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clofilium and Arrhythmia

clofilium has been researched along with Arrhythmia in 13 studies

clofilium: RN given refers to parent cpd; structure

Research Excerpts

ExcerptRelevanceReference
" In adrenergically stimulated anesthetized rabbits, azimilide, clofilium, dofetilide, sematilide, and d,l-sotalol caused premature ventricular contractions and nonsustained and sustained ventricular tachyarrhythmias (NSVT and SVT) at pharmacologically equivalent intravenous doses that increased QTc intervals 20% (ED20)."7.70Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. ( Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE, 2000)
"The total incidences of torsade de pointes were 60%*, 20%, 0% and 0% in clofilium-, terikalant-, erythromycin- and vehicle-treated animals, respectively (*P < 0."5.31Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model. ( Coker, SJ; Farkas, A, 2002)
" In adrenergically stimulated anesthetized rabbits, azimilide, clofilium, dofetilide, sematilide, and d,l-sotalol caused premature ventricular contractions and nonsustained and sustained ventricular tachyarrhythmias (NSVT and SVT) at pharmacologically equivalent intravenous doses that increased QTc intervals 20% (ED20)."3.70Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. ( Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE, 2000)
"When low doses of clofilium were administered to conscious rabbits, ventricular tachyarrhythmia (VT) with features typical of torsades de pointes developed."3.68QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions. ( Almgren, O; Carlsson, L; Duker, G, 1990)
"Clofilium, a new quaternary ammonium antiarrhythmic without apparent ganglion-blocking effect, was evaluated in 25 patients, 22 with a history of ventricular arrhythmias and three with paroxysmal supraventricular arrhythmias."3.67Dose-ranging studies of clofilium, an antiarrhythmic quaternary ammonium. ( Platia, EV; Reid, PR, 1984)
"The total incidences of torsade de pointes were 60%*, 20%, 0% and 0% in clofilium-, terikalant-, erythromycin- and vehicle-treated animals, respectively (*P < 0."1.31Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model. ( Coker, SJ; Farkas, A, 2002)
"1."1.28A dual model for cardiac arrhythmias: coexistence of re-entry and abnormal automaticity and effects of antiarrhythmic agents. ( Hunter, T; Proakis, A; Wu, KM, 1989)
"Clofilium is a model for an antiarrhythmic drug which should be useful in interrupting or suppressing reentrant arrhythmias because it increases refractoriness without major changes in conduction time."1.27Prolongation of cardiac refractory times in man by clofilium phosphate, a new antiarrhythmic agent. ( Cobb, LA; Greene, HL; Gross, BW; Sears, GK; Trobaugh, GB; Werner, JA, 1983)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19904 (30.77)18.7374
1990's4 (30.77)18.2507
2000's3 (23.08)29.6817
2010's2 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Papp, H1
Sarusi, A1
Farkas, AS1
Takacs, H1
Kui, P1
Vincze, D1
Ivany, E1
Varro, A1
Papp, JG1
Forster, T1
Farkas, A2
Belardinelli, L1
Liu, G1
Smith-Maxwell, C1
Wang, WQ1
El-Bizri, N1
Hirakawa, R1
Karpinski, S1
Li, CH1
Hu, L1
Li, XJ1
Crumb, W1
Wu, L1
Koltun, D1
Zablocki, J1
Yao, L1
Dhalla, AK1
Rajamani, S1
Shryock, JC1
Coker, SJ1
Platia, EV1
Reid, PR1
Greene, HL1
Werner, JA1
Gross, BW1
Sears, GK1
Trobaugh, GB1
Cobb, LA1
D'Alonzo, AJ1
Hess, TA1
Darbenzio, RB1
Sewter, JC1
Johna, R1
Mertens, H1
Haverkamp, W1
Eckardt, L1
Niederbröker, T1
Borggrefe, M1
Breithardt, G1
White, CM1
Xie, J1
Chow, MS1
Kluger, J1
Brooks, RR1
Drexler, AP1
Maynard, AE1
Al-Khalidi, H1
Kostreva, DR1
Gbadebo, TD1
Trimble, RW1
Khoo, MS1
Temple, J1
Roden, DM1
Anderson, ME1
Carlsson, L1
Almgren, O1
Duker, G1
Wu, KM1
Hunter, T1
Proakis, A1
Kelliher, GJ1
Kowey, P1
Engel, T1
Wetstein, L1

Reviews

1 review available for clofilium and Arrhythmia

ArticleYear
Clinical pharmacology of antiarrhythmic agents.
    Cardiovascular clinics, 1985, Volume: 16, Issue:1

    Topics: Adrenergic beta-Antagonists; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamid

1985

Other Studies

12 other studies available for clofilium and Arrhythmia

ArticleYear
Hyperventilation assists proarrhythmia development during delayed repolarization in clofilium-treated, anaesthetized, mechanically ventilated rabbits.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2016, Volume: 67, Issue:5

    Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood G

2016
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1

    Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic

2013
Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model.
    European journal of pharmacology, 2002, Aug-02, Volume: 449, Issue:1-2

    Topics: Action Potentials; Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Anti-Bacte

2002
Dose-ranging studies of clofilium, an antiarrhythmic quaternary ammonium.
    Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:2

    Topics: Adult; Aged; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Evaluation; Electrophysiol

1984
Prolongation of cardiac refractory times in man by clofilium phosphate, a new antiarrhythmic agent.
    American heart journal, 1983, Volume: 106, Issue:3

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrioventricular Node; Bundle of His; Dru

1983
Effects of intracoronary glyburide on cesium-induced arrhythmias in anesthetized dogs.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:3

    Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cesium; Coronary Circula

1994
Clofilium in the isolated perfused rabbit heart: a new model to study proarrhythmia induced by class III antiarrhythmic drugs.
    Basic research in cardiology, 1998, Volume: 93, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Electrocardiography;

1998
Prophylactic magnesium to decrease the arrhythmogenic potential of class III antiarrhythmic agents in a rabbit model.
    Pharmacotherapy, 1999, Volume: 19, Issue:5

    Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Magnesium; M

1999
Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 223, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, An

2000
Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes.
    Circulation, 2002, Feb-12, Volume: 105, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Calmodulin; Disease Models, Animal; Electrocardiography; Enzyme Inhib

2002
QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions.
    Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:2

    Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Chloralose; Disea

1990
A dual model for cardiac arrhythmias: coexistence of re-entry and abnormal automaticity and effects of antiarrhythmic agents.
    British journal of pharmacology, 1989, Volume: 98, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Female; Flecain

1989