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clomipramine and Depression

clomipramine has been researched along with Depression in 249 studies

Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"To observe the efficacy of Modified Xiaoyao Decoction (MXD) combining clomipramine in treatment of depression."9.12[Study on Modified Xiaoyao Decoction combining Clomipramine treating depression]. ( Liang, SC; Sun, QZ; Yu, GH, 2007)
") of yohimbine in 12 patients with depression with clomipramine-induced orthostatic hypotension."9.06Effect of yohimbine on blood pressure in patients with depression and orthostatic hypotension induced by clomipramine. ( Bensimon, G; Diquet, B; Isnard, F; Lacomblez, L; Lecrubier, Y; Puech, AJ, 1989)
"Forty-two patients aged between 19 and 70 years (30 women and 12 men) suffering from primary unipolar depression were randomly selected and treated under double-blind conditions with either mianserin (Lantanon; Organon) or clomipramine (Anafranil; Ciba-Geigy) after an initial wash-out period."9.05Mianserin and clomipramine in the treatment of depression. ( Levin, A, 1982)
"A double-blind, randomized trial is described which was designed to compare the clinical effect of 100 mg daily of maprotiline (Ludiomil) and of clomipramine (Anafranil) given by the intravenous route in forty hospitalized female patients with severe and resistant primary depression."9.05Intravenous maprotiline in severe and resistant primary depression: a double-blind comparison with clomipramine. ( Drago, F; Grossi, E; Motta, A, 1983)
" After oral treatment with clomipramine (50 mg/kg/day) for four weeks, most of the depression-like behaviors were reversed, whereas the motivational reduction was not clearly affected."7.88Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews. ( Duan, Y; Li, M; Li, Y; Liang, J; Meng, X; Qi, K; Shen, F; Sui, N, 2018)
"Neonatal rodents chronically treated with the tricyclic antidepressant clomipramine show depression-like behavior, which persists throughout adulthood."7.85Proteomic investigation of the prefrontal cortex in the rat clomipramine model of depression. ( Baracskay, P; Czurkó, A; Darula, Z; Dobolyi, Á; Gellén, B; Györffy, BA; Hernádi, I; Hunyadi-Gulyás, É; Juhász, G; Kékesi, KA; Völgyi, K, 2017)
"The mean concentrations of the pharmacologically active metabolite of clomipramine and desmethylclomipramine changes during pregnancy, where a decrease in mean concentrations was found during pregnancy."7.81Pharmacokinetics of clomipramine during pregnancy. ( de Jong-van de Berg, LT; Proost, JH; Smit, JP; Ter Horst, PG; Vries, MT; Wilffert, B, 2015)
"Using a rat model of CUS-induced depression, we administered clomipramine, one of the typical antidepressants, every day for 3 weeks starting 2 weeks after the beginning of the experiment."7.78Chronic clomipramine treatment restores hippocampal expression of glial cell line-derived neurotrophic factor in a rat model of depression. ( Li, B; Liu, Q; Wang, YQ; Wu, GC; Yu, J; Zhu, HY, 2012)
"Neonatal treatment with clomipramine (CMI) in rats induces multiple behavioral alterations during adulthood that resemble certain symptoms of human depression, such as impairments of pleasure-seeking behaviors."7.76Circadian activity of corticosterone in an animal model of depression: response to muscarinic cholinergic stimulation. ( Arteaga-Silva, M; Bonilla-Jaime, H; Hernández-González, M; Retana-Márquez, S; Vázquez-Palacios, G, 2010)
"The aim of the study was to establish if there are differences in the 24-hour melatonin secretion profile between patients with major depression (before, and after treatment with clomipramine) compared to those in healthy subjects."7.71Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment. ( Karasek, M; Rabe-Jablonska, J; Szymanska, A, 2001)
"This study examined the integrity of hypothalamic-pituitary-adrenal (HPA) axis in clomipramine model of depression."7.70Hyperactivity of hypothalamic pituitary axis in neonatal clomipramine model of depression. ( Karanth, KS; Kumar, KB; Prathiba, J, 1998)
" The present study controlled these variables by using chloral hydrate anesthesia, testing 'depressed' rats at both 2 and 3 months of age, and verifying electrode location using standard histological techniques."7.69Decreased dorsal raphe nucleus neuronal activity in adult chloral hydrate anesthetized rats following neonatal clomipramine treatment: implications for endogenous depression. ( Feng, P; Kinney, GG; Vogel, GW, 1997)
"Trazodone (TZ) was administered to nine patients suffering from obsessive-compulsive disorder (OCD), who failed to respond to either clomipramine (CMI) or to CMI plus lithium carbonate."7.68Trazodone treatment in clomipramine-resistant obsessive-compulsive disorder. ( Aizenberg, D; Hermesh, H; Munitz, H, 1990)
"In an open, uncontrolled trial flupenthixol was administered to 45 patients with endogenous depression."7.65Effect of flupenthixol on depression with special reference to combination use with tricyclic antidepressants. An uncontrolled pilot study with 45 patients. ( Baba, O; Fujiwara, J; Hanaoka, M; Ishino, H; Sasaki, K, 1976)
"Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment."6.67Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992)
" We also examined whether Roman chamomile combined with clomipramine treatment affects hippocampal neurogenesis and serum corticosterone levels."5.51Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. ( Hashikawa, N; Hashikawa-Hobara, N; Ishikawa, R; Otsuka, A, 2019)
"Depression is associated with a deficiency of serotonergic neurons that have been found to suppress orexinergic neurons, which in turn activate these neurons in a feedback loop."5.35Changes in brain orexin levels in a rat model of depression induced by neonatal administration of clomipramine. ( Feng, P; Hu, Y; Strohl, KP; Vurbic, D; Wu, Z, 2008)
"The present study was to investigate the effect of electroacupuncture (EA) combined with chlorimipramine on the sucrose preference of depressive rats induced by chronic mild stress (CMS)."5.33Sucrose preference is restored by electro-acupuncture combined with chlorimipramine in the depression-model rats. ( Cao, XD; Li, XY; Wu, GC; Yu, J, 2006)
"Depression is associated with deficiencies in monoaminergic transmitters and possibly neurotrophins."5.32Impairments of ERK signal transduction in the brain in a rat model of depression induced by neonatal exposure of clomipramine. ( Fang, J; Feng, P; Guan, Z; Yang, X, 2003)
"Because metabolites play a major role in the clinical response to clomipramine, the objective of the current study was to develop a population model and evaluate its performance to describe the pharmacokinetic profiles of clomipramine (C) and its active metabolites desmethylclomipramine (DC), 8-hydroxy-clomipramine (OHC) and 8-hydroxy-desmethylclomipramine (OHDC)."5.31Population pharmacokinetics of clomipramine, desmethylclomipramine, and hydroxylated metabolites in patients with depression receiving chronic treatment: model evaluation. ( Balant, LP; Bechtel, PR; Bizouard, P; Gex-Fabry, M; Haffen, E; Paintaud, G; Sechter, D, 2000)
" infusions of Clomipramine in a high dosage, using a fixed therapy schedule with increasing and decreasing dosage ranging from 250 to 500 mg."5.26[Treatment of therapy resistant depressions with high dose clomipramine]. ( Laux, G; Reimer, F, 1979)
" Outpatients suffering from depression (n=74) received the same antidepressant (clomipramine) and were randomized into two groups, receiving either psychodynamic or supportive psychotherapy."5.14Therapeutic alliance in short-term supportive and psychodynamic psychotherapies: a necessary but not sufficient condition for outcome? ( Andreoli, A; Brunet, A; Burnand, Y; Cailhol, L; Damsa, C; Rodgers, R, 2009)
"Ninety-eight depressed patients were prescribed clomipramine in an open flexible manner and followed for depressive symptoms (Montgomery-Asberg depression scale) over a maximum 12 weeks follow-up period."5.09Clomipramine concentration as a predictor of delayed response: a naturalistic study. ( Balant, LP; Balant-Gorgia, AE; Gex-Fabry, M, 1999)
"Thirty outpatients meeting DSM-III-R or DSM-IV criteria for major depression, single or recurrent episode, and failing to respond to an adequate trial of an antidepressant (>6 weeks at recommended dosage) received buspirone (20-30 mg/day) for 4 or 5 weeks in addition to their existing antidepressant."5.08Buspirone augmentation of antidepressant therapy. ( Dimitriou, CE; Dimitriou, EC, 1998)
"To investigate the possibility of chronotherapy with antidepressants for patients with depression, we gave single daily doses of clomipramine 150 mg/day to 30 patients with depression at three different times of day, i."5.07Double-blind study of the chronopharmacotherapy of depression. ( Ikezaki, A; Nagano, K; Nagayama, H; Tashiro, T, 1991)
") of yohimbine in 12 patients with depression with clomipramine-induced orthostatic hypotension."5.06Effect of yohimbine on blood pressure in patients with depression and orthostatic hypotension induced by clomipramine. ( Bensimon, G; Diquet, B; Isnard, F; Lacomblez, L; Lecrubier, Y; Puech, AJ, 1989)
"On the grounds of different pharmacological properties and possibly different clinical effects, two antidepressants, Anafranil (clomipramine) and Pertofran (desipramine) were compared in the management of depression in general practice."5.04A comparative trial of Anafranil, Pertofran and an Anafranil/Pertofran combination. ( Murphy, JE, 1977)
"In a double-blind study of 24 patients with endogenous depressiona group treated with clomipramine hydrochloride (chlorimipramine) plus tryptophan was compared with a group treated with clomipramine plus placebo."5.04Potentiation of the antidepressant action of clomipramine by tryptophan. ( Bjorn-Erik, R; Carlsson, A; Nagy, A; Skott, A; Walinder, J, 1976)
"The subject of dosage of clomipramine (Anafranil) in depression and in obsessional and phobic disorders is discussed."4.75Practical considerations on the use of clomipramine (Anafranil) in general practice: an updated review. ( Beaumont, G, 1977)
" After oral treatment with clomipramine (50 mg/kg/day) for four weeks, most of the depression-like behaviors were reversed, whereas the motivational reduction was not clearly affected."3.88Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews. ( Duan, Y; Li, M; Li, Y; Liang, J; Meng, X; Qi, K; Shen, F; Sui, N, 2018)
"The mean concentrations of the pharmacologically active metabolite of clomipramine and desmethylclomipramine changes during pregnancy, where a decrease in mean concentrations was found during pregnancy."3.81Pharmacokinetics of clomipramine during pregnancy. ( de Jong-van de Berg, LT; Proost, JH; Smit, JP; Ter Horst, PG; Vries, MT; Wilffert, B, 2015)
" We examined whether the administration of clomipramine, a serotonin reuptake inhibitor, to neonatal mice could result in depression-related behavioral alterations in adult mice."3.79Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice. ( Ahn, HS; Baik, JH; Kim, JW; Yoon, BJ, 2013)
"Neonatal treatment with clomipramine (CMI) in rats induces multiple behavioral alterations during adulthood that resemble certain symptoms of human depression, such as impairments of pleasure-seeking behaviors."3.76Circadian activity of corticosterone in an animal model of depression: response to muscarinic cholinergic stimulation. ( Arteaga-Silva, M; Bonilla-Jaime, H; Hernández-González, M; Retana-Márquez, S; Vázquez-Palacios, G, 2010)
"The present study was designed to evaluate the antidepressant effect of electroacupuncture (EA) and the potential additive or synergistic effects of EA and clomipramine (CLO, a tricyclic antidepressant) in the mouse forced swimming test (FST) and chronic mild stress (CMS) induced depression-model rats."3.74Electroacupuncture combined with clomipramine enhances antidepressant effect in rodents. ( Cao, XD; Li, XY; Liu, Q; Wang, J; Wang, YQ; Wu, GC; Yu, J, 2007)
" She has also been under treatment for obsessive and compulsive neurosis and depression for two years and complained of constipation that was the side effect of the drug clomipramine HCL."3.73[Case report: taeniasis, is it a cause of psychiatric and neural symptoms?]. ( Aksoy, U; Inceboz, T; Yalçin, G, 2006)
" To examine these novel concepts of the pathophysiology of depression and antidepressant medication we have carried out a series of experiments using the chronic psychosocial stress paradigm in male tree shrews, an animal model with a high validity for the pathophysiology of depressive disorders, in which the animals were treated with the tricyclic antidepressant compound clomipramine."3.72Examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews. ( Czéh, B; Flügge, G; Fuchs, E, 2004)
"Olfactory bulbectomy, neonatal clomipramine administration, and maternal deprivation have been employed as animal models of depression."3.71Altered dendritic spine density in animal models of depression and in response to antidepressant treatment. ( Norrholm, SD; Ouimet, CC, 2001)
"Clomipramine (CLI), a REM sleep suppressant, alleviates symptoms of depression in adults but produces depressive behaviors if applied neonatally."3.71Clomipramine suppresses postnatal REM sleep without increasing wakefulness: implications for the production of depressive behaviors. ( Feng, P; Ma, Y, 2002)
" In previous studies on rats, we found that neonatal treatment with clomipramine (CLI) during postnatal days 8--21 (P8-21) produced behavioral and physiological abnormalities in adult rats that resembled the abnormalities found in human endogenous depression."3.71The critical window of brain development from susceptive to insusceptive. Effects of clomipramine neonatal treatment on sexual behavior. ( Feng, P; Ma, Y; Vogel, GW, 2001)
"The aim of the study was to establish if there are differences in the 24-hour melatonin secretion profile between patients with major depression (before, and after treatment with clomipramine) compared to those in healthy subjects."3.71Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment. ( Karasek, M; Rabe-Jablonska, J; Szymanska, A, 2001)
"Neonatal treatment with clomipramine induces behavioral alterations during adulthood that resemble symptoms observed in human depression."3.70Pharmacological features of masculine sexual behavior in an animal model of depression. ( Bonilla-Jaime, H; Retana-Marquez, S; Velazquez-Moctezuma, J, 1998)
