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clomipramine and Autism

clomipramine has been researched along with Autism in 17 studies

Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.

Research Excerpts

ExcerptRelevanceReference
"Clomipramine, haloperidol, and placebo were compared with baseline in the treatment of autism, and overall outcome, specific symptoms, and side effects were examined."9.09Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study. ( Gow, R; Konstantareas, M; Parker, K; Remington, G; Sloman, L, 2001)
"In an open, nonblind clinical trial, clomipramine reduced adventitious movements and compulsions in five previously medicated prepubertal boys with autistic disorder and severe mental retardation."9.07Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation. ( Aisemberg, P; Barnett, JY; Brasic, JR; Clark, A; Kaplan, D; Kowalik, S; Lafargue, RT; Sheitman, BB; Tsaltas, MO; Young, JG, 1994)
"To determine whether clomipramine hydrochloride, a serotonin reuptake blocker with unique anti-obsessional properties, is differentially effective for obsessive-compulsive and stereotyped motor behaviors in autistic disorder compared with placebo and with the noradrenergic tricyclic antidepressant agent, desipramine hydrochloride."9.07A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. ( Gordon, CT; Hamburger, SD; Nelson, JE; Rapoport, JL; State, RC, 1993)
"Clomipramine, a serotonin reuptake blocker that has unique antiobsessional properties, was hypothesized to have a different effect from that of desipramine, a tricyclic antidepressant with selective adrenergic effects, for the stereotyped, repetitive behaviors in autism."9.07Differential response of seven subjects with autistic disorder to clomipramine and desipramine. ( Gordon, CT; Hamburger, SD; Mannheim, GB; Rapoport, JL; State, RC, 1992)
"This report provides preliminary evidence for the efficacy of clomipramine in the treatment of young adults with autistic disorder."7.68Clomipramine in autism: preliminary evidence of efficacy. ( Bregman, J; Cohen, DJ; Goodman, WK; McDougle, CJ; Nielsen, J; Price, LH; Volkmar, FR; Ward-O'Brien, D, 1992)
"Clomipramine, haloperidol, and placebo were compared with baseline in the treatment of autism, and overall outcome, specific symptoms, and side effects were examined."5.09Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study. ( Gow, R; Konstantareas, M; Parker, K; Remington, G; Sloman, L, 2001)
"To assess the short-term efficacy and safety of clomipramine in hospitalized young children with autism."5.08A pilot study of clomipramine in young autistic children. ( Adams, PB; Armenteros, JL; Campbell, M; Cueva, JE; Sanchez, LE; Small, AM, 1996)
"In an open, nonblind clinical trial, clomipramine reduced adventitious movements and compulsions in five previously medicated prepubertal boys with autistic disorder and severe mental retardation."5.07Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation. ( Aisemberg, P; Barnett, JY; Brasic, JR; Clark, A; Kaplan, D; Kowalik, S; Lafargue, RT; Sheitman, BB; Tsaltas, MO; Young, JG, 1994)
"To determine whether clomipramine hydrochloride, a serotonin reuptake blocker with unique anti-obsessional properties, is differentially effective for obsessive-compulsive and stereotyped motor behaviors in autistic disorder compared with placebo and with the noradrenergic tricyclic antidepressant agent, desipramine hydrochloride."5.07A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. ( Gordon, CT; Hamburger, SD; Nelson, JE; Rapoport, JL; State, RC, 1993)
"Clomipramine, a serotonin reuptake blocker that has unique antiobsessional properties, was hypothesized to have a different effect from that of desipramine, a tricyclic antidepressant with selective adrenergic effects, for the stereotyped, repetitive behaviors in autism."5.07Differential response of seven subjects with autistic disorder to clomipramine and desipramine. ( Gordon, CT; Hamburger, SD; Mannheim, GB; Rapoport, JL; State, RC, 1992)
" A 16-year-old young-boy, diagnosed with autism, developed diabetes mellitus type 1 whilst he was on treatment with olanzapine (started 4 months before), clomipramine, valproic acid and lithium."3.85Second-generation antipsychotic and diabetes mellitus in children and adolescents. ( Nurchi, AM; Pinna, AP; Podda, F; Ripoli, C; Tronci, MG; Zanni, R, 2017)
"This report provides preliminary evidence for the efficacy of clomipramine in the treatment of young adults with autistic disorder."3.68Clomipramine in autism: preliminary evidence of efficacy. ( Bregman, J; Cohen, DJ; Goodman, WK; McDougle, CJ; Nielsen, J; Price, LH; Volkmar, FR; Ward-O'Brien, D, 1992)
"A case of a calendar savant with infantile autism and Tourette syndrome is presented."2.38A calendar savant with autism and Tourette syndrome. Response to treatment and thoughts on the interrelationships of these conditions. ( Nelson, EC; Pribor, EF, 1993)
"A girl with high functioning autism who developed transsexualism is described."1.30Gender identity disorder in a girl with autism--a case report. ( Landén, M; Rasmussen, P, 1997)
"A boy with autistic disorder and severe mental retardation developed severe dyskinesias, including objective akathisia (probable) and tics, a month after discontinuation of at least two years of treatment with drugs block dopamine receptors."1.30Dyskinesias subside off all medication in a boy with autistic disorder and severe mental retardation. ( Ahmad, R; Ahn, SC; Aisemberg, P; Barnett, JY; Brasić, JR; Kaplan, D; Mendonça, Mde F; Nadrich, RH, 1997)
"The current study describes successful treatment of trichotillomania in a young autistic girl, using combined clomipramine and behavioral therapy."1.29Comprehensive management of trichotillomania in a young autistic girl. ( Eastman, LE; Holttum, JR; Lubetsky, MJ, 1994)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (82.35)18.2507
2000's1 (5.88)29.6817
2010's2 (11.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ripoli, C1
Pinna, AP1
Podda, F1
Zanni, R1
Tronci, MG1
Nurchi, AM1
Nakamae, T1
Sanchez, LE2
Adams, PB2
Uysal, S1
Hallin, A2
Campbell, M3
Small, AM2
Holttum, JR1
Lubetsky, MJ1
Eastman, LE1
Brasic, JR3
Barnett, JY3
Kaplan, D2
Sheitman, BB2
Aisemberg, P2
Lafargue, RT1
Kowalik, S1
Clark, A1
Tsaltas, MO2
Young, JG1
Nelson, EC1
Pribor, EF1
Magen, J1
Gordon, CT2
State, RC2
Nelson, JE1
Hamburger, SD2
Rapoport, JL2
Schopler, E1
Cueva, JE2
Armenteros, JL1
Oesterheld, J1
Kallepalli, BR1
Landén, M1
Rasmussen, P1
Ahn, SC1
Nadrich, RH1
Ahmad, R1
Mendonça, Mde F1
Remington, G1
Sloman, L1
Konstantareas, M1
Parker, K1
Gow, R1
Mannheim, GB1
McDougle, CJ1
Price, LH1
Volkmar, FR1
Goodman, WK1
Ward-O'Brien, D1
Nielsen, J1
Bregman, J1
Cohen, DJ1

