clomipramine has been researched along with Anxiety in 45 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have re-analysed our previous double-blind, placebo-controlled clomipramine study, changing the focus from depression to anxiety both in the response analysis and in the classification of minor affective states." | 9.14 | The clinical effect of clomipramine in chronic idiopathic pain disorder revisited using the Spielberger State Anxiety Symptom Scale (SSASS) as outcome scale. ( Bech, P; Gormsen, L; Loldrup, D; Lunde, M, 2009) |
| "The purpose of this explorative study was, first, to document changes in physiological parameters and behavior observed in dogs following ground transport and, second, to measure the effects on the above variables of a short-term administration of clomipramine, anecdotally already prescribed in private veterinary practice to reduce fear, anxiety, or both." | 9.12 | Placebo-controlled double-blind clomipramine trial for the treatment of anxiety or fear in beagles during ground transport. ( Bergeron, R; Frank, D; Gauthier, A, 2006) |
| "Day-night differences in locomotor and anxiety-related behavior and brain serotonin metabolism were examined in adult Syrian hamsters that received clomipramine (15 mg/kg) or vehicle from day 8 to day 21 of life." | 7.70 | Effects of neonatal clomipramine treatment on locomotor activity, anxiety-related behavior and serotonin turnover in Syrian hamsters. ( Cardinali, DP; Gregoretti, L; Kargieman, L; Yannielli, PC, 1999) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 6.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| " Our groups included a female and male control group that was injected with a saline solution, a female and male group that was injected with a low dosage of clomipramine, and a female and male group of rats that were injected with a high dosage of clomipramine." | 5.48 | Effects of short-term clomipramine on anxiety-like behavior, cellular metabolism, and oxidative stress in primary fibroblast cells of male and female rats. ( Jimenez, AG; Ragan, CM; Smith, DM; Winward, JD, 2018) |
| "We have re-analysed our previous double-blind, placebo-controlled clomipramine study, changing the focus from depression to anxiety both in the response analysis and in the classification of minor affective states." | 5.14 | The clinical effect of clomipramine in chronic idiopathic pain disorder revisited using the Spielberger State Anxiety Symptom Scale (SSASS) as outcome scale. ( Bech, P; Gormsen, L; Loldrup, D; Lunde, M, 2009) |
| "The purpose of this explorative study was, first, to document changes in physiological parameters and behavior observed in dogs following ground transport and, second, to measure the effects on the above variables of a short-term administration of clomipramine, anecdotally already prescribed in private veterinary practice to reduce fear, anxiety, or both." | 5.12 | Placebo-controlled double-blind clomipramine trial for the treatment of anxiety or fear in beagles during ground transport. ( Bergeron, R; Frank, D; Gauthier, A, 2006) |
| "Differences between the side effect profiles of clomipramine (CMI) and the selective serotonin reuptake inhibitors may be important factors in both treatment outcome and patient selection in obsessive-compulsive disorder (OCD)." | 5.09 | Side effects as predictors of drug response in obsessive-compulsive disorder. ( Ackerman, DL; Bystritsky, A; Greenland, S, 1999) |