"The effects of substituted benzamides, sulpiride and raclopride on experimental models of depression were studied in male rats after acute or chronic administration in comparison to those of the classical antidepressant, clomipramine."3.70Effects of acute or chronic administration of substituted benzamides in experimental models of depression in rats. ( Arezzi, A; Drago, F; Virzì, A, 2000)
"We report the cases of two patients fulfilling DSM-IV criteria for schizophrenia, who developed a marked depressive symptomatology in the first period of a treatment with clozapine, and were treated successfully with serotonergic drugs (paroxetine, clomipramine)."3.70Depressive symptomatology during clozapine treatment: two case reports. ( Altamura, AC; Bignotti, S; Curreli, R; Pioli, R; Tura, G, 1998)
"This study examined the integrity of hypothalamic-pituitary-adrenal (HPA) axis in clomipramine model of depression."3.70Hyperactivity of hypothalamic pituitary axis in neonatal clomipramine model of depression. ( Karanth, KS; Kumar, KB; Prathiba, J, 1998)
" The present study controlled these variables by using chloral hydrate anesthesia, testing 'depressed' rats at both 2 and 3 months of age, and verifying electrode location using standard histological techniques."3.69Decreased dorsal raphe nucleus neuronal activity in adult chloral hydrate anesthetized rats following neonatal clomipramine treatment: implications for endogenous depression. ( Feng, P; Kinney, GG; Vogel, GW, 1997)
"Trazodone (TZ) was administered to nine patients suffering from obsessive-compulsive disorder (OCD), who failed to respond to either clomipramine (CMI) or to CMI plus lithium carbonate."3.68Trazodone treatment in clomipramine-resistant obsessive-compulsive disorder. ( Aizenberg, D; Hermesh, H; Munitz, H, 1990)
" We report the isolation of Rothia dentocariosa from the blood of a septicaemic patient with chronic lymphocytic leukaemia and bone marrow depression following treatment with clomipramine and zuclopentixol."3.67Rothia dentocariosa septicaemia in a patient with chronic lymphocytic leukaemia and toxic granulocytopenia. ( Hansen, NE; Jønsson, V; Kristiansen, JE; Pers, C, 1987)
"The effects of ECT, amitriptyline, clomipramine, maprotiline and desipramine on the course of endogenous depression were compared in 105 patients using repeated self-administered mood questionnaires as the outcome measure."3.66Effects of somatic treatments on mood in endogenous depression. ( Albert, W; Klicpera, C; Strian, F, 1979)
" Results are given from three studies of clomipramine all failing to demonstrate an association between steady-state plasma clomipramine levels and clinical response both measured as effect--change in severity of depression using the GPCRG rating scale--and side-effect."3.66Relating plasma levels of clomipramine and clinical response. ( Seldrup, J, 1980)
"Plasma concentrations of clomipramine and desmethylclomipramine were monitored together with clinical effects over a period of 1--9 months in children and young adolescents (5--19 years of age) receiving clomipramine because of depressive features or enuresis."3.66Preliminary observations of the significance of monitoring tricyclic antidepressant plasma levels in the pediatric patient. ( Dugas, M; Durand, G; Leheuzey, MF; Morselli, PL; Rovei, V; Zarifian, E, 1980)
"Following the observation that two patients with depression and essential orthostatic hypotension recovered from the latter affection after yohimbine administration, an open study was conducted to assess the activity of yohimbine in correcting orthostatic hypotension induced by tricyclic antidepressants."3.66[Treatment of orthostatic hypotension induced by tricyclic antidepressants with yohimbine (author's transl)]. ( Allilaire, JF; des Lauriers, A; Lecrubier, Y; Simon, P; Widlocher, D, 1980)
" In a study designed to assess plasma levels of clomipramine in twenty-eight patients aged between 65 and 75 years and fourteen patients over 75 years of age and compare them with the levels achieved by a control group of patients aged between 18 and 40 years, the severity of depression was assessed initially and after 7, 14, 21 and 28 days using the General Practitioner Clinical Research Group Scale."3.66Clomipramine and age: an interaction study. ( Beaumont, G; Poole, P; Watson, JU, 1980)
"In an open, uncontrolled trial flupenthixol was administered to 45 patients with endogenous depression."3.65Effect of flupenthixol on depression with special reference to combination use with tricyclic antidepressants. An uncontrolled pilot study with 45 patients. ( Baba, O; Fujiwara, J; Hanaoka, M; Ishino, H; Sasaki, K, 1976)
"The authors, by reference to a patient showing acathisia and other dyskinetic disorders following the administration to him of small doses of metoclopramide (Cerucal) and clomipramine, which is a thymoleptic, discuss extrapyramidal disorders attendant upon the therapy of larvated depressions or depressions accompanied by gastrointestinal disorders."3.65[Metoclopramide (Cerucal) side-effects in the form of extrapyramidal disorders in combination with an other antidepressive agent]. ( Felber, W; Ficker, F, 1977)
" In latent of manifest glaucoma (7 patients) Clomipramine increased the tonography in 1 case, whereas Amitriptyline and Noxiptiline reduced it in 4 cases."3.65[Psychotropic drugs and glaucoma (author's transl)]. ( Andrée, G; Meiser, H; Schmitt, W, 1976)
"In a small series of patients, suffering from obsessional disorders, it was found that there seems to be a type of depression which occurs during the course of clomipramine therapy."3.65Depressive reactions in the course of clomipramine therapy used in the treatment of obsessional conditions. ( Capstick, N, 1975)
"In this study, the pharmacokinetic parameters of the sustained-release (SR) dosage form of clomipramine (CMI) were compared with those obtained after the administration of the immediate-release (IR) dosage form."2.69Pharmacokinetics of a sustained-release dosage form of clomipramine. ( Galindo, MC; Herrera, D; Jung, H; Mayet, L, 2000)
"Serum hormone levels of follicle stimulating hormone (FSH), luteotropic hormone (LH), testosterone (T), prolactin (hPRL), estradiol (E2) and GnRH test were carried out in 11 patients after antidepressive therapy with clomipramine at a dosage of 75 mg/day for 3 months."2.67Andrological findings in young patients under long-term antidepressive therapy with clomipramine. ( Koinig, G; Maier, U, 1994)
"Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment."2.67Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992)
"The clomipramine effect was maximum from weeks 10 to 18 and diminished thereafter."2.65Clomipramine and exposure for obsessive-compulsive rituals: i. ( Cobb, J; Marks, IM; Mawson, D; McDonald, R; Stern, RS, 1980)
"In respect of the number of patients : bipolar depressions (10 cases) unipolar (20 cases) it has not been possible to study the results in these 2 sub groups."2.64[The clomipramine-lithium combination: controlled trial]. ( Des Lauriers, A; Luaute, JP; Moinet, A; Monfort, J; Nick, J, 1976)
"Treatment with doxepin is a contraindication to driving during the first two weeks or up to the time when amelioration of symptoms is recorded."2.64Psychomotor skills in depressed out-patients treated with L-tryptophan, doxepin, or chlorimipramine. ( Linnoila, M; Mattila, MJ; Seppälä, T, 1978)
"In the sleep deprivation/chlorimipramine group a quick and long-lasting remission of depressive symptoms could be demonstrated."2.64[Combined sleep deprivation/chlorimipramine therapy of endogenous depression (author's transl)]. ( Amelung, U; Loosen, PT; Merkel, U, 1976)
"Monitoring, prevention, and treatment of hyposalivation induced by antidepressants are encouraged as an adjunct in the clinical management of depression."2.40Risks for oral health with the use of antidepressants. ( deVries, MW; Peeters, FP; Vissink, A, 1998)
"Depression is a highly prevalent concomitant of dementia."2.40Depression and dementia: comorbidities, identification, and treatment. ( Meyers, BS, 1998)
"In addition, depression is characterized by a decreased functioning of the serotonergic system due to changes in the activity or expression of its receptors including, most significantly, 5-HT1A, 5-HT2A, and 5-HT3 in brain regions that regulate mood, emotions, and memory, such as the prefrontal cortex, hippocampus, and amygdala."1.91Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male t ( Arteaga-Silva, M; Bonilla-Jaime, H; Cerbón, M; Limón-Morales, O; Molina-Jiménez, T; Morales-Quintero, K, 2023)
"Depression has recently been referred to as a neuroimmune disease because it is characterized by inflammatory changes in the cerebral cortex and hippocampus."1.51Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine. ( Gong, W; Halim, M; Li, B; Liu, Q; Ma, L; Ma, Y; Ren, Z; Wang, Y; Yu, J; Zhang, J; Zhang, S; Zhou, G; Zong, Y, 2019)
" We also examined whether Roman chamomile combined with clomipramine treatment affects hippocampal neurogenesis and serum corticosterone levels."1.51Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. ( Hashikawa, N; Hashikawa-Hobara, N; Ishikawa, R; Otsuka, A, 2019)
"Depression is a common mental disease affecting a lot of people of all ages around the world."1.51Zinc improves clomipramine effects on depressive and locomotor behavior and reverses its oxidative stress in rats. ( Abdelmelek, H; Ammari, M; Lassoued, A; Othman, H; Sakly, M, 2019)
"Corticosterone levels were increased in the untreated STZ group; SMV and clomipramine significantly decreased corticosterone levels in the STZ groups, but had no effect on the CTR groups."1.42Antidepressant-like effect of simvastatin in diabetic rats. ( ElBatsh, MM, 2015)
"Depression is associated with structural and neurochemical changes in limbic structures, including the hippocampus, that control emotion and mood."1.39Phospholipase D-mTOR signaling is compromised in a rat model of depression. ( Feng, P; Huang, C, 2013)
"The authors present a patient with Gilles de la Tourette syndrome who developed abdominal distension and bloating due to air swallowing."1.35Air swallowing as a tic. ( Cavanna, AE; Robertson, MM; Weil, RS; Willoughby, JM, 2008)
"The present study was to investigate the effect of electroacupuncture (EA) combined with chlorimipramine on the sucrose preference of depressive rats induced by chronic mild stress (CMS)."1.33Sucrose preference is restored by electro-acupuncture combined with chlorimipramine in the depression-model rats. ( Cao, XD; Li, XY; Wu, GC; Yu, J, 2006)
"Depression is associated with deficiencies in monoaminergic transmitters and possibly neurotrophins."1.32Impairments of ERK signal transduction in the brain in a rat model of depression induced by neonatal exposure of clomipramine. ( Fang, J; Feng, P; Guan, Z; Yang, X, 2003)
"Because metabolites play a major role in the clinical response to clomipramine, the objective of the current study was to develop a population model and evaluate its performance to describe the pharmacokinetic profiles of clomipramine (C) and its active metabolites desmethylclomipramine (DC), 8-hydroxy-clomipramine (OHC) and 8-hydroxy-desmethylclomipramine (OHDC)."1.31Population pharmacokinetics of clomipramine, desmethylclomipramine, and hydroxylated metabolites in patients with depression receiving chronic treatment: model evaluation. ( Balant, LP; Bechtel, PR; Bizouard, P; Gex-Fabry, M; Haffen, E; Paintaud, G; Sechter, D, 2000)
" Moreover, long term administration of both imipramine or SKF 38393 down regulated D1 dopamine receptor number in the prefrontal cortex, while the association of the two drugs resulted in a receptor density similar to that of control rats."1.29Desensitization of the D1 dopamine receptors in rats reproduces a model of escape deficit reverted by imipramine, fluoxetine and clomipramine. ( Gambarana, C; Ghiglieri, O; Graziella de Montis, M, 1995)
"Good results have been obtained in the treatment of depression, and obsessive/compulsive/phobic states, and mixed patients."1.26Clinical experience in the treatment of obsessional states (2). ( Rack, PH, 1977)
" As the reciprocal plasma level during multiple dosing is proportional to the clearance of a compound, this parameter was used for linear regression analysis."1.26Intraindividual similarity in the metabolism of amitriptyline and chlorimipramine in depressed patients. ( Asberg, M; Bertilsson, L; Mellström, B; Rollins, D; Sjöqvist, F; Träskman, L, 1979)
" For eight hours after a single dose plasma clomipramine levels behaved in accordance with known pharmacokinetic principles but thereafter, whichever the route used, there were substantial oscillations, minimal in the morning, maximal early in the afternoon and falling in the late afternoon, peak levels being reached on the second or third day."1.26Unusual plasma level oscillations of clomipramine in man: a pharmacokinetic and pharmacodynamic dilemma. ( De Cuyper, H; De Zeeuw, RA; Van Praag, HM; Westenberg, HG, 1980)
" Their mean clomipramine half-life was 36 hours and mean plasma clomipramine clearance 73 litres per hour, with a wide range in each case."1.26Single oral dose pharmacokinetics of clomipramine in depressed patients. ( Braithwaite, RA; Dawling, S; McAuley, R; Montgomery, SA, 1980)
"Depression was by far the most important factor."1.26Cortisol in the CSF of depressed and suicidal patients. ( Asberg, M; Bertilsson, L; Lantto, O; Schalling, D; Träskman, L; Tybring, G, 1980)
"A series of studies on the pharmacokinetic and pharmacodynamic properties of some tricyclic antidepressants is reviewed."1.26Treatment of depression with tricyclic drugs--pharmacokinetic and pharmacodynamic aspects. ( Asberg, M, 1976)
"Patients showing symptoms of depressive illness were treated in general practice with one of four clomipramine (Anafranil) dosage regimes (25 mg t."1.26Plasma level studies with clomipramine (anafranil) ( Jones, RB; Luscombe, DK, 1977)
" No systemic changes of heart frequency and blood pressure were found during the infusions in spite of the high dosage of tricyclic antidepressants given such a short period as 1 hour."1.26Investigation of the orthostatic reaction after intravenous administration of imipramine, chlorimipramine, and inimpramine-N-oxide. ( Bake, B; Dencker, SJ, 1976)
"An open study of four dosage regimes of clomipramine (Anafranil)--10 mg t."1.26Comparisons of various clomipramine (Anafranil) dosage regimes. ( Frank, P, 1977)

