clomipramine has been researched along with Chronic Disease in 36 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary objectives of this multicenter study were to determine the efficacy and safety of moclobemide, a selective reversible inhibitor of monoamino oxidase A, as drug treatment in DSM-III-R panic disorder with and without agoraphobia." | 9.09 | The efficacy and safety of moclobemide compared to clomipramine in the treatment of panic disorder. ( Dahl, AA; Krüger, MB, 1999) |
| "The reduction of pain by two antidepressants, clomipramine and mianserin, was, in this study on 253 patients with chronic idiopathic pain syndrome, found to be not better than a placebo when all patients were compared independently of the classification of pain." | 9.06 | Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study. ( Bech, P; Hansen, HJ; Langemark, M; Loldrup, D; Olesen, J, 1989) |
| "To assess the response to clomipramine in chronic low back pain patients according to baseline MMPI scores." | 7.69 | Influence of psychological factors on the response to clomipramine in hospitalized chronic low back pain patients. Preliminary data from a psychometric study. ( Chalumeau, F; Etienne, T; Fouquet, B; Goupille, P; Jeannou, J; Valat, JP, 1997) |
| "The analgesic effect of clomipramine and the possible relationships between the antalgic action and the plasma levels of this tricyclic drug have been studied in 30 patients with chronic pain induced by nervous lesions determining a deafferentation." | 7.67 | Measurement of plasma levels of clomipramine in the treatment of chronic pain. ( Blanc, M; Charlet, JP; Cotonat, J; David, J; Guiraud-Chaumeil, B; Mansat, M; Montastruc, JL; Patacq-Sapijanskas, M; Rascol, A; Tran, MA, 1985) |
| "The analgesic effect of clomipramine and the possible relationships between the antalgic action, the doses and the plasma levels of this tricyclic drug have been studied in 15 patients with chronic pain induced by nervous lesions determining a deafferentiation." | 7.66 | [Analgesic properties and plasma concentrations of clomipramine in chronic pain]. ( Charlet, JP; Cotonat, J; David, J; Gaillard-Plaza, G; Guiraud, B; Montastruc, JL; Rascol, A; Tran, MA, 1983) |
| "This study investigated the chronic use (6." | 5.31 | Memory performance in panic disorder patients after chronic use of clomipramine. ( Artes, R; de Carvalho, SC; Gorenstein, C; Marcourakis, T, 2002) |
| "They failed clomipramine hydrochloride treatment as the panic attacks resumed, occasionally even with greater frequency." | 5.29 | [The clinico-psychopathological characteristics of patients with panic disorders and the efficacy of clomipramine therapy]. ( Kalinin, VV; Maksimova, MA, 1993) |
| "The primary objectives of this multicenter study were to determine the efficacy and safety of moclobemide, a selective reversible inhibitor of monoamino oxidase A, as drug treatment in DSM-III-R panic disorder with and without agoraphobia." | 5.09 | The efficacy and safety of moclobemide compared to clomipramine in the treatment of panic disorder. ( Dahl, AA; Krüger, MB, 1999) |
| "The reduction of pain by two antidepressants, clomipramine and mianserin, was, in this study on 253 patients with chronic idiopathic pain syndrome, found to be not better than a placebo when all patients were compared independently of the classification of pain." | 5.06 | Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study. ( Bech, P; Hansen, HJ; Langemark, M; Loldrup, D; Olesen, J, 1989) |
