clomipramine has been researched along with Complications, Pregnancy in 11 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clomipramine is one of the drugs for depression during pregnancy; however, pharmacokinetic data of clomipramine and its active metabolite desmethylclomipramine in this vulnerable period are lacking." | 7.81 | Pharmacokinetics of clomipramine during pregnancy. ( de Jong-van de Berg, LT; Proost, JH; Smit, JP; Ter Horst, PG; Vries, MT; Wilffert, B, 2015) |
| "The case is described of a neonate who suffered from withdrawal symptoms within 24 hours after birth as a result of the use of clomipramine by the mother during pregnancy." | 7.68 | [Neonatal withdrawal symptoms following the use of clomipramine during pregnancy]. ( Boringa, JB; de Jong, GM; Touw, DJ, 1992) |
| "Clomipramine is one of the drugs for depression during pregnancy; however, pharmacokinetic data of clomipramine and its active metabolite desmethylclomipramine in this vulnerable period are lacking." | 3.81 | Pharmacokinetics of clomipramine during pregnancy. ( de Jong-van de Berg, LT; Proost, JH; Smit, JP; Ter Horst, PG; Vries, MT; Wilffert, B, 2015) |
| "The case is described of a neonate who suffered from withdrawal symptoms within 24 hours after birth as a result of the use of clomipramine by the mother during pregnancy." | 3.68 | [Neonatal withdrawal symptoms following the use of clomipramine during pregnancy]. ( Boringa, JB; de Jong, GM; Touw, DJ, 1992) |
| "The observed withdrawal symptoms were too short a period of sleep after feeding (6), poor feeding (3), mild to severe tremors (6), hyperactive Moro reflex (3) and respiratory rate >60 breaths min(-1)." | 1.38 | Clomipramine concentration and withdrawal symptoms in 10 neonates. ( De Jong-van den Berg, LT; den Boon, J; Jansman, FG; Smit, JP; ter Horst, PG; van der Linde, S; van Lingen, RA; Wilffert, B, 2012) |
| "Four clomipramine-treated breastfeeding mother-infant pairs were assessed for serum concentrations of clomipramine, N-desmethylclomipramine, and corresponding 8-hydroxymetabolites." | 1.29 | Serum clomipramine and metabolite levels in four nursing mother-infant pairs. ( Foglia, JP; Perel, JM; Wisner, KL, 1995) |
| "Clomipramine is a chlorinated tricyclic antidepressant commonly used in the treatment of depression (1)." | 1.28 | Toxic neonatal effects following maternal clomipramine therapy. ( Katz, EZ; Koren, G; Pastuszak, A; Schimmell, MS; Shaag, Y, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Leutritz, AL | 1 |
| van Braam, L | 1 |
| Preis, K | 1 |
| Gehrmann, A | 1 |
| Scherf-Clavel, M | 1 |
| Fiedler, K | 1 |
| Unterecker, S | 1 |
| Kittel-Schneider, S | 1 |
| Ter Horst, PG | 2 |
| Proost, JH | 1 |
| Smit, JP | 2 |
| Vries, MT | 1 |
| de Jong-van de Berg, LT | 1 |
| Wilffert, B | 2 |
| van der Linde, S | 1 |
| den Boon, J | 1 |
| van Lingen, RA | 1 |
| Jansman, FG | 1 |
| De Jong-van den Berg, LT | 1 |
| Wu, CC | 1 |
| Chen, JY | 1 |
| Tao, PL | 1 |
| Chen, YA | 1 |
| Yeh, GC | 1 |
| Loughhead, AM | 1 |
| Stowe, ZN | 1 |
| Newport, DJ | 1 |
| Ritchie, JC | 1 |
| DeVane, CL | 1 |
| Owens, MJ | 1 |
| Cowe, L | 1 |
| Lloyd, DJ | 1 |
| Dawling, S | 1 |
| Ostergaard, GZ | 1 |
| Pedersen, SE | 1 |
| Wisner, KL | 1 |
| Perel, JM | 1 |
| Foglia, JP | 1 |
| Bromiker, R | 1 |
| Kaplan, M | 1 |
| Boringa, JB | 1 |
| de Jong, GM | 1 |
| Touw, DJ | 1 |
| Schimmell, MS | 1 |
| Katz, EZ | 1 |
| Shaag, Y | 1 |
| Pastuszak, A | 1 |
| Koren, G | 1 |
11 other studies available for clomipramine and Complications, Pregnancy
| Article | Year |
|---|---|
Psychotropic medication in pregnancy and lactation and early development of exposed children.
Topics: Child; Clomipramine; Female; Humans; Infant, Newborn; Lactation; Pregnancy; Pregnancy Complications; | 2023 |
Pharmacokinetics of clomipramine during pregnancy.
Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Clomipramine; Depression; Female; H | 2015 |
Clomipramine concentration and withdrawal symptoms in 10 neonates.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Female; Half-Life; Human | 2012 |
Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine.
Topics: Animals; Animals, Newborn; Behavior, Animal; Citalopram; Clomipramine; Female; Fluoxetine; Maternal- | 2005 |
Placental passage of tricyclic antidepressants.
Topics: Antidepressive Agents, Tricyclic; Birth Weight; Clomipramine; Depressive Disorder, Major; Dose-Respo | 2006 |
Neonatal convulsions caused by withdrawal from maternal clomipramine.
Topics: Adult; Clomipramine; Depressive Disorder; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases | 1982 |
Neonatal effects of maternal clomipramine treatment.
Topics: Acidosis, Respiratory; Clomipramine; Cyanosis; Depressive Disorder; Female; Humans; Infant, Newborn; | 1982 |
Serum clomipramine and metabolite levels in four nursing mother-infant pairs.
Topics: Adult; Breast Feeding; Clomipramine; Female; Half-Life; Humans; Infant; Infant, Newborn; Male; Obses | 1995 |
Apparent intrauterine fetal withdrawal from clomipramine hydrochloride.
Topics: Clomipramine; Female; Fetal Diseases; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Complicati | 1994 |
[Neonatal withdrawal symptoms following the use of clomipramine during pregnancy].
Topics: Adult; Clomipramine; Clonazepam; Depressive Disorder; Female; Humans; Infant, Newborn; Male; Neonata | 1992 |
Toxic neonatal effects following maternal clomipramine therapy.
Topics: Adult; Akathisia, Drug-Induced; Animals; Bottle Feeding; Breast Feeding; Clomipramine; Depressive Di | 1991 |