Research

Studies (249)

TimeframeStudies, this research(%)All Research%
pre-1990148 (59.44)18.7374
1990's31 (12.45)18.2507
2000's39 (15.66)29.6817
2010's25 (10.04)24.3611
2020's6 (2.41)2.80

Authors

AuthorsStudies
Abramova, O1
Zorkina, Y1
Syunyakov, T1
Zubkov, E1
Ushakova, V1
Silantyev, A1
Soloveva, K1
Gurina, O1
Majouga, A1
Morozova, A1
Chekhonin, V1
Zhang, S2
Hu, J1
Liu, G1
Wu, H1
Li, M2
Shi, C1
Liu, Q6
Li, W1
Faucher, P1
Dries, A1
Mousset, PY1
Leboyer, M1
Dore, J1
Beracochea, D1
Abdelmeguid, NE1
Hammad, TM1
Abdel-Moneim, AM1
Salam, SA1
Limón-Morales, O3
Morales-Quintero, K1
Arteaga-Silva, M4
Molina-Jiménez, T2
Cerbón, M2
Bonilla-Jaime, H6
Rojas-Castañeda, JC1
Guadarrama-Cruz, GV1
Chakraborty, S1
Tripathi, SJ1
Raju, TR2
Shankaranarayana Rao, BS1
Shen, F1
Qi, K1
Duan, Y1
Li, Y1
Liang, J1
Meng, X1
Sui, N1
Gong, W1
Zong, Y1
Halim, M1
Ren, Z1
Wang, Y1
Ma, Y3
Li, B4
Ma, L1
Zhou, G1
Yu, J6
Zhang, J1
Hashikawa-Hobara, N1
Otsuka, A1
Ishikawa, R1
Hashikawa, N1
Othman, H1
Ammari, M1
Lassoued, A1
Sakly, M1
Abdelmelek, H1
Yang, CJ1
Yue, N1
Liu, Y1
Wang, YQ4
Wu, GC5
Feng, P6
Huang, C1
Kofune, M1
Kofune, T1
Ohkubo, K1
Watanabe, I1
Adebayo, KO1
Gureje, O1
Nuhu, TF1
Piras, G3
Piludu, MA1
Giorgi, O3
Corda, MG3
Soria-Fregozo, C1
Vázquez-Palacios, G3
Wang, J2
Chai, A1
Zhou, Q1
Lv, L1
Wang, L1
Yang, Y1
Xu, L2
ElBatsh, MM1
Qin, D1
Chu, X1
Feng, X1
Li, Z1
Yang, S1
Lü, L1
Yang, Q1
Pan, L1
Yin, Y1
Li, J1
Chen, L1
Hu, X1
Ter Horst, PG1
Proost, JH1
Smit, JP1
Vries, MT1
de Jong-van de Berg, LT1
Wilffert, B1
Fukushima, N1
Nanao, K1
Fukushima, H1
Namera, A1
Miura, M1
Gellén, B1
Völgyi, K1
Györffy, BA1
Darula, Z1
Hunyadi-Gulyás, É1
Baracskay, P1
Czurkó, A1
Hernádi, I1
Juhász, G1
Dobolyi, Á1
Kékesi, KA1
Mao, Q1
Huang, Z1
Ip, S1
Che, C1
Kopecek, M1
Tislerova, B1
Sos, P1
Bares, M1
Novak, T1
Krajca, V1
Brunovsky, M1
Matrisciano, F1
Caruso, A1
Orlando, R1
Marchiafava, M1
Bruno, V1
Battaglia, G1
Gruber, SH1
Melchiorri, D1
Tatarelli, R1
Girardi, P1
Mathè, AA1
Nicoletti, F1
Vurbic, D1
Wu, Z1
Hu, Y1
Strohl, KP1
Kokras, N1
Antoniou, K1
Dalla, C2
Bekris, S1
Xagoraris, M1
Ovestreet, DH1
Papadopoulou-Daifoti, Z2
Weil, RS1
Cavanna, AE1
Willoughby, JM1
Robertson, MM1
Scinska, A1
Swiecicki, L1
Korkosz, I1
Mierzejewski, P1
Kolaczkowski, M1
Zhu, HY2
Cailhol, L1
Rodgers, R1
Burnand, Y1
Brunet, A1
Damsa, C1
Andreoli, A1
Retana-Márquez, S3
Hernández-González, M1
Tamburella, A1
Micale, V4
Leggio, GM2
Drago, F6
Bhagya, V1
Srikumar, BN1
Rao, BS1
Pitychoutis, PM1
Sideris, AC1
Tsonis, PA1
Lagus, M1
Gass, N1
Saharinen, J1
Savelyev, S1
Porkka-Heiskanen, T1
Paunio, T1
Kim, JW1
Ahn, HS1
Baik, JH1
Yoon, BJ1
Mavanji, V1
Datta, S1
Kudoh, A1
Takase, H1
Takazawa, T1
Lecca, D1
Hansson, S1
Driscoll, P1
Velázquez-Moctezuma, J2
Guan, Z1
Yang, X1
Fang, J1
Kordon, A1
Broocks, A1
Hohagen, F1
Fitzpatrick, RE1
Persinger, MA1
Fuchs, E1
Czéh, B1
Flügge, G1
Consoli, D2
Fedotova, J1
Sapronov, NS1
Inceboz, T1
Yalçin, G1
Aksoy, U1
Yu, GH1
Liang, SC1
Sun, QZ1
Li, XY2
Cao, XD2
Mazzola, C1
Vestergaard, P1
Rejnmark, L1
Mosekilde, L1
Langer, G1
Schönbeck, G1
Koinig, G2
Lesch, O1
Schüssler, M1
Waldhäusl, W1
Brown, WA1
Haier, RJ1
Qualls, CB1
Griffiths, K1
Lecrubier, Y4
Puech, AJ3
Frances, H1
Jouvent, R2
Widlöcher, D3
Simon, P3
Kielholz, P2
Ridges, AP5
Bishop, FM2
Lawton, K2
Goldberg, IJ3
Träskman, L5
Tybring, G3
Asberg, M9
Bertilsson, L5
Lantto, O1
Schalling, D1
van Praag, HM5
de Haan, S1
Klok, CJ1
Brouwer, GJ1
Doogan, D1
Ross, SB1
Aberg-Wistedt, A1
Motta, A1
Grossi, E1
Mavissakalian, M1
Michelson, L1
Ananth, J3
Jørgensen, B1
Nørrelund, N1
Bech, P2
Jakobsen, K1
Møller, SE1
Reisby, N2
Ortmann, J2
Elley, J2
Krautwald, O2
Sgaragli, GP2
Ninci, R1
Della Corte, L2
Borghesi, R1
Nardini, M1
Battistini, N1
Marks, IM1
Stern, RS1
Mawson, D1
Cobb, J1
McDonald, R1
Borg, V1
Gastpar, M2
Hobi, V1
Pöldinger, W1
Goldsmith, S1
Maly, V1
Schmidlin, PE1
Lingjaerde, O1
Lemoine, P1
Achaintre, A1
Balvay, G1
Bonnet, H1
Burgat, R1
Carrier, C1
Perrin, J1
Valle-Jones, JC1
O'Hara, J1
O'Hara, H1
McGhie, RL1
Brodie, NH1
Anderson, JA1
Schiff, AA1
Levin, A1
Hullin, RP1
Parrack, S1
Gringras, M2
Beaumont, G7
Grieve, A2
Watson, JU1
Poole, P1
Gostick, N1
Seldrup, J3
John, VA1
Luscombe, DK8
Kemp, H1
Dugas, M1
Zarifian, E1
Leheuzey, MF1
Rovei, V1
Durand, G1
Morselli, PL1
des Lauriers, A2
Allilaire, JF1
Lapin, A1
Karobath, M1
Finavera, L1
Armocida, G1
Majeron, MA1
Romerio, C1
Dudley, DL1
Volberding, N1
Loebel, P1
Dawling, S2
Braithwaite, RA2
McAuley, R2
Montgomery, SA3
De Zeeuw, RA1
Westenberg, HG1
De Cuyper, H1
Moyes, IC2
Ray, RL1
Moyes, RB1
Montgomery, DB1
Lewis, P1
Rack, PH3
Vaddadi, KS1
Allen, JJ2
John, V3
Laux, G2
Reimer, F2
Maier, U1
Jackson, CW1
Morton, WA1
Lydiard, RB1
Hilakivi-Clarke, L1
Wright, A1
Lippman, ME1
Hilakivi-Clarke, LA1
Goldberg, R1
Gambarana, C1
Ghiglieri, O1
Graziella de Montis, M1
Schlingemann, RO1
Smit, AA1
Lunel, HF1
Hijdra, A1
Maudhuit, C1
Hamon, M1
Adrien, J1
Gillman, PK1
Kinney, GG1
Vogel, GW2
Peeters, FP1
deVries, MW1
Vissink, A1
Altamura, AC1
Bignotti, S1
Tura, G1
Curreli, R1
Pioli, R1
Dwyer, SM1
Rosenwasser, AM1
Dimitriou, EC1
Dimitriou, CE1
Prathiba, J2
Kumar, KB2
Karanth, KS2
Gex-Fabry, M2
Balant-Gorgia, AE2
Balant, LP3
Vijayakumar, M1
Meti, BL1
Meyers, BS1
Rosebush, PI1
Margetts, P1
Mazurek, MF1
Nisijima, K1
Molina-Hernandez, M1
Téllez-Alcántara, P2
Srivastava, SK1
Nath, C1
Arezzi, A1
Virzì, A1
Haffen, E1
Paintaud, G1
Bizouard, P1
Sechter, D1
Bechtel, PR1
Herrera, D1
Mayet, L1
Galindo, MC1
Jung, H1
Turcotte, JE1
Debonnel, G1
de Montigny, C1
Hébert, C1
Blier, P1
Jungkun, G1
Kuss, HJ1
Gsell, W1
Nicolosi, A1
Lo Menzo, G1
Szymanska, A1
Rabe-Jablonska, J1
Karasek, M1
Takamori, K1
Yoshida, S1
Okuyama, S1
Norrholm, SD1
Ouimet, CC1
Molina, M1
Contreras, CM1
Kielholz, VP1
de Sousa, MP1
Lopes, JS1
Figueira, L1
Cardoso, JN1
Ringberger, VA1
Sjöqvist, F3
Thorén, P3
Tuck, JR1
Andrejak, M1
Fournier, A1
Hardin, JM1
Coevoet, B1
Lambrey, G1
De Fremont, JF1
Quichaud, J1
Walinder, J2
Skott, A2
Nagy, A3
Carlsson, A2
Roos, BE2
Loosen, PT2
Merkel, U2
Amelung, U2
Wirz-Justice, A2
Pühringer, W2
Hole, G2
Ravizza, L2
Moyes, R1
Groom, GV2
Murphy, JE1
Zapletálek, M2
Hübsch, T1
Zbytovský, J1
Polácková, J1
Kindernayovä, H1
Van Scheyen, JD3
Korf, J2
Witts, DJ3
Mulgirigama, D1
Turner, P6
Pare, CM4
Mulgirigama, LD2
Wadsworth, J3
Burgess, CD1
Kampman, R1
Nummikko-Pelkonen, A1
Kuha, S1
Dencker, SJ2
Alfredsson, G1
Wiesel, FA1
Fyro, B1
Sedvall, G1
van Kammen, DP1
Broadhurst, AD2
Filippini, S1
Heeley, AF2
James, HD2
Faravelli, C1
Pazzagli, A1
Braithwaite, R1
Garle, M1
Borgå, O1
Sacchetti, E1
Allaria, E1
Negri, F1
Biondi, PA1
Smeraldi, E1
Cazzullo, CL1
Cronholm, B1
Mellström, B2
Neckers, LM1
Klicpera, C2
Albert, W2
Strian, F2
Rollins, D1
Gram, LF2
Sihm, F1
Christiansen, J1
Risch, SC1
Huey, LY1
Janowsky, DS1
Singh, AN1
Sexena, B1
Gent, M1
Corte, LD1
Ehsanullah, RS1
Jones, RB5
Wright, J1
Jain, VK1
Terzani, S1
Lange, E1
Rossner, M1
König, L1
Ficker, F2
Dick, P1
Mahy, GE1
Seppälä, T1
Linnoila, M1
Mattila, MJ1
Reuter, CJ1
Nick, J1
Luaute, JP1
Moinet, A1
Monfort, J1
Brock-Utne, JG1
Cheetham, RW1
Goodwin, NM1
Carey, MS1
Hawkinson, R1
Kornhaber, A1
Wellish, CS1
Wyndowe, J1
Solyom, L1
Green, AR1
Grahame-Smith, DG1
Escobar, JI2
Gomez, O1
Tuason, VB2
Miller, P1
Frank, P1
Felber, W1
Plantey, F1
Bake, B1
Hallstrom, CO1
Rees, WL1
Trenchard, A1
Shaw, DM2
Francis, AF1
Williams, P1
Williams, R1
Link, J1
Cole, EN1
Hughes, D1
Fujiwara, J1
Ishino, H1
Baba, O1
Hanaoka, M1
Sasaki, K1
Souhami, RL1
Ashton, CR1
Lee-Potter, JP1
Bjorn-Erik, R1
Andrée, G1
Schmitt, W1
Meiser, H1
Planche, R1
Gathier, MC1
Lambert, J1
Campbell, P1
Ananth, JV1
Gomez, L1
Pecknold, JC3
Amin, MM1
Ban, TA3
Orbach, L1
Gratton, L1
Klingner, A1
Lehmann, HE1
Ashcroft, GW1
Capstick, N1
Colgan, A1
Wootton, LW1
Bailey, RI1
Macsweeney, DA1
Hewland, R1
Johnson, AL1
Middelburg, ZT1
Pazdírek, S1
Hanus, H1
Teeter, RR1
Schiele, BC1
Cohen, LJ1
Grothe, DR1
Nielsen, KK1
Brøsen, K1
Hewlett, WA1
Vinogradov, S1
Agras, WS1
Sundblad, C1
Modigh, K1
Andersch, B1
Eriksson, E1
Anderson, I1
Cowen, P1
Nagayama, H1
Nagano, K1
Ikezaki, A1
Tashiro, T1
Hermesh, H1
Aizenberg, D1
Munitz, H1
Golden, RN1
Ruegg, R1
Brown, TM1
Haggerty, J1
Garbutt, JC1
Pedersen, CA1
Evans, DL1
Mavissakalian, MR1
Jones, B1
Olson, S1
Wong, SH1
Dellafera, SS1
Fernandes, R1
Kranzler, H1
Turkington, D1
Geddes, J1
Tapie, M1
Garnier, JP1
Tremine, T1
Bousquet, B1
Manet, L1
Dreux, C1
Lauzel, JP1
Pledger, DR1
Mathew, H1
Dunbar, GC1
Naarala, M1
Hiltunen, H1
Genet, C1
Dayer, P1
Aeschlimann, JM1
Garrone, G1
Lacomblez, L1
Bensimon, G1
Isnard, F1
Diquet, B1
Vogel, G1
Hartley, P1
Neill, D1
Hagler, M1
Kors, D1
Pers, C1
Kristiansen, JE1
Jønsson, V1
Hansen, NE1
Casas, M1
Garcia-Ribera, C1
Alvarez, E1
Udina, C1
Queralto, JM1
Grau, JM1
Schrader, GD1
Levien, HE1
Masciocchi, A1
Reitano, S1
Vanini, M1
Cicchetti, V1
Smulevich, AB1
Vorob'ev, VIu1
Zavidovskaia, GI1
Lobova, EK1
Balashova, MG1

Clinical Trials (26)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness of the Norepinephrine and Serotonin Reuptake Inhibitor Levomilnacipran in Healthy Males[NCT03249311]Phase 436 participants (Actual)Interventional2018-03-02Active, not recruiting
Controlled Trial of Deep Brain Stimulation for Obsessive-Compulsive Disorder[NCT00640133]Phase 427 participants (Actual)Interventional2008-03-31Active, not recruiting
Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD[NCT03932773]Phase 2330 participants (Anticipated)Interventional2019-05-01Recruiting
Randomised Controlled Trial of Neurostimulation for Symptoms of Anorexia Nervosa[NCT05788042]70 participants (Anticipated)Interventional2023-08-02Recruiting
A Multisite, Assessor-blinded, Randomized Controlled Trial of Acupuncture for Post-stroke Depression[NCT02644161]91 participants (Actual)Interventional2015-10-31Completed
Understanding the Neurocognitive Effects of Fecal Microbiota Transplantation in Major Depressive Disorder Patients With and Without Irritable Bowel Syndrome[NCT05174273]Phase 2/Phase 3180 participants (Anticipated)Interventional2022-04-06Recruiting
The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression: a Proof of Concept Randomized Controlled Trial[NCT02155972]Phase 216 participants (Actual)Interventional2013-05-31Terminated (stopped due to The trial was terminated because of inability to recruit the needed number of participants)
A Single Ketamine Infusion Combined With Music for Suicidal Ideation During a Depressive Episode: A Randomized Open Label Clinical Trial[NCT04658420]Phase 2200 participants (Anticipated)Interventional2021-07-01Not yet recruiting
Structural Brain Plasticity in Elderly Depressed Patients Following Electroconvulsive Therapy[NCT02667353]110 participants (Actual)Interventional2011-06-30Completed
A Double-Blind, Randomized, Placebo-Controlled Trial of Ramelteon for the Treatment of Insomnia and Mood Stability in Patients With Euthymic Bipolar Disorder.[NCT00552760]Phase 490 participants (Actual)Interventional2007-11-30Completed
Clinical Validation Study for EDIT-B Test: an Aid for Differential Diagnosis of Bipolar Disorder, Based on RNA Editing Blood Biomarkers[NCT05603819]436 participants (Anticipated)Observational2022-06-29Recruiting
The Role of Orexin in Human Panic Disorder[NCT02593682]Phase 43 participants (Actual)Interventional2016-05-31Completed
Physical Fitness and Brain - Interventional Study of the Importance of Physical Fitness on Symptoms of Anxiety, Cognitive Ability and Sick Leave, in Primary Care.[NCT03247270]168 participants (Actual)Interventional2017-08-21Completed
Novel Neural Circuit Biomarkers of Major Depression Response to Computer-augmented CBT[NCT03096886]90 participants (Anticipated)Interventional2017-06-05Active, not recruiting
A Randomized Controlled Trial of the Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder[NCT03279224]Phase 2/Phase 335 participants (Actual)Interventional2018-01-01Active, not recruiting
Pre-treatment Biomarker for Clinical Response to Neuronavigation Repetitive Transcranial Magnetic Stimulation (rTMS) in the Acute Phase Treatment of Refractory Major Depressive Episode- Role of Intrinsic Functional Connectivity[NCT03348761]128 participants (Anticipated)Interventional2015-08-04Recruiting
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776]Phase 254 participants (Actual)Interventional2017-08-07Completed
Study of Antidepressants in Parkinson's Disease[NCT00086190]Phase 3115 participants (Actual)Interventional2005-06-30Completed
Targeted Alterations in n-3 and n-6 Fatty Acids for the Management of Mood Variability in the Maintenance Phase of Bipolar Disorder[NCT02272010]83 participants (Actual)Interventional2014-10-31Completed
ED Treatment of Suicidal Patients With Ketamine Infusion[NCT03502551]Phase 20 participants (Actual)Interventional2019-04-01Withdrawn (stopped due to Trial never received funding.)
Prediction of the Therapeutic Response in Depression Based on an Early Neuro-computational Modeling Assessment of Motivation[NCT05866575]136 participants (Anticipated)Interventional2023-06-01Not yet recruiting
A Safe Ketamine-Based Therapy for Treatment Resistant Depression[NCT01179009]20 participants (Actual)Interventional2012-04-30Completed
Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)[NCT01920555]Phase 299 participants (Actual)Interventional2014-12-31Completed
The Impact of Spiritual Healing on Moderate Depression in Adults: A Pilot Randomized Controlled Trial (RCT)[NCT04766242]28 participants (Anticipated)Interventional2021-03-01Not yet recruiting
Double-blind Trial of Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery[NCT03861988]Phase 445 participants (Actual)Interventional2019-08-22Completed
Analisi Dei Marcatori di Stress Ossidativo in Pazienti Affetti da Tumore Della Mammella, Sottoposte a Radioterapia Postoperatoria e Psicoterapia Con Elementi di Musicoterapia[NCT04446624]60 participants (Actual)Interventional2018-02-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Behavioral Activation for Depression Scale (BADS)

The Behavioral Activation for Depression Scale (BADS) is a 29-item scale that measures the role of aversive controlling stimuli and escape and avoidance behavior in depression, specifically when and how participants become more activated over the course of treatment. Total scores range from 29-203 and lower scores indicate higher levels of escape and avoidance behavior from depression in the past week. (NCT00640133)
Timeframe: Total BADS score observed means at month-12 time point.

Interventionunits on a scale (Mean)
Active DBS85.3
Sham DBS80.3

Global Assessment of Functioning Scale (GAF)

A numeric scale (0 through 100) used to rate the social, occupational, and psychological overall functioning during the week of poorest functioning in the past month. Higher scores indicate a higher level of functioning, while low scores indicate impaired global functioning. (NCT00640133)
Timeframe: GAF score observed means at month-12

Interventionunits on a scale (Mean)
Active DBS54.8
Sham DBS53.7

Hamilton Anxiety Rating Scale (HARS)

Hamilton Anxiety Rating Scale (HARS) is a 14-item test measuring the severity of anxiety symptoms. It provides measures of overall anxiety, psychic anxiety (mental agitation and psychological distress), and somatic anxiety (physical complaints related to anxiety); total scores range from 0-56. Higher scores indicate higher levels of anxiety over the past week. (NCT00640133)
Timeframe: HARS total score observed means at month-12 time point.

Interventionunits on a scale (Mean)
Active DBS12.6
Sham DBS15.7

Hamilton Depression Rating Scale (HDRS)

The Hamilton Depression Rating Scale (HDRS) measures the severity of depressive symptoms in adults. The evaluator-administered ratings measure depressed mood, guilt, suicide, insomnia, work/activities, retardation, agitation, psychic and somatic anxiety, genital symptoms, hypochondriasis, and insight during the past week. Total scores range from 0-72 and higher scores indicate the presence of more severe depression over the past week. Note: this measure was only administered at baseline and month-3. (NCT00640133)
Timeframe: Total HDRS score observed means at month-3 time point.

Interventionunits on a scale (Mean)
Active DBS16.8
Sham DBS19.4

Montgomery-Asberg Depression Rating Scale (MADRS)

"The Montgomery Asberg Depression Rating Scale (MADRS) is an interviewer-administered measure assessing the ten symptoms of depression most sensitive to change. Apparent sadness, reported sadness, inner tension, reduced sleep, reduced appetite, concentration difficulties, lassitude, inability to feel, pessimistic thoughts, and suicidal thoughts are assessed and total scores range from 0-60 with higher scores representing the presence of more severe depression over the past week.~interviewer-administered measure assessing" (NCT00640133)
Timeframe: MADRS total score observed means at month-12 time point.

Interventionunits on a scale (Mean)
Active DBS17.1
Sham DBS18.5

Quality of Life Enjoyment and Satisfaction Questionnaire (QLESQ)

The Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) is a self-administered measure to assess the degree of enjoyment and satisfaction experienced by participants in various areas of daily functioning. We used the 16-item short form with total scores ranging from 16-80. Higher scores indicate greater satisfaction experienced during the past week. (NCT00640133)
Timeframe: QLESQ total score observed means at month-12 time point.

