clofibric acid has been researched along with Carcinoma, Hepatocellular in 9 studies
Clofibric Acid: An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
clofibric acid : A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alterations in DNA ploidy accompany hepatocellular carcinoma (HCC)." | 5.29 | Flow cytometric analysis of neoplastic nodules and hepatocellular carcinomas induced by ciprofibrate in the rat. ( Goolsby, CL; Rao, MS, 1996) |
| "Ciprofibrate was more toxic to Fao cells than to MH1C1 and HepG2 cells which is also the order of the acyl-CoA oxidase stimulation by ciprofibrate." | 1.29 | Stimulation of peroxisomal palmitoyl-CoA oxidase activity by ciprofibrate in hepatic cell lines: comparative studies in Fao, MH1C1 and HepG2 cells. ( Bournot, P; Brocard, C; Es-Souni, M; Latruffe, N; Ramirez, LC, 1993) |
| "Alterations in DNA ploidy accompany hepatocellular carcinoma (HCC)." | 1.29 | Flow cytometric analysis of neoplastic nodules and hepatocellular carcinomas induced by ciprofibrate in the rat. ( Goolsby, CL; Rao, MS, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meyer, K | 1 |
| Lee, JS | 1 |
| Dyck, PA | 1 |
| Cao, WQ | 1 |
| Rao, MS | 2 |
| Thorgeirsson, SS | 1 |
| Reddy, JK | 2 |
| Thibaut, R | 1 |
| Porte, C | 1 |
| Chung, C | 1 |
| Doll, JA | 1 |
| Stellmach, VM | 1 |
| Gonzales, J | 1 |
| Surapureddi, S | 1 |
| Cornwell, M | 1 |
| Crawford, SE | 1 |
| Brocard, C | 1 |
| Es-Souni, M | 1 |
| Ramirez, LC | 1 |
| Latruffe, N | 2 |
| Bournot, P | 1 |
| Goolsby, CL | 1 |
| Passilly, P | 1 |
| Jannin, B | 1 |
| Hassell, SJ | 1 |
| Herbert, JM | 1 |
| Bernat, A | 1 |
| Chatenet-Duchène, L | 1 |
| Bécuwe, P | 2 |
| Bianchi, A | 2 |
| Keller, JM | 2 |
| Dauça, M | 2 |
| Collet, P | 1 |
| Domenjoud, L | 1 |
9 other studies available for clofibric acid and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen.
Topics: Acyl Coenzyme A; Acyl-CoA Oxidase; Animals; Biomarkers, Tumor; Blotting, Northern; Carcinoma, Hepato | 2003 |
Effects of fibrates, anti-inflammatory drugs and antidepressants in the fish hepatoma cell line PLHC-1: cytotoxicity and interactions with cytochrome P450 1A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carcinoma, Hepatocellular; | 2008 |
Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Movement; Chromans; Clofibric Acid; Endothelium, Vascu | 2008 |
Stimulation of peroxisomal palmitoyl-CoA oxidase activity by ciprofibrate in hepatic cell lines: comparative studies in Fao, MH1C1 and HepG2 cells.
Topics: Animals; Carcinoma, Hepatocellular; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents; Live | 1993 |
Flow cytometric analysis of neoplastic nodules and hepatocellular carcinomas induced by ciprofibrate in the rat.
Topics: Aneuploidy; Animals; Carcinoma, Hepatocellular; Clofibric Acid; DNA, Neoplasm; Fibric Acids; Flow Cy | 1996 |
Human HepG2 and rat Fao hepatic-derived cell lines show different responses to ciprofibrate, a peroxisome proliferator: analysis by flow cytometry.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cell Size; Clofibric Acid; Cytoplasmi | 1996 |
Effect of ciprofibrate on fibrinogen synthesis in vitro on hepatoma cells and in vivo in genetically obese Zucker rats.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Clofibric Acid; Dose-Response Relationshi | 1999 |
Effects of the peroxisome proliferator clofibric acid on superoxide dismutase expression in the human HepG2 hepatoma cell line.
Topics: Apoproteins; Carcinoma, Hepatocellular; Clofibric Acid; DNA; Gene Expression; Humans; Lipid Peroxida | 1999 |
Clofibric acid down-regulation of metallothionein IIA in HepG2 human hepatoma cells.
Topics: Carcinoma, Hepatocellular; Clofibric Acid; Down-Regulation; Gene Expression Regulation; Humans; Hypo | 2002 |