clomipramine has been researched along with Cancer of Lung in 3 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clomipramine is an FDA-approved antidepressant drug, able to inhibit in vitro the E3 ubiquitin ligase Itch and potentiate the pro-apoptotic effects of DNA damaging induced agents in several cancer cell lines." | 1.42 | Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells. ( Bongiorno-Borbone, L; Compagnone, M; De Maria, R; Eramo, A; Giacobbe, A; Melino, G; Peschiaroli, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bongiorno-Borbone, L | 1 |
| Giacobbe, A | 1 |
| Compagnone, M | 1 |
| Eramo, A | 1 |
| De Maria, R | 1 |
| Peschiaroli, A | 1 |
| Melino, G | 2 |
| Wilkie, D | 1 |
3 other studies available for clomipramine and Cancer of Lung
| Article | Year |
|---|---|
Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell | 2015 |
Antidepressants synergize with chemotherapy against cancer stem cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Clomipramine; Humans; Lung Neoplasms; Neoplastic Stem Cells; | 2015 |
Antimitochondrial drugs in cancer chemotherapy: preliminary communication.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Clofazimine; Clomipramine; Cricetinae; Lung Neoplas | 1979 |