clofilium has been researched along with Torsade de Pointes in 17 studies
clofilium: RN given refers to parent cpd; structure
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to compare the proarrhythmic activity of the antimalarial drug, halofantrine and the antihistamine, terfenadine, with that of clofilium a K(+) channel blocking drug that can induce torsade de pointes." | 7.71 | Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes. ( Batey, AJ; Coker, SJ, 2002) |
| "We tested whether the adenosine A1 receptor agonist, R-PIA, suppressed torsade de pointes (TdP) induced by the delayed rectifier potassium channel blocker clofilium." | 7.70 | Effects of adenosine A1-receptor activation on torsade de pointes in rabbits. ( Hou, CJ; Sung, RJ; Tan, HL, 1999) |
| "The total incidences of torsade de pointes were 60%*, 20%, 0% and 0% in clofilium-, terikalant-, erythromycin- and vehicle-treated animals, respectively (*P < 0." | 5.31 | Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model. ( Coker, SJ; Farkas, A, 2002) |
| " This study was designed to compare the proarrhythmic activity of the antimalarial drug, halofantrine and the antihistamine, terfenadine, with that of clofilium a K(+) channel blocking drug that can induce torsade de pointes." | 3.71 | Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes. ( Batey, AJ; Coker, SJ, 2002) |
| "We tested whether the adenosine A1 receptor agonist, R-PIA, suppressed torsade de pointes (TdP) induced by the delayed rectifier potassium channel blocker clofilium." | 3.70 | Effects of adenosine A1-receptor activation on torsade de pointes in rabbits. ( Hou, CJ; Sung, RJ; Tan, HL, 1999) |
| "Data analysis was performed on premature ventricular complexes, couplets, and torsades de pointes (TdP) induced during intravenous administration of clofilium and phenylephrine with combinations of various infusion rates." | 1.39 | Noninvasive cardiac activation imaging of ventricular arrhythmias during drug-induced QT prolongation in the rabbit heart. ( Han, C; He, B; Killingsworth, CR; Pogwizd, SM; Zhou, Z, 2013) |
| "Bradycardia is a risk factor for the development of torsade de pointes (TdP)." | 1.35 | Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model. ( Coker, SJ; Dempster, J; Farkas, A, 2008) |
| "Pretreatment with ranolazine (480 microg/kg/min) or lidocaine (200 microg/kg/min) reduced the clofilium-induced prolongation of QTc (15 +/- 3 and 19 +/- 3%, respectively, p < 0." | 1.35 | Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. ( Belardinelli, L; Dhalla, AK; Robertson, C; Wang, WQ, 2008) |
| "The total incidences of torsade de pointes were 60%*, 20%, 0% and 0% in clofilium-, terikalant-, erythromycin- and vehicle-treated animals, respectively (*P < 0." | 1.31 | Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model. ( Coker, SJ; Farkas, A, 2002) |
| "In the d,l-sotalol- and erythromycin-treated hearts, torsades de pointes occurred only in the presence of hypokalemia and bradycardia, whereas, in the presence of clofilium, bradycardia alone caused torsades de pointes." | 1.30 | Drug-related torsades de pointes in the isolated rabbit heart: comparison of clofilium, d,l-sotalol, and erythromycin. ( Borggrefe, M; Breithardt, G; Clague, JR; Eckardt, L; Haverkamp, W; Johna, R; Mertens, H, 1998) |
| "The ventricular arrhythmia torsade de pointes (TdP) occurs after QT interval prolongation and is associated with sudden cardiac death." | 1.30 | Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits. ( Anderson, ME; Mazur, A; Roden, DM, 1999) |
| " Agents were compared over dosage ranges that produced maximal increases in QTc interval and monophasic action potential duration (MAPD)." | 1.29 | Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia. ( Brunden, MN; Buchanan, LV; Gibson, JK; Kabell, G, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Han, C | 1 |
