clofibrate has been researched along with Pregnancy in 48 studies
angiokapsul: contains clofibrate & insoitolnicotinate
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clofibrate-treated breeders manifested reduction in blood pressure and in the incidence and severity of arterial disease characteristic of repeatedly-bred rats." | 5.26 | Clofibrate retardation of naturally-occurring arteriosclerosis in repeatedly-bred male and female rats. ( Greenberg, BP; Wexler, BC, 1978) |
| " On day 21 of pregnancy, placentas from control and diabetic rats were cultured in the presence of PPARα agonists (clofibrate and leukotriene B(4) (LTB(4))) for further evaluation of levels, synthesis, and peroxidation of lipids as well as NO production." | 3.77 | PPARα agonists regulate lipid metabolism and nitric oxide production and prevent placental overgrowth in term placentas from diabetic rats. ( Capobianco, E; Higa, R; Jawerbaum, A; Kurtz, M; Martínez, N; White, V, 2011) |
| "Morphological and morphometric parameters (volume density (Vv), numerical density (NA) and mean diameter (D)) of newborn liver peroxisomes were measured throughout the first week of life in rats born to mothers treated with clofibrate (ethyl 2 p-chlorophenoxy isobutyrate) during the last five days of pregnancy." | 3.68 | Liver peroxisomes in newborns from clofibrate-treated rats. I. A morphometric study of the recovery period. ( Bernardo, A; Cerù, MP; Sartori, C; Stefanini, S, 1992) |
| "The effect of various doses of clofibrate on the incidence of pregnancy, on the weight of gonads and seminal vesicles, on the estrous cycle, and on the elimination of 17-ketosteroids and estrogen through the urine was studied on the rat and the rabbit." | 3.65 | [Studies of the interactions of clofibrate with the reproductive function]. ( Pantaleoni, GC; Valeri, P, 1974) |
| "Treatment with clofibrate significantly accelerated normalization of barrier function." | 1.35 | Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification. ( Crumrine, D; Elias, PM; Feingold, KR; Fluhr, JW; Hachem, JP; Man, MQ; Mauro, TM, 2009) |
| "Clofibrate is a better enhancer of glucuronosyl transferase induction than phenobarbital and causes 100% increase of hepatic bilirubin clearance within 6 hours." | 1.30 | [Pharmacologic treatment of neonatal jaundice. A new approach]. ( Gabilan, JC, 1998) |
| "Clofibrate was capable of traversing the placenta and modulating the fetal CYP4A mRNA expression as demonstrated by a 3-fold elevation in the mRNA levels in those fetuses explanted from drug-induced mothers, compared with those fetuses removed from untreated mothers." | 1.29 | Placental transfer of the hypolipidemic drug, clofibrate, induces CYP4A expression in 18.5-day fetal rats. ( Brammar, WJ; Cockcroft, N; Elcombe, CR; Pratten, MK; Simpson, AE, 1996) |
| "Clofibrate treatment in vivo (of which clofibric acid is the ester hydrolysis product) had no effect on clofibric acid glucuronidation in vitro." | 1.27 | Hepatic microsomal glucuronidation of clofibric acid in the adult and neonate albino rat. ( Odum, J; Orton, TC, 1983) |