| "In a double-blind study of 24 patients with endogenous depressiona group treated with clomipramine hydrochloride (chlorimipramine) plus tryptophan was compared with a group treated with clomipramine plus placebo." | 5.04 | Potentiation of the antidepressant action of clomipramine by tryptophan. ( Bjorn-Erik, R; Carlsson, A; Nagy, A; Skott, A; Walinder, J, 1976) |
| "OCD-like behaviors are emerging during adolescence, but sucrose consumption and fat bingeing in CMI-treated animals significantly precedes the appearance of anxiety and perseveration." | 3.81 | Developmental emergence of an obsessive-compulsive phenotype and binge behavior in rats. ( Andersen, SL; Einhorn, P; Freund, N; Norman, KJ; Thompson, BS, 2015) |
| "Day-night differences in locomotor and anxiety-related behavior and brain serotonin metabolism were examined in adult Syrian hamsters that received clomipramine (15 mg/kg) or vehicle from day 8 to day 21 of life." | 3.70 | Effects of neonatal clomipramine treatment on locomotor activity, anxiety-related behavior and serotonin turnover in Syrian hamsters. ( Cardinali, DP; Gregoretti, L; Kargieman, L; Yannielli, PC, 1999) |
| "Antidepressant therapy for panic attacks, exposure therapy for stimulus-dependent anxieties, and, to a lesser extent, clomipramine therapy for obsessive-compulsive symptoms have transformed the treatment of anxiety disorders and ushered in an era of rapid progress in research on anxiety and anxiety disorders." | 3.67 | New findings in anxiety. A synthesis for clinical practice in 1985. ( Curtis, GC, 1985) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 2.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| "Clomipramine-treated animals had shifts in the laterality of monoamines in limbic regions with lower serotonin levels on the right side while vehicle-treated animals had lower serotonin on the left side." | 1.31 | Differences in behavior and monoamine laterality following neonatal clomipramine treatment. ( Andersen, SL; Dumont, NL; Teicher, MH, 2002) |
| "2 patients with withdrawal symptoms following discontinuation of clomipramine are presented." | 1.28 | [Withdrawal reactions after clomipramine]. ( Aizenberg, D; Hermesh, H; Weizman, A; Zemishlany, Z, 1992) |
| " A tapering schedule was carried out during a 12-day stay in the hospital in which the diazepam dosage was reduced by a fixed quantity every day, corresponding to about ten percent of the initial dosage." | 1.28 | Panic attacks and major depression after discontinuation of long-term diazepam abuse. ( Magni, G; Schifano, F, 1989) |
| "5 mg/kg/day, revealed a similar profile to that seen after chronic administration of benzodiazepines in the adult." | 1.27 | Prenatal treatment with clomipramine: effects on the behaviour of male and female adolescent rats. ( File, SE; Tucker, JC, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (42.22) | 18.7374 |
| 1990's | 10 (22.22) | 18.2507 |
| 2000's | 9 (20.00) | 29.6817 |
| 2010's | 6 (13.33) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Chakraborty, S | 1 |
| Tripathi, SJ | 1 |
| Raju, TR | 1 |
| Shankaranarayana Rao, BS | 1 |
| Jimenez, AG | 1 |
| Winward, JD | 1 |
| Smith, DM | 1 |
| Ragan, CM | 1 |
| Li, B | 1 |
| Yang, CJ | 1 |
| Yue, N | 1 |
| Liu, Y | 1 |
| Yu, J | 2 |
| Wang, YQ | 1 |
| Liu, Q | 1 |
| Wu, GC | 1 |
| Freund, N | 1 |
| Thompson, BS | 1 |
| Norman, KJ | 1 |
