clomipramine has been researched along with Canine Diseases in 22 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this explorative study was, first, to document changes in physiological parameters and behavior observed in dogs following ground transport and, second, to measure the effects on the above variables of a short-term administration of clomipramine, anecdotally already prescribed in private veterinary practice to reduce fear, anxiety, or both." | 9.12 | Placebo-controlled double-blind clomipramine trial for the treatment of anxiety or fear in beagles during ground transport. ( Bergeron, R; Frank, D; Gauthier, A, 2006) |
| "Clomipramine was effective and well-tolerated in controlling signs of obsessive-compulsive disorder and/or separation anxiety and/or noise phobia in 16 of 24 assessable cases, when used in combination with behaviour modification, and improvement in clinical signs was noted in 5 others." | 7.71 | Use of clomipramine in treatment of obsessive-compulsive disorder, separation anxiety and noise phobia in dogs: a preliminary, clinical study. ( Lindeman, MJ; Seksel, K, 2001) |
| "The purpose of this explorative study was, first, to document changes in physiological parameters and behavior observed in dogs following ground transport and, second, to measure the effects on the above variables of a short-term administration of clomipramine, anecdotally already prescribed in private veterinary practice to reduce fear, anxiety, or both." | 5.12 | Placebo-controlled double-blind clomipramine trial for the treatment of anxiety or fear in beagles during ground transport. ( Bergeron, R; Frank, D; Gauthier, A, 2006) |
| "Clomipramine was effective and well-tolerated in controlling signs of obsessive-compulsive disorder and/or separation anxiety and/or noise phobia in 16 of 24 assessable cases, when used in combination with behaviour modification, and improvement in clinical signs was noted in 5 others." | 3.71 | Use of clomipramine in treatment of obsessive-compulsive disorder, separation anxiety and noise phobia in dogs: a preliminary, clinical study. ( Lindeman, MJ; Seksel, K, 2001) |
| "Alprazolam was given at a dosage of 0." | 2.71 | Use of clomipramine, alprazolam, and behavior modification for treatment of storm phobia in dogs. ( Crowell-Davis, SL; Curtis, TM; Parthasarathy, V; Seibert, LM; Sung, W, 2003) |
| "Canine acral lick dermatitis is a naturally occurring disorder in which excessive licking of paws or flank can produce ulcers and infection that require medical treatment." | 2.67 | Drug treatment of canine acral lick. An animal model of obsessive-compulsive disorder. ( Kriete, M; Rapoport, JL; Ryland, DH, 1992) |
| "Clomipramine was significantly more efficacious for treatment in dogs than was amitriptyline." | 1.31 | Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 cases (1989-2000). ( Dunham, AE; Overall, KL, 2002) |
| "Separation anxiety is a common behavioral problem in dogs." | 1.31 | Behavior modification and pharmacotherapy for separation anxiety in a 2-year-old pointer cross. ( Lem, M, 2002) |
| " It was recommended that all dogs in the study be given clomipramine orally at a dosage of 1 to 2 mg/kg (0." | 1.30 | Description and development of compulsive tail chasing in terriers and response to clomipramine treatment. ( Dodman, NH; Moon-Fanelli, AA, 1998) |
| "Clomipramine is a tricyclic antidepressant that has been recommended for the treatment of canine compulsive disorder." | 1.30 | The pharmacokinetics of clomipramine and desmethylclomipramine in dogs: parameter estimates following a single oral dose and 28 consecutive daily oral doses of clomipramine. ( Ball, RO; Conlon, PD; Hewson, CJ; Luescher, UA, 1998) |
| "Treatment with clomipramine, along with other psychotropic medications and behavioral modification, suppressed the inappropriate behavior in all dogs; in 2 of the 3 dogs, the condition worsened when clomipramine treatment was withdrawn." | 1.29 | Use of clomipramine to treat ritualistic stereotypic motor behavior in three dogs. ( Overall, KL, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (50.00) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martin, KM | 1 |
| Kook, PH | 1 |
| Kranjc, A | 1 |
| Dennler, M | 1 |
| Glaus, TM | 1 |
| Overall, KL | 4 |
| Dunham, AE | 2 |
| Crowell-Davis, SL | 1 |
| Seibert, LM | 1 |
| Sung, W | 1 |
| Parthasarathy, V | 1 |
| Curtis, TM | 1 |
| Gaultier, E | 1 |
| Bonnafous, L | 1 |
| Bougrat, L | 1 |
| Lafont, C | 1 |
| Pageat, P | 1 |
| Frank, D | 1 |
| Gauthier, A | 1 |
| Bergeron, R | 1 |
| Thornton, LA | 1 |
| Moon-Fanelli, AA | 1 |
| Dodman, NH | 1 |
| Casey, RA | 1 |
| Hewson, CJ | 4 |
| Conlon, PD | 2 |
| Luescher, UA | 3 |
| Ball, RO | 3 |
| Parent, JM | 2 |
| Dorsey, M | 1 |
| Pellicaan, CH | 1 |
| Knol, BW | 1 |
| de Ligt, R | 1 |
| Reich, MR | 1 |
| Ohad, DG | 1 |
| Seksel, K | 1 |
| Lindeman, MJ | 1 |
| Lem, M | 1 |
| Rapoport, JL | 2 |
| Ryland, DH | 1 |
| Kriete, M | 1 |
1 review available for clomipramine and Canine Diseases
| Article | Year |
|---|---|
[Veterinary drug profile. Clomipramine (Clomicalm)].
