clofibric acid has been researched along with Liver Neoplasms in 18 studies
Clofibric Acid: An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
clofibric acid : A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have examined the ability of HepG2 human hepatoblastoma cells and 7800 C1 Morris rat hepatoma cells to convert 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid (THCA) and 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid (DHCA) to cholic acid and chenodeoxycholic acid, respectively." | 3.68 | Human hepatoblastoma cells (HepG2) and rat hepatoma cells are defective in important enzyme activities in the oxidation of the C27 steroid side chain in bile acid formation. ( Farrants, AK; Nilsson, A; Pedersen, JI, 1993) |
| "Ciprofibrate was more toxic to Fao cells than to MH1C1 and HepG2 cells which is also the order of the acyl-CoA oxidase stimulation by ciprofibrate." | 1.29 | Stimulation of peroxisomal palmitoyl-CoA oxidase activity by ciprofibrate in hepatic cell lines: comparative studies in Fao, MH1C1 and HepG2 cells. ( Bournot, P; Brocard, C; Es-Souni, M; Latruffe, N; Ramirez, LC, 1993) |
| " Thus, in contrast to the non-mutagenicity of peroxisome proliferators in short-term assays, chronic administration of these compounds led to DNA alterations that were detectable by 32P-postlabeling assay." | 1.28 | Induction of rat liver DNA alterations by chronic administration of peroxisome proliferators as detected by 32P-postlabeling. ( Danna, TF; Randerath, E; Randerath, K; Rao, MS; Reddy, JK; Reddy, R, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 10 (55.56) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meyer, K | 1 |
| Lee, JS | 1 |
| Dyck, PA | 1 |
| Cao, WQ | 1 |
| Rao, MS | 4 |
| Thorgeirsson, SS | 1 |
| Reddy, JK | 6 |
| Thibaut, R | 1 |
| Porte, C | 1 |
| Chung, C | 1 |
| Doll, JA | 1 |
| Stellmach, VM | 1 |
| Gonzales, J | 1 |
| Surapureddi, S | 1 |
| Cornwell, M | 1 |
| Crawford, SE | 1 |
| Lalwani, ND | 1 |
| Watanabe, TK | 1 |
| Farrants, AK | 1 |
| Nilsson, A | 1 |
| Pedersen, JI | 1 |
| Brocard, C | 1 |
| Es-Souni, M | 1 |
| Ramirez, LC | 2 |
| Latruffe, N | 2 |
| Bournot, P | 2 |
| Passilly, P | 1 |
| Jannin, B | 1 |
| Hassell, SJ | 1 |
| Duclos, S | 1 |
| Bride, J | 1 |
| Herbert, JM | 1 |
| Bernat, A | 1 |
| Chatenet-Duchène, L | 1 |
| Bécuwe, P | 2 |
| Bianchi, A | 2 |
| Keller, JM | 2 |
| Dauça, M | 2 |
| Collet, P | 1 |
| Domenjoud, L | 1 |
| Lindroos, P | 1 |
| Tsai, WH | 1 |
| Zarnegar, R | 1 |
| Michalopoulos, GK | 1 |
| Randerath, E | 1 |
| Randerath, K | 1 |
| Reddy, R | 1 |
| Danna, TF | 1 |
| Nilsson, R | 1 |
| Beije, B | 1 |
| Préat, V | 1 |
| Erixon, K | 1 |
| Ramel, C | 1 |
| Fox, TR | 1 |
| Schumann, AM | 1 |
| Watanabe, PG | 1 |
| Yano, BL | 1 |
| Maher, VM | 1 |
| McCormick, JJ | 1 |
| Yeldandi, AV | 1 |
| Subbarao, V | 1 |
| Rajan, A | 1 |
| Roomi, MW | 1 |
| Mitranic, MM | 1 |
| Farber, E | 1 |
| Moscarello, MA | 1 |
| Gupta, RC | 1 |
| Goel, SK | 1 |
| Earley, K | 1 |
| Singh, B | 1 |
18 other studies available for clofibric acid and Liver Neoplasms
| Article | Year |
|---|---|
Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen.
