clomipramine has been researched along with Electrocardiogram QT Prolonged in 3 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clomipramine is a tricyclic antidepressant for psychiatric disorders that can induce QT prolongation, which may lead to torsades de pointes." | 1.35 | Clomipramine block of the hERG K+ channel: accessibility to F656 and Y652. ( Choe, H; Chong, SH; Hong, HK; Jo, SH; Jung, SJ; Won, KH, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukushima, N | 1 |
| Nanao, K | 1 |
| Fukushima, H | 1 |
| Namera, A | 1 |
| Miura, M | 1 |
| Jo, SH | 1 |
| Hong, HK | 1 |
| Chong, SH | 1 |
| Won, KH | 1 |
| Jung, SJ | 1 |
| Choe, H | 1 |
| Oesterheld, J | 1 |
3 other studies available for clomipramine and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants.
Topics: Abnormalities, Drug-Induced; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Female; Hum | 2016 |
Clomipramine block of the hERG K+ channel: accessibility to F656 and Y652.
Topics: Algorithms; Animals; Cells, Cultured; Clomipramine; Ether-A-Go-Go Potassium Channels; Humans; Long Q | 2008 |
TCA cardiotoxicity: the latest.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Biotransformation; Child; Clomipramine; Desipramine; D | 1996 |