Reviews

3 reviews available for clomipramine and Autism

ArticleYear
[Diversity of obsessive-compulsive disorder and pharmacotherapy associated with obsessive-compulsive spectrum disorders].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2011, Volume: 113, Issue:10

    Topics: Antipsychotic Agents; Autistic Disorder; Body Dysmorphic Disorders; Clomipramine; Comorbidity; Disru

2011
A calendar savant with autism and Tourette syndrome. Response to treatment and thoughts on the interrelationships of these conditions.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 1993, Volume: 5, Issue:2

    Topics: Aptitude; Autistic Disorder; Clomipramine; Comorbidity; Humans; Intellectual Disability; Male; Middl

1993
Treatment of autistic disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1996, Volume: 35, Issue:2

    Topics: Antipsychotic Agents; Autistic Disorder; Behavior Therapy; Clomipramine; Clonidine; Fenfluramine; Hu

1996

Trials

7 trials available for clomipramine and Autism

ArticleYear
A comparison of live and videotape ratings: clomipramine and haloperidol in autism.
    Psychopharmacology bulletin, 1995, Volume: 31, Issue:2

    Topics: Autistic Disorder; Child; Child, Preschool; Clomipramine; Double-Blind Method; Female; Haloperidol;

1995
Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation.
    Neurology, 1994, Volume: 44, Issue:7

    Topics: Autistic Disorder; Child; Clomipramine; Humans; Intellectual Disability; Male; Movement Disorders; P

1994
A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder.
    Archives of general psychiatry, 1993, Volume: 50, Issue:6

    Topics: Adolescent; Adult; Ambulatory Care; Autistic Disorder; Child; Clomipramine; Desipramine; Double-Blin

1993
A pilot study of clomipramine in young autistic children.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1996, Volume: 35, Issue:4

    Topics: Autistic Disorder; Child; Child, Preschool; Clomipramine; Female; Humans; Male; Matched-Pair Analysi

1996
Adverse effects of clomipramine.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1997, Volume: 36, Issue:9

    Topics: Aggression; Akathisia, Drug-Induced; Autistic Disorder; Child; Clomipramine; Compulsive Behavior; Hu

1997
Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study.
    Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Autistic Disorder; Basal

2001
Differential response of seven subjects with autistic disorder to clomipramine and desipramine.
    The American journal of psychiatry, 1992, Volume: 149, Issue:3

    Topics: Adolescent; Anger; Autistic Disorder; Child; Clomipramine; Compulsive Behavior; Desipramine; Double-

1992

Other Studies

7 other studies available for clomipramine and Autism

ArticleYear
Second-generation antipsychotic and diabetes mellitus in children and adolescents.
    La Pediatria medica e chirurgica : Medical and surgical pediatrics, 2017, Dec-13, Volume: 39, Issue:4

    Topics: Adolescent; Antipsychotic Agents; Autistic Disorder; Benzodiazepines; Blood Glucose; Clomipramine; D

2017
Comprehensive management of trichotillomania in a young autistic girl.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1994, Volume: 33, Issue:4

    Topics: Autistic Disorder; Behavior Therapy; Child, Preschool; Clomipramine; Combined Modality Therapy; Fema

1994
Negative results with clomipramine.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1993, Volume: 32, Issue:5

    Topics: Autistic Disorder; Child; Clomipramine; Humans; Male; Self Mutilation; Social Behavior

1993
Grapefruit juice and clomipramine: shifting metabolitic ratios.
    Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:1

    Topics: Adolescent; Autistic Disorder; Beverages; Biological Availability; Child; Citrus; Clomipramine; Drug

1997
Gender identity disorder in a girl with autism--a case report.
    European child & adolescent psychiatry, 1997, Volume: 6, Issue:3

    Topics: Adolescent; Autistic Disorder; Clomipramine; Female; Follow-Up Studies; Gender Identity; Humans; Int

1997
Dyskinesias subside off all medication in a boy with autistic disorder and severe mental retardation.
    Psychological reports, 1997, Volume: 81, Issue:3 Pt 1

    Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Autistic Disorder; Child; Clomipramine; Dopamine Anta

1997
Clomipramine in autism: preliminary evidence of efficacy.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Aggression; Autistic Disorder; Clomipramine; Dose-Response Relationship, Drug; Dr

1992