clomipramine has been researched along with Aggression in 27 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare effects of the serotonergic drug clomipramine hydrochloride with those of placebo for treatment of dominance-related aggression in dogs." | 9.09 | Effects of clomipramine hydrochloride on dominance-related aggression in dogs. ( Cliff, KD; Hart, BL; Neilson, JC; White, MM, 1999) |
| "This report provides preliminary evidence for the efficacy of clomipramine in the treatment of young adults with autistic disorder." | 7.68 | Clomipramine in autism: preliminary evidence of efficacy. ( Bregman, J; Cohen, DJ; Goodman, WK; McDougle, CJ; Nielsen, J; Price, LH; Volkmar, FR; Ward-O'Brien, D, 1992) |
| "Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-compulsive disorder." | 3.71 | Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder. ( Ferris, CF; Koppel, G; Messenger, T; Rasmussen, MF, 2001) |
| "This report provides preliminary evidence for the efficacy of clomipramine in the treatment of young adults with autistic disorder." | 3.68 | Clomipramine in autism: preliminary evidence of efficacy. ( Bregman, J; Cohen, DJ; Goodman, WK; McDougle, CJ; Nielsen, J; Price, LH; Volkmar, FR; Ward-O'Brien, D, 1992) |
| "Clomipramine treatment also decreased the incidence of "growling" during a mirror image stimulation test, relative to non-test periods (P < 0." | 1.43 | Characterization of multiple pathways modulating aggression in the male clouded leopard (Neofelis nebulosa). ( DeCaluwe, HB; Howard, J; Ottinger, MA; Pelican, KM; Wielebnowski, NC, 2016) |
| " Clinical effects from the medications were measured in relation to and shown to be a function of dosage level." | 1.31 | Therapeutic effects and long-term efficacy of antidepressant medication for persons with developmental disabilities. Behavioral assessment in two cases of treatment-resistant aggression and self-injury. ( Blew, P; Luiselli, JK; Thibadeau, S, 2001) |
| ", systemic subcutaneous administration and microinjection into the medial amygdala were employed to examine the effect of chronic administration of psychotropic drugs on muricide in olfactory bulbectomized rats." | 1.27 | Effects of chronic administration of antidepressants on mouse-killing behavior (muricide) in olfactory bulbectomized rats. ( Nakanishi, H; Shibata, S; Ueki, S; Watanabe, S, 1984) |
| "Maprotiline in particular was more efficacious than any of the other compounds in preventing or suppressing aggressiveness after chronic treatment at doses inactive upon acute administration." | 1.26 | The effects of antidepressants on aggressiveness induced by social deprivation in mice. ( Delini-Stula, A; Vassout, A, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (33.33) | 18.7374 |
| 1990's | 10 (37.04) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DeCaluwe, HB | 1 |
| Wielebnowski, NC | 1 |
| Howard, J | 1 |
| Pelican, KM | 1 |
| Ottinger, MA | 1 |
| Mavanji, V | 1 |
| Datta, S | 1 |
| Janowsky, DS | 1 |
| Shetty, M | 1 |
| Barnhill, J | 1 |
| Elamir, B | 1 |
| Davis, JM | 1 |
| Fontenelle, LF | 1 |
| Mendlowicz, MV | 1 |
| Kalaf, J | 1 |
| Domingues, AM | 1 |
| Versiani, M | 1 |
| Duxbury, MM | 1 |
| Apter, A | 1 |
| Bernhout, E | 1 |
| Tyano, S | 1 |
| Shibata, S | 1 |
| Nakanishi, H | 1 |
| Watanabe, S | 1 |
| Ueki, S | 2 |
| File, SE | 1 |
| Tucker, JC | 1 |
| Delini-Stula, A | 1 |
| Vassout, A | 1 |
| Mirmiran, M | 1 |
