clomipramine has been researched along with Ache in 35 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have re-analysed our previous double-blind, placebo-controlled clomipramine study, changing the focus from depression to anxiety both in the response analysis and in the classification of minor affective states." | 9.14 | The clinical effect of clomipramine in chronic idiopathic pain disorder revisited using the Spielberger State Anxiety Symptom Scale (SSASS) as outcome scale. ( Bech, P; Gormsen, L; Loldrup, D; Lunde, M, 2009) |
| "The reduction of pain by two antidepressants, clomipramine and mianserin, was, in this study on 253 patients with chronic idiopathic pain syndrome, found to be not better than a placebo when all patients were compared independently of the classification of pain." | 9.06 | Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study. ( Bech, P; Hansen, HJ; Langemark, M; Loldrup, D; Olesen, J, 1989) |
| "We aimed to review systematically the evidence from randomised controlled trials for the efficacy of tramadol in treating neuropathic pain." | 8.83 | Tramadol for neuropathic pain. ( Cornblath, DR; Dühmke, RM; Hollingshead, J, 2006) |
| "We aimed to review systematically the evidence from randomised controlled trials for the efficacy of tramadol in treating neuropathic pain." | 8.82 | Tramadol for neuropathic pain. ( Cornblath, DD; Duhmke, RM; Hollingshead, JR, 2004) |
| "The analgesic effect of clomipramine and the possible relationships between the antalgic action and the plasma levels of this tricyclic drug have been studied in 30 patients with chronic pain induced by nervous lesions determining a deafferentation." | 7.67 | Measurement of plasma levels of clomipramine in the treatment of chronic pain. ( Blanc, M; Charlet, JP; Cotonat, J; David, J; Guiraud-Chaumeil, B; Mansat, M; Montastruc, JL; Patacq-Sapijanskas, M; Rascol, A; Tran, MA, 1985) |
| "The analgesic effect of clomipramine and the possible relationships between the antalgic action, the doses and the plasma levels of this tricyclic drug have been studied in 15 patients with chronic pain induced by nervous lesions determining a deafferentiation." | 7.66 | [Analgesic properties and plasma concentrations of clomipramine in chronic pain]. ( Charlet, JP; Cotonat, J; David, J; Gaillard-Plaza, G; Guiraud, B; Montastruc, JL; Rascol, A; Tran, MA, 1983) |
| "Forty-six patients were admitted to an open general practice study of clomipramine (Anafranil) in the treatment of long-standing rheumatic pain; forty-one patients completed the trial." | 7.65 | Clomipramine (Anafranil) and musculo-skeletal pain in general practice: a pilot, open, non-comparative study of long-standing rheumatic pain. ( Regalado, RG, 1977) |
| "We have re-analysed our previous double-blind, placebo-controlled clomipramine study, changing the focus from depression to anxiety both in the response analysis and in the classification of minor affective states." | 5.14 | The clinical effect of clomipramine in chronic idiopathic pain disorder revisited using the Spielberger State Anxiety Symptom Scale (SSASS) as outcome scale. ( Bech, P; Gormsen, L; Loldrup, D; Lunde, M, 2009) |
| "The reduction of pain by two antidepressants, clomipramine and mianserin, was, in this study on 253 patients with chronic idiopathic pain syndrome, found to be not better than a placebo when all patients were compared independently of the classification of pain." | 5.06 | Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study. ( Bech, P; Hansen, HJ; Langemark, M; Loldrup, D; Olesen, J, 1989) |