| Einhorn, P | 1 |
| Andersen, SL | 3 |
| Yang, L | 1 |
| Shi, LJ | 1 |
| Zhang, YQ | 1 |
| Bech, P | 1 |
| Gormsen, L | 1 |
| Loldrup, D | 1 |
| Lunde, M | 1 |
| Rogel-Salazar, G | 1 |
| López-Rubalcava, C | 1 |
| Greene-Schloesser, DM | 1 |
| Van der Zee, EA | 1 |
| Sheppard, DK | 1 |
| Castillo, MR | 1 |
| Gregg, KA | 1 |
| Burrow, T | 1 |
| Foltz, H | 1 |
| Slater, M | 1 |
| Bult-Ito, A | 1 |
| Dumont, NL | 1 |
| Teicher, MH | 2 |
| Giorgi, O | 1 |
| Piras, G | 1 |
| Lecca, D | 1 |
| Hansson, S | 1 |
| Driscoll, P | 1 |
| Corda, MG | 1 |
| Garcia-Leal, C | 1 |
| Parente, AC | 1 |
| Del-Ben, CM | 1 |
| Guimarães, FS | 1 |
| Moreira, AC | 1 |
| Elias, LL | 1 |
| Graeff, FG | 1 |
| Gallelli, L | 1 |
| De Fazio, S | 1 |
| Corace, E | 1 |
| De Sarro, G | 1 |
| Garcia, CS | 1 |
| De Fazio, P | 1 |
| Duxbury, MM | 1 |
| Frank, D | 1 |
| Gauthier, A | 1 |
| Bergeron, R | 1 |
| Consoli, D | 1 |
| Leggio, GM | 2 |
| Mazzola, C | 2 |
| Micale, V | 2 |
| Drago, F | 2 |
| Tamburella, A | 1 |
| Li Volsi, V | 1 |
| Mavissakalian, M | 1 |
| Michelson, L | 1 |
| File, SE | 2 |
| Tucker, JC | 2 |
| Valle-Jones, JC | 1 |
| O'Hara, J | 1 |
| O'Hara, H | 1 |
| McGhie, RL | 1 |
| Brodie, NH | 1 |
| Anderson, JA | 1 |
| Schiff, AA | 1 |
| Mawson, D | 1 |
| Marks, IM | 1 |
| Ramm, L | 1 |
| Tollefson, GD | 1 |
| Souetre, E | 1 |
| Thomander, L | 1 |
| Potvin, JH | 1 |
| Suetsugi, M | 1 |
| Mizuki, Y | 1 |
| Ushijima, I | 1 |
| Yamada, M | 1 |
| Imaizumi, J | 1 |
| Yannielli, PC | 1 |
| Kargieman, L | 1 |
| Gregoretti, L | 1 |
| Cardinali, DP | 1 |
| Ackerman, DL | 1 |
| Greenland, S | 1 |
| Bystritsky, A | 1 |
| Schubert, DS | 1 |
| Ananth, J | 3 |
| Carey, MS | 1 |
| Hawkinson, R | 1 |
| Kornhaber, A | 1 |
| Wellish, CS | 1 |
| Wyndowe, J | 1 |
| Solyom, L | 1 |
| Walinder, J | 1 |
| Skott, A | 1 |
| Carlsson, A | 1 |
| Nagy, A | 1 |
| Bjorn-Erik, R | 1 |
| Planche, R | 1 |
| Gathier, MC | 1 |
| Lambert, J | 1 |
| Ashcroft, GW | 1 |
| Kelly, D | 1 |
| Zemishlany, Z | 1 |
| Aizenberg, D | 1 |
| Hermesh, H | 1 |
| Weizman, A | 1 |
| Hewlett, WA | 1 |
| Vinogradov, S | 1 |
| Agras, WS | 1 |
| Lemoine, P | 1 |
| Boulenger, JP | 1 |
| Caillard, V | 1 |
| Tanne, N | 1 |
| Bonnet, D | 1 |
| Nisijima, K | 1 |
| Hirayama, M | 1 |
| Mavissakalian, MR | 1 |
| Jones, B | 1 |
| Olson, S | 1 |
| Schifano, F | 1 |
| Magni, G | 1 |
| Curtis, GC | 1 |
| Dunbar, GC | 1 |
| Naarala, M | 1 |
| Hiltunen, H | 1 |
| Versiani, M | 1 |
| Mundim, FD | 1 |
| Nardi, AE | 1 |
| Liebowitz, MR | 1 |
| Masciocchi, A | 1 |
| Reitano, S | 1 |
| Vanini, M | 1 |
| Cicchetti, V | 1 |
1 review available for clomipramine and Anxiety
| Article | Year |
|---|---|
Clomipramine: an antiobsessive drug.
Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive D | 1986 |
12 trials available for clomipramine and Anxiety
| Article | Year |
|---|---|
The clinical effect of clomipramine in chronic idiopathic pain disorder revisited using the Spielberger State Anxiety Symptom Scale (SSASS) as outcome scale.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Anxiety; Clomipramine; Double-Blind Metho | 2009 |
Placebo-controlled double-blind clomipramine trial for the treatment of anxiety or fear in beagles during ground transport.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Clomipramine; Dog Diseases; Dogs; Double-Bl | 2006 |
Tricyclic antidepressants in obsessive-compulsive disorder. Antiobsessional or antidepressant agents?