| "She developed eruptive xanthomata with a grossly raised serum triglyceride concentration and chylomicronaemia when pregnant and also when taking a combined oral contraceptive pill containing 50 microgram of oestrogen." | 1.26 | The effect of pregnancy and two different contraceptive pills on serum lipids and lipoproteins in a woman with a type III hyperlipoproteinaemia pattern. ( McLintock, D; Muller, DP; Pavlou, C; Whitelaw, AG, 1978) |
| "Clofibrate-treated breeders manifested reduction in blood pressure and in the incidence and severity of arterial disease characteristic of repeatedly-bred rats." | 1.26 | Clofibrate retardation of naturally-occurring arteriosclerosis in repeatedly-bred male and female rats. ( Greenberg, BP; Wexler, BC, 1978) |
| "In clofibrate-treated rats, the tumor cells showed a slight increase in the size of microbodies and in catalase activity; however, the tumor microbodies did not increase in number." | 1.25 | Response of microbodies in Morris hepatoma 9618A to clofibrate. ( Gotoh, M; Itabashi, M; Mochizuki, Y; Morris, HP; Tsukada, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (62.50) | 18.7374 |
| 1990's | 12 (25.00) | 18.2507 |
| 2000's | 3 (6.25) | 29.6817 |
| 2010's | 3 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, SH | 1 |
| Chao, PM | 1 |
| Fluhr, JW | 1 |
| Man, MQ | 1 |
| Hachem, JP | 1 |
| Crumrine, D | 2 |
| Mauro, TM | 1 |
| Elias, PM | 2 |
| Feingold, KR | 2 |
| Palkar, PS | 1 |
| Anderson, CR | 1 |
| Ferry, CH | 1 |
| Gonzalez, FJ | 1 |
| Peters, JM | 1 |
| Martínez, N | 1 |
| Kurtz, M | 1 |
| Capobianco, E | 1 |
| Higa, R | 1 |
| White, V | 1 |
| Jawerbaum, A | 1 |
| Ringseis, R | 1 |
| Gutgesell, A | 1 |
| Dathe, C | 1 |
| Brandsch, C | 1 |
| Eder, K | 1 |
| Odum, J | 1 |
| Orton, TC | 1 |
| Nyitray, M | 1 |
| Szaszovsky, E | 1 |
| Druga, A | 1 |
| Sterner, W | 1 |
| Korn, WD | 1 |
| Sanfeliu, C | 1 |
| Zapatero, J | 1 |
| Bruseghini, L | 1 |
| Blane, GF | 1 |
| Pinaroli, F | 1 |
| de la Fuente, R | 1 |
| Santos, M | 1 |
| Robinson, AG | 1 |
| Verbalis, JG | 1 |
| Wennberg, RP | 1 |
| Yin, J | 1 |
| Miller, M | 1 |
| Maynard, A | 1 |
| Palmer, CN | 1 |
| Griffin, KJ | 1 |
| Johnson, EF | 1 |
| Simpson, AE | 1 |
| Brammar, WJ | 1 |
| Pratten, MK | 1 |
| Cockcroft, N | 1 |
| Elcombe, CR | 1 |
| Gabilan, JC | 1 |
| Hanley, K | 1 |
| Kömüves, LG | 1 |
| Bass, NM | 1 |
| He, SS | 1 |
| Jiang, Y | 1 |
| Appel, R | 1 |
| Friedman, M | 1 |
| Bettencourt, J | 1 |
| Min, K | 1 |
| Williams, ML | 1 |
| Ouali, F | 1 |
| Djouadi, F | 1 |
| Merlet-Bénichou, C | 1 |
| Riveau, B | 1 |
| Bastin, J | 1 |
| Laclide-Drouin, H | 1 |
| Masutti, JP | 1 |
| Hatier, R | 1 |
| Dauça, M | 1 |
| Grignon, G | 1 |
| Miguel, SG | 1 |
| Abraham, S | 1 |
| Tsukada, H | 1 |
| Mochizuki, Y | 1 |
| Itabashi, M | 1 |
| Gotoh, M | 1 |
| Morris, HP | 1 |
| Bruns, W | 1 |
| Dilman, VM | 1 |
| Bennion, LJ | 1 |
| Grundy, SM | 1 |
| Dry, J | 1 |
| Pradalier, A | 1 |
| Calvert, R | 1 |
| Malka, D | 1 |
| Ménard, D | 1 |
| Schiffman, FJ | 1 |
| Fisher, JM | 1 |
| Rabinovitz, M | 1 |
| Muller, DP | 1 |
| Pavlou, C | 1 |
| Whitelaw, AG | 1 |
| McLintock, D | 1 |
| Wexler, BC | 1 |
| Greenberg, BP | 1 |
| Chhabra, S | 1 |
| Kurup, CK | 1 |
| Naess, K | 1 |
| Göttlicher, M | 1 |
| Widmark, E | 1 |
| Li, Q | 1 |
| Gustafsson, JA | 1 |
| Nourooz-Zadeh, J | 1 |
| Winder, BS | 1 |