Interventionunits on a scale (Mean)
Active DBS39.8
Sham DBS42.7

Social and Occupational Functioning Assessment Scale (SOFAS)

A numeric scale (0 through 100) used to rate the social, occupational, and psychological functioning during the week of poorest functioning in the past month. Higher scores indicate higher levels of social and occupational functioning, while low scores represent social and occupational impairment. (NCT00640133)
Timeframe: SOFAS score observed means at month-12 time point.

Interventionunits on a scale (Mean)
Active DBS55.9
Sham DBS53.9

Yale-Brown Obsessive-Compulsive Scale (YBOCS Severity Ratings)

The Yale-Brown Obsessive-Compulsive Scale (YBOCS) is a 10 question evaluator-administered measure assessing the severity of obsessions and compulsions over the past week. Obsession and compulsion severity are evaluated separately (ratings from 0-20 for each category) with total scores ranging from 0-40. Higher scores for obsessions, compulsions and total score indicate more severe symptoms over the past week. (NCT00640133)
Timeframe: YBOCS total score observed means at month-12

Interventionunits on a scale (Mean)
Active DBS20.5
Sham DBS20.9

Clinical Global Impressions Bipolar Version(CGI-BP) Severity of Illness Overall Score

3-part (mania, depression, overall bipolar illness), physician-administered scale used to assess global illness severity; used to measure change. Each part is rated from 1-7, higher scores represent more severe mental illness. Only overall bipolar rating was used. (NCT00552760)
Timeframe: Monthly for 6 months

,
Interventionunits on scale (Mean)
BaselineMonth 1Month 2Month 3Month 4Month 5Month 6
Placebo2.152.252.902.932.982.992.41
Ramelteon2.142.292.242.532.362.462.54

Cumulative Proportion of Participants in Each Arm Surviving Without Relapse

Survival analysis techniques, including Kaplan Meier curves, were used to evaluate group differences in time to relapse. Relapse was defined as a medication initiation or change for manic/depressed/mixed symptoms, a hospitalization for manic/depressed/mixed symptoms, MADRS score >= 16, YMRS score > 14, and suicide risk or imminent risk of suicide. Time to relapse was measured discretely in terms of the number of assessment visits until discontinued from the study. (NCT00552760)
Timeframe: Monthly for 6 months

,
InterventionCumulative proportion of participants (Number)
BaselineMonth 1Month 2Month 3Month 4Month 5Month 6
Placebo1.000.9510.5880.4480.3840.3200.320
Ramelteon1.000.9290.8490.7160.6610.6320.566

Montgomery-Asberg Depression Rating Scale (MADRS) Total Score

10-item, standardized, well-validated scale used to measure severity of depressive symptoms; sensitive to treatment effects in depressed outpatients. Scores range from 0-60, higher scores represent more severe depressive symptoms. (NCT00552760)
Timeframe: Monthly for 6 months

,
Interventionunits on scale (Mean)
BaselineMonth 1Month 2Month 3Month 4Month 5Month 6
Placebo8.278.9011.1311.8513.0311.5910.46
Ramelteon7.798.347.239.178.458.5610.40

Pittsburgh Sleep Quality Index (PSQI) Global Score

Self-rated scale to measure quality of sleep via questions regarding sleep latency, duration, efficiency, disturbances, use of sleep medication, and daytime dysfunction. Scores range from 0-21, higher scores represent more significant sleep disturbance. (NCT00552760)
Timeframe: Monthly for 6 months

,
Interventionunits on scale (Mean)
BaselineMonth 1Month 2Month 3Month 4Month 5Month 6
Placebo10.889.289.7110.389.038.668.76
Ramelteon10.178.167.937.897.216.626.90

Young Mania Rating Scale (YMRS) Total Score

11-item standardized, well-validated scale used to measure manic symptoms; sensitive to treatment effects in manic patients. Scores range from 0-60, higher scores represent more severe manic symptoms. (NCT00552760)
Timeframe: Monthly for 6 months

,
Interventionunits on scale (Mean)
BaselineMonth 1Month 2Month 3Month 4Month 5Month 6
Placebo6.596.467.758.094.955.716.72
Ramelteon7.025.895.916.605.935.186.51

Prefrontal GABA+ Concentrations

Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine3.90
Gabapentin3.93
Placebo Oral Tablet3.73

Prefrontal Glx Concentrations

Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine21.59
Gabapentin21.69
Placebo Oral Tablet22.25

Change in Beck Depression Inventory II (BDI-II)

Beck Depression Inventory II ranges from 0-63. Higher score indicates more severe depression. 0-13 minimal depression, 14-19 mild depression, 20-28 moderate depression, 29-63 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in BDI-II score (Mean)
Paroxetine-9.7
Venlafaxine Extended Release-9.6
Placebo-5.2

Change in Brief Psychiatric Rating Scale (BPRS)

Brief Psychiatric Rating Scale. Maximum score 126. Higher score indicates greater psychiatric difficulties. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in BPRS score (Mean)
Paroxetine-9.0
Venlafaxine Extended Release-9.8
Placebo-4.4

Change in Geriatric Depression Rating Scale (GDS)

Geriatric Depression Scale ranges from 0-30. Higher score indicates more severe depression. 0-9 normal, 10-19 mild depression, 20-30 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in GDS score (Mean)
Paroxetine-6.9
Venlafaxine Extended Release-6.9
Placebo-2.8

Change in Hamilton Depression Rating Scale (HAM-D) Scores

Change in Hamilton Rating Scale for Depression over 12 weeks. Hamilton Depression Rating Scale ranges from 0-50. Higher scores represent more significant depression. Mild depression ranges from 8-13, moderate depression from 14-18, severe 19-22 and very severe any score over 23. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in HAM-D score (Mean)
Paroxetine-13.0
Venlafaxine Extended Release-11.0
Placebo-6.8

Change in Montgomery-Asberg Depression Rating Scale (MADRS)

Montgomery-Asberg Depression Rating Scale ranges from 0-60. Higher score indicates more severe depression. 0-6 normal, 7-19 mild depression, 20-34 moderate depression, greater than 34 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in MADRS score (Mean)
Paroxetine-13.6
Venlafaxine Extended Release-10.9
Placebo-6.6

Change in Parkinson's Disease Questionnaire (PDQ) - 39 - Emotional Well-Being

Parkinson's Disease Questionnaire (PDQ-39) - Emotional Well-Being maximum score 24, minimum score of 0.Lower score indicates a better perceived health status. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in PDQ-39 Emotional score (Mean)
Paroxetine-21.4
Venlafaxine Extended Release-20.7
Placebo-10.9

Change in Parkinson's Disease Questionnaire (PDQ) - 39 - Overall

Parkinson's Disease Questionnaire (PDQ-39) Total. Range 0-100. Lower score indicates a better perceived health status. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in PDQ-39 score (Mean)
Paroxetine-8.0
Venlafaxine Extended Release-8.4
Placebo-5.3

Change in Pittsburgh Sleep Quality Index (PSQI)

Pittsburgh Sleep Quality Index scores range from 0-21, with higher scores indicating severe sleep difficulties. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in PQSI score (Mean)
Paroxetine-2.1
Venlafaxine Extended Release-2.6
Placebo-1.1

Change in Short Form 36 Health Survey - Mental Component Summary

Short Form 36 Health Survey. Range 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in SF-36 mental score (Mean)
Paroxetine11.4
Venlafaxine Extended Release9.5
Placebo4.8

Change in Short Form 36 Health Survey - Mental Health

Short Form 36 Health Survey - Mental Health subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in SF-36 Mental Health score (Mean)
Paroxetine16.7
Venlafaxine Extended Release17.4
Placebo9.7

Change in Short Form 36 Health Survey - Role-Emotional

Short Form 36 Health Survey - Emotional subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in SF-36 Role score (Mean)
Paroxetine39.5
Venlafaxine Extended Release26.9
Placebo12.7

Change in Short Form 36 Health Survey - Vitality

Short Form 36 Health Survey - Vitality subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in SF-36 vitality score (Mean)
Paroxetine13.5
Venlafaxine Extended Release9.1
Placebo4.7

Change in Snaith Clinical Anxiety Scale (CAS)

Snaith Clinical Anxiety Scale. Range 0-21. Higher scores indicate increased anxiety. Score greater than 8 indicates clinical anxiety. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in CAS score (Mean)
Paroxetine-3.6
Venlafaxine Extended Release-3.2
Placebo-2.4

Change in Unified Parkinson's Disease Rating Scale (UPDRS)

Unified Parkinson's Disease Rating Scale. Higher score indicates more severe Parkinson's disease symptoms. Total maximum = 176. Mental maximum = 52, Activities of Daily Living maximum = 52, Motor maximum = 72. Minimum = 0. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in UPDRS score (Mean)
Paroxetine-8.7
Venlafaxine Extended Release-7.0
Placebo-4.3

Change in Unified Parkinson's Disease Rating Scale (UPDRS) - Bulbar

Unified Parkinson's Disease Rating Scale - Bulbar maximum score 24, minimum score of 0. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in UPDRS-Bulbar score (Mean)
Paroxetine-1.4
Venlafaxine Extended Release-1.4
Placebo-0.5

Change in Unified Parkinson's Disease Rating Scale (UPDRS) - Motor

Unified Parkinson's Disease Rating Scale - Motor has a maximum score of 72, minimum score of 0. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in UPDRS-motor score (Mean)
Paroxetine-4.3
Venlafaxine Extended Release-2.0
Placebo-1.0

Change in Unified Parkinson's Disease Rating Scale (UPDRS) - Tremor

Unified Parkinson's Disease Rating Scale - Tremor subscale ranges from 0-23. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in UPDRS-tremor score (Mean)
Paroxetine0.4
Venlafaxine Extended Release0.5
Placebo-0.6

Montgomery-Asberg Depression Rating Scale (MADRS) Total Score

The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item scale that measures the severity of depression, with a higher score indicating a higher level of depression. The range of scores is 0 to 60. (NCT01179009)
Timeframe: 8 weeks

InterventionScores on a scale (Mean)
Ketamine 100-hour Infusion-9.0
Ketamine 40-minute Infusion-6.4

Clinical Global Impressions-Improvement (CGI-I) Scale

"The CGI-I is a clinician rated single-item scale: Compared to the patient's condition at admission, how much has the patient changed?, rated on a 7-point response scale: 1 = Very much improved, 2 = Much improved, 3 = Minimally improved, 4 = No change, 5 = Minimally worse, 6 = Much worse, and 7 = Very much worse. In this case, admission referred to the CGI-S screening assessments performed between Day -28 an -7, one conducted during the screening visit, and a second rating conducted by a remote, independent rater." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1 and 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg3.88888893.06250002.9333333
Ketamine 0.2mg4.05000003.36842112.8421053
Ketamine 0.5mg4.13636362.63636362.5714286
Ketamine 1.0mg4.00000003.05000002.5500000
Midazolam 0.045mg4.15789473.61111113.1666667

Clinical Global Impressions-Severity (CGI-S)

"The CGI-S is a clinician rated single-item scale: How depressed is the patient at this time?, rated on a 7-point response scale: 1 = Normal, not at all depressed, 2 = Borderline depressed, 3 = Mildly depressed, 4 = Moderately depressed. 5 = Markedly depressed, 6 = severely depressed, 7 = Among the most severely depressed patients. When rating patients, clinicians were asked to consider the past 24 hours." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1 and 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg5.00000003.56250003.4000000
Ketamine 0.2mg5.20000004.26315793.7368421
Ketamine 0.5mg4.86363643.27272733.1428571
Ketamine 1.0mg5.20000003.50000003.3000000
Midazolam 0.045mg5.0000004.5555564.1666667

Clinical Positive Affect Scale (CPAS)

"The CPAS is a 16-item self-report scale to assess the level to which participants experience persistent distress due to feeling that they have not returned to their normal or premorbid state. Items (e.g., I look forward to things) are rated on a 5-point scale (0=not at all, 1=very much less than normal, 2=much less than normal, 3=slightly less than normal, 4=same as best or normal self). The possible scale range is 0 to 64, with higher scores indicating greater recovery from depression. Patients were asked to rate their experience of the past 24 hours." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1 and 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg19.333333335.250000038.8666667
Ketamine 0.2mg20.500000027.052631628.3888889
Ketamine 0.5mg20.636363640.869696439.7619048
Ketamine 1.0mg21.250000033.000000037.4500000
Midazolam 0.045mg21.263157924.444444433.3750000

Clinician-Administered Dissociative States Scale (CADSS) Scores During Infusion

"The CADSS is a 23-item self-report scale for the assessment of dissociative states. It is a reliable, valid self-report instrument. The severity of each dissociative symptom ranges from 0 (not present) to 4 (extreme). The total score is calculated by summing across items, with a total possible range of 0-92. The CADSS was administered right before infusion, and 40, 80 minute and 120 minutes after the start of infusion. The timeframe is at this moment." (NCT01920555)
Timeframe: Day 0/baseline at 0, 40, 80, and 120 minutes

,,,,
Interventionunits on a scale (Mean)
Minute 0Minute 40Minute 80Minute 120
Ketamine 0.1mg0.11111113.00000000.44444440.0555556
Ketamine 0.2mg0.10000004.05000000.10000000
Ketamine 0.5mg014.27272730.77272730.1363636
Ketamine 1.0mg0.100000024.68421051.80000000.6500000
Midazolam 0.045mg0.42105262.68421051.15789470.5789474

Hamilton Rating Scale for Depression - 6 Items

The HAMD6 is a 6-item clinician-rated scale, where clinicians rate the presence of depression symptoms (i.e., depressed mood, guilt, work and interests, psychomotor retardation, psychic anxiety, somatic symptoms) on a 5-point scale, where 0 = not present, and 1-4 represent increasingly severe symptoms. One item (i.e., somatic symptoms) is rated on only a 3-point scale, ranging from 0-2. The possible scale range is 0-22, where higher values represent more severe depression. This instrument is completed with a structured interview guide by the clinician based on his/her assessment of the patient's symptoms. This structured interview has been validated for use with time frames shorter than one week. In this study, the HAMD6 was used to assess symptoms occurring in the past 24 hours. (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1, & 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg12.55555567.50000006.8000000
Ketamine 0.2mg12.75000009.26315798.4736842
Ketamine 0.5mg12.59090915.86363645.9047619
Ketamine 1.0mg12.63157896.90000007.2000000
Midazolam 0.045mg13.052631610.66666679.0555556

Montgomery-Asberg Depression Rating Scale (MADRS)

"The MADRS is a 10-item clinician-rated scale measuring depression severity. Symptoms are rated on a 7-point scale, where 0 = not present, and 1-6 represent increasing severity. Values 2, 4, and 6 have specific anchoring text (e.g., 2=Difficulties in starting activities. 4=Difficulties in starting simple routine activities which are carried out with effort, 6=Complete lassitude. Unable to do anything without help.) Values 1, 3, and 5 do not have specific text. The possible scale range is 0-60, where higher values represent higher severity. In this study, the MADRS was used to rate symptoms occurring in the past 3 days." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0 and 3.

