clomipramine has been researched along with Chemical and Drug Induced Liver Injury in 13 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 67-year-old man developed concurrent severe agranulocytosis and elevation of hepatic transaminases as a result of treatment with clomipramine." | 7.68 | Concurrent agranulocytosis and hepatitis secondary to clomipramine therapy. ( Alderman, CP; Atchison, MM; McNeece, JI, 1993) |
| "A 67-year-old man developed concurrent severe agranulocytosis and elevation of hepatic transaminases as a result of treatment with clomipramine." | 3.68 | Concurrent agranulocytosis and hepatitis secondary to clomipramine therapy. ( Alderman, CP; Atchison, MM; McNeece, JI, 1993) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "In this patient, an initial episode of photosensitization, probably elicited by clomipramine, was accompanied by contact allergy to this drug and to carbamazepine." | 1.28 | A case of photosensitivity and contact allergy to systemic tricyclic drugs, with unusual features. ( Bojs, G; Ljunggren, B, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Bizerra, PFV | 1 |
| Itou da Silva, FS | 1 |
| Gilglioni, EH | 1 |
| Nanami, LF | 1 |
| Klosowski, EM | 1 |
| de Souza, BTL | 1 |
| Raimundo, AFG | 1 |
| Dos Santos, KBP | 1 |
| Mewes, JM | 1 |
| Constantin, RP | 2 |
| Mito, MS | 1 |
| Ishii-Iwamoto, EL | 1 |
| Constantin, J | 1 |
| Mingatto, FE | 1 |
| Esquissato, GNM | 1 |
| Marchiosi, R | 1 |
| Dos Santos, WD | 1 |
| Ferrarese-Filho, O | 1 |
| Saito, K | 1 |
| Maekawa, K | 1 |
| Ishikawa, M | 1 |
| Senoo, Y | 1 |
| Urata, M | 1 |
| Murayama, M | 1 |
| Nakatsu, N | 1 |
| Yamada, H | 1 |
| Saito, Y | 1 |
| Janeiro, M | 1 |
| Camblor, E | 1 |
| Fernández, R | 1 |
| Núñez, D | 1 |
| Alderman, CP | 1 |
| Atchison, MM | 1 |
| McNeece, JI | 1 |
| Ljunggren, B | 1 |
| Bojs, G | 1 |
| Larrey, D | 1 |
| Rueff, B | 1 |
| Pessayre, D | 1 |
| Danan, G | 1 |
| Algard, M | 1 |
| Geneve, J | 1 |
| Benhamou, JP | 1 |
1 review available for clomipramine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
12 other studies available for clomipramine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
The harmful acute effects of clomipramine in the rat liver: Impairments in mitochondrial bioenergetics.
Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Clomipramine; Energy Metabo | 2023 |
Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.
Topics: Amitriptyline; Animals; Bile Ducts; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatograp | 2014 |
[Narcolepsy and anesthesia].
Topics: Analgesia, Epidural; Anesthesia, Intravenous; Antiemetics; Benzhydryl Compounds; Chemical and Drug I | 2007 |
Concurrent agranulocytosis and hepatitis secondary to clomipramine therapy.
Topics: Aged; Agranulocytosis; Chemical and Drug Induced Liver Injury; Clomipramine; Depressive Disorder; Hu | 1993 |
A case of photosensitivity and contact allergy to systemic tricyclic drugs, with unusual features.
Topics: Adult; Carbamazepine; Chemical and Drug Induced Liver Injury; Clomipramine; Cross Reactions; Dermati | 1991 |
Cross hepatotoxicity between tricyclic antidepressants.
Topics: Acute Disease; Adult; Antidepressive Agents, Tricyclic; Chemical and Drug Induced Liver Injury; Clom | 1986 |