clofibric acid has been researched along with Precancerous Conditions in 9 studies
Clofibric Acid: An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
clofibric acid : A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
Excerpt | Relevance | Reference |
---|---|---|
"Clofibric acid (CLO) is a nongenotoxic hepatocarcinogen in rodents that causes altered hepatocellular foci and/or neoplasms." | 1.34 | Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat. ( Boitier, E; Desdouets, C; Isaacs, KR; Michel, C; Roberts, RA; Slaoui, M, 2007) |
"Clofibrate (CF) was therefore administered for 2 or 4 weeks following performance of the Solt-Farber protocol using diethylnitrosamine and 2-acetylaminofluorene." | 1.29 | Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase. ( Hatayama, I; Sato, K; Tsuchida, S; Yokoyama, Y, 1993) |
"In ciprofibrate-treated animals 52% and 75% of AA were negative for GST-P and GGT, respectively, and 16% was positive for both the enzymes." | 1.27 | Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase. ( Ito, N; Rao, MS; Reddy, JK; Subbarao, V; Tatematsu, M, 1986) |
"Altered areas (AA), neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced by chronic administration of ciprofibrate and Wy-14,643 were examined for iron accumulation after systemic iron overload." | 1.27 | Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats. ( Rao, MS; Reddy, JK; Subbarao, V, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (66.67) | 18.7374 |
1990's | 2 (22.22) | 18.2507 |
2000's | 1 (11.11) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Michel, C | 1 |
Desdouets, C | 1 |
Slaoui, M | 1 |
Isaacs, KR | 1 |
Roberts, RA | 1 |
Boitier, E | 1 |
Yokoyama, Y | 1 |
Tsuchida, S | 1 |
Hatayama, I | 1 |
Sato, K | 1 |
Roomi, MW | 2 |
Farber, E | 2 |
Parke, DV | 1 |
Yeldandi, AV | 1 |
Subbarao, V | 4 |
Rajan, A | 1 |
Reddy, JK | 4 |
Rao, MS | 5 |
Tatematsu, M | 1 |
Ito, N | 1 |
Mitranic, MM | 1 |
Moscarello, MA | 1 |
Wirth, PJ | 1 |
Evarts, RP | 1 |
9 other studies available for clofibric acid and Precancerous Conditions
Article | Year |
---|---|
Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Anticholesteremic Agents; Carcinogens; Clofibric Acid; Cocarcinogenesis; | 2007 |
Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase.
Topics: Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Dexamethasone; Enoyl-CoA Hydratase; Enzyme Ind | 1993 |
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Carcinogens; Clofibric Acid; Cocarcinogen | 1997 |
gamma-Glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; | 1989 |
Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase.
Topics: Animals; Cell Division; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Glutathione Transfe | 1986 |
Peroxisome proliferator-induced hepatocarcinogenesis: histochemical analysis of ciprofibrate-induced preneoplastic and neoplastic lesions for gamma-glutamyl transpeptidase activity.
Topics: Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Histocytochemistry; Li | 1986 |
The galactosyltransferase activity of hepatic nodules during rat liver carcinogenesis.
Topics: Animals; Clofibric Acid; Fibric Acids; Galactosyltransferases; Kinetics; Liver Neoplasms; Precancero | 1988 |
Coordinate polypeptide expression during hepatocarcinogenesis in male F-344 rats: comparison of the Solt-Farber and Reddy models.
Topics: Animals; Clofibric Acid; Computers; Cytosol; Diethylnitrosamine; Dihydrolipoamide Dehydrogenase; Dis | 1987 |
Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Iron; Liver; Liver Neoplasms, Expe | 1986 |