clofibric acid has been researched along with Adverse Drug Event in 5 studies
Clofibric Acid: An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
clofibric acid : A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
| Excerpt | Relevance | Reference |
|---|---|---|
| "(1) Renal failure, either pre-existing or induced by a nephrotoxic drug, increases the risk of adverse effects in patients taking colchicine; (2) Combining colchicines with a macrolide (except for spiramycin) carries a risk of life-threatening pancytopenia; (3) Ciclosporin co-administration can aggravate the neuromuscular adverse effects of colchicine; (4) Combining colchicine with lipid-lowering drugs (statins and fibrates) can cause myopathy; (5) Several mechanisms have been implicated: competition for cytochrome P450 or P-glycoprotein, additive adverse effects (especially on muscle), and colchicine accumulation due to a reduction in its renal excretion; (6) Patients with gout should use colchicine only after failure of symptomatic treatment: ice application, paracetamol, and possibly ibuprofen, a nonsteroidal antiinflammatory drug with well-documented adverse effects; (7) If colchicine is nevertheless used, it should be at the minimum effective dose." | 3.74 | Colchicine: serious interactions. ( , 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wierzbicki, AS | 1 |
| Ferrari, B | 1 |
| Mons, R | 1 |
| Vollat, B | 1 |
| Fraysse, B | 1 |
| Paxéus, N | 1 |
| Lo Giudice, R | 1 |
| Pollio, A | 1 |
| Garric, J | 1 |
| Fountoulakis, M | 1 |
| Drillia, P | 1 |
| Stamatelatou, K | 1 |
| Lyberatos, G | 1 |
| Boyd, GR | 1 |
| Grimm, DA | 1 |
1 review available for clofibric acid and Adverse Drug Event
| Article | Year |
|---|---|
Fibrates: no ACCORD on their use in the treatment of dyslipidaemia.
Topics: Clinical Trials as Topic; Clofibric Acid; Drug Therapy, Combination; Drug-Related Side Effects and A | 2010 |
4 other studies available for clofibric acid and Adverse Drug Event
| Article | Year |
|---|---|
Colchicine: serious interactions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Clofibric Acid; Colchicine; Cycl | 2008 |
Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?
Topics: Animals; Carbamazepine; Clofibric Acid; Diclofenac; Drug-Related Side Effects and Adverse Reactions; | 2004 |
Toxic effect of pharmaceuticals on methanogenesis.
Topics: Bacteria, Anaerobic; Biomass; Carbamazepine; Clofibric Acid; Diclofenac; Drug-Related Side Effects a | 2004 |
Occurrence of pharmaceutical contaminants and screening of treatment alternatives for southeastern Louisiana.
Topics: Animals; Carbon; Clofibric Acid; Drug-Related Side Effects and Adverse Reactions; Environmental Moni | 2001 |