| "Several studies have reported that both imipramine and clomipramine are valuable adjuncts in the management of chronic pain, in particular that associated with the arthritides." | 5.05 | A comparative trial of clomipramine and placebo as adjunctive therapy in arthralgia. ( Beaumont, G; Ganvir, P; Seldrup, J, 1980) |
| "A clinical trial is being conducted in which single, nightly doses of 10 mg or 25 mg of clomipramine are added to the conventional analgesic therapy of patients with chronic painful conditions of the locomotor system." | 5.04 | Anafranil in the management of long-term pain: a preliminary report. ( Regalado, RG, 1976) |
| "We aimed to review systematically the evidence from randomised controlled trials for the efficacy of tramadol in treating neuropathic pain." | 4.83 | Tramadol for neuropathic pain. ( Cornblath, DR; Dühmke, RM; Hollingshead, J, 2006) |
| "We aimed to review systematically the evidence from randomised controlled trials for the efficacy of tramadol in treating neuropathic pain." | 4.82 | Tramadol for neuropathic pain. ( Cornblath, DD; Duhmke, RM; Hollingshead, JR, 2004) |
| " The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation." | 3.72 | Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003) |
| " A 78-year-old female with DDST and pain disorder was treated by clomipramine 20-100 mg/day." | 3.70 | Possible association between delusional disorder, somatic type and reduced regional cerebral blood flow. ( Kawakatsu, S; Komatani, A; Okuyama, N; Otani, K; Wada, T, 1999) |
| "Painful ejaculation following the administration of imipramine and clomipramine is described in four patients." | 3.68 | Painful ejaculation associated with antidepressants in four patients. ( Aizenberg, D; Hermesh, H; Karp, L; Weizman, A; Zemishlany, Z, 1991) |
| "The effect of clomipramine (CMI), a tricyclic antidepressant, was studied on an acute inflammatory pain model in an attempt to understand its potential antinociceptive activity, the involvement of a central and/or peripheral component and its influence on the inflammatory process." | 3.68 | Evidence for a central but not a peripheral analgesic effect of clomipramine in rats. ( Ardid, D; Eschalier, A; Lavarenne, J, 1991) |
| "The analgesic effect of clomipramine and the possible relationships between the antalgic action and the plasma levels of this tricyclic drug have been studied in 30 patients with chronic pain induced by nervous lesions determining a deafferentation." | 3.67 | Measurement of plasma levels of clomipramine in the treatment of chronic pain. ( Blanc, M; Charlet, JP; Cotonat, J; David, J; Guiraud-Chaumeil, B; Mansat, M; Montastruc, JL; Patacq-Sapijanskas, M; Rascol, A; Tran, MA, 1985) |
| "The analgesic effect of clomipramine and the possible relationships between the antalgic action, the doses and the plasma levels of this tricyclic drug have been studied in 15 patients with chronic pain induced by nervous lesions determining a deafferentiation." | 3.66 | [Analgesic properties and plasma concentrations of clomipramine in chronic pain]. ( Charlet, JP; Cotonat, J; David, J; Gaillard-Plaza, G; Guiraud, B; Montastruc, JL; Rascol, A; Tran, MA, 1983) |
| "Forty-six patients were admitted to an open general practice study of clomipramine (Anafranil) in the treatment of long-standing rheumatic pain; forty-one patients completed the trial." | 3.65 | Clomipramine (Anafranil) and musculo-skeletal pain in general practice: a pilot, open, non-comparative study of long-standing rheumatic pain. ( Regalado, RG, 1977) |
