clofibric acid has been researched along with Chemical and Drug Induced Liver Injury in 8 studies
Clofibric Acid: An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
clofibric acid : A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study the influence of a four-week daily oral administration of 2 mg/kg body weight ciprofibrate (CAS 52214-84-3) or of 100 mg/kg body weight clofibric acid (CAS 882-09-7) was compared to that of the respective doses of their newly synthesized glycine conjugates in adult male lean and obese Zucker rats." | 3.74 | Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats. ( Deufel, T; Fleck, C; Karge, E; Lupp, A; Oelschlägers, H, 2008) |
| "A systematic review of cohort studies, randomized trials, voluntary notifications to national regulatory authorities, and published case reports was undertaken to assess the incidence and characteristics of adverse effects in patients treated with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins." | 2.43 | Statin safety: a systematic review. ( Law, M; Rudnicka, AR, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lupp, A | 1 |
| Karge, E | 1 |
| Deufel, T | 1 |
| Oelschlägers, H | 1 |
| Fleck, C | 1 |
| Suzuki, A | 1 |
| Yuen, N | 1 |
| Walsh, J | 1 |
| Papay, J | 1 |
| Hunt, CM | 1 |
| Diehl, AM | 1 |
| Pflumio, F | 1 |
| Andrès, E | 1 |
| Ubrich, M | 1 |
| Geisler, F | 1 |
| Imbs, JL | 1 |
| Di Liberatore, M | 1 |
| Law, M | 1 |
| Rudnicka, AR | 1 |
| Florentin, M | 1 |
| Liberopoulos, EN | 1 |
| Mikhailidis, DP | 1 |
| Elisaf, MS | 1 |
| Ganne-Carrié, N | 1 |
| de Leusse, A | 1 |
| Guettier, C | 1 |
| Castera, L | 1 |
| Levecq, H | 1 |
| Bertrand, HJ | 1 |
| Plumet, Y | 1 |
| Trinchet, JC | 1 |
| Beaugrand, M | 1 |
| Dumortier, J | 1 |
| Slim, R | 1 |
| Chevallier, M | 1 |
| Boillot, O | 1 |
| Thaunat, JL | 1 |
| Vaillant, E | 1 |
| Vial, T | 1 |
| Bellemin, B | 1 |
| Paliard, P | 1 |
| Scoazec, JY | 1 |
| Perault, MC | 1 |
| Fievre, JL | 1 |
| Dejean, C | 1 |
| Martin, A | 1 |
| Vandel, B | 1 |
2 reviews available for clofibric acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Statin safety: a systematic review.
Topics: Adverse Drug Reaction Reporting Systems; Chemical and Drug Induced Liver Injury; Clofibric Acid; Cre | 2006 |
Fibrate-associated adverse effects beyond muscle and liver toxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Clofibric Acid; Humans; L | 2008 |
6 other studies available for clofibric acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Clofibric Acid; Cytochrome P-450 Enzym | 2008 |
Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury.
Topics: Acetaminophen; Adrenergic Agonists; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensi | 2009 |
[Ciprofibrate-induced acute cholestatic hepatitis].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Clofibric Acid; Fibric Acids; Hu | 2003 |
[Autoimmune hepatitis induced by fibrates].
Topics: Aged; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Clofibric Acid; Female; Fenofibra | 1998 |
[Acute severe fibrosing hepatitis associated with ciprofibrate treatment].
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Clofibric Acid; Female; Fibric Acids; H | 1999 |
[Cytolytic hepatic damage caused by ciprofibrate].
Topics: Aged; Chemical and Drug Induced Liver Injury; Clofibric Acid; Female; Fibric Acids; Humans; Hypercho | 1992 |