clofilium has been researched along with Arrhythmia in 13 studies
clofilium: RN given refers to parent cpd; structure
| Excerpt | Relevance | Reference |
|---|---|---|
| " In adrenergically stimulated anesthetized rabbits, azimilide, clofilium, dofetilide, sematilide, and d,l-sotalol caused premature ventricular contractions and nonsustained and sustained ventricular tachyarrhythmias (NSVT and SVT) at pharmacologically equivalent intravenous doses that increased QTc intervals 20% (ED20)." | 7.70 | Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. ( Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE, 2000) |
| "The total incidences of torsade de pointes were 60%*, 20%, 0% and 0% in clofilium-, terikalant-, erythromycin- and vehicle-treated animals, respectively (*P < 0." | 5.31 | Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model. ( Coker, SJ; Farkas, A, 2002) |
| " In adrenergically stimulated anesthetized rabbits, azimilide, clofilium, dofetilide, sematilide, and d,l-sotalol caused premature ventricular contractions and nonsustained and sustained ventricular tachyarrhythmias (NSVT and SVT) at pharmacologically equivalent intravenous doses that increased QTc intervals 20% (ED20)." | 3.70 | Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. ( Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE, 2000) |
| "When low doses of clofilium were administered to conscious rabbits, ventricular tachyarrhythmia (VT) with features typical of torsades de pointes developed." | 3.68 | QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions. ( Almgren, O; Carlsson, L; Duker, G, 1990) |
| "Clofilium, a new quaternary ammonium antiarrhythmic without apparent ganglion-blocking effect, was evaluated in 25 patients, 22 with a history of ventricular arrhythmias and three with paroxysmal supraventricular arrhythmias." | 3.67 | Dose-ranging studies of clofilium, an antiarrhythmic quaternary ammonium. ( Platia, EV; Reid, PR, 1984) |
| "The total incidences of torsade de pointes were 60%*, 20%, 0% and 0% in clofilium-, terikalant-, erythromycin- and vehicle-treated animals, respectively (*P < 0." | 1.31 | Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model. ( Coker, SJ; Farkas, A, 2002) |
| "1." | 1.28 | A dual model for cardiac arrhythmias: coexistence of re-entry and abnormal automaticity and effects of antiarrhythmic agents. ( Hunter, T; Proakis, A; Wu, KM, 1989) |
| "Clofilium is a model for an antiarrhythmic drug which should be useful in interrupting or suppressing reentrant arrhythmias because it increases refractoriness without major changes in conduction time." | 1.27 | Prolongation of cardiac refractory times in man by clofilium phosphate, a new antiarrhythmic agent. ( Cobb, LA; Greene, HL; Gross, BW; Sears, GK; Trobaugh, GB; Werner, JA, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Papp, H | 1 |
| Sarusi, A | 1 |
| Farkas, AS | 1 |
| Takacs, H | 1 |
| Kui, P | 1 |
| Vincze, D | 1 |
| Ivany, E | 1 |
| Varro, A | 1 |
| Papp, JG | 1 |
| Forster, T | 1 |
| Farkas, A | 2 |
| Belardinelli, L | 1 |
| Liu, G | 1 |
| Smith-Maxwell, C | 1 |
| Wang, WQ | 1 |
| El-Bizri, N | 1 |
| Hirakawa, R | 1 |
| Karpinski, S | 1 |
| Li, CH | 1 |
| Hu, L | 1 |
| Li, XJ | 1 |
| Crumb, W | 1 |
| Wu, L | 1 |
| Koltun, D | 1 |
| Zablocki, J | 1 |
| Yao, L | 1 |
| Dhalla, AK | 1 |
| Rajamani, S | 1 |
| Shryock, JC | 1 |
| Coker, SJ | 1 |
| Platia, EV | 1 |
| Reid, PR | 1 |
| Greene, HL | 1 |
| Werner, JA | 1 |
| Gross, BW | 1 |
| Sears, GK | 1 |
| Trobaugh, GB | 1 |
| Cobb, LA | 1 |
| D'Alonzo, AJ | 1 |
| Hess, TA | 1 |
| Darbenzio, RB | 1 |
| Sewter, JC | 1 |
| Johna, R | 1 |
| Mertens, H | 1 |
| Haverkamp, W | 1 |
| Eckardt, L | 1 |
| Niederbröker, T | 1 |
| Borggrefe, M | 1 |
| Breithardt, G | 1 |
| White, CM | 1 |
| Xie, J | 1 |
| Chow, MS | 1 |
| Kluger, J | 1 |
| Brooks, RR | 1 |
| Drexler, AP | 1 |
| Maynard, AE | 1 |
| Al-Khalidi, H | 1 |
| Kostreva, DR | 1 |
| Gbadebo, TD | 1 |
| Trimble, RW | 1 |
| Khoo, MS | 1 |
| Temple, J | 1 |
| Roden, DM | 1 |
| Anderson, ME | 1 |
| Carlsson, L | 1 |
| Almgren, O | 1 |
| Duker, G | 1 |
| Wu, KM | 1 |
| Hunter, T | 1 |
| Proakis, A | 1 |
| Kelliher, GJ | 1 |
| Kowey, P | 1 |
| Engel, T | 1 |
| Wetstein, L | 1 |
1 review available for clofilium and Arrhythmia
| Article | Year |
|---|---|
Clinical pharmacology of antiarrhythmic agents.
Topics: Adrenergic beta-Antagonists; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamid | 1985 |
12 other studies available for clofilium and Arrhythmia
| Article | Year |
|---|---|
Hyperventilation assists proarrhythmia development during delayed repolarization in clofilium-treated, anaesthetized, mechanically ventilated rabbits.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood G | 2016 |
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias.
Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic | 2013 |
Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Anti-Bacte | 2002 |
Dose-ranging studies of clofilium, an antiarrhythmic quaternary ammonium.
Topics: Adult; Aged; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Evaluation; Electrophysiol | 1984 |
Prolongation of cardiac refractory times in man by clofilium phosphate, a new antiarrhythmic agent.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrioventricular Node; Bundle of His; Dru | 1983 |
Effects of intracoronary glyburide on cesium-induced arrhythmias in anesthetized dogs.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cesium; Coronary Circula | 1994 |
Clofilium in the isolated perfused rabbit heart: a new model to study proarrhythmia induced by class III antiarrhythmic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Electrocardiography; | 1998 |
Prophylactic magnesium to decrease the arrhythmogenic potential of class III antiarrhythmic agents in a rabbit model.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Magnesium; M | 1999 |
Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, An | 2000 |
Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes.
Topics: Animals; Arrhythmias, Cardiac; Calmodulin; Disease Models, Animal; Electrocardiography; Enzyme Inhib | 2002 |
QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Chloralose; Disea | 1990 |
A dual model for cardiac arrhythmias: coexistence of re-entry and abnormal automaticity and effects of antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Female; Flecain | 1989 |