clomipramine has been researched along with Autism in 17 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clomipramine, haloperidol, and placebo were compared with baseline in the treatment of autism, and overall outcome, specific symptoms, and side effects were examined." | 9.09 | Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study. ( Gow, R; Konstantareas, M; Parker, K; Remington, G; Sloman, L, 2001) |
| "In an open, nonblind clinical trial, clomipramine reduced adventitious movements and compulsions in five previously medicated prepubertal boys with autistic disorder and severe mental retardation." | 9.07 | Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation. ( Aisemberg, P; Barnett, JY; Brasic, JR; Clark, A; Kaplan, D; Kowalik, S; Lafargue, RT; Sheitman, BB; Tsaltas, MO; Young, JG, 1994) |
| "To determine whether clomipramine hydrochloride, a serotonin reuptake blocker with unique anti-obsessional properties, is differentially effective for obsessive-compulsive and stereotyped motor behaviors in autistic disorder compared with placebo and with the noradrenergic tricyclic antidepressant agent, desipramine hydrochloride." | 9.07 | A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. ( Gordon, CT; Hamburger, SD; Nelson, JE; Rapoport, JL; State, RC, 1993) |
| "Clomipramine, a serotonin reuptake blocker that has unique antiobsessional properties, was hypothesized to have a different effect from that of desipramine, a tricyclic antidepressant with selective adrenergic effects, for the stereotyped, repetitive behaviors in autism." | 9.07 | Differential response of seven subjects with autistic disorder to clomipramine and desipramine. ( Gordon, CT; Hamburger, SD; Mannheim, GB; Rapoport, JL; State, RC, 1992) |
| "This report provides preliminary evidence for the efficacy of clomipramine in the treatment of young adults with autistic disorder." | 7.68 | Clomipramine in autism: preliminary evidence of efficacy. ( Bregman, J; Cohen, DJ; Goodman, WK; McDougle, CJ; Nielsen, J; Price, LH; Volkmar, FR; Ward-O'Brien, D, 1992) |
| "Clomipramine, haloperidol, and placebo were compared with baseline in the treatment of autism, and overall outcome, specific symptoms, and side effects were examined." | 5.09 | Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study. ( Gow, R; Konstantareas, M; Parker, K; Remington, G; Sloman, L, 2001) |
| "To assess the short-term efficacy and safety of clomipramine in hospitalized young children with autism." | 5.08 | A pilot study of clomipramine in young autistic children. ( Adams, PB; Armenteros, JL; Campbell, M; Cueva, JE; Sanchez, LE; Small, AM, 1996) |
| "In an open, nonblind clinical trial, clomipramine reduced adventitious movements and compulsions in five previously medicated prepubertal boys with autistic disorder and severe mental retardation." | 5.07 | Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation. ( Aisemberg, P; Barnett, JY; Brasic, JR; Clark, A; Kaplan, D; Kowalik, S; Lafargue, RT; Sheitman, BB; Tsaltas, MO; Young, JG, 1994) |
| "To determine whether clomipramine hydrochloride, a serotonin reuptake blocker with unique anti-obsessional properties, is differentially effective for obsessive-compulsive and stereotyped motor behaviors in autistic disorder compared with placebo and with the noradrenergic tricyclic antidepressant agent, desipramine hydrochloride." | 5.07 | A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. ( Gordon, CT; Hamburger, SD; Nelson, JE; Rapoport, JL; State, RC, 1993) |
| "Clomipramine, a serotonin reuptake blocker that has unique antiobsessional properties, was hypothesized to have a different effect from that of desipramine, a tricyclic antidepressant with selective adrenergic effects, for the stereotyped, repetitive behaviors in autism." | 5.07 | Differential response of seven subjects with autistic disorder to clomipramine and desipramine. ( Gordon, CT; Hamburger, SD; Mannheim, GB; Rapoport, JL; State, RC, 1992) |
| " A 16-year-old young-boy, diagnosed with autism, developed diabetes mellitus type 1 whilst he was on treatment with olanzapine (started 4 months before), clomipramine, valproic acid and lithium." | 3.85 | Second-generation antipsychotic and diabetes mellitus in children and adolescents. ( Nurchi, AM; Pinna, AP; Podda, F; Ripoli, C; Tronci, MG; Zanni, R, 2017) |
| "This report provides preliminary evidence for the efficacy of clomipramine in the treatment of young adults with autistic disorder." | 3.68 | Clomipramine in autism: preliminary evidence of efficacy. ( Bregman, J; Cohen, DJ; Goodman, WK; McDougle, CJ; Nielsen, J; Price, LH; Volkmar, FR; Ward-O'Brien, D, 1992) |
| "A case of a calendar savant with infantile autism and Tourette syndrome is presented." | 2.38 | A calendar savant with autism and Tourette syndrome. Response to treatment and thoughts on the interrelationships of these conditions. ( Nelson, EC; Pribor, EF, 1993) |
| "A girl with high functioning autism who developed transsexualism is described." | 1.30 | Gender identity disorder in a girl with autism--a case report. ( Landén, M; Rasmussen, P, 1997) |