Topics: Adolescent; Adult; Aged; Anxiety; Clinical Trials as Topic; Clomipramine; Depression; Female; Humans | 1983 |
Doctor's versus patient's judgement in the assessment of mixed anxiety/depressive illness. Implications for measurement of therapeutic response.
Topics: Adult; Aged; Anxiety; Clinical Trials as Topic; Clomipramine; Depression; Drug Combinations; Female; | 1981 |
Clomipramine and exposure for chronic obsessive-compulsive rituals: III. Two year follow-up and further findings.
Topics: Anxiety; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Double-Blind Method; Female; F | 1982 |
Side effects as predictors of drug response in obsessive-compulsive disorder.
Topics: Adolescent; Adult; Anxiety; Clomipramine; Dose-Response Relationship, Drug; Ejaculation; Female; Flu | 1999 |
Anafranil in obsessive compulsive neurosis.
Topics: Adult; Anxiety; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Female; Humans; | 1975 |
Potentiation of the antidepressant action of clomipramine by tryptophan.
Topics: Adolescent; Adult; Aged; Anxiety; Clomipramine; Depression; Dibenzazepines; Drug Synergism; Drug The | 1976 |
Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder.
Topics: Adult; Analysis of Variance; Anxiety; Clomipramine; Clonazepam; Clonidine; Depression; Double-Blind | 1992 |
Compared efficacy of prazepam and clomipramine in major depression with anxiety: a multicenter controlled study.
Topics: Adolescent; Adult; Aged; Anxiety; Child; Clomipramine; Depressive Disorder; Double-Blind Method; Fem | 1991 |
A double-blind group comparison of mianserin and clomipramine in the treatment of mildly depressed psychiatric out-patients.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; | 1985 |
Clomipramine: an antiobsessive drug.
Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive D | 1986 |
33 other studies available for clomipramine and Anxiety
| Article | Year |
|---|---|
Brain stimulation rewarding experience attenuates neonatal clomipramine-induced adulthood anxiety by reversal of pathological changes in the amygdala.
Topics: Amygdala; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Anxiety; Biogenic Monoamines; | 2020 |
Effects of short-term clomipramine on anxiety-like behavior, cellular metabolism, and oxidative stress in primary fibroblast cells of male and female rats.
Topics: Animals; Anxiety; Clomipramine; Female; Fibroblasts; Glycolysis; Male; Oxidative Stress; Oxygen Cons | 2018 |
Clomipramine reverses hypoalgesia/hypoesthesia and improved depressive-like behaviors induced by inescapable shock in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety; Avoidance Learning; Clomipramine; Depression; El | 2013 |
Developmental emergence of an obsessive-compulsive phenotype and binge behavior in rats.
Topics: Adaptation, Psychological; Aging; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Anim | 2015 |
Activation of protein kinase A in the amygdala modulates anxiety-like behaviors in social defeat exposed mice.
Topics: Amygdala; Animals; Anxiety; Avoidance Learning; Clomipramine; Cyclic AMP Response Element-Binding Pr | 2016 |
Evaluation of the anxiolytic-like effects of clomipramine in two rat strains with different anxiety vulnerability (Wistar and Wistar-Kyoto rats): participation of 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Clo | 2011 |
Predictive validity of a non-induced mouse model of compulsive-like behavior.
Topics: Animals; Anxiety; Behavior, Animal; Clomipramine; Compulsive Behavior; Desipramine; Disease Models, | 2011 |
Differences in behavior and monoamine laterality following neonatal clomipramine treatment.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Anxiety; Behavior | 2002 |
Differential neurochemical properties of central serotonergic transmission in Roman high- and low-avoidance rats.
Topics: Animals; Anxiety; Autoradiography; Avoidance Learning; Behavior, Animal; Binding, Competitive; Brain | 2003 |
Anxiety and salivary cortisol in symptomatic and nonsymptomatic panic patients and healthy volunteers performing simulated public speaking.
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Circadian Rhythm; Clomipramine; Female; Healthy Vo | 2005 |
Generalised urticaria in a young woman treated with clomipramine and after ingestion of codfish.
Topics: Adult; Alprazolam; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl | 2006 |
Animal behavior case of the month. Separation anxiety.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Clomipramine; Dogs; Male; Saliv | 2006 |
Behavioral effects of the beta3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs?