| van de Poll, NE | 1 |
| Corner, MA | 1 |
| van Oyen, HG | 1 |
| Bour, HL | 1 |
| Cai, B | 1 |
| Matsumoto, K | 1 |
| Ohta, H | 1 |
| Watanabe, H | 1 |
| Hilakivi-Clarke, LA | 1 |
| Goldberg, R | 1 |
| Steele, M | 1 |
| Fisman, S | 1 |
| Brasić, JR | 1 |
| Barnett, JY | 1 |
| Sheitman, BB | 1 |
| Tsaltas, MO | 1 |
| Vijayakumar, M | 1 |
| Meti, BL | 1 |
| Weller, EB | 1 |
| Rowan, A | 1 |
| Elia, J | 1 |
| Weller, RA | 1 |
| White, MM | 1 |
| Neilson, JC | 1 |
| Hart, BL | 1 |
| Cliff, KD | 1 |
| Luiselli, JK | 1 |
| Blew, P | 1 |
| Thibadeau, S | 1 |
| Vargas, LC | 1 |
| Schenberg, LC | 1 |
| Ferris, CF | 1 |
| Rasmussen, MF | 1 |
| Messenger, T | 1 |
| Koppel, G | 1 |
| Yamamoto, T | 1 |
| Sheard, M | 1 |
| Astrachan, D | 1 |
| Davis, M | 1 |
| Marks, PC | 1 |
| O'Brien, M | 1 |
| Paxinos, G | 1 |
| McDougle, CJ | 1 |
| Price, LH | 1 |
| Volkmar, FR | 1 |
| Goodman, WK | 1 |
| Ward-O'Brien, D | 1 |
| Nielsen, J | 1 |
| Bregman, J | 1 |
| Cohen, DJ | 1 |
| Alarcon, RD | 1 |
| Johnson, BR | 1 |
| Lucas, JP | 1 |
| Meyer, L | 1 |
| Wiklund, N | 1 |
| Lidberg, L | 1 |
| Vogel, G | 1 |
| Hartley, P | 1 |
| Neill, D | 1 |
| Hagler, M | 1 |
| Kors, D | 1 |
1 review available for clomipramine and Aggression
| Article | Year |
|---|---|
Aggressive behavior in patients with attention-deficit/hyperactivity disorder, conduct disorder, and pervasive developmental disorders.
Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Child D | 1999 |
2 trials available for clomipramine and Aggression
| Article | Year |
|---|---|
Adverse effects of clomipramine.
Topics: Aggression; Akathisia, Drug-Induced; Autistic Disorder; Child; Clomipramine; Compulsive Behavior; Hu | 1997 |
Effects of clomipramine hydrochloride on dominance-related aggression in dogs.
Topics: Aggression; Animals; Behavior, Animal; Clomipramine; Dogs; Double-Blind Method; Male; Selective Sero | 1999 |
24 other studies available for clomipramine and Aggression
| Article | Year |
|---|---|
Characterization of multiple pathways modulating aggression in the male clouded leopard (Neofelis nebulosa).
Topics: Aggression; Androgens; Animals; Animals, Zoo; Antidepressive Agents, Tricyclic; Clomipramine; Enzyme | 2016 |
Sleep-wake effects of yohimbine and atropine in rats with a clomipramine-based model of depression.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Aggression; Animals; Animals, Newborn; Antidepressive Agen | 2002 |
Serotonergic antidepressant effects on aggressive, self-injurious and destructive/disruptive behaviours in intellectually disabled adults: a retrospective, open-label, naturalistic trial.
Topics: Adolescent; Adult; Aged; Aggression; Antidepressive Agents; Attention Deficit and Disruptive Behavio | 2005 |
Obsessions with aggressive content emerging during the course of panic disorder: a different subtype of obsessive-compulsive disorder?
Topics: Adult; Aggression; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Clomipram | 2005 |
Animal behavior case of the month. Separation anxiety.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Clomipramine; Dogs; Male; Saliv | 2006 |
Severe obsessive compulsive disorder in adolescence: a report of eight cases.
Topics: Adolescent; Aggression; Behavior Therapy; Child; Clomipramine; Combined Modality Therapy; Fantasy; F | 1984 |
Effects of chronic administration of antidepressants on mouse-killing behavior (muricide) in olfactory bulbectomized rats.
