clomipramine has been researched along with Aging in 22 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with Down's syndrome or Alzheimer's disease, beta-endorphin concentrations in peripheral blood mononuclear cells behave similarly to those in age-matched normal subjects." | 5.28 | Beta-endorphin concentrations in resting peripheral mononuclear cells and after treatment with PHA or serotoninergic drugs in human aging, Alzheimer's disease, and Down's syndrome. ( Manfredi, B; Panerai, AE; Sacerdote, P, 1992) |
| "OCD-like behaviors are emerging during adolescence, but sucrose consumption and fat bingeing in CMI-treated animals significantly precedes the appearance of anxiety and perseveration." | 3.81 | Developmental emergence of an obsessive-compulsive phenotype and binge behavior in rats. ( Andersen, SL; Einhorn, P; Freund, N; Norman, KJ; Thompson, BS, 2015) |
| " In a study designed to assess plasma levels of clomipramine in twenty-eight patients aged between 65 and 75 years and fourteen patients over 75 years of age and compare them with the levels achieved by a control group of patients aged between 18 and 40 years, the severity of depression was assessed initially and after 7, 14, 21 and 28 days using the General Practitioner Clinical Research Group Scale." | 3.66 | Clomipramine and age: an interaction study. ( Beaumont, G; Poole, P; Watson, JU, 1980) |
| " Results are given from three studies of clomipramine all failing to demonstrate an association between steady-state plasma clomipramine levels and clinical response both measured as effect--change in severity of depression using the GPCRG rating scale--and side-effect." | 3.66 | Relating plasma levels of clomipramine and clinical response. ( Seldrup, J, 1980) |
| "In patients with Down's syndrome or Alzheimer's disease, beta-endorphin concentrations in peripheral blood mononuclear cells behave similarly to those in age-matched normal subjects." | 1.28 | Beta-endorphin concentrations in resting peripheral mononuclear cells and after treatment with PHA or serotoninergic drugs in human aging, Alzheimer's disease, and Down's syndrome. ( Manfredi, B; Panerai, AE; Sacerdote, P, 1992) |
| " Potential implications of the proposed model-based approach include adaptation of the dosage regimen to individual characteristics at the very beginning of antidepressant therapy, and early detection of patients with impaired metabolising capacities." | 1.28 | Clomipramine metabolism. Model-based analysis of variability factors from drug monitoring data. ( Balant, LP; Balant-Gorgia, AE; Garrone, G; Gex-Fabry, M, 1990) |
| "5 mg/kg/day, revealed a similar profile to that seen after chronic administration of benzodiazepines in the adult." | 1.27 | Prenatal treatment with clomipramine: effects on the behaviour of male and female adolescent rats. ( File, SE; Tucker, JC, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (45.45) | 18.7374 |
| 1990's | 5 (22.73) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Limón-Morales, O | 1 |
| Soria-Fregozo, C | 1 |
| Arteaga-Silva, M | 1 |
| Vázquez-Palacios, G | 1 |
| Bonilla-Jaime, H | 1 |
| Freund, N | 1 |
| Thompson, BS | 1 |
| Norman, KJ | 1 |
| Einhorn, P | 1 |
| Andersen, SL | 1 |
| Kuramochi, M | 1 |
| Nakamura, S | 1 |
| Mavanji, V | 1 |
| Datta, S | 1 |
| Jourdan, D | 1 |
| Pickering, G | 1 |
| Marchand, F | 1 |
| Gaulier, JM | 1 |
| Alliot, J | 1 |
| Eschalier, A | 1 |
| Fernández-Guasti, A | 2 |
| Ulloa, RE | 2 |
| Nicolini, H | 2 |
| Corner, MA | 2 |
| Bour, HL | 2 |
| File, SE | 1 |
| Tucker, JC | 1 |
| Mirmiran, M | 2 |
| Corner, M | 1 |
| van de Poll, NE | 1 |
| van Oyen, HG | 1 |
| Watson, JU | 1 |
| Beaumont, G | 1 |
| Poole, P | 1 |
| Seldrup, J | 1 |
| John, VA | 1 |
| Luscombe, DK | 2 |
| Kemp, H | 1 |
| John, V | 1 |
| Golden, RN | 1 |
| Gilmore, JH | 1 |
| Ekstrom, RD | 1 |
| Knight, B | 1 |
| Ruegg, RG | 1 |
| Miller, HL | 1 |
| Carson, SW | 1 |
| Schiffman, SS | 1 |
| Graham, BG | 1 |
| Suggs, MS | 1 |
| Sattely-Miller, EA | 1 |
| Mandell, AJ | 1 |
| Panerai, AE | 1 |
| Manfredi, B | 1 |
| Sacerdote, P | 1 |
| Hartley, P | 1 |
| Neill, D | 1 |
| Hagler, M | 1 |
| Kors, D | 1 |
| Vogel, G | 1 |
| Gex-Fabry, M | 1 |
| Balant-Gorgia, AE | 1 |
| Balant, LP | 1 |
| Garrone, G | 1 |
| Rodríguez Echandía, EL | 1 |
| Fóscolo, MR | 1 |
| Gonzalez, A | 1 |
1 review available for clomipramine and Aging
| Article | Year |
|---|---|
Effect of perinatal exposure to therapeutic doses of chlorimipramine on grooming behavior in the adult rat.