| "There have been reports that tricyclic antidepressants, such as clomipramine (Anafranil), alleviate some forms of chronic pain in man." | 3.65 | Antidepressants and pain: a review of the pharmacological data supporting the use of certain tricyclics in chronic pain. ( Lee, R; Spencer, PS, 1977) |
| "Clomipramine and mianserin were significantly superior to placebo in the topographical pain subgroup with headache using area under the improvement curves as criteria (p less than 0." | 2.66 | Discomfort or disability in patients with chronic pain syndrome. ( Bech, P; Hansen, HJ; Langemark, M; Olesen, J; Poulsen, DL, 1987) |
| "Clomipramine was inactive alone and did not alter the effects of mu agonists." | 1.36 | Antinociceptive interactions between Mu-opioid receptor agonists and the serotonin uptake inhibitor clomipramine in rhesus monkeys: role of Mu agonist efficacy. ( Banks, ML; Negus, SS; Rice, KC, 2010) |
| " A dosing strategy for the combbination of clomipramine and haloperidol is described." | 1.26 | [The treatment of chronic pain symptoms with psychotropic drugs (author's transl)]. ( Kocher, R, 1976) |
| " A clearcut dosage schedule for in- and out-patients using imipramine (Tofranil) or chlorimipramine (Anafranil) and haloperidol (Haldol) is established." | 1.26 | [The treatment of chronic pain with psychotropic drugs]. ( Kocher, R, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (54.29) | 18.7374 |
| 1990's | 6 (17.14) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bech, P | 4 |
| Gormsen, L | 1 |
| Loldrup, D | 2 |
| Lunde, M | 1 |
| Banks, ML | 1 |
| Rice, KC | 1 |
| Negus, SS | 1 |
| Jourdan, D | 1 |
| Pickering, G | 1 |
| Marchand, F | 1 |
| Gaulier, JM | 1 |
| Alliot, J | 1 |
| Eschalier, A | 3 |
| Abdel-Salam, OM | 1 |
| Nofal, SM | 1 |
| El-Shenawy, SM | 1 |
| Duhmke, RM | 2 |
| Cornblath, DD | 1 |
| Hollingshead, JR | 1 |
| Kozian, R | 1 |
| Hollingshead, J | 1 |
| Cornblath, DR | 1 |
| Pruidze, MV | 1 |
| Maloletnev, VI | 1 |
| Kellstein, DE | 1 |
| Malseed, RT | 1 |
| Goldstein, FJ | 1 |
| Jørgensen, B | 1 |
| Nørrelund, N | 1 |
| Jakobsen, K | 1 |
| Montastruc, JL | 3 |
| Tran, MA | 3 |
| Charlet, JP | 2 |
| Gaillard-Plaza, G | 1 |
| David, J | 2 |
| Cotonat, J | 2 |
| Guiraud, B | 1 |
| Rascol, A | 3 |
| Ganvir, P | 1 |
| Beaumont, G | 2 |
| Seldrup, J | 2 |
| Balon, R | 1 |
| Yeragani, VK | 1 |
| Pohl, R | 1 |
| Ramesh, C | 1 |
| Kurokawa, K | 1 |
| Tanino, R | 1 |
| Wada, T | 1 |
| Kawakatsu, S | 1 |
| Komatani, A | 1 |
| Okuyama, N | 1 |
| Otani, K | 1 |
| Coudoré-Civiale, MA | 1 |
| Courteix, C | 1 |
| Boucher, M | 1 |
| Méen, M | 1 |
| Fialip, J | 1 |
| Ardid, D | 2 |
| Kocher, R | 3 |
| Regalado, RG | 2 |
| Kielholz, P | 1 |
| Adams, C | 1 |
| Auád Juri, AO | 1 |
| Lee, R | 1 |
| Spencer, PS | 1 |
| Aizenberg, D | 1 |
| Zemishlany, Z | 1 |
| Hermesh, H | 1 |
| Karp, L | 1 |
| Weizman, A | 1 |
| Lavarenne, J | 1 |
| Panerai, AE | 2 |
| Monza, G | 1 |
| Movilia, P | 1 |
| Bianchi, M | 1 |
| Francucci, BM | 1 |
| Tiengo, M | 1 |
| Bourgoin, S | 1 |
| Cesselin, F | 1 |
| Gozlan, H | 1 |
| Fattaccini, CM | 1 |
| Hamon, M | 1 |
| Langemark, M | 2 |
| Hansen, HJ | 2 |
| Olesen, J | 2 |
| Eberhard, G | 1 |
| von Knorring, L | 1 |
| Nilsson, HL | 1 |
| Sundequist, U | 1 |
| Björling, G | 1 |
| Linder, H | 1 |
| Svärd, KO | 1 |
| Tysk, L | 1 |
| Poulsen, DL | 1 |
| Blanc, M | 1 |
| Mansat, M | 1 |
| Patacq-Sapijanskas, M | 1 |
| Guiraud-Chaumeil, B | 1 |
| Rohrer, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain[NCT05311774] | 400 participants (Anticipated) | Interventional | 2022-04-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for clomipramine and Ache
| Article | Year |
|---|---|
Tramadol for neuropathic pain.
