clofilium has been researched along with Ventricular Fibrillation in 8 studies
clofilium: RN given refers to parent cpd; structure
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration." | 7.67 | Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986) |
| " This study was designed to determine whether clofilium exhibits antifibrillatory activity in a pinacidil + hypoxia-induced model of ventricular fibrillation (VF) in Langendorff-perfused hearts." | 3.69 | Antifibrillatory effects of clofilium in the rabbit isolated heart. ( Chi, L; Friedrichs, GS; Green, AL; Lucchesi, BR, 1994) |
| "Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration." | 3.67 | Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986) |
| "Six clofilium-treated and six control dogs underwent repeated testing on days 14, 21, and 28 after surgery." | 1.28 | Oral clofilium produces sustained lowering of defibrillation energy requirements in a canine model. ( David, I; Dorian, P; Feindel, C; Wang, M, 1991) |
| "Clofilium was studied in three experimental models." | 1.27 | Antiarrhythmic and electrophysiologic actions of clofilium in experimental canine models. ( Eller, BT; Kopia, GA; Lucchesi, BR; Patterson, E; Shea, MJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Friedrichs, GS | 1 |
| Chi, L | 1 |
| Green, AL | 1 |
| Lucchesi, BR | 2 |
| Sweeney, RJ | 1 |
| Gill, RM | 1 |
| Steinberg, MI | 1 |
| Reid, PR | 1 |
| Dorian, P | 1 |
| Wang, M | 1 |
| David, I | 1 |
| Feindel, C | 1 |
| Echt, DS | 1 |
| Black, JN | 1 |
| Barbey, JT | 1 |
| Coxe, DR | 1 |
| Cato, E | 1 |
| Johnson, GL | 1 |
| Ehrreich, SJ | 1 |
| el-Hage, AN | 1 |
| Balazs, T | 1 |
| Euler, DE | 1 |
| Zeman, TW | 1 |
| Wallock, ME | 1 |
| Scanlon, PJ | 1 |
| Kowey, PR | 1 |
| Friehling, TD | 1 |
| O'Connor, KM | 1 |
| Wetstein, L | 1 |
| Kelliher, GJ | 1 |
| Kopia, GA | 1 |
| Eller, BT | 1 |
| Patterson, E | 1 |
| Shea, MJ | 1 |
8 other studies available for clofilium and Ventricular Fibrillation
| Article | Year |
|---|---|
Antifibrillatory effects of clofilium in the rabbit isolated heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Decanoic Acids; Disease Models, Animal; Glyburid | 1994 |
Effects of flecainide, encainide, and clofilium on ventricular refractory period extension by transcardiac shocks.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dogs; Electric Countershock; Encainide; | 1996 |
Oral clofilium produces sustained lowering of defibrillation energy requirements in a canine model.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Dogs; Electric Countershock; Electrodes, Impl | 1991 |
Evaluation of antiarrhythmic drugs on defibrillation energy requirements in dogs. Sodium channel block and action potential prolongation.
Topics: Acecainide; Action Potentials; Animals; Anti-Arrhythmia Agents; Cesium; Dogs; Electric Countershock; | 1989 |
Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death.
Topics: Animals; Anti-Arrhythmia Agents; Body Weight; Bretylium Tosylate; Death, Sudden; Disease Models, Ani | 1986 |
Deleterious effects of bretylium on hemodynamic recovery from ventricular fibrillation.
Topics: Animals; Blood Pressure; Bretylium Compounds; Bretylium Tosylate; Carbonates; Dogs; Electric Counter | 1986 |
The effect of bretylium and clofilium on dispersion of refractoriness and vulnerability to ventricular fibrillation in the ischemic feline heart.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Bretylium Compounds; Bretylium Tosylate; Cats; Coro | 1985 |
Antiarrhythmic and electrophysiologic actions of clofilium in experimental canine models.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Death, Sudden; Dogs; Electric Stimulation; Heart Ra | 1985 |