| "Several studies have reported that both imipramine and clomipramine are valuable adjuncts in the management of chronic pain, in particular that associated with the arthritides." | 5.05 | A comparative trial of clomipramine and placebo as adjunctive therapy in arthralgia. ( Beaumont, G; Ganvir, P; Seldrup, J, 1980) |
| "A clinical trial is being conducted in which single, nightly doses of 10 mg or 25 mg of clomipramine are added to the conventional analgesic therapy of patients with chronic painful conditions of the locomotor system." | 5.04 | Anafranil in the management of long-term pain: a preliminary report. ( Regalado, RG, 1976) |
| "To assess the response to clomipramine in chronic low back pain patients according to baseline MMPI scores." | 3.69 | Influence of psychological factors on the response to clomipramine in hospitalized chronic low back pain patients. Preliminary data from a psychometric study. ( Chalumeau, F; Etienne, T; Fouquet, B; Goupille, P; Jeannou, J; Valat, JP, 1997) |
| "The analgesic effect of clomipramine and the possible relationships between the antalgic action and the plasma levels of this tricyclic drug have been studied in 30 patients with chronic pain induced by nervous lesions determining a deafferentation." | 3.67 | Measurement of plasma levels of clomipramine in the treatment of chronic pain. ( Blanc, M; Charlet, JP; Cotonat, J; David, J; Guiraud-Chaumeil, B; Mansat, M; Montastruc, JL; Patacq-Sapijanskas, M; Rascol, A; Tran, MA, 1985) |
| "The analgesic effect of clomipramine and the possible relationships between the antalgic action, the doses and the plasma levels of this tricyclic drug have been studied in 15 patients with chronic pain induced by nervous lesions determining a deafferentiation." | 3.66 | [Analgesic properties and plasma concentrations of clomipramine in chronic pain]. ( Charlet, JP; Cotonat, J; David, J; Gaillard-Plaza, G; Guiraud, B; Montastruc, JL; Rascol, A; Tran, MA, 1983) |
| "There have been reports that tricyclic antidepressants, such as clomipramine (Anafranil), alleviate some forms of chronic pain in man." | 3.65 | Antidepressants and pain: a review of the pharmacological data supporting the use of certain tricyclics in chronic pain. ( Lee, R; Spencer, PS, 1977) |
| "This study investigated the chronic use (6." | 1.31 | Memory performance in panic disorder patients after chronic use of clomipramine. ( Artes, R; de Carvalho, SC; Gorenstein, C; Marcourakis, T, 2002) |
| "They failed clomipramine hydrochloride treatment as the panic attacks resumed, occasionally even with greater frequency." | 1.29 | [The clinico-psychopathological characteristics of patients with panic disorders and the efficacy of clomipramine therapy]. ( Kalinin, VV; Maksimova, MA, 1993) |
| "Seven patients suffering from severe endogenous depression who had proven resistant to lengthy trials of treatment with tricyclic and other antidepressants are described." | 1.27 | Clomipramine, tryptophan and lithium in combination for resistant endogenous depression: seven case studies. ( Bridges, PK; Hale, AS; Procter, AW, 1987) |
| " Data in adult patients illustrate on the one hand possible causes of variability in plasma levels of haloperidol and, on the other hand, the fact that poor bioavailability is not the cause of lack of response in 'resistant' schizophrenic patients." | 1.26 | Clinical significance of monitoring plasma levels of psychotropic drugs. ( Morselli, PL; Zarifian, E, 1979) |