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Dog Diseases; Dogs; Selec | 1999 |
5 trials available for clomipramine and Canine Diseases
| Article | Year |
|---|---|
Use of clomipramine, alprazolam, and behavior modification for treatment of storm phobia in dogs.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Behavior Therapy; Behavi | 2003 |
Comparison of the efficacy of a synthetic dog-appeasing pheromone with clomipramine for the treatment of separation-related disorders in dogs.
Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety, Separation; Behavior, Animal; Clomipramine; Dog | 2005 |
Placebo-controlled double-blind clomipramine trial for the treatment of anxiety or fear in beagles during ground transport.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Clomipramine; Dog Diseases; Dogs; Double-Bl | 2006 |
Efficacy of clomipramine in the treatment of canine compulsive disorder.
Topics: Animals; Antidepressive Agents, Tricyclic; Appetite; Behavior, Animal; Clomipramine; Compulsive Beha | 1998 |
Drug treatment of canine acral lick. An animal model of obsessive-compulsive disorder.
Topics: 1-Naphthylamine; Animals; Clomipramine; Dermatitis; Desipramine; Disease Models, Animal; Dog Disease | 1992 |
16 other studies available for clomipramine and Canine Diseases
| Article | Year |
|---|---|
Animal Behavior Case of the Month. Compulsive disorder.
Topics: Animals; Antidepressive Agents, Tricyclic; Clomipramine; Compulsive Behavior; Dermatitis; Diagnosis, | 2015 |
Pancreatitis associated with clomipramine administration in a dog.
Topics: Animals; Anxiety, Separation; Clomipramine; Dog Diseases; Dogs; Male; Pancreatitis; Selective Seroto | 2009 |
Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 cases (1989-2000).
Topics: Age of Onset; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior Therapy; Behavior, | 2002 |
Use of clomipramine to treat ritualistic stereotypic motor behavior in three dogs.
Topics: Animals; Behavior, Animal; Clomipramine; Diagnosis, Differential; Dog Diseases; Dogs; Male; Neurolog | 1994 |
Animal behavior case of the month. The owners observed tail chasing and left hind lameness in their dog.
Topics: Amputation, Surgical; Animals; Anterior Cruciate Ligament Injuries; Behavior, Animal; Clomipramine; | 1995 |
Description and development of compulsive tail chasing in terriers and response to clomipramine treatment.
Topics: Age of Onset; Animals; Behavior, Animal; Breeding; Clomipramine; Compulsive Behavior; Dog Diseases; | 1998 |
Use of clomipramine for separation anxiety in dogs.
Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety, Separation; Behavior, Animal; Clomipramine; Dog | 1998 |
The pharmacokinetics of clomipramine and desmethylclomipramine in dogs: parameter estimates following a single oral dose and 28 consecutive daily oral doses of clomipramine.
Topics: Administration, Oral; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Dog Diseases; Dogs; G | 1998 |
Concerns regarding study of obsessive-compulsive disorder in dogs.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Contraindications; Dog Di | 1998 |
Questions timing of publicity on new drug.
Topics: Advertising; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Dog Diseases; Dogs; Drug Appro | 1999 |
Clomipramine and behavioural therapy in the treatment of separation-related problems in dogs.
Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety, Separation; Behavior Therapy; Clomipramine; Dog | 2000 |
Effect of clomipramine on monoamine metabolites in the cerebrospinal fluid of behaviorally normal dogs.
Topics: Administration, Oral; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Compulsive Behavior; | 2000 |
Electrocardiographic assessment of antianxiety medication in dogs and correlation with serum drug concentration.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Dog Diseas | 2000 |
Use of clomipramine in treatment of obsessive-compulsive disorder, separation anxiety and noise phobia in dogs: a preliminary, clinical study.
Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety, Separation; Behavior Therapy; Behavior, Animal; | 2001 |
Behavior modification and pharmacotherapy for separation anxiety in a 2-year-old pointer cross.
Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety, Separation; Behavior Therapy; Behavior, Animal; | 2002 |
Treatment of behavioral disorders in animals.
Topics: Animal Diseases; Animals; Animals, Domestic; Clomipramine; Desipramine; Disease Models, Animal; Dog | 1990 |