Topics: Analgesics, Opioid; Clomipramine; Humans; Morphine; Nervous System Diseases; Pain; Randomized Contro | 2004 |
Tramadol for neuropathic pain.
Topics: Analgesics, Opioid; Clomipramine; Humans; Morphine; Nervous System Diseases; Pain; Randomized Contro | 2006 |
9 trials available for clomipramine and Ache
| Article | Year |
|---|---|
The clinical effect of clomipramine in chronic idiopathic pain disorder revisited using the Spielberger State Anxiety Symptom Scale (SSASS) as outcome scale.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Anxiety; Clomipramine; Double-Blind Metho | 2009 |
[Pain and depressive symptoms in general practice. A controlled study of Anafranil (clomipramine) versus placebo].
Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Diagnosis, Differential; Double-Blind Met | 1984 |
A comparative trial of clomipramine and placebo as adjunctive therapy in arthralgia.
Topics: Adult; Arthritis; Chronic Disease; Clinical Trials as Topic; Clomipramine; Double-Blind Method; Fema | 1980 |
Anafranil in the management of long-term pain: a preliminary report.
Topics: Analgesics; Chronic Disease; Clinical Trials as Topic; Clomipramine; Dibenzazepines; Drug Evaluation | 1976 |
A randomized, within-patient, cross-over, placebo-controlled trial on the efficacy and tolerability of the tricyclic antidepressants chlorimipramine and nortriptyline in central pain.
Topics: Adult; Clomipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Pl | 1990 |
Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study.
Topics: Adolescent; Adult; Aged; Chronic Disease; Clinical Trials as Topic; Clomipramine; Female; Humans; Ma | 1989 |
A double-blind randomized study of clomipramine versus maprotiline in patients with idiopathic pain syndromes.
Topics: Adult; Aged; Anthracenes; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Double-Blind | 1988 |
Discomfort or disability in patients with chronic pain syndrome.
Topics: Clinical Trials as Topic; Clomipramine; Disability Evaluation; Double-Blind Method; Humans; Mianseri | 1987 |
[Treatment of severe chronic pains with a combination of thymoleptics and neuroleptics (author's transl)].
Topics: Adult; Antidepressive Agents; Atropine; Chlorpromazine; Clinical Trials as Topic; Clomipramine; Drug | 1974 |
24 other studies available for clomipramine and Ache
| Article | Year |
|---|---|
Antinociceptive interactions between Mu-opioid receptor agonists and the serotonin uptake inhibitor clomipramine in rhesus monkeys: role of Mu agonist efficacy.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Clomipramine; Disease Models, Animal; Dose-Response R | 2010 |
Impact of ageing on the antinociceptive effect of reference analgesics in the Lou/c rat.
Topics: Acetaminophen; Aging; Analgesics; Animals; Aspirin; Clomipramine; Dose-Response Relationship, Drug; | 2002 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise | 2003 |
[Olanzapine in therapy of a somatoform disorder].
Topics: Antipsychotic Agents; Benzodiazepines; Chest Pain; Clomipramine; Depressive Disorder; Dose-Response | 2003 |
[Peculiarities of tactics in the treatment of chronic pain syndrome in women].
Topics: Adult; Chronic Disease; Clomipramine; Female; Humans; Menstruation; Middle Aged; Pain; Selective Ser | 2006 |
Contrasting effects of acute vs. chronic tricyclic antidepressant treatment on central morphine analgesia.
