clofilium has been researched along with Arrhythmias, Cardiac in 13 studies
clofilium: RN given refers to parent cpd; structure
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In adrenergically stimulated anesthetized rabbits, azimilide, clofilium, dofetilide, sematilide, and d,l-sotalol caused premature ventricular contractions and nonsustained and sustained ventricular tachyarrhythmias (NSVT and SVT) at pharmacologically equivalent intravenous doses that increased QTc intervals 20% (ED20)." | 7.70 | Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. ( Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE, 2000) |
| "The total incidences of torsade de pointes were 60%*, 20%, 0% and 0% in clofilium-, terikalant-, erythromycin- and vehicle-treated animals, respectively (*P < 0." | 5.31 | Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model. ( Coker, SJ; Farkas, A, 2002) |
| " In adrenergically stimulated anesthetized rabbits, azimilide, clofilium, dofetilide, sematilide, and d,l-sotalol caused premature ventricular contractions and nonsustained and sustained ventricular tachyarrhythmias (NSVT and SVT) at pharmacologically equivalent intravenous doses that increased QTc intervals 20% (ED20)." | 3.70 | Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. ( Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE, 2000) |
| "When low doses of clofilium were administered to conscious rabbits, ventricular tachyarrhythmia (VT) with features typical of torsades de pointes developed." | 3.68 | QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions. ( Almgren, O; Carlsson, L; Duker, G, 1990) |
| "Clofilium, a new quaternary ammonium antiarrhythmic without apparent ganglion-blocking effect, was evaluated in 25 patients, 22 with a history of ventricular arrhythmias and three with paroxysmal supraventricular arrhythmias." | 3.67 | Dose-ranging studies of clofilium, an antiarrhythmic quaternary ammonium. ( Platia, EV; Reid, PR, 1984) |
| "The total incidences of torsade de pointes were 60%*, 20%, 0% and 0% in clofilium-, terikalant-, erythromycin- and vehicle-treated animals, respectively (*P < 0." | 1.31 | Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model. ( Coker, SJ; Farkas, A, 2002) |
| "1." | 1.28 | A dual model for cardiac arrhythmias: coexistence of re-entry and abnormal automaticity and effects of antiarrhythmic agents. ( Hunter, T; Proakis, A; Wu, KM, 1989) |
| "Clofilium is a model for an antiarrhythmic drug which should be useful in interrupting or suppressing reentrant arrhythmias because it increases refractoriness without major changes in conduction time." | 1.27 | Prolongation of cardiac refractory times in man by clofilium phosphate, a new antiarrhythmic agent. ( Cobb, LA; Greene, HL; Gross, BW; Sears, GK; Trobaugh, GB; Werner, JA, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Papp, H | 1 |
| Sarusi, A | 1 |
| Farkas, AS | 1 |
| Takacs, H | 1 |
| Kui, P | 1 |
| Vincze, D | 1 |
| Ivany, E | 1 |
| Varro, A | 1 |
| Papp, JG | 1 |
| Forster, T | 1 |
| Farkas, A | 2 |
| Belardinelli, L | 1 |
| Liu, G | 1 |
| Smith-Maxwell, C | 1 |
| Wang, WQ | 1 |
| El-Bizri, N | 1 |
| Hirakawa, R | 1 |
| Karpinski, S | 1 |
| Li, CH | 1 |
| Hu, L | 1 |
| Li, XJ | 1 |
| Crumb, W | 1 |
| Wu, L | 1 |
| Koltun, D | 1 |
| Zablocki, J | 1 |
| Yao, L | 1 |
| Dhalla, AK | 1 |
| Rajamani, S | 1 |
| Shryock, JC | 1 |
| Coker, SJ | 1 |
| Platia, EV | 1 |
| Reid, PR | 1 |
| Greene, HL | 1 |
| Werner, JA | 1 |
| Gross, BW | 1 |
| Sears, GK | 1 |
| Trobaugh, GB | 1 |
| Cobb, LA | 1 |
| D'Alonzo, AJ | 1 |
| Hess, TA | 1 |
| Darbenzio, RB | 1 |
| Sewter, JC | 1 |
| Johna, R | 1 |
| Mertens, H | 1 |
| Haverkamp, W | 1 |
| Eckardt, L | 1 |
| Niederbröker, T | 1 |
| Borggrefe, M | 1 |
| Breithardt, G | 1 |
| White, CM | 1 |
| Xie, J | 1 |
| Chow, MS | 1 |
| Kluger, J | 1 |
| Brooks, RR | 1 |
| Drexler, AP | 1 |
| Maynard, AE | 1 |
| Al-Khalidi, H | 1 |
| Kostreva, DR | 1 |
| Gbadebo, TD | 1 |
| Trimble, RW | 1 |
| Khoo, MS | 1 |
| Temple, J | 1 |
| Roden, DM | 1 |
| Anderson, ME | 1 |
| Carlsson, L | 1 |
| Almgren, O | 1 |
| Duker, G | 1 |
| Wu, KM | 1 |
| Hunter, T | 1 |
| Proakis, A | 1 |
| Kelliher, GJ | 1 |
| Kowey, P | 1 |
| Engel, T | 1 |
| Wetstein, L | 1 |
1 review available for clofilium and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Clinical pharmacology of antiarrhythmic agents.
Topics: Adrenergic beta-Antagonists; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamid | 1985 |
12 other studies available for clofilium and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Hyperventilation assists proarrhythmia development during delayed repolarization in clofilium-treated, anaesthetized, mechanically ventilated rabbits.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood G | 2016 |
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias.
Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic | 2013 |
Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Anti-Bacte | 2002 |
Dose-ranging studies of clofilium, an antiarrhythmic quaternary ammonium.
Topics: Adult; Aged; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Evaluation; Electrophysiol | 1984 |
Prolongation of cardiac refractory times in man by clofilium phosphate, a new antiarrhythmic agent.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrioventricular Node; Bundle of His; Dru | 1983 |
Effects of intracoronary glyburide on cesium-induced arrhythmias in anesthetized dogs.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cesium; Coronary Circula | 1994 |
Clofilium in the isolated perfused rabbit heart: a new model to study proarrhythmia induced by class III antiarrhythmic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Electrocardiography; | 1998 |
Prophylactic magnesium to decrease the arrhythmogenic potential of class III antiarrhythmic agents in a rabbit model.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Magnesium; M | 1999 |
Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, An | 2000 |
Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes.
Topics: Animals; Arrhythmias, Cardiac; Calmodulin; Disease Models, Animal; Electrocardiography; Enzyme Inhib | 2002 |
QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Chloralose; Disea | 1990 |
A dual model for cardiac arrhythmias: coexistence of re-entry and abnormal automaticity and effects of antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Female; Flecain | 1989 |