clomipramine has been researched along with Diabetic Neuropathies in 5 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Desipramine levels were 130-910 nM, vs 860 and 880 nM." | 2.67 | Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms. A double-blind cross-over study. ( Beck-Nielsen, H; Brøsen, K; Gram, LF; Grodum, E; Sindrup, SH; Skjold, T, 1990) |
| "We report two case of intractable painful diabetic neuropathy which occurred after the rapid lowering of blood sugar level." | 1.39 | [Two cases of medicinal treatment of diabetic post treatment painful neuropathy]. ( Hamada, K; Higuchi, H; Iwade, M; Ozaki, K; Ozaki, M; Yamagata, K; Yanaki, M, 2013) |
| "The basis of the treatment of painful diabetic neuropathy is the use of drugs that block the transmission of pain (antineuritics) and a good metabolic control of underlying disease." | 1.33 | [Intensified insulin therapy plus antineuritic medication is more effective than antineuritics alone in painful diabetic neuropathy]. ( Bastías A, MJ; Olmos C, P; Toro C, L, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Suehiro, K | 1 |
| Funao, T | 1 |
| Fujimoto, Y | 1 |
| Yamada, T | 1 |
| Mori, T | 1 |
| Nishikawa, K | 1 |
| Yanaki, M | 1 |
| Iwade, M | 1 |
| Yamagata, K | 1 |
| Hamada, K | 1 |
| Ozaki, K | 1 |
| Higuchi, H | 1 |
| Ozaki, M | 1 |
| Hearn, L | 1 |
| Moore, RA | 1 |
| Derry, S | 1 |
| Wiffen, PJ | 1 |
| Phillips, T | 1 |
| Bastías A, MJ | 1 |
| Toro C, L | 1 |
| Olmos C, P | 1 |
| Sindrup, SH | 1 |
| Gram, LF | 1 |
| Skjold, T | 1 |
| Grodum, E | 1 |
| Brøsen, K | 1 |
| Beck-Nielsen, H | 1 |
1 review available for clomipramine and Diabetic Neuropathies
| Article | Year |
|---|---|
Desipramine for neuropathic pain in adults.
Topics: Aged; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Chronic Pain; Clomipramine; Desip | 2014 |
1 trial available for clomipramine and Diabetic Neuropathies
| Article | Year |
|---|---|
Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms. A double-blind cross-over study.
Topics: Adult; Aged; Clomipramine; Desipramine; Diabetic Neuropathies; Double-Blind Method; Drug Evaluation; | 1990 |
3 other studies available for clomipramine and Diabetic Neuropathies
| Article | Year |
|---|---|
Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy.
Topics: Adrenergic Neurons; Analgesics; Animals; Clomipramine; Diabetes Mellitus, Experimental; Diabetic Neu | 2013 |
[Two cases of medicinal treatment of diabetic post treatment painful neuropathy].
Topics: Adult; Blood Glucose; Clomipramine; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans | 2013 |
[Intensified insulin therapy plus antineuritic medication is more effective than antineuritics alone in painful diabetic neuropathy].
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Amines; Analgesics; Clomipramine; Cyclohexanecarboxylic A | 2006 |