,,,,
Interventionunits on a scale (Mean)
Day 0Day 3
Ketamine 0.1mg33.833333319.6666667
Ketamine 0.2mg34.450000022.6315789
Ketamine 0.5mg31.590909114.7619048
Ketamine 1.0mg32.650000017.1000000
Midazolam 0.045mg33.631578924.8333333

Number of Participants Reporting Suicidal Ideation/Behavior on the Columbia Suicide Severity Rating Scale (C-SSRS)

The Columbia Suicide Severity Rating Scale (C-SSRS): The C-SSRS is a low-burden measure of the spectrum of suicidal ideation and behavior that was developed in the National Institute of Mental Health Treatment of Adolescent Suicide Attempters Study to assess severity and track suicidal events through any treatment. It is a clinical interview providing a summary of both ideation and behavior that can be administered during any evaluation or risk assessment to identify the level and type of suicidality present. The C-SSRS can also be used during treatment to monitor for clinical worsening or improvement. It contains 5 rating scale questions (yes/no) for suicidal ideation increasing severity and 5 rating scale questions (yes/no) for suicidal behavior of increasing severity. The time frame is for both lifetime and the past six months for the Baseline/Screening scale and since the last visit for the Since Last Visit scale. (NCT01920555)
Timeframe: Screening Visit and Days 0, 1, 3, 5, 7, 14 and 30 combined

,,,,
InterventionParticipants (Count of Participants)
Screening: # with suicidal ideation/behaviorFollow-Up: # with suicidal ideation/behavior
Ketamine 0.1mg1715
Ketamine 0.2mg159
Ketamine 0.5mg1710
Ketamine 1.0mg146
Midazolam 0.045mg1713

Number of Participants With Abnormal and Clinically Significant CBC and Chemistry Labs by Treatment

"CBC~Chemistry (Total bilirubin, AST, ALT, GGT, ALK Phosphatase, Creatinine, BUN/Urea, Glucose, Uric Acid)~Testing was performed by study site laboratories and used institutional normal lab value ranges." (NCT01920555)
Timeframe: Day 3 and Early Termination Visit (approximately 3 weeks following intervention)

,,,,
InterventionParticipants (Count of Participants)
Chemistry ALT(SGPT)Chemistry AST(SGOT)Chemistry Total BilirubinChemistry Remaining TestsCBC
Ketamine 0.1mg00000
Ketamine 0.2mg11100
Ketamine 0.5mg00000
Ketamine 1.0mg00000
Midazolam 0.045mg00000

Snaith-Hamilton Pleasure-Scale (SHAPS)

"The SHAPS is a 14-item self-report scale to measure hedonic tone. Items (e.g., I would enjoy reading a book, magazine, or newspaper.) are rated on a 4-point scale (1=strongly disagree, 2=disagree, 3=agree, 4=strongly agree). Either of the 'disagree' responses scores 1 point, and either of the 'agree' responses scores 0 points, for a total scale range of 0-14. Higher scores indicate greater inability to experience pleasure. Patients were asked to rate their experience of the past 24 hours." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1 and 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg7.22222223.93750003.5333333
Ketamine 0.2mg7.55000005.73684216.3888889
Ketamine 0.5mg6.59090912.227272733.0000000
Ketamine 1.0mg7.35000004.30000003.6500000
Midazolam 0.045mg6.47368425.00000004.2500000

Symptoms of Depression Questionnaire (SDQ)

"The SDQ is a 44-item self-report scale, which aims to measure depression more comprehensively by including the assessment of symptoms in the anxiety-depression spectrum, including symptoms of irritability, anger attacks, and anxiety. Items are rated on an 6-point Likert scale, where participants are asked to rate if a specific symptom (e.g. How has your mood been over the past 24 hours?) is normal for him or her (score = 2), what is better than normal (score = 1), and what is worse than normal (scores = 3-6). The total scale score is calculated by averaging across the items, resulting in a possible range from 1 to 6. Higher scores indicate greater depression severity. When rating, patients were asked to consider their symptoms during the past 24 hours." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1 and 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg3.51641412.57528432.5106061
Ketamine 0.2mg3.46363642.90961952.7828283
Ketamine 0.5mg3.53925622.31095042.5573593
Ketamine 1.0mg3.41136362.61136362.5909091
Midazolam 0.045mg3.42645072.92005732.8751353

Hospital Length of Stay

Number of days from admission (day of surgery) through discharge after surgery. (NCT03861988)
Timeframe: Average approximately 3 days post-intervention

Interventiondays (Mean)
Open Label Ketamine3.7
Double Blind Ketamine1.9
Double Blind Placebo4.0

Number of Participants With Remission

Remission defined as a MADRS score of <=12 on day 14. MADRS score range: 0 to 60, a lower score indicates lower severity of symptoms. (NCT03861988)
Timeframe: Post-intervention day 14

InterventionParticipants (Count of Participants)
Open Label Ketamine3
Double Blind Ketamine8
Double Blind Placebo10

Brief Pain Inventory Pain Intensity Scale Score

"Average pain intensity in the past 24 hours, rated on a numerical scale from 0 to 10 (with 0 representing No pain and 10 representing Pain as bad as you can imagine)." (NCT03861988)
Timeframe: Post-intervention days 1, 2, 3, 5, 7 and 14

,,
Interventionscore on a scale (Mean)
Day 1Day 2Day 3Day 5Day 7Day 14
Double Blind Ketamine6.05.35.55.55.14.8
Double Blind Placebo5.26.05.24.44.43.7
Open Label Ketamine4.65.53.54.44.84.4

Brief Pain Inventory Pain Interference Scale Score

"Pain interference in the past 24 hours, rated on a numerical scale from 0 to 10 (with 0 representing Does not interfere and 10 representing Completely interferes)." (NCT03861988)
Timeframe: Post-intervention days 1, 2, 3, 5, 7 and 14

,,
Interventionunits on a scale (Mean)
Day 1Day 2Day 3Day 5Day 7Day 14
Double Blind Ketamine8.18.07.57.06.76.2
Double Blind Placebo7.68.17.77.07.25.7
Open Label Ketamine6.06.34.86.67.64.8

Cumulative Opioid Use

This outcome measures how many cumulative morphine-equivalents milligrams of opioid pain medication the patient has taken as an inpatient and after discharge from hospital (NCT03861988)
Timeframe: Post-intervention days 1, 2, 3, 5, 7 and 14

Interventionmilligram morphine equivalents (Mean)
Day 1Day 2Day 3
Open Label Ketamine108.5249.3361.5

Cumulative Opioid Use

This outcome measures how many cumulative morphine-equivalents milligrams of opioid pain medication the patient has taken as an inpatient and after discharge from hospital (NCT03861988)
Timeframe: Post-intervention days 1, 2, 3, 5, 7 and 14

,
Interventionmilligram morphine equivalents (Mean)
Day 1Day 2Day 3Day 5Day 7Day 14
Double Blind Ketamine60.9104.6137.9150.6171.6206.1
Double Blind Placebo56.1107.7144.3156.2163.3186.4

Hospital Anxiety and Depression Scale (HADS) Scale Score

This outcome measures self-reported symptoms of anxiety and depression on a scale that ranges from 0 to 42. A lower score indicates lower severity of symptoms. (NCT03861988)
Timeframe: Post-intervention days 1, 2, 3, 5, 7 and 14

,,
Interventionscore on a scale (Mean)
Day 1Day 2Day 3Day 5Day 7Day 14
Double Blind Ketamine17.818.819.318.318.416.4
Double Blind Placebo19.921.220.818.919.617.2
Open Label Ketamine14.822.613.016.619.214.0

Montgomery-Asberg Depression Rating Scale (MADRS) Score

The MADRS is a 10-item scale for the evaluation of depressive symptoms (Montgomery et al 1979). Each MADRS item is rated on a 0 to 6 scale. Total score range from 0-60, where lower MADRS scores indicate lower levels of depressive symptoms. The assessment for this outcome will be taken once daily on days 1, 2 and 3 post procedure. A mixed model for repeated measures (MMRM) was used to analyze the difference in postoperative MADRS score between ketamine and placebo groups.. (NCT03861988)
Timeframe: Post-intervention days 1, 2 and 3

,,
Interventionscore on a scale (Mean)
Day 1Day 2Day 3
Double Blind Ketamine12.715.117.0
Double Blind Placebo16.417.517.2
Open Label Ketamine17.025.410.5

Number of Participants With Clinical Response

Clinical response defined as >=50% reduction in MADRS score from baseline. MADRS score range: 0 to 60, a lower score indicates lower severity of symptoms. (NCT03861988)
Timeframe: Post-intervention days 1, 2 and 3

,,
InterventionParticipants (Count of Participants)
Day 1Day 2Day 3
Double Blind Ketamine12109
Double Blind Placebo101210
Open Label Ketamine213

Reviews

14 reviews available for clomipramine and Depression

ArticleYear
Body dysmorphic disorder in a Nigerian boy presenting as depression: a case report and literature review.
    International journal of psychiatry in medicine, 2012, Volume: 44, Issue:4

    Topics: Adolescent; Body Dysmorphic Disorders; Clomipramine; Depression; Diagnosis, Differential; Humans; Ma

2012
[Obsessive-compulsive disorders in general practice. How the obsessive-compulsive neurotic is revealed by skin and hair].
    MMW Fortschritte der Medizin, 2003, May-26, Volume: 145 Suppl 2

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Age

2003
[Current treatment of depression].
    Therapeutische Umschau. Revue therapeutique, 1983, Volume: 40, Issue:9

    Topics: Administration, Oral; Antidepressive Agents; Antipsychotic Agents; Clomipramine; Depression; Depress

1983
Central serotonin deficiency--a factor which increases depression vulnerability?
    Acta psychiatrica Scandinavica. Supplementum, 1980, Volume: 280

    Topics: 5-Hydroxytryptophan; Adult; Biogenic Amines; Brain Chemistry; Clomipramine; Depression; Female; Huma

1980
Clomipramine in obsessive-compulsive disorder: a review.
    Psychosomatics, 1983, Volume: 24, Issue:8

    Topics: Behavior Therapy; Clomipramine; Depression; Double-Blind Method; Humans; Obsessive Behavior; Obsessi

1983
Antidepressants and the serotonin uptake in platelets.
    Acta psychiatrica Scandinavica. Supplementum, 1980, Volume: 280

    Topics: Amitriptyline; Antidepressive Agents; Blood Platelets; Brain; Clomipramine; Depression; Dose-Respons

1980
Risks for oral health with the use of antidepressants.
    General hospital psychiatry, 1998, Volume: 20, Issue:3

    Topics: Antidepressive Agents; Clomipramine; Dental Caries; Depression; Diagnosis, Differential; Humans; Mal

1998
Depression and dementia: comorbidities, identification, and treatment.
    Journal of geriatric psychiatry and neurology, 1998,Winter, Volume: 11, Issue:4

    Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Benzamides; Citalopram; Clomipramine; Cog

1998
A review of the relationship between endocrinopathy and depression or antidepressant drugs, with particular respect to novel theories involving the opiate receptor.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Circadian Rhythm; Clomipramine; Depression; Dibenzazepines; Endorphins; Enkephalins; Hormones; Human

1977
Practical considerations on the use of clomipramine (Anafranil) in general practice: an updated review.
    The Journal of international medical research, 1977, Volume: 5, Issue:1 Suppl

    Topics: Clomipramine; Depression; Dibenzazepines; Drug Interactions; Female; Humans; Male; Phobic Disorders;

1977
A review of the CNS effects of fenfluramine, 780SE and norfenfluramine on animals and man.
    Postgraduate medical journal, 1975, Volume: 51 Suppl 1

    Topics: Acetylcholine; Amphetamine; Analgesia; Animals; Behavior; Biogenic Amines; Body Temperature Regulati

1975
Effects of drugs on the processes regulating the functional activity of brain 5-hydroxytryptamine.
    Nature, 1976, Apr-08, Volume: 260, Issue:5551

    Topics: Animals; Brain; Clomipramine; Depression; Dopamine; Humans; Hydroxyindoleacetic Acid; Lithium; Model

1976
Major depression: its recognition and treatment. Part 2. Second-generation and newer antidepressants.
    American pharmacy, 1992, Volume: NS32, Issue:11

    Topics: Antidepressive Agents; Bupropion; Clomipramine; Depression; Female; Fluoxetine; Humans; Male; Maprot

1992
Individualization of treatment with tricyclic compounds.
    The Medical clinics of North America, 1974, Volume: 58, Issue:5

    Topics: Animals; Antidepressive Agents; Chromatography, Gas; Clomipramine; Depression; Drug Interactions; El

1974

Trials

58 trials available for clomipramine and Depression

ArticleYear
Therapeutic alliance in short-term supportive and psychodynamic psychotherapies: a necessary but not sufficient condition for outcome?
    Psychiatry research, 2009, Dec-30, Volume: 170, Issue:2-3

    Topics: Adult; Aged; Analysis of Variance; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Femal

2009
Chronic treatment with antidepressants decreases intraoperative core hypothermia.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:1

    Topics: Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricy

2003
[Study on Modified Xiaoyao Decoction combining Clomipramine treating depression].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2007, Volume: 27, Issue:4

    Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Drug Therapy, Combina

2007
Fluvoxamine and clomipramine in depressed patients. A double-blind clinical study.
    Acta psychiatrica Scandinavica, 1981, Volume: 64, Issue:1

    Topics: Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Clomipramine; Depression; Diazepam; Do

1981
Inhibitors of serotonin and noradrenaline uptake in human plasma after withdrawal of zimelidine and clomipramine treatment.
    Psychopharmacology, 1983, Volume: 79, Issue:4

    Topics: Adult; Blood Platelets; Brompheniramine; Carbon Radioisotopes; Clomipramine; Depression; Female; Hum

1983
Intravenous maprotiline in severe and resistant primary depression: a double-blind comparison with clomipramine.
    The Journal of international medical research, 1983, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Aged; Anthracenes; Clinical Trials as Topic; Clomipramine; Depression; Double-Bli

1983
Tricyclic antidepressants in obsessive-compulsive disorder. Antiobsessional or antidepressant agents?
    The Journal of nervous and mental disease, 1983, Volume: 171, Issue:5

    Topics: Adolescent; Adult; Aged; Anxiety; Clinical Trials as Topic; Clomipramine; Depression; Female; Humans

1983
[Pain and depressive symptoms in general practice. A controlled study of Anafranil (clomipramine) versus placebo].
    Ugeskrift for laeger, 1984, Sep-19, Volume: 146, Issue:38

    Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Diagnosis, Differential; Double-Blind Met

1984
Clomipramine and exposure for obsessive-compulsive rituals: i.
    The British journal of psychiatry : the journal of mental science, 1980, Volume: 136

    Topics: Adolescent; Adult; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Depression; Double-Blin

1980
[Clinical trial of Tegretol and Anafranil/Sinequan in alcohol abstinence symptoms].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1980, Feb-20, Volume: 100, Issue:5

    Topics: Alcoholism; Carbamazepine; Clinical Trials as Topic; Clomipramine; Depression; Double-Blind Method;

1980
A beta adrenergic stimulant (salbutamol) versus clomipramine in depression: a controlled study.
    The British journal of psychiatry : the journal of mental science, 1980, Volume: 136

    Topics: Adolescent; Adult; Aged; Albuterol; Clinical Trials as Topic; Clomipramine; Depression; Female; Huma

1980
A placebo-controlled comparative study of the combined effects of oxprenolol and clomipramine in depressed patients.
    International pharmacopsychiatry, 1980, Volume: 15, Issue:1

    Topics: Adult; Aged; Clinical Trials as Topic; Clomipramine; Depression; Double-Blind Method; Drug Therapy,

1980
Double-blind trial of amineptine and clomipramine in the treatment of depression.
    Current medical research and opinion, 1981, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Clomipramine; D

1981
Doctor's versus patient's judgement in the assessment of mixed anxiety/depressive illness. Implications for measurement of therapeutic response.
    Acta psychiatrica Scandinavica, 1981, Volume: 63, Issue:5

    Topics: Adult; Aged; Anxiety; Clinical Trials as Topic; Clomipramine; Depression; Drug Combinations; Female;

1981
Mianserin and clomipramine in the treatment of depression.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, May-08, Volume: 61, Issue:19

    Topics: Adult; Aged; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Double-Blind Method

1982
Urinary amine metabolites in depression: a combined biochemical and general practice study: I. Clinical aspects.
    The Journal of international medical research, 1980, Volume: 8 Suppl 3

    Topics: Adolescent; Adult; Aged; Biogenic Amines; Clomipramine; Depression; Diet; Family Practice; Female; H

1980
Andrological findings in young patients under long-term antidepressive therapy with clomipramine.
    Psychopharmacology, 1994, Volume: 116, Issue:3

    Topics: Adult; Androgens; Clomipramine; Depression; Erectile Dysfunction; Humans; Male; Middle Aged; Semen;

1994
Buspirone augmentation of antidepressant therapy.
    Journal of clinical psychopharmacology, 1998, Volume: 18, Issue:6

    Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Buspirone; Clomipramine; Depression; Female

1998
Clomipramine concentration as a predictor of delayed response: a naturalistic study.
    European journal of clinical pharmacology, 1999, Volume: 54, Issue:12

    Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Depression; Dose-Respons

1999
Pharmacokinetics of a sustained-release dosage form of clomipramine.
    Journal of clinical pharmacology, 2000, Volume: 40, Issue:12 Pt 2

    Topics: Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Clomipramine; Cross-Over Studies; Del

2000
Assessment of the serotonin and norepinephrine reuptake blocking properties of duloxetine in healthy subjects.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:5

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Blood Pressure; Brain; Brain Chemistry; Clomipramin

2001
Long-term effects of tricyclic antidepressants on norepinephrine kinetics in humans.
    Journal of neural transmission (Vienna, Austria : 1996), 2001, Volume: 108, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Blood Pressure; Brain; Brain Chemistry; Clom

2001
[Comparative study of three psychotropics for treatment of depressions].
    International pharmacopsychiatry, 1976, Volume: 11, Issue:1

    Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Doxepin; Female; Humans;

1976
Letter: Potentiation of antidepressant action of clomipramine by tryptophan.
    Lancet (London, England), 1975, Apr-26, Volume: 1, Issue:7913

    Topics: Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Drug Synergism; Drug Therapy, Co

1975
Letter: Combined sleep deprivation and clomipramine in primary depression.
    Lancet (London, England), 1976, Jul-17, Volume: 2, Issue:7977

    Topics: Adult; Clomipramine; Depression; Dibenzazepines; Humans; Middle Aged; Remission, Spontaneous; Sleep

1976
A comparative trial of Anafranil, Pertofran and an Anafranil/Pertofran combination.
    The Journal of international medical research, 1977, Volume: 5, Issue:1 Suppl

    Topics: Adolescent; Adult; Clinical Trials as Topic; Clomipramine; Depression; Desipramine; Dibenzazepines;

1977
[Clinical and experimental experiences with maprotiline, clomipramine, sydnocarb and mefexamide in mentally-ill patients and in healthy persons].
    Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie, 1977, Volume: 120, Issue:2

    Topics: Adult; Anthracenes; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Female; Glyc

1977
Controlled study comparing nomifensine and clomipramine in unipolar depression, using the probenecid technique.
    British journal of clinical pharmacology, 1977, Volume: 4Suppl 2

    Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Double-Blind Method; Fema

1977
Some observations on patient compliance in an antidepressive trial.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Anthracenes; Chromatography, Gas; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines

1977
Clinical responses in depressed patients in relation to plasma levels of tricyclic antidepressants and tyramine pressor response.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Adjustment Disorders; Adult; Aged; Anthracenes; Clinical Trials as Topic; Clomipramine; Depression;

1977
Second-generation antidepressants as research tools--some preliminary findings with clomipramine and maprotiline.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Adolescent; Adult; Aged; Anthracenes; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazep

1977
Tyramine pressor responses and plasma levels during tricyclic antidepressant therapy.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Anthracenes; Blood Pressure; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Dou

1977
Cardiovascular responses to mianserin hydrochloride: a comparison with tricyclic antidepressant drugs.
    British journal of clinical pharmacology, 1978, Volume: 5 Suppl 1

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bethanidine; Blood Pressure; Cardiovascular

1978
Tricyclic antidepressants in the treatment of depressions. A double-blind clinical comparison of clomipramine (Anafranil) and amitriptyline.
    Acta psychiatrica Scandinavica, 1978, Volume: 58, Issue:2

    Topics: Adult; Aged; Ambulatory Care; Amitriptyline; Clinical Trials as Topic; Clomipramine; Depression; Dib

1978
Single versus divided daily dosages of clomipramine. Plasma concentration and clinical effect.
    Acta psychiatrica Scandinavica, 1979, Volume: 59, Issue:3

    Topics: Adolescent; Adult; Blood Pressure; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepine

1979
Clomipramine-induced mania in unipolar depression.
    Archives of general psychiatry, 1979, Volume: 36, Issue:5

    Topics: Adult; Age Factors; Aged; Amitriptyline; Bipolar Disorder; Brain Chemistry; Clomipramine; Depression

1979
Plasma prolactin concentrations in normal subjects and depressive patients following oral clomipramine.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Administration, Oral; Adolescent; Adult; Aged; Clomipramine; Depression; Dibenzazepines; Female; Hum

1977
[Comparative study of the pharmacological and clinical effects of clorimipramine and metaprimine (19560 R.P.)].
    L'Encephale, 1978, Volume: 4, Issue:1

    Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Dibenzazepines; Female; Humans; M

1978
Psychomotor skills in depressed out-patients treated with L-tryptophan, doxepin, or chlorimipramine.
    Annals of clinical research, 1978, Volume: 10, Issue:4

    Topics: Adult; Attention; Clomipramine; Depression; Dibenzazepines; Doxepin; Female; Humans; Male; Middle Ag

1978
Plasma concentrations of clomipramine and its N-desmethyl metabolite in depressive patients following treatment with various dosage regimes of clomipramine.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Adolescent; Adult; Clomipramine; Depression; Dibenzazepines; Drug Administration Schedule; Female; H

1977
[The clomipramine-lithium combination: controlled trial].
    L'Encephale, 1976, Volume: 2, Issue:1

    Topics: Adjustment Disorders; Adult; Aged; Bipolar Disorder; Clinical Trials as Topic; Clomipramine; Depress

1976
Tryptophan, 5-hydroxytryptophan and tricyclic antidepressants in the treatment of depression.
    Monographs in neural sciences, 1976, Volume: 3

    Topics: 5-Hydroxytryptophan; Catecholamines; Clinical Trials as Topic; Clomipramine; Depression; Depression,

1976
Anafranil in obsessive compulsive neurosis.
    Current therapeutic research, clinical and experimental, 1975, Volume: 18, Issue:5

    Topics: Adult; Anxiety; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Female; Humans;

1975
Potentiation of the antidepressant action of clomipramine by tryptophan.
    Archives of general psychiatry, 1976, Volume: 33, Issue:11

    Topics: Adolescent; Adult; Aged; Anxiety; Clomipramine; Depression; Dibenzazepines; Drug Synergism; Drug The

1976
[Combined sleep deprivation/chlorimipramine therapy of endogenous depression (author's transl)].
    Arzneimittel-Forschung, 1976, Volume: 26, Issue:6

    Topics: Adult; Clomipramine; Depression; Dibenzazepines; Humans; Middle Aged; Sleep Deprivation; Time Factor

1976
Changes in obsessive/compulsive patients as measured by the Leyton Inventory before and after treatment with clomipramine.
    Scottish medical journal, 1975, Volume: 20, Issue:1 SUPPL

    Topics: Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Humans; Obsessive-Compulsive Dis

1975
Proceedings: Systematic clinical studies with clomipramine in depressed psychiatric patients--I. Report on an uncontrolled clinical trial.
    Psychopharmacology bulletin, 1976, Volume: 12, Issue:1

    Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Mid

1976
Proceedings: Systematic clinical studies with clomipramine in depressed psychiatric patients--II. Report on a placebo-controlled clinical trial.
    Psychopharmacology bulletin, 1976, Volume: 12, Issue:1

    Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Mid

1976
Proceedings: Systematic clinical studies with clomipramine in depressed psychiatric patients--III. Standard-controlled clinical trial.
    Psychopharmacology bulletin, 1976, Volume: 12, Issue:1

    Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Female; Humans; Imipramin

1976
Proceedings: Systematic clinical studies with clomipramine in depressed psychiatric patients--IV. A summary report.
    Psychopharmacology bulletin, 1976, Volume: 12, Issue:1

    Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Mid

1976
Tricyclic antidepressants and tryptophan in unipolar depression.
    Psychological medicine, 1975, Volume: 5, Issue:3

    Topics: Clomipramine; Depression; Desipramine; Dibenzazepines; Drug Therapy, Combination; Female; Humans; Ma

1975
Steady-state plasma levels of clomipramine and its metabolites: impact of the sparteine/debrisoquine oxidation polymorphism. Danish University Antidepressant Group.
    European journal of clinical pharmacology, 1992, Volume: 43, Issue:4

    Topics: Adult; Aged; Clomipramine; Cytochrome P-450 Enzyme System; Debrisoquin; Depression; Female; Humans;

1992
Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder.
    Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:6

    Topics: Adult; Analysis of Variance; Anxiety; Clomipramine; Clonazepam; Clonidine; Depression; Double-Blind

1992
Clomipramine effectively reduces premenstrual irritability and dysphoria: a placebo-controlled trial.
    Acta psychiatrica Scandinavica, 1992, Volume: 85, Issue:1

    Topics: Adult; Brain; Clomipramine; Depression; Double-Blind Method; Female; Humans; Irritable Mood; Persona

1992
Double-blind study of the chronopharmacotherapy of depression.
    Chronobiology international, 1991, Volume: 8, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Clomipramine; Depression; Double-Blind Method; Drug A

1991
A double-blind group comparison of mianserin and clomipramine in the treatment of mildly depressed psychiatric out-patients.
    Acta psychiatrica Scandinavica. Supplementum, 1985, Volume: 320

    Topics: Adult; Anti-Anxiety Agents; Anxiety; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male;

1985
Effect of yohimbine on blood pressure in patients with depression and orthostatic hypotension induced by clomipramine.
    Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:3

    Topics: Adult; Blood Pressure; Clomipramine; Depression; Double-Blind Method; Female; Heart Rate; Humans; Hy

1989
Differential effect of chlorimipramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression.
    European journal of clinical pharmacology, 1974, Aug-23, Volume: 7, Issue:5

    Topics: Clomipramine; Depression; Dibenzazepines; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglyc

1974

Other Studies

177 other studies available for clomipramine and Depression

ArticleYear
Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression.
    International journal of molecular sciences, 2021, Sep-04, Volume: 22, Issue:17

    Topics: Administration, Intranasal; Animals; Antidepressive Agents; Behavior, Animal; Brain; Clomipramine; D

2021
Chronic clomipramine treatment increases hippocampal volume in rats exposed to chronic unpredictable mild stress.
    Translational psychiatry, 2022, 06-10, Volume: 12, Issue:1

    Topics: Animals; Antidepressive Agents; Clomipramine; Depression; Disease Models, Animal; Hippocampus; Human

2022
Synergistic effects of
    Beneficial microbes, 2022, Aug-03, Volume: 13, Issue:3

    Topics: Animals; Clomipramine; Curcumin; Depression; Depressive Disorder; Disease Models, Animal; Glutamine;

2022
Effect of Epigallocatechin-3-gallate on Stress-Induced Depression in a Mouse Model: Role of Interleukin-1β and Brain-Derived Neurotrophic Factor.
    Neurochemical research, 2022, Volume: 47, Issue:11

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antioxidants; Brain-Derived Neurot

2022
Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male t
    Behavioural brain research, 2023, 10-18, Volume: 455

    Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Clomipramine; Depression; Disease Models, Animal;

2023
Neonatal treatment with clomipramine modifies the expression of estrogen receptors in brain areas of male adult rats.
    Brain research, 2019, 12-01, Volume: 1724

    Topics: Amygdala; Animals; Animals, Newborn; Behavior, Animal; Brain; Clomipramine; Depression; Estradiol; E

2019
Brain stimulation rewarding experience attenuates neonatal clomipramine-induced adulthood anxiety by reversal of pathological changes in the amygdala.
    Progress in neuro-psychopharmacology & biological psychiatry, 2020, 12-20, Volume: 103

    Topics: Amygdala; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Anxiety; Biogenic Monoamines;

2020
Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews.
    Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:10

    Topics: Anhedonia; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Depression; Di

2018
Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine.
    Journal of affective disorders, 2019, 07-01, Volume: 254

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Clomipramine; Cytokines; Depression; Depre

2019
Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 118

    Topics: Animals; Behavior, Animal; Cell Proliferation; Chamaemelum; Clomipramine; Corticosterone; Cytokines;

2019
Zinc improves clomipramine effects on depressive and locomotor behavior and reverses its oxidative stress in rats.
    Behavioural brain research, 2019, 11-18, Volume: 374

    Topics: Animals; Antidepressive Agents; Clomipramine; Depression; Depressive Disorder; Disease Models, Anima

2019
Clomipramine reverses hypoalgesia/hypoesthesia and improved depressive-like behaviors induced by inescapable shock in rats.
    Neuroscience letters, 2013, Apr-29, Volume: 541

    Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety; Avoidance Learning; Clomipramine; Depression; El

2013
Phospholipase D-mTOR signaling is compromised in a rat model of depression.
    Journal of psychiatric research, 2013, Volume: 47, Issue:5

    Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Brain; Choline; Clomipramine; Depressio

2013
Electrocardiographic changes upon tricyclic antidepressant administration mimicking Brugada syndrome.
    Internal medicine (Tokyo, Japan), 2013, Volume: 52, Issue:12

    Topics: Antidepressive Agents, Tricyclic; Brugada Syndrome; Bundle-Branch Block; Clomipramine; Depression; E

2013
Effects of chronic antidepressant treatments in a putative genetic model of vulnerability (Roman low-avoidance rats) and resistance (Roman high-avoidance rats) to stress-induced depression.
    Psychopharmacology, 2014, Volume: 231, Issue:1

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Avoidance Learning; Behavior, Anim

2014
Altered expression of 5-HT1A receptors in adult rats induced by neonatal treatment with clomipramine.
    Physiology & behavior, 2014, Jan-30, Volume: 124

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Body Temperature; Clomipra

2014
Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Depression; Humans; Hydro

2013
Antidepressant-like effect of simvastatin in diabetic rats.
    Canadian journal of physiology and pharmacology, 2015, Volume: 93, Issue:8

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Corticosterone; Depression; Diabetes

2015
The first observation of seasonal affective disorder symptoms in Rhesus macaque.
    Behavioural brain research, 2015, Oct-01, Volume: 292

    Topics: Animals; Antidepressive Agents, Tricyclic; Body Weight; Clomipramine; Depression; Disease Models, An

2015
Pharmacokinetics of clomipramine during pregnancy.
    European journal of clinical pharmacology, 2015, Volume: 71, Issue:12

    Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Clomipramine; Depression; Female; H

2015
A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants.
    European journal of pediatrics, 2016, Volume: 175, Issue:8

    Topics: Abnormalities, Drug-Induced; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Female; Hum

2016
Proteomic investigation of the prefrontal cortex in the rat clomipramine model of depression.
    Journal of proteomics, 2017, 02-05, Volume: 153

    Topics: Animals; Animals, Newborn; Clomipramine; Depression; Female; Intramolecular Oxidoreductases; Macroph

2017
Antidepressant-like effect of ethanol extract from Paeonia lactiflora in mice.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:11

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Blepharoptosis; Clomipramine; Depression; Dise

2008
QEEG changes during switch from depression to hypomania/mania: a case report.
    Neuro endocrinology letters, 2008, Volume: 29, Issue:3

    Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Clomipramine; Depression; Electroencephal

2008
Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats.
    Neuropharmacology, 2008, Volume: 55, Issue:4

    Topics: Amino Acids; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Bridged Bicyclo Compounds,

2008
Changes in brain orexin levels in a rat model of depression induced by neonatal administration of clomipramine.
    Journal of psychopharmacology (Oxford, England), 2008, Volume: 22, Issue:7

    Topics: Animals; Animals, Newborn; Brain Chemistry; Clomipramine; Depression; Enzyme-Linked Immunosorbent As

2008
Sex-related differential response to clomipramine treatment in a rat model of depression.
    Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:8

    Topics: Animals; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Disease Models, Animal; Female;

2009
Air swallowing as a tic.
    Journal of psychosomatic research, 2008, Volume: 65, Issue:5

    Topics: Aerophagy; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Diagnosis, Differential; Gast

2008
Immobility in the tail suspension test predicts quinine but not saccharin intake in mice.
    Neuroscience letters, 2009, Sep-25, Volume: 461, Issue:3

    Topics: Animals; Antidepressive Agents, Tricyclic; Choice Behavior; Clomipramine; Depression; Drinking Behav

2009
Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depression.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:11

    Topics: Animals; Clomipramine; Depression; Disease Models, Animal; Exploratory Behavior; Freezing Reaction,

2009
Circadian activity of corticosterone in an animal model of depression: response to muscarinic cholinergic stimulation.
    Physiology & behavior, 2010, Jun-16, Volume: 100, Issue:4

    Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Behavior, Animal; Cholinergic A

2010
The beta3 adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2010, Volume: 20, Issue:10

    Topics: Adrenergic beta-3 Receptor Agonists; Animals; Antidepressive Agents; Antidepressive Agents, Tricycli

2010
Effects of antidepressants on the performance in the forced swim test of two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions.
    Psychopharmacology, 2010, Volume: 211, Issue:4

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Clomipramine; Depression; Desi

2010
Chronic escitalopram treatment restores spatial learning, monoamine levels, and hippocampal long-term potentiation in an animal model of depression.
    Psychopharmacology, 2011, Volume: 214, Issue:2

    Topics: Acetylcholinesterase; Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents, Second

2011
5-HT(1A), 5-HT(2A), and 5-HT(2C) receptor mRNA modulation by antidepressant treatment in the chronic mild stress model of depression: sex differences exposed.
    Neuroscience, 2012, May-17, Volume: 210

    Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Depression; Disease Models, Animal;

2012
Chronic clomipramine treatment restores hippocampal expression of glial cell line-derived neurotrophic factor in a rat model of depression.
    Journal of affective disorders, 2012, Dec-10, Volume: 141, Issue:2-3

    Topics: Animals; Antidepressive Agents; Clomipramine; Depression; Glial Cell Line-Derived Neurotrophic Facto

2012
Inter-tissue networks between the basal forebrain, hippocampus, and prefrontal cortex in a model for depression caused by disturbed sleep.
    Journal of neurogenetics, 2012, Volume: 26, Issue:3-4

    Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Disease Model

2012
Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice.
    Journal of psychopharmacology (Oxford, England), 2013, Volume: 27, Issue:2

    Topics: Animals; Animals, Newborn; Antidepressive Agents; Behavior, Animal; Clomipramine; Depression; Female

2013
Clomipramine treatment in neonatal rats alters the brain acetylcholinesterase activity in adulthood.
    Neuroscience letters, 2002, Sep-13, Volume: 330, Issue:1

    Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; Brain; Clomipramine; Depression; Enzyme Acti

2002
Differential neurochemical properties of central serotonergic transmission in Roman high- and low-avoidance rats.
    Journal of neurochemistry, 2003, Volume: 86, Issue:2

    Topics: Animals; Anxiety; Autoradiography; Avoidance Learning; Behavior, Animal; Binding, Competitive; Brain

2003
Corticosterone and testosterone levels after chronic stress in an animal model of depression.
    Neuropsychobiology, 2003, Volume: 48, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Behavior, Animal;

2003
Impairments of ERK signal transduction in the brain in a rat model of depression induced by neonatal exposure of clomipramine.
    Brain research, 2003, Nov-21, Volume: 991, Issue:1-2

    Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Blotting, Western; Brain; Clomipramine;

2003
Weekly treatments with a burst-firing magnetic field alters behavior in the elevated plus maze after two sessions.
    Perceptual and motor skills, 2004, Volume: 98, Issue:3 Pt 1

    Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Conditioning, Psychologic

2004
Examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews.
    Behavioural pharmacology, 2004, Volume: 15, Issue:5-6