| " A dosage schedule for in- and outpatients has been established, using imipramine (Tofranil) or chlorimipramine (Anafranil), and haloperidol (Haldol)." | 1.26 | The use of psychotropic drugs in the treatment of chronic, severe pains. ( Kocher, R, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (44.44) | 18.7374 |
| 1990's | 6 (16.67) | 18.2507 |
| 2000's | 13 (36.11) | 29.6817 |
| 2010's | 1 (2.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arco, L | 1 |
| Pitychoutis, PM | 1 |
| Griva, E | 1 |
| Ioannou, K | 1 |
| Tsitsilonis, OE | 1 |
| Papadopoulou-Daifoti, Z | 1 |
| de Carvalho, SC | 1 |
| Marcourakis, T | 1 |
| Artes, R | 1 |
| Gorenstein, C | 1 |
| van der Hart, MG | 1 |
| Czéh, B | 1 |
| de Biurrun, G | 1 |
| Michaelis, T | 1 |
| Watanabe, T | 1 |
| Natt, O | 1 |
| Frahm, J | 1 |
| Fuchs, E | 1 |
| Kaplan, A | 1 |
| Hollander, E | 2 |
| Fujii, S | 1 |
| Asakura, M | 1 |
| Kanai, S | 1 |
| Tanaka, D | 1 |
| Hishinumai, T | 1 |
| Nagashima, H | 1 |
| Pruidze, MV | 1 |
| Maloletnev, VI | 1 |
| Dell'Osso, B | 1 |
| Altamura, AC | 1 |
| Mundo, E | 1 |
| Marazziti, D | 1 |
| Andrés, S | 1 |
| Lázaro, L | 1 |
| Salamero, M | 1 |
| Boget, T | 1 |
| Penadés, R | 1 |
| Castro-Fornieles, J | 1 |
| Yang, LM | 1 |
| Hu, B | 1 |
| Xia, YH | 1 |
| Zhang, BL | 1 |
| Zhao, H | 1 |
| Liu, Q | 1 |
| Yu, J | 1 |
| Mao-Ying, QL | 1 |
| Mi, WL | 1 |
| Li, B | 1 |
| Wang, YQ | 1 |
| Wang, J | 1 |
| Wu, GC | 1 |
| Montastruc, JL | 3 |
| Tran, MA | 3 |
| Charlet, JP | 2 |
| Gaillard-Plaza, G | 1 |
| David, J | 2 |
| Cotonat, J | 2 |
| Guiraud, B | 1 |
| Rascol, A | 3 |
| Ganvir, P | 1 |
| Beaumont, G | 1 |
| Seldrup, J | 1 |
| Hoes, MJ | 1 |
| Colla, P | 1 |
| Folgering, H | 1 |
| Kalinin, VV | 1 |
| Maksimova, MA | 1 |
| Kurokawa, K | 1 |
| Tanino, R | 1 |
| Fouquet, B | 1 |
| Goupille, P | 1 |
| Jeannou, J | 1 |
| Etienne, T | 1 |
| Chalumeau, F | 1 |
| Valat, JP | 1 |
| Krüger, MB | 1 |
| Dahl, AA | 1 |
| Angelopoulos, EK | 1 |
| Markianos, M | 2 |
| Daskalopoulou, EG | 1 |
| Hatzimanolis, J | 2 |
| Tzemos, J | 1 |
| Lykouras, L | 1 |
| Christodoulou, GN | 1 |
| Kocher, R | 2 |
| Morselli, PL | 1 |
| Zarifian, E | 1 |
| Auád Juri, AO | 1 |
| Regalado, RG | 1 |
| Lee, R | 1 |
| Spencer, PS | 1 |
| Bark, N | 1 |
| Lindenmayer, JP | 1 |
| O'Sullivan, G | 1 |
| Noshirvani, H | 1 |
| Marks, I | 1 |
| Monteiro, W | 1 |
| Lelliott, P | 1 |
| Bourgoin, S | 1 |
| Cesselin, F | 1 |
| Gozlan, H | 1 |
| Fattaccini, CM | 1 |
| Hamon, M | 1 |
| Adell, A | 1 |
| García-Marquez, C | 1 |
| Armario, A | 1 |
| Gelpí, E | 1 |
| Loldrup, D | 1 |
| Langemark, M | 1 |
| Hansen, HJ | 1 |
| Olesen, J | 1 |
| Bech, P | 1 |
| Jegede, RO | 1 |
| Baiyewu, O | 1 |
| Hale, AS | 1 |
| Procter, AW | 1 |
| Bridges, PK | 1 |
| Blanc, M | 1 |
| Mansat, M | 1 |
| Patacq-Sapijanskas, M | 1 |
| Guiraud-Chaumeil, B | 1 |
| Masciocchi, A | 1 |
| Reitano, S | 1 |
| Vanini, M | 1 |
| Cicchetti, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Respiratory Rehabilitation on Quality of Life, Measures by the SF-36 Score, in Patients With Hyperventilation Syndrome: Crossover, Prospective and Randomized Study[NCT04668638] | 40 participants (Anticipated) | Interventional | 2021-03-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for clomipramine and Chronic Disease
| Article | Year |
|---|---|
A review of pharmacologic treatments for obsessive-compulsive disorder.
Topics: Antidepressive Agents, Tricyclic; Chronic Disease; Clinical Trials as Topic; Clomipramine; Comorbidi | 2003 |
Diagnosis and treatment of obsessive-compulsive disorder and related disorders.
