamine; Humans; Narcolepsy; Piperidines; Random | 2008 |
Narcolepsy associated with arteriovenous malformation of the diencephalon.
Topics: Adult; Cerebral Angiography; Clomipramine; Diencephalon; HLA Antigens; Humans; Intracranial Arteriov | 1995 |
Introduction to the mechanism of action of different treatments of narcolepsy.
Topics: Amphetamine; Brain; Clomipramine; Drug Therapy, Combination; Humans; Imipramine; Narcolepsy | 1994 |
[Narcolepsy].
Topics: Antidepressive Agents, Tricyclic; Central Nervous System Stimulants; Clomipramine; Diagnosis, Differ | 1998 |
[Unwanted napping].
Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Clomipramine; Diagnosis, Di | 2001 |
[Narcolepsy].
Topics: Adolescent; Adult; Amphetamine; Cataplexy; Child; Clomipramine; Diagnosis, Differential; Female; Hum | 1990 |
1 trial available for clomipramine and Gelineau Syndrome
| Article | Year |
|---|---|
[Treatment of associated symptoms in narcolepsy with clomipramine (Anafranil)].
Topics: Adult; Clinical Trials as Topic; Clomipramine; Female; Humans; Male; Middle Aged; Narcolepsy | 1981 |
23 other studies available for clomipramine and Gelineau Syndrome
| Article | Year |
|---|---|
Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1.
Topics: Clomipramine; HLA Antigens; Humans; Male; Middle Aged; Narcolepsy; Orexins; Sleep, REM | 2022 |
Status Cataplecticus Following Abrupt Withdrawal of Clomipramine
Topics: Adult; Cataplexy; Clomipramine; Humans; Male; Narcolepsy; Orexins; Selective Serotonin Reuptake Inhi | 2019 |
Pseudo
Topics: Adolescent; Cataplexy; Clomipramine; Electroencephalography; Female; Humans; Narcolepsy; Polysomnogr | 2018 |
Status cataplecticus as initial presentation of late onset narcolepsy.
Topics: Benzhydryl Compounds; Cataplexy; Clomipramine; Diagnosis, Differential; Electroencephalography; Foll | 2014 |
Natural history, symptoms and treatment of the narcoleptic syndrome.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Cataplexy; Central Nervous System Stimulants; Clomipr | 1975 |
Pathological gambling associated with modafinil.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Clomipramine; Disruptive, Impulse Co | 2010 |
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes.
Topics: Animals; Arousal; Carrier Proteins; Cells, Cultured; Clomipramine; Disease Models, Animal; Efferent | 2003 |
New-onset narcolepsy with cataplexy in a geriatric patient.
Topics: Age Factors; Aged; Benzothiazoles; Clomipramine; Disorders of Excessive Somnolence; Dopamine Agonist | 2006 |
Narcolepsy in Saudi Arabia. Demographic and clinical perspective of an under-recognized disorder.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Aged; Antidepressive Agents, Second-Generation; Ant | 2006 |
[Narcolepsy and anesthesia].
Topics: Analgesia, Epidural; Anesthesia, Intravenous; Antiemetics; Benzhydryl Compounds; Chemical and Drug I | 2007 |
[Narcolepsy--epilepsy. Differential diagnosis].
Topics: Amnesia; Cataplexy; Clomipramine; Diagnosis, Differential; Electroencephalography; Epilepsy; Halluci | 1984 |
Fluvoxamine and clomipramine in the treatment of cataplexy.
Topics: Adult; Aged; Cataplexy; Clomipramine; Dose-Response Relationship, Drug; Female; Fluvoxamine; Humans; | 1980 |
The use of clomipramine as an REM sleep suppressant in narcolepsy.
Topics: Clomipramine; Depression, Chemical; Humans; Male; Middle Aged; Narcolepsy; Sleep; Sleep, REM | 1980 |
The origin of excessive daytime sleepiness in the Prader-Willi syndrome.
Topics: Adolescent; Adult; Catalepsy; Clomipramine; Female; Humans; Hypoventilation; Imipramine; Male; Middl | 1993 |
[Narcolepsy in a prepubertal boy].
Topics: Child; Clomipramine; HLA-DQ Antigens; HLA-DQ beta-Chains; HLA-DR2 Antigen; Humans; Male; Methylpheni | 2001 |
Editorial: Narcolepsy and cataplexy.
Topics: Brain; Catalepsy; Catecholamines; Clomipramine; Dextroamphetamine; Humans; Metabolism, Inborn Errors | 1975 |
Severe hypermotility during sleep in treatment of cataplexy with clomipramine.
Topics: Cataplexy; Clomipramine; Humans; Male; Middle Aged; Motor Activity; Narcolepsy; Sleep | 1979 |
[Hypersomnias. 1. Narcolepsy].
Topics: Amphetamines; Clomipramine; Humans; Imipramine; Methylphenidate; Monoamine Oxidase Inhibitors; Narco | 1977 |
Amphetamines, growth hormone and narcolepsy.
Topics: Adult; Aged; Amphetamine; Arousal; Clomipramine; Dextroamphetamine; Drug Interactions; Drug Toleranc | 1977 |
Evaluation of short-term and long-term treatment of the narcolepsy syndrome with clomipramine hydrochloride.
Topics: Adult; Cataplexy; Clomipramine; Dibenzazepines; Drug Evaluation; Female; Humans; Male; Methysergide; | 1976 |
[Too weak with laughing].
Topics: Adult; Cataplexy; Clomipramine; Emotions; Female; Humans; Imipramine; Male; Methylphenidate; Middle | 1990 |
[Value of mazindol in Gélineau's disease. Apropos of 10 cases].
Topics: Adolescent; Adult; Catalepsy; Clomipramine; Drug Therapy, Combination; Female; Humans; Indoles; Male | 1986 |
Does memory impairment exist in narcolepsy-cataplexy?
Topics: Adult; Aged; Cataplexy; Clomipramine; Desipramine; Drug Therapy, Combination; Female; Humans; Male; | 1985 |