| Dietze, EC | 1 |
| Giometti, CS | 1 |
| Tollaksen, SL | 1 |
| Hammock, BD | 1 |
| Stefanini, S | 3 |
| Sartori, C | 2 |
| Bernardo, A | 1 |
| Cerù, MP | 3 |
| Cimini, A | 1 |
| Di Giulio, A | 1 |
| Wilson, GN | 1 |
| King, T | 1 |
| Argyle, JC | 1 |
| Garcia, RF | 1 |
| Hosokawa, S | 1 |
| Tatematsu, M | 1 |
| Aoki, T | 1 |
| Nakanowatari, J | 1 |
| Igarashi, T | 1 |
| Ito, N | 1 |
| Ujházy, E | 1 |
| Onderová, E | 1 |
| Horáková, M | 1 |
| Bencová, E | 1 |
| Durisová, M | 1 |
| Nosál, R | 1 |
| Balonová, T | 1 |
| Zeljenková, D | 1 |
| Cibelli, A | 1 |
| Kane, JP | 1 |
| Havel, RJ | 1 |
| O'Reilly, RA | 1 |
| Jolly, H | 1 |
| Wolff, OH | 1 |
| Albeaux-Fernet, M | 1 |
| Gelinet, M | 1 |
| Deribreux, J | 1 |
| Salvati, A | 1 |
| Saheta, NP | 1 |
| Cuculanu, MP | 1 |
| Vasile, VV | 1 |
| Popescu, TA | 1 |
| Opincaru, A | 1 |
| Crîsnic, I | 1 |
| Tapalagå, D | 1 |
| Pantaleoni, GC | 1 |
| Valeri, P | 1 |
6 reviews available for clofibrate and Pregnancy
| Article | Year |
|---|---|
Recommendations for treatment of hyperlipidemia in adults. A joint statement of the Nutrition Committee and the Council on Arteriosclerosis.
Topics: Cholesterol; Clofibrate; Coronary Disease; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hyperl | 1984 |
Risk factors for the development of cholelithiasis in man (second of two parts).
Topics: Adolescent; Adult; Age Factors; Anemia, Hemolytic; Bile; Cholelithiasis; Clofibrate; Contraceptives, | 1978 |
[Therapeutics in 1978].
Topics: Amenorrhea; Anticholesteremic Agents; Artificial Organs; Biliary Tract Diseases; Bromocriptine; Chol | 1978 |
Treatment of hypercholesterolemia.
Topics: Animals; Cholestyramine Resin; Clofibrate; Colestipol; Cricetinae; Dogs; Drug Therapy, Combination; | 1986 |
Hazards of anticoagulant treatment: other drugs, other diseases.
Topics: Administration, Oral; Animals; Anticoagulants; Barbiturates; Biological Transport; Blood Coagulation | 1973 |
Iatrogenic cardiovascular disease (an aspect of preventive cardiology).
Topics: Abnormalities, Drug-Induced; Analgesics; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antidepressi | 1968 |
1 trial available for clofibrate and Pregnancy
| Article | Year |
|---|---|
Fetal cocaine exposure and neonatal bilirubinemia.
Topics: Animals; Bilirubin; Case-Control Studies; Clofibrate; Cocaine; Female; Humans; Infant, Newborn; Live | 1994 |
41 other studies available for clofibrate and Pregnancy
| Article | Year |
|---|---|
Prenatal PPARα activation by clofibrate increases subcutaneous fat browning in male C57BL/6J mice fed a high-fat diet during adulthood.
Topics: Adipose Tissue, Brown; Animals; Clofibrate; Diet, High-Fat; Female; Growth; Male; Mice; Mice, Inbred | 2017 |
Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification.
Topics: Acids; Animals; Animals, Newborn; Anticholesteremic Agents; Clofibrate; Epidermis; Female; Homeostas | 2009 |
Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development.
Topics: Animals; Clofibrate; Female; Genotype; Liver; Male; Mice; Mice, Knockout; Organ Size; Peroxisome Pro | 2010 |
PPARα agonists regulate lipid metabolism and nitric oxide production and prevent placental overgrowth in term placentas from diabetic rats.
