clofilium has been researched along with Disease Models, Animal in 13 studies
clofilium: RN given refers to parent cpd; structure
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to compare the proarrhythmic activity of the antimalarial drug, halofantrine and the antihistamine, terfenadine, with that of clofilium a K(+) channel blocking drug that can induce torsade de pointes." | 7.71 | Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes. ( Batey, AJ; Coker, SJ, 2002) |
| " In adrenergically stimulated anesthetized rabbits, azimilide, clofilium, dofetilide, sematilide, and d,l-sotalol caused premature ventricular contractions and nonsustained and sustained ventricular tachyarrhythmias (NSVT and SVT) at pharmacologically equivalent intravenous doses that increased QTc intervals 20% (ED20)." | 7.70 | Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. ( Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE, 2000) |
| "Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration." | 7.67 | Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986) |
| " This study was designed to compare the proarrhythmic activity of the antimalarial drug, halofantrine and the antihistamine, terfenadine, with that of clofilium a K(+) channel blocking drug that can induce torsade de pointes." | 3.71 | Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes. ( Batey, AJ; Coker, SJ, 2002) |
| " In adrenergically stimulated anesthetized rabbits, azimilide, clofilium, dofetilide, sematilide, and d,l-sotalol caused premature ventricular contractions and nonsustained and sustained ventricular tachyarrhythmias (NSVT and SVT) at pharmacologically equivalent intravenous doses that increased QTc intervals 20% (ED20)." | 3.70 | Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. ( Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE, 2000) |
| " This study was designed to determine whether clofilium exhibits antifibrillatory activity in a pinacidil + hypoxia-induced model of ventricular fibrillation (VF) in Langendorff-perfused hearts." | 3.69 | Antifibrillatory effects of clofilium in the rabbit isolated heart. ( Chi, L; Friedrichs, GS; Green, AL; Lucchesi, BR, 1994) |
| "When low doses of clofilium were administered to conscious rabbits, ventricular tachyarrhythmia (VT) with features typical of torsades de pointes developed." | 3.68 | QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions. ( Almgren, O; Carlsson, L; Duker, G, 1990) |
| "Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration." | 3.67 | Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986) |
| "Data analysis was performed on premature ventricular complexes, couplets, and torsades de pointes (TdP) induced during intravenous administration of clofilium and phenylephrine with combinations of various infusion rates." | 1.39 | Noninvasive cardiac activation imaging of ventricular arrhythmias during drug-induced QT prolongation in the rabbit heart. ( Han, C; He, B; Killingsworth, CR; Pogwizd, SM; Zhou, Z, 2013) |
| "Bradycardia is a risk factor for the development of torsade de pointes (TdP)." | 1.35 | Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model. ( Coker, SJ; Dempster, J; Farkas, A, 2008) |
| "The ventricular arrhythmia torsade de pointes (TdP) occurs after QT interval prolongation and is associated with sudden cardiac death." | 1.30 | Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits. ( Anderson, ME; Mazur, A; Roden, DM, 1999) |
| "1." | 1.28 | A dual model for cardiac arrhythmias: coexistence of re-entry and abnormal automaticity and effects of antiarrhythmic agents. ( Hunter, T; Proakis, A; Wu, KM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Facchinello, N | 1 |
| Laquatra, C | 1 |
| Locatello, L | 1 |
| Beffagna, G | 1 |
| Brañas Casas, R | 1 |
| Fornetto, C | 1 |
| Dinarello, A | 1 |
| Martorano, L | 1 |
| Vettori, A | 1 |
| Risato, G | 1 |
| Celeghin, R | 1 |
| Meneghetti, G | 1 |
| Santoro, MM | 1 |
| Delahodde, A | 1 |
| Vanzi, F | 1 |
| Rasola, A | 1 |
| Dalla Valle, L | 1 |
| Rasotto, MB | 1 |
| Lodi, T | 1 |
| Baruffini, E | 1 |
| Argenton, F | 1 |
| Tiso, N | 1 |
| Han, C | 1 |
| Pogwizd, SM | 1 |
| Killingsworth, CR | 1 |
| Zhou, Z | 1 |
| He, B | 1 |
| Farkas, A | 1 |
| Dempster, J | 1 |
| Coker, SJ | 2 |
| Friedrichs, GS | 1 |
| Chi, L | 1 |
| Green, AL | 1 |
| Lucchesi, BR | 1 |
| Johna, R | 1 |
| Mertens, H | 1 |
| Haverkamp, W | 1 |
| Eckardt, L | 1 |
| Niederbröker, T | 1 |
| Borggrefe, M | 1 |
| Breithardt, G | 1 |
| Idée, JM | 1 |
| Bourgoin-Balut, C | 1 |
| Lefevre, T | 1 |
| Zamia, P | 1 |
| Goulas, V | 1 |
| Gaillard, S | 1 |
| Mathias, C | 1 |
| Bonnemain, B | 1 |
| Mazur, A | 1 |
| Roden, DM | 2 |
| Anderson, ME | 2 |
| Brooks, RR | 1 |
| Drexler, AP | 1 |
| Maynard, AE | 1 |
| Al-Khalidi, H | 1 |
| Kostreva, DR | 1 |
| Gbadebo, TD | 1 |
| Trimble, RW | 1 |
| Khoo, MS | 1 |
| Temple, J | 1 |
| Batey, AJ | 1 |
| Carlsson, L | 1 |
| Almgren, O | 1 |
| Duker, G | 1 |
| Wu, KM | 1 |
| Hunter, T | 1 |
| Proakis, A | 1 |
| Johnson, GL | 1 |
| Ehrreich, SJ | 1 |
| el-Hage, AN | 1 |
| Balazs, T | 1 |
13 other studies available for clofilium and Disease Models, Animal
| Article | Year |
|---|---|
Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish.
Topics: Animals; Disease Models, Animal; Mitochondrial Diseases; Phenotype; Quaternary Ammonium Compounds; Z | 2021 |
Noninvasive cardiac activation imaging of ventricular arrhythmias during drug-induced QT prolongation in the rabbit heart.
Topics: Animals; Anti-Arrhythmia Agents; Body Surface Potential Mapping; Cardiotonic Agents; Disease Models, | 2013 |
Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model.
Topics: Action Potentials; Adrenergic alpha-Agonists; Angiotensin II; Animals; Anti-Arrhythmia Agents; Blood | 2008 |
Antifibrillatory effects of clofilium in the rabbit isolated heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Decanoic Acids; Disease Models, Animal; Glyburid | 1994 |
Clofilium in the isolated perfused rabbit heart: a new model to study proarrhythmia induced by class III antiarrhythmic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Electrocardiography; | 1998 |
Role of sodium in contrast medium-induced polymorphic ventricular tachycardia: results in a rabbit model of lengthened QT interval.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Contrast Media; Coronary Angiography; Co | 1998 |
Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, An | 2000 |
Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes.
Topics: Animals; Arrhythmias, Cardiac; Calmodulin; Disease Models, Animal; Electrocardiography; Enzyme Inhib | 2002 |
Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes.
Topics: Animals; Antimalarials; Disease Models, Animal; Electrocardiography; Histamine Antagonists; Male; Ph | 2002 |
QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Chloralose; Disea | 1990 |
A dual model for cardiac arrhythmias: coexistence of re-entry and abnormal automaticity and effects of antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Female; Flecain | 1989 |
Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death.
Topics: Animals; Anti-Arrhythmia Agents; Body Weight; Bretylium Tosylate; Death, Sudden; Disease Models, Ani | 1986 |