clofibric acid has been researched along with Cocarcinogenesis in 4 studies
Clofibric Acid: An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
clofibric acid : A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
Cocarcinogenesis: The combination of two or more different factors in the production of cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clofibric acid (CLO) is a nongenotoxic hepatocarcinogen in rodents that causes altered hepatocellular foci and/or neoplasms." | 1.34 | Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat. ( Boitier, E; Desdouets, C; Isaacs, KR; Michel, C; Roberts, RA; Slaoui, M, 2007) |
| "Ciprofibrate treatment did not increase the number or volume of altered hepatic foci (putative preneoplastic lesions)." | 1.28 | Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis. ( Clark, TD; Glauert, HP, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Michel, C | 1 |
| Desdouets, C | 1 |
| Slaoui, M | 1 |
| Isaacs, KR | 1 |
| Roberts, RA | 1 |
| Boitier, E | 1 |
| Roomi, MW | 1 |
| Farber, E | 1 |
| Parke, DV | 1 |
| Orellana, A | 1 |
| Hidalgo, PC | 1 |
| Morales, MN | 1 |
| Mezzano, D | 1 |
| Bronfman, M | 1 |
| Glauert, HP | 1 |
| Clark, TD | 1 |
4 other studies available for clofibric acid and Cocarcinogenesis
| Article | Year |
|---|---|
Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Anticholesteremic Agents; Carcinogens; Clofibric Acid; Cocarcinogenesis; | 2007 |
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Carcinogens; Clofibric Acid; Cocarcinogen | 1997 |
Palmitoyl-CoA and the acyl-CoA thioester of the carcinogenic peroxisome-proliferator ciprofibrate potentiate diacylglycerol-activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme.
Topics: Acyl Coenzyme A; Animals; Blood Platelets; Brain; Calcium; Clofibrate; Clofibric Acid; Cocarcinogene | 1990 |
Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis.
Topics: Animals; Clofibrate; Clofibric Acid; Cocarcinogenesis; Diet; Dose-Response Relationship, Drug; Femal | 1989 |