| "A boy with autistic disorder and severe mental retardation developed severe dyskinesias, including objective akathisia (probable) and tics, a month after discontinuation of at least two years of treatment with drugs block dopamine receptors." | 1.30 | Dyskinesias subside off all medication in a boy with autistic disorder and severe mental retardation. ( Ahmad, R; Ahn, SC; Aisemberg, P; Barnett, JY; Brasić, JR; Kaplan, D; Mendonça, Mde F; Nadrich, RH, 1997) |
| "The current study describes successful treatment of trichotillomania in a young autistic girl, using combined clomipramine and behavioral therapy." | 1.29 | Comprehensive management of trichotillomania in a young autistic girl. ( Eastman, LE; Holttum, JR; Lubetsky, MJ, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (82.35) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ripoli, C | 1 |
| Pinna, AP | 1 |
| Podda, F | 1 |
| Zanni, R | 1 |
| Tronci, MG | 1 |
| Nurchi, AM | 1 |
| Nakamae, T | 1 |
| Sanchez, LE | 2 |
| Adams, PB | 2 |
| Uysal, S | 1 |
| Hallin, A | 2 |
| Campbell, M | 3 |
| Small, AM | 2 |
| Holttum, JR | 1 |
| Lubetsky, MJ | 1 |
| Eastman, LE | 1 |
| Brasic, JR | 3 |
| Barnett, JY | 3 |
| Kaplan, D | 2 |
| Sheitman, BB | 2 |
| Aisemberg, P | 2 |
| Lafargue, RT | 1 |
| Kowalik, S | 1 |
| Clark, A | 1 |
| Tsaltas, MO | 2 |
| Young, JG | 1 |
| Nelson, EC | 1 |
| Pribor, EF | 1 |
| Magen, J | 1 |
| Gordon, CT | 2 |
| State, RC | 2 |
| Nelson, JE | 1 |
| Hamburger, SD | 2 |
| Rapoport, JL | 2 |
| Schopler, E | 1 |
| Cueva, JE | 2 |
| Armenteros, JL | 1 |
| Oesterheld, J | 1 |
| Kallepalli, BR | 1 |
| Landén, M | 1 |
| Rasmussen, P | 1 |
| Ahn, SC | 1 |
| Nadrich, RH | 1 |
| Ahmad, R | 1 |
| Mendonça, Mde F | 1 |
| Remington, G | 1 |
| Sloman, L | 1 |
| Konstantareas, M | 1 |
| Parker, K | 1 |
| Gow, R | 1 |
| Mannheim, GB | 1 |
| McDougle, CJ | 1 |
| Price, LH | 1 |
| Volkmar, FR | 1 |
| Goodman, WK | 1 |
| Ward-O'Brien, D | 1 |
| Nielsen, J | 1 |
| Bregman, J | 1 |
| Cohen, DJ | 1 |
3 reviews available for clomipramine and Autism
| Article | Year |
|---|---|
[Diversity of obsessive-compulsive disorder and pharmacotherapy associated with obsessive-compulsive spectrum disorders].
Topics: Antipsychotic Agents; Autistic Disorder; Body Dysmorphic Disorders; Clomipramine; Comorbidity; Disru | 2011 |
A calendar savant with autism and Tourette syndrome. Response to treatment and thoughts on the interrelationships of these conditions.
Topics: Aptitude; Autistic Disorder; Clomipramine; Comorbidity; Humans; Intellectual Disability; Male; Middl | 1993 |
Treatment of autistic disorder.
Topics: Antipsychotic Agents; Autistic Disorder; Behavior Therapy; Clomipramine; Clonidine; Fenfluramine; Hu | 1996 |
7 trials available for clomipramine and Autism
| Article | Year |
|---|---|
A comparison of live and videotape ratings: clomipramine and haloperidol in autism.
Topics: Autistic Disorder; Child; Child, Preschool; Clomipramine; Double-Blind Method; Female; Haloperidol; | 1995 |
Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation.
Topics: Autistic Disorder; Child; Clomipramine; Humans; Intellectual Disability; Male; Movement Disorders; P | 1994 |
A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder.
Topics: Adolescent; Adult; Ambulatory Care; Autistic Disorder; Child; Clomipramine; Desipramine; Double-Blin | 1993 |
A pilot study of clomipramine in young autistic children.
Topics: Autistic Disorder; Child; Child, Preschool; Clomipramine; Female; Humans; Male; Matched-Pair Analysi | 1996 |
Adverse effects of clomipramine.
Topics: Aggression; Akathisia, Drug-Induced; Autistic Disorder; Child; Clomipramine; Compulsive Behavior; Hu | 1997 |
Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study.
Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Autistic Disorder; Basal | 2001 |
Differential response of seven subjects with autistic disorder to clomipramine and desipramine.
Topics: Adolescent; Anger; Autistic Disorder; Child; Clomipramine; Compulsive Behavior; Desipramine; Double- | 1992 |
7 other studies available for clomipramine and Autism
| Article | Year |
|---|---|
Second-generation antipsychotic and diabetes mellitus in children and adolescents.
Topics: Adolescent; Antipsychotic Agents; Autistic Disorder; Benzodiazepines; Blood Glucose; Clomipramine; D | 2017 |
Comprehensive management of trichotillomania in a young autistic girl.
Topics: Autistic Disorder; Behavior Therapy; Child, Preschool; Clomipramine; Combined Modality Therapy; Fema | 1994 |
Negative results with clomipramine.
Topics: Autistic Disorder; Child; Clomipramine; Humans; Male; Self Mutilation; Social Behavior | 1993 |
Grapefruit juice and clomipramine: shifting metabolitic ratios.
Topics: Adolescent; Autistic Disorder; Beverages; Biological Availability; Child; Citrus; Clomipramine; Drug | 1997 |
Gender identity disorder in a girl with autism--a case report.
Topics: Adolescent; Autistic Disorder; Clomipramine; Female; Follow-Up Studies; Gender Identity; Humans; Int | 1997 |
Dyskinesias subside off all medication in a boy with autistic disorder and severe mental retardation.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Autistic Disorder; Child; Clomipramine; Dopamine Anta | 1997 |
Clomipramine in autism: preliminary evidence of efficacy.
Topics: Adolescent; Adult; Aggression; Autistic Disorder; Clomipramine; Dose-Response Relationship, Drug; Dr | 1992 |