Topics: Chronic Disease; Clomipramine; Humans; Obsessive-Compulsive Disorder; Psychotherapy; Selective Serot | 2007 |
5 trials available for clomipramine and Chronic Disease
| Article | Year |
|---|---|
A comparative trial of clomipramine and placebo as adjunctive therapy in arthralgia.
Topics: Adult; Arthritis; Chronic Disease; Clinical Trials as Topic; Clomipramine; Double-Blind Method; Fema | 1980 |
The efficacy and safety of moclobemide compared to clomipramine in the treatment of panic disorder.
Topics: Adult; Aged; Benzamides; Chi-Square Distribution; Chronic Disease; Clomipramine; Female; Humans; Mal | 1999 |
Anafranil in the management of long-term pain: a preliminary report.
Topics: Analgesics; Chronic Disease; Clinical Trials as Topic; Clomipramine; Dibenzazepines; Drug Evaluation | 1976 |
Six-year follow-up after exposure and clomipramine therapy for obsessive compulsive disorder.
Topics: Antidepressive Agents, Tricyclic; Behavior Therapy; Chronic Disease; Clomipramine; Double-Blind Meth | 1991 |
Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study.
Topics: Adolescent; Adult; Aged; Chronic Disease; Clinical Trials as Topic; Clomipramine; Female; Humans; Ma | 1989 |
29 other studies available for clomipramine and Chronic Disease
| Article | Year |
|---|---|
A case study in treating chronic comorbid obsessive-compulsive disorder and depression with behavioral activation and pharmacotherapy.
Topics: Amitriptyline; Antidepressive Agents; Behavior Therapy; Chronic Disease; Clomipramine; Depressive Di | 2015 |
Chronic antidepressant treatment exerts sexually dimorphic immunomodulatory effects in an experimental model of major depression: do females lack an advantage?
Topics: Animals; Antidepressive Agents, Tricyclic; Cell Proliferation; Cells, Cultured; Chronic Disease; Clo | 2009 |
Memory performance in panic disorder patients after chronic use of clomipramine.
Topics: Adult; Agoraphobia; Antidepressive Agents, Tricyclic; Chronic Disease; Clomipramine; Female; Humans; | 2002 |
Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume.
Topics: Animals; Antidepressive Agents, Tricyclic; Body Weight; Brain Chemistry; Cell Division; Chronic Dise | 2002 |
[Effect of concurrent treatment of SSRI on the tyrosine hydroxylase immunoreactivity in the rat locus coeruleus treated with chronic variable stress].
Topics: Animals; Antidepressive Agents, Tricyclic; Chronic Disease; Clomipramine; Corticotropin-Releasing Ho | 2004 |
[Peculiarities of tactics in the treatment of chronic pain syndrome in women].
Topics: Adult; Chronic Disease; Clomipramine; Female; Humans; Menstruation; Middle Aged; Pain; Selective Ser | 2006 |
Changes in cognitive dysfunction in children and adolescents with obsessive-compulsive disorder after treatment.
Topics: Adolescent; Child; Chronic Disease; Clomipramine; Cognition Disorders; Counseling; Female; Follow-Up | 2008 |
Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus.
Topics: Animals; Antidepressive Agents; Chronic Disease; Clomipramine; Depressive Disorder; Disease Models, | 2008 |
Repeated clomipramine treatment reversed the inhibition of cell proliferation in adult hippocampus induced by chronic unpredictable stress.
Topics: Animals; Behavior, Animal; Cell Proliferation; Chronic Disease; Clomipramine; Hippocampus; Male; Rat | 2008 |
[Analgesic properties and plasma concentrations of clomipramine in chronic pain].
Topics: Adult; Aged; Analgesics; Chronic Disease; Clomipramine; Female; Follow-Up Studies; Humans; Kinetics; | 1983 |
Clomipramine treatment of hyperventilation syndrome.
Topics: Adult; Chronic Disease; Clomipramine; Female; Humans; Hyperventilation; Male | 1980 |
[The clinico-psychopathological characteristics of patients with panic disorders and the efficacy of clomipramine therapy].
Topics: Adult; Chronic Disease; Clomipramine; Drug Evaluation; Female; Humans; Male; Middle Aged; Panic Diso | 1993 |
Effectiveness of clomipramine for obsessive-compulsive symptoms and chronic pain in two patients with schizophrenia.