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-3 Receptor Antagonists; Adrenergic beta-Antagon | 2007 |
Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Benzamide | 2008 |
Prenatal treatment with clomipramine: effects on the behaviour of male and female adolescent rats.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Clomipramine; Female; Humans; Interpersonal Relations; Ma | 1984 |
Prenatal treatment with clomipramine has an anxiolytic profile in the adolescent rat.
Topics: Age Factors; Aggression; Animals; Anxiety; Behavior, Animal; Body Weight; Clomipramine; Environment; | 1983 |
Comorbid anxious signs and symptoms in major depression: impact on functional work capacity and comparative treatment outcomes.
Topics: Absenteeism; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety; Clomipramine; Comorbid | 1993 |
Anxiolytic effects of low-dose clomipramine in highly anxious healthy volunteers assessed by frontal midline theta activity.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Clomipramine; Cross-Over Studies; Dose-Response Relationship, D | 1998 |
Effects of neonatal clomipramine treatment on locomotor activity, anxiety-related behavior and serotonin turnover in Syrian hamsters.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Brain Chemis | 1999 |
Serotonin laterality in amygdala predicts performance in the elevated plus maze in rats.
Topics: Amygdala; Animals; Anxiety; Chromatography, High Pressure Liquid; Clomipramine; Dopamine; Fear; Fema | 1999 |
A biphasic change in mood with a tricyclic antidepressant.
Topics: Adjustment Disorders; Anxiety; Clomipramine; Dibenzazepines; Emotions; Humans | 1979 |
Treatment of obsessive-compulsive neurosis with clomipramine (Anafranil).
Topics: Adult; Aged; Anxiety; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male; Middle Aged; O | 1977 |
The use of clomipramine in phobic patients. Preliminary research report.
Topics: Adolescent; Adult; Anxiety; Clomipramine; Depression; Dibenzazepines; Drug Evaluation; Drug Toleranc | 1975 |
[Description of a simple graphic model permitting the comparison of the course of depressive states].
Topics: Adjustment Disorders; Adult; Antidepressive Agents; Anxiety; Clomipramine; Depression; Doxepin; Fema | 1976 |
Psychological medicine. Management of depression.
Topics: Amitriptyline; Antidepressive Agents; Anxiety; Clomipramine; Depression; Drug Interactions; Electroc | 1975 |
Physiological measurements in phobic and obsessional disorders.
Topics: Anxiety; Behavior Therapy; Blood Pressure; Cardiac Output; Chlordiazepoxide; Clomipramine; Diazepam; | 1975 |
[Withdrawal reactions after clomipramine].
Topics: Anxiety; Clomipramine; Fatigue; Female; Headache; Humans; Male; Middle Aged; Sleep Initiation and Ma | 1992 |
[ICU syndrome].
Topics: Aged; Anxiety; Benzodiazepines; Clomipramine; Critical Care; Delirium; Depressive Disorder; Female; | 1991 |
Absence of placebo response in obsessive-compulsive disorder.
Topics: Adolescent; Adult; Aged; Anxiety; Clomipramine; Depression; Double-Blind Method; Fear; Female; Human | 1990 |
Panic attacks and major depression after discontinuation of long-term diazepam abuse.
Topics: Adult; Anxiety; Clomipramine; Depressive Disorder; Diazepam; Fear; Female; Humans; Panic; Substance | 1989 |
New findings in anxiety. A synthesis for clinical practice in 1985.
Topics: Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Anxiety Disorders; Behavior Therapy; | 1985 |
Tranylcypromine in social phobia.
Topics: Adolescent; Adult; Anxiety; Bromazepam; Clomipramine; Female; Humans; Male; Middle Aged; Phobic Diso | 1988 |
[Preliminary results of a controlled trial with sulpiride versus chlorimipramine in chronic schizophrenic patients with marked ideo-emotional poverty (author's transl)].
Topics: Affect; Anxiety; Chronic Disease; Clomipramine; Depression; Dibenzazepines; Humans; Mental Processes | 1974 |