Topics: Acyl Coenzyme A; Acyl-CoA Oxidase; Animals; Biomarkers, Tumor; Blotting, Northern; Carcinoma, Hepato | 2003 |
Effects of fibrates, anti-inflammatory drugs and antidepressants in the fish hepatoma cell line PLHC-1: cytotoxicity and interactions with cytochrome P450 1A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carcinoma, Hepatocellular; | 2008 |
Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Movement; Chromans; Clofibric Acid; Endothelium, Vascu | 2008 |
Inhibitory effect of antioxidants ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator.
Topics: Animals; Anisoles; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinogens; Clofibrate; Clo | 1984 |
Human hepatoblastoma cells (HepG2) and rat hepatoma cells are defective in important enzyme activities in the oxidation of the C27 steroid side chain in bile acid formation.
Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Cholestanols; Cholesterol 7-alpha-Hydroxylase; | 1993 |
Stimulation of peroxisomal palmitoyl-CoA oxidase activity by ciprofibrate in hepatic cell lines: comparative studies in Fao, MH1C1 and HepG2 cells.
Topics: Animals; Carcinoma, Hepatocellular; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents; Live | 1993 |
Human HepG2 and rat Fao hepatic-derived cell lines show different responses to ciprofibrate, a peroxisome proliferator: analysis by flow cytometry.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cell Size; Clofibric Acid; Cytoplasmi | 1996 |
Peroxisome proliferation and beta-oxidation in Fao and MH1C1 rat hepatoma cells, HepG2 human hepatoblastoma cells and cultured human hepatocytes: effect of ciprofibrate.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Cells, Cultured; Clofibric Acid; Enoyl-CoA Hydratase; Fen | 1997 |
Effect of ciprofibrate on fibrinogen synthesis in vitro on hepatoma cells and in vivo in genetically obese Zucker rats.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Clofibric Acid; Dose-Response Relationshi | 1999 |
Effects of the peroxisome proliferator clofibric acid on superoxide dismutase expression in the human HepG2 hepatoma cell line.
Topics: Apoproteins; Carcinoma, Hepatocellular; Clofibric Acid; DNA; Gene Expression; Humans; Lipid Peroxida | 1999 |
Clofibric acid down-regulation of metallothionein IIA in HepG2 human hepatoma cells.
Topics: Carcinoma, Hepatocellular; Clofibric Acid; Down-Regulation; Gene Expression Regulation; Humans; Hypo | 2002 |
Plasma levels of HGF in rats treated with tumor promoters.
Topics: Animals; Carcinogens; Clofibric Acid; Fibric Acids; Growth Substances; Hepatocyte Growth Factor; Hex | 1992 |
Induction of rat liver DNA alterations by chronic administration of peroxisome proliferators as detected by 32P-postlabeling.
Topics: Affinity Labels; Animals; Clofibric Acid; DNA Damage; DNA, Neoplasm; Fibric Acids; Hypolipidemic Age | 1991 |
On the mechanism of the hepatocarcinogenicity of peroxisome proliferators.
Topics: Animals; Caprylates; Carcinogens; Clofibrate; Clofibric Acid; DNA; DNA Damage; DNA Repair; Fibric Ac | 1991 |
Mutational analysis of the H-ras oncogene in spontaneous C57BL/6 x C3H/He mouse liver tumors and tumors induced with genotoxic and nongenotoxic hepatocarcinogens.
Topics: Animals; Base Sequence; Benzidines; Chloroform; Clofibric Acid; Codon; DNA Mutational Analysis; DNA, | 1990 |
gamma-Glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; | 1989 |
The galactosyltransferase activity of hepatic nodules during rat liver carcinogenesis.
Topics: Animals; Clofibric Acid; Fibric Acids; Galactosyltransferases; Kinetics; Liver Neoplasms; Precancero | 1988 |
32P-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro.
Topics: Animals; Anticholesteremic Agents; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; | 1985 |