Topics: Adult; Antidepressive Agents, Tricyclic; Chronic Disease; Clomipramine; Humans; Male; Obsessive-Comp | 1997 |
Influence of psychological factors on the response to clomipramine in hospitalized chronic low back pain patients. Preliminary data from a psychometric study.
Topics: Adult; Antidepressive Agents, Tricyclic; Chronic Disease; Clomipramine; Female; Hospitalization; Hum | 1997 |
[A classic antidepressant as an analgesic. Chronic pain under secure control].
Topics: Analgesics; Antidepressive Agents, Tricyclic; Chronic Disease; Clomipramine; Humans; Pain | 2001 |
Changes in central serotonergic function as a correlate of duration of illness in paranoid schizophrenia.
Topics: Adolescent; Adult; Brain; Chronic Disease; Clomipramine; Dopamine; Haloperidol; Humans; Male; Progno | 2002 |
Prolactin responses to acute clomipramine and haloperidol of male schizophrenic patients in a drug-free state and after treatment with clozapine or with olanzapine.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Clomipramine; Clozapine; Haloperidol; | 2002 |
[The treatment of chronic low back pain with psychotropic drugs (author's transl)].
Topics: Antidepressive Agents; Back Pain; Central Nervous System; Chronic Disease; Clomipramine; Drug Therap | 1977 |
Clinical significance of monitoring plasma levels of psychotropic drugs.
Topics: Adult; Child; Chronic Disease; Clomipramine; Haloperidol; Humans; Mental Disorders; Parasympatholyti | 1979 |
[Psychopharmaceutics and pain (thymolepto analgesia treatment of chronic pain with the antidepressive chlorimipramine].
Topics: Chronic Disease; Clomipramine; Dibenzazepines; Drug Evaluation; Female; Humans; Male; Pain; Pain, Po | 1978 |
Antidepressants and pain: a review of the pharmacological data supporting the use of certain tricyclics in chronic pain.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Central Nervous System; Chronic Disease; Clom | 1977 |
The use of psychotropic drugs in the treatment of chronic, severe pains.
Topics: Chronic Disease; Clomipramine; Drug Evaluation; Drug Therapy, Combination; Haloperidol; Humans; Imip | 1976 |
Ineffectiveness of clomipramine for obsessive-compulsive symptoms in a patient with schizophrenia.
Topics: Adult; Chronic Disease; Clomipramine; Humans; Male; Obsessive-Compulsive Disorder; Schizophrenia; Sc | 1992 |
Chronic chlorimipramine does not reverse the reduction of cerebrospinal fluid Met-enkephalin-like immunoreactivity in chronic-pain patients.
Topics: Adult; Aged; Chronic Disease; Clomipramine; Enkephalin, Methionine; Enkephalins; Female; Humans; Hyd | 1987 |
Chronic administration of clomipramine prevents the increase in serotonin and noradrenaline induced by chronic stress.
Topics: Animals; Brain Chemistry; Chronic Disease; Clomipramine; Hydroxyindoleacetic Acid; Male; Norepinephr | 1989 |
A study of chronic neurotic illness in Nigeria.
Topics: Adult; Aged; Anxiety Disorders; Chronic Disease; Clomipramine; Drug Therapy, Combination; Female; Hu | 1989 |
Clomipramine, tryptophan and lithium in combination for resistant endogenous depression: seven case studies.
Topics: Adult; Antidepressive Agents, Tricyclic; Chronic Disease; Clomipramine; Depressive Disorder; Drug Re | 1987 |
Measurement of plasma levels of clomipramine in the treatment of chronic pain.
Topics: Chronic Disease; Clomipramine; Female; Humans; Kinetics; Male; Middle Aged; Pain | 1985 |
[Preliminary results of a controlled trial with sulpiride versus chlorimipramine in chronic schizophrenic patients with marked ideo-emotional poverty (author's transl)].
Topics: Affect; Anxiety; Chronic Disease; Clomipramine; Depression; Dibenzazepines; Humans; Mental Processes | 1974 |