Topics: Aggression; Amitriptyline; Amygdala; Animals; Antidepressive Agents; Chlorpromazine; Clomipramine; D | 1984 |
Prenatal treatment with clomipramine has an anxiolytic profile in the adolescent rat.
Topics: Age Factors; Aggression; Animals; Anxiety; Behavior, Animal; Body Weight; Clomipramine; Environment; | 1983 |
The effects of antidepressants on aggressiveness induced by social deprivation in mice.
Topics: Aggression; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Humans; Imiprami | 1981 |
Suppression of active sleep by chronic treatment with chlorimipramine during early postnatal development: effects upon adult sleep and behavior in the rat.
Topics: Aggression; Aging; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Weight; Bra | 1981 |
Biphasic effects of typical antidepressants and mianserin, an atypical antidepressant, on aggressive behavior in socially isolated mice.
Topics: Aggression; Amitriptyline; Animals; Antidepressive Agents; Brain Chemistry; Clomipramine; Male; Mapr | 1993 |
Effects of tryptophan and serotonin uptake inhibitors on behavior in male transgenic transforming growth factor alpha mice.
Topics: Aggression; Animals; Behavior, Animal; Clomipramine; Depression; Male; Mice; Mice, Transgenic; Selec | 1993 |
Bipolar disorder in children and adolescents: current challenges.
Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Child; Clom | 1997 |
Alterations in the levels of monoamines in discrete brain regions of clomipramine-induced animal model of endogenous depression.
Topics: Aggression; Animals; Biogenic Monoamines; Brain; Brain Stem; Clomipramine; Depression; Disease Model | 1999 |
Therapeutic effects and long-term efficacy of antidepressant medication for persons with developmental disabilities. Behavioral assessment in two cases of treatment-resistant aggression and self-injury.
Topics: Adolescent; Adult; Aggression; Antidepressive Agents; Behavior Therapy; Clomipramine; Combined Modal | 2001 |
Long-term effects of clomipramine and fluoxetine on dorsal periaqueductal grey-evoked innate defensive behaviours of the rat.
Topics: Aggression; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Clo | 2001 |
Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder.
Topics: Adrenergic Uptake Inhibitors; Aggression; Animals; Arginine Vasopressin; Behavior, Animal; Clomipram | 2001 |
Effects of drugs on hyperactivity and aggression induced by raphe lesions in rats.
Topics: 5-Hydroxytryptophan; Aggression; Animals; Atropine; Brain Stem; Clomipramine; Desipramine; Humans; I | 1978 |
Tricyclic antidepressant drugs: antagonism of effect of D-lysergic acid diethylamide (LSD) on shock elicited aggression.
Topics: Aggression; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Desipramine; Electroshock; Huma | 1977 |
Chlorimipramine inhibition of muricide: the role of the ascending 5-HT projection.
Topics: 5,7-Dihydroxytryptamine; Aggression; Animals; Brain Stem; Cerebral Cortex; Clomipramine; Dibenzazepi | 1978 |
Clomipramine in autism: preliminary evidence of efficacy.
Topics: Adolescent; Adult; Aggression; Autistic Disorder; Clomipramine; Dose-Response Relationship, Drug; Dr | 1992 |
Paranoid and aggressive behavior in two obsessive-compulsive adolescents treated with clomipramine.
Topics: Adolescent; Aggression; Carbamazepine; Child; Clomipramine; Dose-Response Relationship, Drug; Fluoxe | 1991 |
[Does clomipramine in combination with alcohol provoke violent crimes?].
Topics: Adult; Aggression; Alcohol Drinking; Clomipramine; Compulsive Behavior; Crime; Drug Interactions; Hu | 1991 |
Animal depression model by neonatal clomipramine: reduction of shock induced aggression.
Topics: Age Factors; Aggression; Animals; Animals, Newborn; Clomipramine; Depression; Disease Models, Animal | 1988 |