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clofibric acid and Precancerous Conditions

clofibric acid has been researched along with Precancerous Conditions in 9 studies

Clofibric Acid: An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
clofibric acid : A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.

Precancerous Conditions: Pathological conditions that tend eventually to become malignant.

Research Excerpts

ExcerptRelevanceReference
"Clofibric acid (CLO) is a nongenotoxic hepatocarcinogen in rodents that causes altered hepatocellular foci and/or neoplasms."1.34Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat. ( Boitier, E; Desdouets, C; Isaacs, KR; Michel, C; Roberts, RA; Slaoui, M, 2007)
"Clofibrate (CF) was therefore administered for 2 or 4 weeks following performance of the Solt-Farber protocol using diethylnitrosamine and 2-acetylaminofluorene."1.29Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase. ( Hatayama, I; Sato, K; Tsuchida, S; Yokoyama, Y, 1993)
"In ciprofibrate-treated animals 52% and 75% of AA were negative for GST-P and GGT, respectively, and 16% was positive for both the enzymes."1.27Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase. ( Ito, N; Rao, MS; Reddy, JK; Subbarao, V; Tatematsu, M, 1986)
"Altered areas (AA), neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced by chronic administration of ciprofibrate and Wy-14,643 were examined for iron accumulation after systemic iron overload."1.27Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats. ( Rao, MS; Reddy, JK; Subbarao, V, 1986)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19906 (66.67)18.7374
1990's2 (22.22)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Michel, C1
Desdouets, C1
Slaoui, M1
Isaacs, KR1
Roberts, RA1
Boitier, E1
Yokoyama, Y1
Tsuchida, S1
Hatayama, I1
Sato, K1
Roomi, MW2
Farber, E2
Parke, DV1
Yeldandi, AV1
Subbarao, V4
Rajan, A1
Reddy, JK4
Rao, MS5
Tatematsu, M1
Ito, N1
Mitranic, MM1
Moscarello, MA1
Wirth, PJ1
Evarts, RP1

Other Studies

9 other studies available for clofibric acid and Precancerous Conditions

ArticleYear
Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 99, Issue:1

    Topics: Alkylating Agents; Animals; Anticholesteremic Agents; Carcinogens; Clofibric Acid; Cocarcinogenesis;

2007
Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase.
    Carcinogenesis, 1993, Volume: 14, Issue:3

    Topics: Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Dexamethasone; Enoyl-CoA Hydratase; Enzyme Ind

1993
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
    Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:9

    Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Carcinogens; Clofibric Acid; Cocarcinogen

1997
gamma-Glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration.
    Carcinogenesis, 1989, Volume: 10, Issue:4

    Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase;

1989
Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase.
    Cancer research, 1986, Volume: 46, Issue:10

    Topics: Animals; Cell Division; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Glutathione Transfe

1986
Peroxisome proliferator-induced hepatocarcinogenesis: histochemical analysis of ciprofibrate-induced preneoplastic and neoplastic lesions for gamma-glutamyl transpeptidase activity.
    Journal of the National Cancer Institute, 1986, Volume: 77, Issue:4

    Topics: Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Histocytochemistry; Li

1986
The galactosyltransferase activity of hepatic nodules during rat liver carcinogenesis.
    Cancer letters, 1988, Dec-01, Volume: 43, Issue:1-2

    Topics: Animals; Clofibric Acid; Fibric Acids; Galactosyltransferases; Kinetics; Liver Neoplasms; Precancero

1988
Coordinate polypeptide expression during hepatocarcinogenesis in male F-344 rats: comparison of the Solt-Farber and Reddy models.
    Cancer research, 1987, Jun-01, Volume: 47, Issue:11

    Topics: Animals; Clofibric Acid; Computers; Cytosol; Diethylnitrosamine; Dihydrolipoamide Dehydrogenase; Dis

1987
Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats.
    Cancer letters, 1986, Volume: 32, Issue:1

    Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Iron; Liver; Liver Neoplasms, Expe

1986