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cell Differentiation; Clomipramine

2004
Stressors affect the response of male and female rats to clomipramine in a model of behavioral despair (forced swim test).
    European journal of pharmacology, 2005, Sep-27, Volume: 520, Issue:1-3

    Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Corticosterone; Depressio

2005
[Case report: taeniasis, is it a cause of psychiatric and neural symptoms?].
    Turkiye parazitolojii dergisi, 2006, Volume: 30, Issue:3

    Topics: Adult; Animals; Anticestodal Agents; Antidepressive Agents, Tricyclic; Cathartics; Clomipramine; Con

2006
Electroacupuncture combined with clomipramine enhances antidepressant effect in rodents.
    Neuroscience letters, 2007, Jun-21, Volume: 421, Issue:1

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Dep

2007
Sucrose preference is restored by electro-acupuncture combined with chlorimipramine in the depression-model rats.
    Acupuncture & electro-therapeutics research, 2006, Volume: 31, Issue:3-4

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Combined Modality Therapy; Depressio

2006
Behavioral effects of the beta3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs?
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-3 Receptor Antagonists; Adrenergic beta-Antagon

2007
Selective serotonin reuptake inhibitors and other antidepressants and risk of fracture.
    Calcified tissue international, 2008, Volume: 82, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Second-Generation;

2008
Antidepressant drugs and the hypothalamic-pituitary-thyroid axis.
    Lancet (London, England), 1980, Jan-12, Volume: 1, Issue:8159

    Topics: Clomipramine; Depression; Female; Hormones; Humans; Prognosis; Recurrence; Thyrotropin; Thyrotropin-

1980
Dexamethasone suppression test identifies subtypes of depression which respond to different antidepressants.
    Lancet (London, England), 1980, Apr-26, Volume: 1, Issue:8174

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Depression, Chemic

1980
Biological aspects of clomiprimine III. Preface.
    Postgraduate medical journal, 1980, Volume: 56 Suppl 1

    Topics: Clomipramine; Congresses as Topic; Depression; Drug Evaluation; Humans

1980
Beta-adrenergic stimulation and antidepressant activity.
    Acta psychiatrica Scandinavica. Supplementum, 1981, Volume: 290

    Topics: Adrenergic beta-Agonists; Albuterol; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine;

1981
Amine metabolism, thyroid function and response to clomipramine and maprotiline medication in depression.
    Postgraduate medical journal, 1980, Volume: 56 Suppl 1

    Topics: Adolescent; Adult; Aged; Anthracenes; Clomipramine; Depression; Female; Humans; Hydroxyindoleacetic

1980
Cortisol in the CSF of depressed and suicidal patients.
    Archives of general psychiatry, 1980, Volume: 37, Issue:7

    Topics: Adjustment Disorders; Clomipramine; Depression; Female; Homovanillic Acid; Humans; Hydrocortisone; H

1980
Urinary amine metabolites in depression: a combined biochemical and general practice study: II. Biochemical aspects.
    The Journal of international medical research, 1980, Volume: 8 Suppl 3

    Topics: Adolescent; Adult; Aged; Biogenic Amines; Clomipramine; Depression; Family Practice; Female; Humans;

1980
Studies of CSF 5-HIAA in depression and suicidal behaviour.
    Advances in experimental medicine and biology, 1981, Volume: 133

    Topics: Blood Platelets; Clomipramine; Depression; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortis

1981
Relevance of tryptophan and tyrosine availability in endogenous and 'non-endogenous' depressives treated with imipramine or clomipramine.
    Journal of affective disorders, 1981, Volume: 3, Issue:3

    Topics: Biological Availability; Clomipramine; Depression; Depressive Disorder; Humans; Imipramine; Time Fac

1981
[N-dealkylation of chlorimipramine and chlorpromazine in patients undergoing chronic treatment with both drugs: preliminary results].
    Bollettino della Societa italiana di biologia sperimentale, 1984, Sep-30, Volume: 60, Issue:9

    Topics: Chlorpromazine; Clomipramine; Depression; Dissociative Disorders; Humans; Imipramine

1984
Variation in plasma concentrations of clomipramine and desmethylclomipramine during clomipramine therapy.
    Postgraduate medical journal, 1980, Volume: 56 Suppl 1

    Topics: Adolescent; Adult; Aged; Circadian Rhythm; Clomipramine; Depression; Female; Humans; Male; Middle Ag

1980
Clomipramine and oral contraceptives: an interaction study--clinical findings.
    The Journal of international medical research, 1980, Volume: 8 Suppl 3

    Topics: Adolescent; Adult; Clomipramine; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Depression; D

1980
Clomipramine and age: an interaction study.
    The Journal of international medical research, 1980, Volume: 8 Suppl 3

    Topics: Adolescent; Adult; Aged; Aging; Clomipramine; Depression; Female; Humans; Male; Psychiatric Status R

1980
Clomipramine and smoking: an interaction study--clinical findings.
    The Journal of international medical research, 1980, Volume: 8 Suppl 3

    Topics: Adult; Aged; Clomipramine; Depression; Female; Humans; Male; Middle Aged; Psychiatric Status Rating

1980
Relating plasma levels of clomipramine and clinical response.
    The Journal of international medical research, 1980, Volume: 8 Suppl 3

    Topics: Adult; Aged; Aging; Clomipramine; Contraceptives, Oral, Hormonal; Depression; Female; Humans; Male;

1980
Effects of age, cigarette smoking and the oral contraceptive on the pharmacokinetics of clomipramine and its desmethyl metabolite during chronic dosing.
    The Journal of international medical research, 1980, Volume: 8 Suppl 3

    Topics: Adolescent; Adult; Aged; Aging; Clomipramine; Contraceptives, Oral; Contraceptives, Oral, Hormonal;

1980
Preliminary observations of the significance of monitoring tricyclic antidepressant plasma levels in the pediatric patient.
    Therapeutic drug monitoring, 1980, Volume: 2, Issue:4

    Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Clomipramine; Depressi

1980
[Treatment of orthostatic hypotension induced by tricyclic antidepressants with yohimbine (author's transl)].
    Annales de medecine interne, 1980, Volume: 131, Issue:8

    Topics: Blood Pressure; Clomipramine; Depression; Double-Blind Method; Humans; Hypotension, Orthostatic; Yoh

1980
A sensitive and specific method for the determination of chlorimipramine and desmethylchlorimipramine in plasma using selected ion monitoring with chemical ionization.
    Biomedical mass spectrometry, 1980, Volume: 7, Issue:11-12

    Topics: Antidepressive Agents, Tricyclic; Clomipramine; Depression; Gas Chromatography-Mass Spectrometry; Hu

1980
[Latent or masked depression and depressive equivalents. Presentation of 2 clinical cases].
    Minerva medica, 1980, Apr-14, Volume: 71, Issue:15

    Topics: Adult; Antidepressive Agents; Clomipramine; Depression; Female; Humans; Male; Middle Aged; Psychophy

1980
Intravenous chlorimipramine and refractory depression.
    General hospital psychiatry, 1980, Volume: 2, Issue:1

    Topics: Adult; Bipolar Disorder; Clomipramine; Depression; Hemodynamics; Humans; Infusions, Parenteral; Male

1980
Single oral dose pharmacokinetics of clomipramine in depressed patients.
    Postgraduate medical journal, 1980, Volume: 56 Suppl 1

    Topics: Administration, Oral; Adult; Aged; Clomipramine; Depression; Drug Administration Schedule; Female; H

1980
Unusual plasma level oscillations of clomipramine in man: a pharmacokinetic and pharmacodynamic dilemma.
    Postgraduate medical journal, 1980, Volume: 56 Suppl 1

    Topics: Administration, Oral; Adult; Clomipramine; Depression; Humans; Infusions, Parenteral; Kinetics; Male

1980
Plasma levels and clinical improvement--a comparative study of clomipramine and amitriptyline in depression.
    Postgraduate medical journal, 1980, Volume: 56 Suppl 1

    Topics: Amitriptyline; Clomipramine; Depression; Female; Humans; Male; Nortriptyline

1980
Plasma concentration of clomipramine and desmethylclomipramine and clinical response in depressed patients.
    Postgraduate medical journal, 1980, Volume: 56 Suppl 1

    Topics: Adult; Aged; Clomipramine; Depression; Female; Humans; Male; Middle Aged; Time Factors

1980
Ethnic differences in drug response.
    Postgraduate medical journal, 1980, Volume: 56 Suppl 1

    Topics: Asia; Clomipramine; Depression; Environment; Ethnicity; Humans; Kinetics; United Kingdom; United Sta

1980
Influence of age, cigarette smoking and the oral contraceptive on plasma concentrations of clomipramine.
    Postgraduate medical journal, 1980, Volume: 56 Suppl 1

    Topics: Adolescent; Adult; Aged; Aging; Clomipramine; Contraceptives, Oral; Depression; Female; Humans; Male

1980
[Infusion treatment of depression].
    Medizinische Klinik, 1980, Apr-25, Volume: 75, Issue:9

    Topics: Administration, Oral; Ambulatory Care; Antidepressive Agents, Tricyclic; Clomipramine; Depression; D

1980
Pharmacologic management of obsessive-compulsive disorder.
    Southern medical journal, 1994, Volume: 87, Issue:3

    Topics: 1-Naphthylamine; Antidepressive Agents; Anxiety Disorders; Clomipramine; Depression; Dopamine; Fluox

1994
DMBA-induced mammary tumor growth in rats exhibiting increased or decreased ability to cope with stress due to early postnatal handling or antidepressant treatment.
    Physiology & behavior, 1993, Volume: 54, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adaptation, Psychological; Animals; Animals, Newborn; Arousal; Clo

1993
Effects of tryptophan and serotonin uptake inhibitors on behavior in male transgenic transforming growth factor alpha mice.
    European journal of pharmacology, 1993, Jun-11, Volume: 237, Issue:1

    Topics: Aggression; Animals; Behavior, Animal; Clomipramine; Depression; Male; Mice; Mice, Transgenic; Selec

1993
Desensitization of the D1 dopamine receptors in rats reproduces a model of escape deficit reverted by imipramine, fluoxetine and clomipramine.
    Progress in neuro-psychopharmacology & biological psychiatry, 1995, Volume: 19, Issue:5

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Clomipramine; Depression; Disea

1995
Amaurosis fugax on standing and angle-closure glaucoma with clomipramine.
    Lancet (London, England), 1996, Feb-17, Volume: 347, Issue:8999

    Topics: Antidepressive Agents, Tricyclic; Blindness; Clomipramine; Depression; Female; Glaucoma, Angle-Closu

1996
Effects of chronic treatment with zimelidine and REM sleep deprivation on the regulation of raphe neuronal activity in a rat model of depression.
    Psychopharmacology, 1996, Volume: 124, Issue:3

    Topics: Animals; Citalopram; Clomipramine; Depression; Dose-Response Relationship, Drug; Electrophysiology;

1996
Successful treatment of serotonin syndrome with chlorpromazine.
    The Medical journal of Australia, 1996, Sep-16, Volume: 165, Issue:6

    Topics: Central Nervous System Diseases; Chlorpromazine; Clomipramine; Depression; Drug Interactions; Humans

1996
Decreased dorsal raphe nucleus neuronal activity in adult chloral hydrate anesthetized rats following neonatal clomipramine treatment: implications for endogenous depression.
    Brain research, 1997, May-09, Volume: 756, Issue:1-2

    Topics: Anesthesia; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Chloral Hydrate; Clomiprami

1997
Pharmacological features of masculine sexual behavior in an animal model of depression.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Clo

1998
Depressive symptomatology during clozapine treatment: two case reports.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1998, Volume: 8, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic Age

1998
Neonatal clomipramine treatment, alcohol intake and circadian rhythms in rats.
    Psychopharmacology, 1998, Volume: 138, Issue:2

    Topics: Alcohol Drinking; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Circadian Rhythm; Clo

1998
Hyperactivity of hypothalamic pituitary axis in neonatal clomipramine model of depression.
    Journal of neural transmission (Vienna, Austria : 1996), 1998, Volume: 105, Issue:10-12

    Topics: Animals; Animals, Newborn; Clomipramine; Depression; Depression, Chemical; Dexamethasone; Disease Mo

1998
Alterations in the levels of monoamines in discrete brain regions of clomipramine-induced animal model of endogenous depression.
    Neurochemical research, 1999, Volume: 24, Issue:3

    Topics: Aggression; Animals; Biogenic Monoamines; Brain; Brain Stem; Clomipramine; Depression; Disease Model

1999
Serotonin syndrome as a result of clomipramine monotherapy.
    Journal of clinical psychopharmacology, 1999, Volume: 19, Issue:3

    Topics: Antidepressive Agents, Tricyclic; Clomipramine; Depression; Female; Humans; Middle Aged; Selective S

1999
Abnormal monoamine metabolism in cerebrospinal fluid in a case of serotonin syndrome.
    Journal of clinical psychopharmacology, 2000, Volume: 20, Issue:1

    Topics: Adult; Amoxapine; Biogenic Monoamines; Clomipramine; Depression; Humans; Male; Selective Serotonin R

2000
Long photoperiod regimen may produce antidepressant actions in the male rat.
    Progress in neuro-psychopharmacology & biological psychiatry, 2000, Volume: 24, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Clomipramine; Conditioning, Operant; Depression; Desipram

2000
Effects of REM sleep deprivation on cholinergic receptor sensitivity and passive avoidance behavior in clomipramine model of depression.
    Brain research, 2000, Jun-09, Volume: 867, Issue:1-2

    Topics: Animals; Animals, Newborn; Avoidance Learning; Clomipramine; Depression; Male; Motor Activity; Musca

2000
The differential effects of calcium channel blockers in the behavioural despair test in mice.
    Pharmacological research, 2000, Volume: 42, Issue:4

    Topics: Animals; Antidepressive Agents; Calcium Channel Blockers; Clomipramine; Clonidine; Cyproheptadine; D

2000
Effects of acute or chronic administration of substituted benzamides in experimental models of depression in rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2000, Volume: 10, Issue:6

    Topics: Animals; Antidepressive Agents; Benzamides; Clomipramine; Depression; Disease Models, Animal; Dose-R

2000
Population pharmacokinetics of clomipramine, desmethylclomipramine, and hydroxylated metabolites in patients with depression receiving chronic treatment: model evaluation.
    Therapeutic drug monitoring, 2000, Volume: 22, Issue:6

    Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Clomipramine; Computer Simulation; Depression; Drug A

2000
Placebo affects the performance of rats in models of depression: is it a good control for behavioral experiments?
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2001, Volume: 11, Issue:3

    Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Depression; Disease Model

2001
Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment.
    Neuro endocrinology letters, 2001, Volume: 22, Issue:3

    Topics: Adult; Affect; Antidepressive Agents; Circadian Rhythm; Clomipramine; Depression; Female; Humans; Ma

2001
The critical window of brain development from susceptive to insusceptive. Effects of clomipramine neonatal treatment on sexual behavior.
    Brain research. Developmental brain research, 2001, Jul-23, Volume: 129, Issue:1

    Topics: Animals; Animals, Newborn; Brain; Clomipramine; Critical Period, Psychological; Depression; Disease

2001
Availability of learned helplessness test as a model of depression compared to a forced swimming test in rats.
    Pharmacology, 2001, Volume: 63, Issue:3

    Topics: Amoxapine; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Depression; Disease Model

2001
Altered dendritic spine density in animal models of depression and in response to antidepressant treatment.
    Synapse (New York, N.Y.), 2001, Dec-01, Volume: 42, Issue:3

    Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Clomipramine; Dendrites; Denervation; D

2001
Clomipramine suppresses postnatal REM sleep without increasing wakefulness: implications for the production of depressive behaviors.
    Sleep, 2002, Mar-15, Volume: 25, Issue:2

    Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Depress

2002
Mimosa pudica may possess antidepressant actions in the rat.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 1999, Volume: 6, Issue:5

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Depression; Desipramine; Fabaceae; M

1999
[The pharmacotherapy of masked depression].
    Wiener medizinische Wochenschrift (1946), 1975, May-23, Volume: 125, Issue:21

    Topics: Adrenergic beta-Agonists; Anthracenes; Clomipramine; Depression; Dibenzazepines; Drug Therapy, Combi

1975
Treatment of depression with tricyclic drugs--pharmacokinetic and pharmacodynamic aspects.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1976, Volume: 9, Issue:1

    Topics: Antidepressive Agents, Tricyclic; Clomipramine; Depression; Homovanillic Acid; Humans; Hydroxyindole

1976
Monoamine metabolites in cerebrospinal fluid and serotonin uptake inhibition during treatment with chlorimipramine.
    Clinical pharmacology and therapeutics, 1977, Volume: 21, Issue:2

    Topics: Biogenic Amines; Clomipramine; Depression; Depression, Chemical; Dibenzazepines; Homovanillic Acid;

1977
[Suppression of the antihypertensive effect of clonidine by the simultaneous intake of a tricyclic antidepressive agent. Practical problem in the treatment of a depressed hypertensive patient].
    La Nouvelle presse medicale, 1977, Sep-10, Volume: 6, Issue:29

    Topics: Adrenergic beta-Antagonists; Adult; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Clomi