Topics: Animals; Cholesterol; Clofibrate; Diabetes Mellitus, Experimental; Female; Fetus; In Vitro Technique | 2011 |
Feeding oxidized fat during pregnancy up-regulates expression of PPARalpha-responsive genes in the liver of rat fetuses.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenase, Long-Chain; Acyl-CoA Oxidase; Animals; Anticholester | 2007 |
Hepatic microsomal glucuronidation of clofibric acid in the adult and neonate albino rat.
Topics: Aging; Animals; Animals, Newborn; Clofibrate; Clofibric Acid; Digitonin; Enzyme Activation; Enzyme I | 1983 |
Clofibrate and the development of rats.
Topics: Animals; Body Weight; Clofibrate; Female; Gestational Age; Growth; Liver; Organ Size; Pregnancy; Rat | 1980 |
[Pharmacology and toxicology of etofylline clofibrate].
Topics: Animals; Clofibrate; Dogs; Female; Hypolipidemic Agents; Male; Mice; Motor Activity; Pregnancy; Rats | 1980 |
Toxicological studies of plafibride. Part 3: Study of teratogenic activity in rats and rabbits.
Topics: Animals; Clofibrate; Clofibric Acid; Female; Fetus; Pregnancy; Rabbits; Rats; Rats, Inbred Strains; | 1981 |
[Fenofibrate: animal toxicology in relation to side-effects in man (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Biopsy; Clofibrate; Cricetinae; Dogs; Female; Fenofibrate; Hum | 1980 |
[Toxicological and pharmacological studies on a new drug: pirfibrate (EL-466) (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Clofibrate; Clofibric Acid; Diet, Atherogenic; Dogs; Female; F | 1980 |
Diabetes insipidus.
Topics: Benzothiadiazines; Carbamazepine; Chlorpropamide; Clofibrate; Diabetes Insipidus; Diuretics; Female; | 1994 |
Rabbit prostaglandin omega-hydroxylase (CYP4A4): gene structure and expression.
Topics: Amino Acid Sequence; Animals; Base Sequence; Clofibrate; Cloning, Molecular; Cytochrome P-450 Enzyme | 1993 |
Placental transfer of the hypolipidemic drug, clofibrate, induces CYP4A expression in 18.5-day fetal rats.
Topics: Animals; Base Sequence; Clofibrate; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA Prob | 1996 |
[Pharmacologic treatment of neonatal jaundice. A new approach].
Topics: Clofibrate; Combined Modality Therapy; Enzyme Inhibitors; Female; Humans; Infant, Newborn; Jaundice, | 1998 |
Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators.
Topics: alpha-Linolenic Acid; Amnion; Animals; Cell Differentiation; Clofibrate; DNA-Binding Proteins; Farne | 1999 |
Regulation of fatty acid transport protein and mitochondrial and peroxisomal beta-oxidation gene expression by fatty acids in developing rats.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenase, Long-Chain; Acyl-CoA Oxidase; Animals; Carrier Prote | 2000 |
Effect of clofibrate on the peroxisomes of the intestine of the rat during foetal development.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Catalase; Clofibrate; Enoyl-CoA Hydratase; Epithelial Cel | 1995 |
Effect of maternal diet on fetal hepatic lipogenesis.
Topics: Acetates; Acetyl-CoA Carboxylase; Animals; Clofibrate; Cyclic AMP; Dietary Fats; Fasting; Fatty Acid | 1976 |
Response of microbodies in Morris hepatoma 9618A to clofibrate.
Topics: Animals; Animals, Newborn; Carcinoma, Hepatocellular; Catalase; Clofibrate; Female; Liver Neoplasms; | 1975 |
[Secondary hyperlipoproteinemias].
Topics: Acute Disease; Clofibrate; Female; Hepatitis; Humans; Hyperlipidemias; Hypothyroidism; Lipoproteins, | 1977 |
Ageing, metabolic immunodepression and carcinogenesis.
Topics: Adult; Aged; Aging; Cell Transformation, Neoplastic; Cholesterol; Clofibrate; Coronary Disease; Diab | 1978 |
Effect of clofibrate on the small intestine of fetal mice.