Topics: Aging; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Clomipramine; Female; Grooming; | 1988 |
1 trial available for clomipramine and Aging
| Article | Year |
|---|---|
The effects of age, gender, and season on serotonergic function in healthy subjects.
Topics: Adult; Aging; Blood Proteins; Clomipramine; Female; Humans; Injections, Intravenous; Male; Middle Ag | 1996 |
20 other studies available for clomipramine and Aging
| Article | Year |
|---|---|
Altered expression of 5-HT1A receptors in adult rats induced by neonatal treatment with clomipramine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Body Temperature; Clomipra | 2014 |
Developmental emergence of an obsessive-compulsive phenotype and binge behavior in rats.
Topics: Adaptation, Psychological; Aging; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Anim | 2015 |
Effects of postnatal isolation rearing and antidepressant treatment on the density of serotonergic and noradrenergic axons and depressive behavior in rats.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Antidepressive Agents; Antidepressive Agents, Tricycl | 2009 |
Clomipramine treatment in neonatal rats alters the brain acetylcholinesterase activity in adulthood.
Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; Brain; Clomipramine; Depression; Enzyme Acti | 2002 |
Impact of ageing on the antinociceptive effect of reference analgesics in the Lou/c rat.
Topics: Acetaminophen; Aging; Analgesics; Animals; Aspirin; Clomipramine; Dose-Response Relationship, Drug; | 2002 |
Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Antidepressive Agents, Tricyclic; Clomiprami | 2003 |
Age differences in an animal model of obsessive-compulsive disorder: participation of dopamine: dopamine in an animal model of OCD.
Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Dopamine; Dopamine Agonists; Male; M | 2004 |
Postnatal development of spontaneous neuronal discharges in the pontine reticular formation of free-moving rats during sleep and wakefulness.
Topics: Aging; Animals; Arousal; Clomipramine; Evoked Potentials; Male; Neurons; Pons; Rats; Rats, Inbred St | 1984 |
Prenatal treatment with clomipramine: effects on the behaviour of male and female adolescent rats.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Clomipramine; Female; Humans; Interpersonal Relations; Ma | 1984 |
Neuronal discharge patterns in the occipital cortex of developing rats during active and quiet sleep.
Topics: Aging; Animals; Clomipramine; Evoked Potentials; Male; Neurons; Occipital Lobe; Rats; Rats, Inbred S | 1982 |
Suppression of active sleep by chronic treatment with chlorimipramine during early postnatal development: effects upon adult sleep and behavior in the rat.
Topics: Aggression; Aging; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Weight; Bra | 1981 |
Clomipramine and age: an interaction study.
Topics: Adolescent; Adult; Aged; Aging; Clomipramine; Depression; Female; Humans; Male; Psychiatric Status R | 1980 |
Relating plasma levels of clomipramine and clinical response.
Topics: Adult; Aged; Aging; Clomipramine; Contraceptives, Oral, Hormonal; Depression; Female; Humans; Male; | 1980 |
Effects of age, cigarette smoking and the oral contraceptive on the pharmacokinetics of clomipramine and its desmethyl metabolite during chronic dosing.
Topics: Adolescent; Adult; Aged; Aging; Clomipramine; Contraceptives, Oral; Contraceptives, Oral, Hormonal; | 1980 |
Influence of age, cigarette smoking and the oral contraceptive on plasma concentrations of clomipramine.
Topics: Adolescent; Adult; Aged; Aging; Clomipramine; Contraceptives, Oral; Depression; Female; Humans; Male | 1980 |
Effect of psychotropic drugs on taste responses in young and elderly persons.
Topics: Adult; Aged; Aging; Amitriptyline; Clomipramine; Desipramine; Doxepin; Female; Humans; Imipramine; M | 1998 |
On a mechanism for the mood and personality changes of adult and later life. A psychobiological hypothesis.
Topics: Affect; Aging; Animals; Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Clomipramine; Dom | 1979 |
Beta-endorphin concentrations in resting peripheral mononuclear cells and after treatment with PHA or serotoninergic drugs in human aging, Alzheimer's disease, and Down's syndrome.
Topics: Adult; Aged; Aging; Alzheimer Disease; beta-Endorphin; Clomipramine; Down Syndrome; Female; Humans; | 1992 |
Procedure- and age-dependent hyperactivity in a new animal model of endogenous depression.
Topics: Aging; Animals; Antidepressive Agents; Clomipramine; Depressive Disorder; Disease Models, Animal; Hy | 1990 |
Clomipramine metabolism. Model-based analysis of variability factors from drug monitoring data.
Topics: Adult; Aged; Aging; Biotransformation; Chromatography, High Pressure Liquid; Clomipramine; Dealkylat | 1990 |