1977
Sleep deprivation and clomipramine in endogenous depression.
    Lancet (London, England), 1976, Oct-23, Volume: 2, Issue:7991

    Topics: Clomipramine; Depression; Dibenzazepines; Humans; Maprotiline; Sleep Deprivation

1976
[Clinical and biochemical contributions on the action of maprotiline and clomipramine in depressive states (preliminary observation)].
    Psychiatria clinica, 1979, Volume: 13, Issue:3

    Topics: Adult; Bipolar Disorder; Clomipramine; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; M

1979
[Clinical and biochemical contributions on the effect of maprotiline and clomipramine in depressive states (preliminary observation)].
    Psychiatria clinica, 1979, Volume: 12, Issue:3

    Topics: Adjustment Disorders; Adult; Anthracenes; Blood Platelets; Clomipramine; Depression; Female; Humans;

1979
Urinary adenosine 3',5'-cyclic monophosphate: effects of electroconvulsive therapy.
    The British journal of psychiatry : the journal of mental science, 1976, Volume: 129

    Topics: Clomipramine; Cyclic AMP; Depression; Electroconvulsive Therapy; Humans; Psychiatric Status Rating S

1976
Mass fragmentographic analysis of clomipramine and its mono-demethylated metabolite in human plasma.
    Psychopharmacology, 1977, Mar-23, Volume: 52, Issue:1

    Topics: Adult; Clomipramine; Dealkylation; Depression; Dibenzazepines; Female; Gas Chromatography-Mass Spect

1977
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
Clinical response and tricyclic plasma levels during treatment with clomipramine.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Administration, Oral; Adult; Aged; Clomipramine; Depression; Dibenzazepines; Drug Administration Sch

1979
Techniques for plasma protein binding of demethylchlorimipramine.
    Clinical pharmacology and therapeutics, 1979, Volume: 26, Issue:2

    Topics: Blood Proteins; Clomipramine; Compulsive Personality Disorder; Depression; Dialysis; Dibenzazepines;

1979
Response to sleep deprivation as a predictor of therapeutic results with antidepressant drugs.
    The American journal of psychiatry, 1979, Volume: 136, Issue:9

    Topics: Antidepressive Agents, Tricyclic; Clomipramine; Depression; Female; Humans; Imipramine; Male; Maprot

1979
3-Methoxy-4-hydroxyphenylglycol and primary depression: clinical and pharmacological considerations.
    Biological psychiatry, 1979, Volume: 14, Issue:3

    Topics: Adult; Aged; Amitriptyline; Bipolar Disorder; Clomipramine; Depression; Female; Glycols; Humans; Mal

1979
Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression.
    Clinical pharmacology and therapeutics, 1979, Volume: 26, Issue:5

    Topics: Adult; Age Factors; Aged; Animals; Biological Transport; Brain; Clomipramine; Depression; Female; Hu

1979
Effects of somatic treatments on mood in endogenous depression.
    Acta psychiatrica Scandinavica, 1979, Volume: 60, Issue:2

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Clomipramine; Depression; Desipramine

1979
[Treatment of therapy resistant depressions with high dose clomipramine].
    International pharmacopsychiatry, 1979, Volume: 14, Issue:5

    Topics: Adult; Aged; Clomipramine; Depression; Drug Resistance; Female; Humans; Male; Middle Aged

1979
Intraindividual similarity in the metabolism of amitriptyline and chlorimipramine in depressed patients.
    Pharmacology, 1979, Volume: 19, Issue:5

    Topics: Amitriptyline; Clomipramine; Dealkylation; Depression; Humans; Kinetics

1979
Antidepressive treatment and mood swing patterns in endogenous depression.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1979, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Clomipra

1979
Clomipramine: plasma levels and clinical effects.
    Communications in psychopharmacology, 1979, Volume: 3, Issue:5

    Topics: Adult; Aged; Clomipramine; Dealkylation; Depression; Female; Humans; Male; Middle Aged; Placebos; Ps

1979
Plasma levels of tricyclic antidepressants and clinical efficacy: review of the literature -- part II.
    The Journal of clinical psychiatry, 1979, Volume: 40, Issue:2

    Topics: Antidepressive Agents, Tricyclic; Biotransformation; Clomipramine; Depression; Desipramine; Dibenzoc

1979
Clomipramine (Anafranil) in depressive patients with obsessive neurosis.
    The Journal of international medical research, 1977, Volume: 5 Suppl 5

    Topics: Adult; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Obsessive-Compulsive Disorder

1977
Treatment of obsessive-compulsive neurosis with clomipramine (Anafranil).
    The Journal of international medical research, 1977, Volume: 5 Suppl 5

    Topics: Adult; Aged; Anxiety; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Middle Aged; O

1977
Clinical experience in the treatment of obsessional states (2).
    The Journal of international medical research, 1977, Volume: 5 Suppl 5

    Topics: Clomipramine; Depression; Dibenzazepines; Humans; Obsessive-Compulsive Disorder; Phobic Disorders

1977
Clomipramine plasma level and clinical response.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Administration, Oral; Adult; Aged; Body Weight; Clomipramine; Depression; Dibenzazepines; Female; Hu

1977
Clomipramine and maprotiline on human platelet uptake of 5-hydroxytryptamine and dopamine in vitro: what relevance to their antidepressive and other central actions?
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Anthracenes; Blood Platelets; Clomipramine; Depression; Dibenzazepines; Dopamine; Humans; In Vitro T

1977
The effect of depression and its treatment on serum thyroxine.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Clomipramine; Depression; Dibenzazepines; Humans; Maprotiline; Thyroxine

1977
Plasma level studies of clomipramine and desmethylclomipramine following intravenous infusions of clomipramine in depressive patients.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Adolescent; Adult; Clomipramine; Depression; Dibenzazepines; Female; Humans; Infusions, Parenteral;

1977
[Management of treatment-resistant depression (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1978, Feb-10, Volume: 103, Issue:6

    Topics: Administration, Oral; Antidepressive Agents; Autogenic Training; Bipolar Disorder; Clomipramine; Dep

1978
[Clomipramine (monochlorimipramine) produced in the GDR].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1978, Volume: 30, Issue:2

    Topics: Clomipramine; Depression; Dibenzazepines; Germany, East; Humans

1978
The effects of clomipramine on depression in Barbadian patients.
    The West Indian medical journal, 1978, Volume: 27, Issue:2

    Topics: Adult; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Pilot Projects

1978
Psychiatric problems in intensive care. Five patients with acute confusional states and depression.
    Anaesthesia, 1976, Volume: 31, Issue:3

    Topics: Adult; Aged; Clomipramine; Cognition Disorders; Confusion; Consciousness Disorders; Critical Care; D

1976
The use of clomipramine in phobic patients. Preliminary research report.
    Current therapeutic research, clinical and experimental, 1975, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Anxiety; Clomipramine; Depression; Dibenzazepines; Drug Evaluation; Drug Toleranc

1975
Depressive subtypes, blood pressure changes and response to treatment.
    Diseases of the nervous system, 1977, Volume: 38, Issue:2

    Topics: Adult; Age Factors; Aged; Anxiety Disorders; Bipolar Disorder; Blood Pressure; Clomipramine; Depress

1977
Relationships between clinical response, plasma levels and side-effects of clomipramine (Anafranil) in general practitioner trials.
    The Journal of international medical research, 1977, Volume: 5, Issue:1 Suppl

    Topics: Adolescent; Adult; Aged; Clomipramine; Depression; Dibenzazepines; Dose-Response Relationship, Drug;

1977
A clinical trial of a 50 mg formulation of clomipramine (Anafranil) with steady-state plasma level measurements.
    The Journal of international medical research, 1977, Volume: 5, Issue:1 Suppl

    Topics: Adult; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Middle Aged; Pilot Projects;

1977
Comparisons of various clomipramine (Anafranil) dosage regimes.
    The Journal of international medical research, 1977, Volume: 5, Issue:1 Suppl

    Topics: Adult; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Middle Aged; Psychiatric Stat

1977
Sexual side-effects of clomipramine (Anafranil).
    The Journal of international medical research, 1977, Volume: 5, Issue:1 Suppl

    Topics: Adult; Clomipramine; Coitus; Depression; Dibenzazepines; Female; Humans; Male; Orgasm; Sexual Behavi

1977
Plasma level studies with clomipramine (anafranil)
    The Journal of international medical research, 1977, Volume: 5, Issue:1 Suppl

    Topics: Adult; Aged; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Middle Aged

1977
[Metoclopramide (Cerucal) side-effects in the form of extrapyramidal disorders in combination with an other antidepressive agent].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1977, Volume: 29, Issue:5

    Topics: Adult; Basal Ganglia Diseases; Clomipramine; Depression; Drug Combinations; Female; Gastrointestinal

1977
[Tricyclic antidepressive agents in refractory depressions].
    La Nouvelle presse medicale, 1977, Sep-10, Volume: 6, Issue:29

    Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Dose-Response Relationship, Drug;

1977
Investigation of the orthostatic reaction after intravenous administration of imipramine, chlorimipramine, and inimpramine-N-oxide.
    Acta psychiatrica Scandinavica, 1976, Volume: 54, Issue:1

    Topics: Adult; Aged; Blood Pressure; Clomipramine; Depression; Dibenzazepines; Dose-Response Relationship, D

1976
Platelet uptake of 5-hydroxytryptamine and dopamine in depression.
    Postgraduate medical journal, 1976, Volume: 52, Issue:3 suppl

    Topics: Blood Platelets; Clomipramine; Depression; Dopamine; Humans; Protriptyline; Serotonin

1976
Tricyclic antidepressants, tryptophan and affective disorder.
    Postgraduate medical journal, 1976, Volume: 52, Issue:3 suppl

    Topics: Antidepressive Agents, Tricyclic; Clomipramine; Depression; Desipramine; Humans; Serotonin; Tryptoph

1976
The effect of clomipramine on prolactin levels--pilot studies.
    Postgraduate medical journal, 1976, Volume: 52, Issue:3 suppl

    Topics: Adult; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Prolactin

1976
Effect of flupenthixol on depression with special reference to combination use with tricyclic antidepressants. An uncontrolled pilot study with 45 patients.
    Acta psychiatrica Scandinavica, 1976, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Clomipramine; Depre

1976
Agranulocytosis and systemic candidiasis following clomipramine therapy.
    Postgraduate medical journal, 1976, Volume: 52, Issue:609

    Topics: Adult; Agranulocytosis; Candidiasis; Clomipramine; Depression; Dibenzazepines; Female; Flucytosine;

1976
[Psychotropic drugs and glaucoma (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1976, Volume: 168, Issue:05

    Topics: Adult; Aged; Clomipramine; Depression; Desipramine; Dibenzocycloheptenes; Female; Fluphenazine; Glau

1976
[Description of a simple graphic model permitting the comparison of the course of depressive states].
    Annales medico-psychologiques, 1976, Volume: 2, Issue:4

    Topics: Adjustment Disorders; Adult; Antidepressive Agents; Anxiety; Clomipramine; Depression; Doxepin; Fema

1976
Central monoamine deficiency in depressions: causative of secondary phenomenon?
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1975, Volume: 8, Issue:5

    Topics: 5-Hydroxytryptophan; Clomipramine; Depression; Dopamine; Homovanillic Acid; Humans; Serotonin

1975
Psychological medicine. Management of depression.
    British medical journal, 1975, May-17, Volume: 2, Issue:5967

    Topics: Amitriptyline; Antidepressive Agents; Anxiety; Clomipramine; Depression; Drug Interactions; Electroc

1975
Depressive reactions in the course of clomipramine therapy used in the treatment of obsessional conditions.
    Scottish medical journal, 1975, Volume: 20, Issue:1 SUPPL

    Topics: Adult; Aged; Amitriptyline; Clomipramine; Depression; Dibenzazepines; Female; Flupenthixol; Humans;

1975
A pilot study of anafranil in the treatment of phobic states.
    Scottish medical journal, 1975, Volume: 20, Issue:1 SUPPL

    Topics: Administration, Oral; Adult; Alcoholism; Blood Pressure; Clomipramine; Depression; Dibenzazepines; D

1975
A preliminary report on the use of clomipramine in general practice.
    Scottish medical journal, 1975, Volume: 20, Issue:1 SUPPL

    Topics: Administration, Oral; Adult; Aged; Alcoholism; Clomipramine; Depression; Dibenzazepines; Family Prac

1975
[Mania complicating treatment of unipolar vital depression].
    Nederlands tijdschrift voor geneeskunde, 1975, Oct-11, Volume: 119, Issue:71

    Topics: Adult; Aged; Amitriptyline; Bipolar Disorder; Clomipramine; Depression; Dibenzazepines; Female; Huma

1975
Proceedings: Clomipramine in the treatment of depressions.
    Activitas nervosa superior, 1975, Volume: 17, Issue:4

    Topics: Adult; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Middle Aged

1975
Intravenous chlorimipramine and depressive subtypes.
    Diseases of the nervous system, 1976, Volume: 37, Issue:6

    Topics: Adult; Aged; Bipolar Disorder; Blood Pressure; Clomipramine; Depression; Dibenzazepines; Drug Evalua

1976
Neuroendocrine responses to L-tryptophan as an index of brain serotonin function: effect of weight loss.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Adult; Biological Transport, Active; Brain Chemistry; Clomipramine; Depression; Diet, Reducing; Fema

1991
Trazodone treatment in clomipramine-resistant obsessive-compulsive disorder.
    Clinical neuropharmacology, 1990, Volume: 13, Issue:4

    Topics: Adult; Analysis of Variance; Clinical Trials as Topic; Clomipramine; Depression; Drug Resistance; Fe

1990
Abnormal neuroendocrine responsivity to clomipramine in depression.
    Psychopharmacology bulletin, 1990, Volume: 26, Issue:3

    Topics: Adult; Clomipramine; Depression; Female; Humans; Male; Neurosecretory Systems; Prolactin; Thyroid Fu

1990
Absence of placebo response in obsessive-compulsive disorder.
    The Journal of nervous and mental disease, 1990, Volume: 178, Issue:4

    Topics: Adolescent; Adult; Aged; Anxiety; Clomipramine; Depression; Double-Blind Method; Fear; Female; Human

1990
Determination of fluoxetine and norfluoxetine by high-performance liquid chromatography.
    Journal of chromatography, 1990, Jan-19, Volume: 499

    Topics: Chromatography, High Pressure Liquid; Clomipramine; Depression; Fluoxetine; Humans

1990
Delusional depression responding to clomipramine in Binswanger's disease.
    The Journal of nervous and mental disease, 1990, Volume: 178, Issue:7

    Topics: Clomipramine; Delusions; Dementia; Depression; Female; Humans; Middle Aged

1990
[Determination of 3-methoxy-4-hydroxyphenyethylene-glycol and its urinary conjugates. Value in the diagnosis and therapeutic follow-up of depression].
    Pathologie-biologie, 1988, Volume: 36, Issue:3

    Topics: Clomipramine; Depression; Drug Therapy, Combination; Follow-Up Studies; Glycols; Humans; Hydroxyindo

1988
Hyponatraemia and clomipramine therapy.
    The British journal of psychiatry : the journal of mental science, 1989, Volume: 154

    Topics: Clomipramine; Depression; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Middle Aged

1989
Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites.
    European journal of clinical pharmacology, 1986, Volume: 31, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Benzodiazepines; Clomipramine; Debrisoquin; Dep

1986
Animal depression model by neonatal clomipramine: reduction of shock induced aggression.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:1

    Topics: Age Factors; Aggression; Animals; Animals, Newborn; Clomipramine; Depression; Disease Models, Animal

1988
Rothia dentocariosa septicaemia in a patient with chronic lymphocytic leukaemia and toxic granulocytopenia.
    Danish medical bulletin, 1987, Volume: 34, Issue:6

    Topics: Actinomycetaceae; Actinomycetales Infections; Aged; Agranulocytosis; Clomipramine; Clopenthixol; Dep

1987
Myoclonic movements as a side-effect of treatment with therapeutic doses of clomipramine.
    International clinical psychopharmacology, 1987, Volume: 2, Issue:4

    Topics: Adult; Aged; Clomipramine; Depression; Female; Humans; Male; Middle Aged; Myoclonus

1987
Response to sequential administration of clomipramine and lithium carbonate in treatment-resistant depression.
    The British journal of psychiatry : the journal of mental science, 1985, Volume: 147

    Topics: Aged; Clomipramine; Depression; Drug Synergism; Drug Therapy, Combination; Humans; Lithium; Lithium

1985
[Preliminary results of a controlled trial with sulpiride versus chlorimipramine in chronic schizophrenic patients with marked ideo-emotional poverty (author's transl)].
    Rivista di patologia nervosa e mentale, 1974, Volume: 95, Issue:1

    Topics: Affect; Anxiety; Chronic Disease; Clomipramine; Depression; Dibenzazepines; Humans; Mental Processes

1974
[Problems of differentiated thymoleptic therapy in phasic depressions].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1974, Volume: 74, Issue:6

    Topics: Adolescent; Adult; Amitriptyline; Anthracenes; Antidepressive Agents; Azocines; Benzoates; Benzofura

1974