| Pogwizd, SM | 1 |
| Killingsworth, CR | 1 |
| Zhou, Z | 1 |
| He, B | 1 |
| Farkas, A | 3 |
| Dempster, J | 1 |
| Coker, SJ | 4 |
| Orth, PM | 1 |
| Hesketh, JC | 1 |
| Mak, CK | 1 |
| Yang, Y | 1 |
| Lin, S | 1 |
| Beatch, GN | 1 |
| Ezrin, AM | 1 |
| Fedida, D | 1 |
| Kijtawornrat, A | 1 |
| Nishijima, Y | 1 |
| Roche, BM | 1 |
| Keene, BW | 1 |
| Hamlin, RL | 1 |
| Hasumi, H | 1 |
| Matsuda, R | 1 |
| Shimamoto, K | 1 |
| Hata, Y | 1 |
| Kaneko, N | 1 |
| Wang, WQ | 1 |
| Robertson, C | 1 |
| Dhalla, AK | 1 |
| Belardinelli, L | 1 |
| Buchanan, LV | 1 |
| Kabell, G | 1 |
| Brunden, MN | 1 |
| Gibson, JK | 1 |
| Johna, R | 2 |
| Mertens, H | 2 |
| Haverkamp, W | 2 |
| Eckardt, L | 2 |
| Niederbröker, T | 1 |
| Borggrefe, M | 2 |
| Breithardt, G | 2 |
| Clague, JR | 1 |
| White, CM | 1 |
| Xie, J | 1 |
| Chow, MS | 1 |
| Kluger, J | 1 |
| Tan, HL | 1 |
| Hou, CJ | 1 |
| Sung, RJ | 1 |
| Mazur, A | 1 |
| Roden, DM | 2 |
| Anderson, ME | 2 |
| Gbadebo, TD | 1 |
| Trimble, RW | 1 |
| Khoo, MS | 1 |
| Temple, J | 1 |
| Batey, AJ | 1 |
| Carlsson, L | 1 |
| Abrahamsson, C | 1 |
| Drews, L | 1 |
| Duker, G | 1 |
17 other studies available for clofilium and Torsade de Pointes
| Article | Year |
|---|---|
Noninvasive cardiac activation imaging of ventricular arrhythmias during drug-induced QT prolongation in the rabbit heart.
Topics: Animals; Anti-Arrhythmia Agents; Body Surface Potential Mapping; Cardiotonic Agents; Disease Models, | 2013 |
Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model.
Topics: Action Potentials; Adrenergic alpha-Agonists; Angiotensin II; Animals; Anti-Arrhythmia Agents; Blood | 2008 |
Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Anti-Bacte | 2002 |
Prevention of clofilium-induced torsade de pointes by prostaglandin E2 does not involve ATP-dependent K+ channels.
Topics: Adenosine Triphosphate; Animals; Dinoprostone; Male; Potassium Channels; Quaternary Ammonium Compoun | 2003 |
RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Dose-Response Rela | 2006 |
Use of a failing rabbit heart as a model to predict torsadogenicity.
Topics: Amiodarone; Animals; Cardiac Output, Low; Cisapride; Dose-Response Relationship, Drug; Electrocardio | 2006 |
K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Bl | 2007 |
Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits.
Topics: Acetanilides; Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; A | 2008 |
Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Heart Conduction System; Heart | 1993 |
Clofilium in the isolated perfused rabbit heart: a new model to study proarrhythmia induced by class III antiarrhythmic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Electrocardiography; | 1998 |
Drug-related torsades de pointes in the isolated rabbit heart: comparison of clofilium, d,l-sotalol, and erythromycin.
Topics: Animals; Bradycardia; Electrocardiography; Erythromycin; Hypokalemia; In Vitro Techniques; Male; Qua | 1998 |
Prophylactic magnesium to decrease the arrhythmogenic potential of class III antiarrhythmic agents in a rabbit model.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Magnesium; M | 1999 |
Effects of adenosine A1-receptor activation on torsade de pointes in rabbits.
Topics: Adenosine; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; | 1999 |
Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes.
Topics: Animals; Arrhythmias, Cardiac; Calmodulin; Disease Models, Animal; Electrocardiography; Enzyme Inhib | 2002 |
Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes.
Topics: Animals; Antimalarials; Disease Models, Animal; Electrocardiography; Histamine Antagonists; Male; Ph | 2002 |
Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization.
Topics: Animals; Anti-Arrhythmia Agents; Electrocardiography; Glyburide; Guanidines; Heart Conduction System | 1992 |