clofilium has been researched along with Bradycardia in 3 studies
clofilium: RN given refers to parent cpd; structure
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bradycardia is a risk factor for the development of torsade de pointes (TdP)." | 1.35 | Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model. ( Coker, SJ; Dempster, J; Farkas, A, 2008) |
| "In the d,l-sotalol- and erythromycin-treated hearts, torsades de pointes occurred only in the presence of hypokalemia and bradycardia, whereas, in the presence of clofilium, bradycardia alone caused torsades de pointes." | 1.30 | Drug-related torsades de pointes in the isolated rabbit heart: comparison of clofilium, d,l-sotalol, and erythromycin. ( Borggrefe, M; Breithardt, G; Clague, JR; Eckardt, L; Haverkamp, W; Johna, R; Mertens, H, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Farkas, A | 1 |
| Dempster, J | 1 |
| Coker, SJ | 1 |
| Yamagishi, T | 1 |
| Ishii, K | 1 |
| Taira, N | 1 |
| Eckardt, L | 1 |
| Haverkamp, W | 1 |
| Mertens, H | 1 |
| Johna, R | 1 |
| Clague, JR | 1 |
| Borggrefe, M | 1 |
| Breithardt, G | 1 |
3 other studies available for clofilium and Bradycardia
| Article | Year |
|---|---|
Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model.
Topics: Action Potentials; Adrenergic alpha-Agonists; Angiotensin II; Animals; Anti-Arrhythmia Agents; Blood | 2008 |
Antiarrhythmic and bradycardic drugs inhibit currents of cloned K+ channels, KV1.2 and KV1.4.
Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Cloning, Molecular; Disopyramide; Dose-Response Relati | 1995 |
Drug-related torsades de pointes in the isolated rabbit heart: comparison of clofilium, d,l-sotalol, and erythromycin.
Topics: Animals; Bradycardia; Electrocardiography; Erythromycin; Hypokalemia; In Vitro Techniques; Male; Qua | 1998 |