Topics: Animals; Catalase; Clofibrate; Female; Fetus; Histocytochemistry; Intestine, Small; Maternal-Fetal E | 1979 |
Serum displacing agents in cancer chemotherapy.
Topics: Animals; Cattle; Cells, Cultured; Chemical Phenomena; Chemistry; Chlorambucil; Clofibrate; Culture M | 1977 |
The effect of pregnancy and two different contraceptive pills on serum lipids and lipoproteins in a woman with a type III hyperlipoproteinaemia pattern.
Topics: Adult; Cholesterol; Chylomicrons; Clofibrate; Contraceptives, Oral; Contraceptives, Oral, Combined; | 1978 |
Clofibrate retardation of naturally-occurring arteriosclerosis in repeatedly-bred male and female rats.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Animals; Aorta; Aortic Diseases; Arteriosclerosis; Clofibra | 1978 |
Maternal transport of chlorophenoxyisobutyrate at the foetal and neonatal stages of development.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Clofibrate; Female; Fetus; In Vitro Techniques; Liver | 1978 |
[Editorial: Drugs and abnormalities. Background and consequences of warnings].
Topics: Abnormalities, Drug-Induced; Carbimazole; Clofibrate; Female; Humans; Maternal-Fetal Exchange; Metro | 1976 |
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Anticholesteremic Agents; Base Sequence; Chimera | 1992 |
Biochemical characterization of a variant form of cytosolic epoxide hydrolase induced by parental exposure to N-ethyl-N-nitrosourea.
Topics: Animals; Blotting, Western; Chromatography, Affinity; Clofibrate; Cytosol; Electrophoresis, Polyacry | 1992 |
Liver peroxisomes in newborns from clofibrate-treated rats. I. A morphometric study of the recovery period.
Topics: Animals; Animals, Newborn; Animals, Suckling; Catalase; Clofibrate; Female; Liver; Maternal-Fetal Ex | 1992 |
Liver peroxisomes in newborns from clofibrate-treated rats. II. A biochemical study of the recovery period.
Topics: Acyl-CoA Oxidase; Animals; Animals, Newborn; Animals, Suckling; Catalase; Clofibrate; Female; Kineti | 1992 |
Maternal clofibrate administration amplifies fetal peroxisomes.
Topics: Acyltransferases; Animals; ATP-Binding Cassette Transporters; Clofibrate; Female; Fetus; Liver; Mate | 1991 |
Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; Female; Glutathione Transferase; Immunoenzyme | 1989 |
Teratological study of the hypolipidaemic drugs etofylline clofibrate (VULM) and fenofibrate in Swiss mice.
Topics: Animals; Body Weight; Clofibrate; Female; Fenofibrate; Fetus; Gestational Age; Hypolipidemic Agents; | 1989 |
Peroxisomal beta-oxidation and catalase activities in fetal rat liver: effect of maternal treatment with clofibrate.
Topics: Animals; Body Weight; Catalase; Clofibrate; Female; Liver; Maternal-Fetal Exchange; Microbodies; Org | 1988 |
New frontiers in paediatrics. Looking at handicapped children today.
Topics: Affective Symptoms; Anxiety; Child Care; Cholesterol; Cholestyramine Resin; Clofibrate; Diet Therapy | 1971 |
[Sheehan's disease followed by severe arterial hypertension with right renal artery stenosis. Discussion of the role of hypopituitarism in atherogenesis].
Topics: Adrenal Cortex Hormones; Adult; Androgens; Arteriosclerosis; Clofibrate; Coronary Disease; Female; H | 1973 |
[Drugs which influence plasma fatty acids and lipoproteins. Opinion of Prof. Rodolfo Paoletti].
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Clofibrate; Estrogens; Fatty Acids, Nonesterified; Fema | 1973 |
Clinical studies concerning factor XIII; with special reference to hyperlipemia.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Arteriosclerosis; Blood Cell Count; Blood Coagulation | 1973 |
[Studies of the interactions of clofibrate with the reproductive function].
Topics: 17-Ketosteroids; Animals; Animals, Newborn; Aspirin; Clofibrate; Estrogens; Estrus; Female; Fertilit | 1974 |