Topics: Analgesia; Animals; Clomipramine; Desipramine; Male; Morphine; Pain; Periaqueductal Gray; Rats; Rats | 1984 |
[Analgesic properties and plasma concentrations of clomipramine in chronic pain].
Topics: Adult; Aged; Analgesics; Chronic Disease; Clomipramine; Female; Follow-Up Studies; Humans; Kinetics; | 1983 |
Comparative trial of clomipramine and placebo in the treatment of terminal pain.
Topics: Clomipramine; Double-Blind Method; Humans; Pain; Placebos; Terminal Care | 1980 |
Sexual dysfunction during antidepressant treatment.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Anxiety Disorders; Clomipramine; Depressive Disorder; | 1993 |
Effectiveness of clomipramine for obsessive-compulsive symptoms and chronic pain in two patients with schizophrenia.
Topics: Adult; Antidepressive Agents, Tricyclic; Chronic Disease; Clomipramine; Humans; Male; Obsessive-Comp | 1997 |
Possible association between delusional disorder, somatic type and reduced regional cerebral blood flow.
Topics: Aged; Antidepressive Agents, Tricyclic; Cerebral Angiography; Cerebral Cortex; Clomipramine; Female; | 1999 |
Potentiation of morphine and clomipramine analgesia by cholecystokinin -B antagonist CI-988 in diabetic rats.
Topics: Analgesia; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Clomi | 2000 |
[A classic antidepressant as an analgesic. Chronic pain under secure control].
Topics: Analgesics; Antidepressive Agents, Tricyclic; Chronic Disease; Clomipramine; Humans; Pain | 2001 |
[The treatment of chronic pain symptoms with psychotropic drugs (author's transl)].
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Bone Diseases; Clomipramine; Drug Therapy, C | 1976 |
[The treatment of chronic pain with psychotropic drugs].
Topics: Clomipramine; Haloperidol; Humans; Imipramine; Methotrimeprazine; Muscle Contraction; Pain; Psychotr | 1978 |
Clomipramine (Anafranil) and musculo-skeletal pain in general practice: a pilot, open, non-comparative study of long-standing rheumatic pain.
Topics: Clomipramine; Dibenzazepines; Female; Humans; Male; Middle Aged; Pain; Pilot Projects; Rheumatic Dis | 1977 |
[Diagnosis and treatment of depressive states in everyday practice (author's transl)].
Topics: Adjustment Disorders; Antidepressive Agents; Bipolar Disorder; Clomipramine; Family Practice; Fatigu | 1978 |
[Psychopharmaceutics and pain (thymolepto analgesia treatment of chronic pain with the antidepressive chlorimipramine].
Topics: Chronic Disease; Clomipramine; Dibenzazepines; Drug Evaluation; Female; Humans; Male; Pain; Pain, Po | 1978 |
Antidepressants and pain: a review of the pharmacological data supporting the use of certain tricyclics in chronic pain.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Central Nervous System; Chronic Disease; Clom | 1977 |
Painful ejaculation associated with antidepressants in four patients.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Ejaculation; Humans; Imi | 1991 |
Evidence for a central but not a peripheral analgesic effect of clomipramine in rats.
Topics: Analgesics; Animals; Central Nervous System; Clomipramine; Edema; Foot; Injections; Injections, Intr | 1991 |
Chronic chlorimipramine does not reverse the reduction of cerebrospinal fluid Met-enkephalin-like immunoreactivity in chronic-pain patients.
Topics: Adult; Aged; Chronic Disease; Clomipramine; Enkephalin, Methionine; Enkephalins; Female; Humans; Hyd | 1987 |
[Potentiation concept in pharmacology].
Topics: 5-Hydroxytryptophan; Animals; Baclofen; Clomipramine; Diazepam; Drug Synergism; Drug Therapy, Combin | 1988 |
Measurement of plasma levels of clomipramine in the treatment of chronic pain.
Topics: Chronic Disease; Clomipramine; Female; Humans; Kinetics; Male; Middle Aged; Pain | 1985 |