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clofibrate and Obesity

clofibrate has been researched along with Obesity in 46 studies

angiokapsul: contains clofibrate & insoitolnicotinate

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
" To determine whether PPARalpha activators also improve insulin sensitivity, we measured the capacity of three PPARalpha-selective agonists, fenofibrate, ciprofibrate, and the new compound GW9578, in two rodent models of high fat diet-induced (C57BL/6 mice) or genetic (obese Zucker rats) IR."3.70Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. ( Berge, RK; Derudas, B; Fruchart, JC; Gervois, P; Guerre-Millo, M; Herbert, JM; Madsen, L; Poulain, P; Raspé, E; Staels, B; Willson, TM; Winegar, DA, 2000)
" Major risk factors associated with cholesterol gallstone formation are American Indian ancestry, female sex, obesity, and ingestion of lithogenic drugs, such as estrogen-containing preparations and clofibrate."3.66Who gets gallstones and why. ( Tangedahl, TN, 1979)
"Pretreatment with acetone, dexamethasone and clofibrate resulted in enhanced p-nitrophenol hydroxylase (CYP2E), erythromycin N-demethylase (CYP3A) and lauric acid hydroxylase (CYP4A) activities respectively in the liver of the lean Zucker rat but, in contrast, the obese Zucker rat was refractive to such treatment; similarly, hepatic apoprotein levels of the CYP2E and CYP4A subfamilies were increased markedly only in the lean Zucker rat."1.29Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat. ( Barnett, CR; Flatt, PR; Ioannides, C; Irizar, A, 1995)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199037 (80.43)18.7374
1990's5 (10.87)18.2507
2000's4 (8.70)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Willson, TM2
Brown, PJ1
Sternbach, DD1
Henke, BR1
Yang, BX1
Li, Y1
Liao, R1
Tian, Q1
Loizeau, E1
Epstein, LH1
Hüdepohl, JM1
Zielke, R1
Grundy, SM2
Nicoll, A1
Miller, NE1
Lewis, B2
Tan, MH1
Takikawa, H1
Yamanaka, M1
Irizar, A1
Barnett, CR1
Flatt, PR1
Ioannides, C1
Wang, MY1
Koyama, K1
Shimabukuro, M1
Mangelsdorf, D1
Newgard, CB1
Unger, RH1
Guerre-Millo, M1
Gervois, P1
Raspé, E1
Madsen, L1
Poulain, P1
Derudas, B1
Herbert, JM1
Winegar, DA1
Fruchart, JC1
Berge, RK1
Staels, B1
Bremer, J1
Jung, W1
Kremer, GJ1
Müller, D1
Schwandt, P1
Weisweiler, P1
Neureuther, G1
Wilkening, J1
Yü, TF1
Dorph, DJ1
Smith, H1
Bennion, LJ1
Tangedahl, TN1
Simonelli, C1
Eaton, RP2
Kuppurajan, K1
Rajagopalan, SS1
Rao, TK1
Sitaraman, R1
Pagliano, FM1
Bombara, R1
Giraldi, B1
Visca, U1
Pontiroli, AE1
Viberti, G1
Pozza, G1
Schade, DS1
Lueker, R1
Russell, JC1
Koeslag, DG1
Amy, RM1
Dolphin, PJ1
Brady, LJ1
Ramsay, RR1
Brady, PS1
Mohan, PF1
Cleary, MP3
Miettinen, TA1
Huttunen, JK1
Naukkarinen, V1
Strandberg, T1
Vanhanen, H1
Kasiske, BL1
O'Donnell, MP2
Keane, WF2
Kasiske, B1
Parker, F1
Wilson, DE1
Lees, RS1
Stone, MC1
Lufkin, EG1
Stifel, FB1
Greene, HL1
Herman, RH1
Taunton, OD1
Ditschuneit, H1
Neugebauer, A1
Trenckmann, H1
Duck, HJ1
Fleischmann, HJ1
Schauer, J1
Bruns, W1
Rjasanowski, I1
Wulfert, P1
Michael, R1
Knospe, S1
Hildmann, W1
Begg, TB1
Mirouze, J1
Orsetti, A1
Cartry, E1
Borrie, P1
Slack, J1
Mabuchi, H1
Mibayashi, Y1
Ota, M1
Miyamoto, S1
Yamada, S1
Bagdade, JD1
Bierman, EL1
Porte, D1
Chrétien, M1
Lewis, W1
Bergqvist, N1
Fanta, D1
Formanek, I1
Niebauer, G1

Reviews

10 reviews available for clofibrate and Obesity

ArticleYear
The PPARs: from orphan receptors to drug discovery.
    Journal of medicinal chemistry, 2000, Feb-24, Volume: 43, Issue:4

    Topics: Animals; Diabetes Mellitus; Drug Design; Humans; Hyperlipidemias; Hypertension; Inflammation; Ligand

2000
The direct effects of compliance on health outcome.
    Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 1984, Volume: 3, Issue:4

    Topics: Alcoholism; Chlorpromazine; Chorionic Gonadotropin; Clofibrate; Coronary Disease; Disulfiram; Drug T

1984
High-density lipoprotein metabolism.
    Advances in lipid research, 1980, Volume: 17

    Topics: Animals; Apolipoproteins; Chemical Phenomena; Chemistry; Cholesterol; Chylomicrons; Clofibrate; Diet

1980
HDL-cholesterol: the negative risk factor for coronary heart disease.
    Annals of the Academy of Medicine, Singapore, 1980, Volume: 9, Issue:4

    Topics: Adult; Age Factors; Alcoholism; Child; Cholesterol; Cholesterol, HDL; Cholestyramine Resin; Clofibra

1980
[Diseases of the biliary system in obesity].
    Nihon rinsho. Japanese journal of clinical medicine, 1995, Volume: 53 Suppl

    Topics: Cholelithiasis; Cholesterol; Clofibrate; Diet, Reducing; Female; Gastric Bypass; Humans; Male; Obesi

1995
The biochemistry of hypo- and hyperlipidemic fatty acid derivatives: metabolism and metabolic effects.
    Progress in lipid research, 2001, Volume: 40, Issue:4

    Topics: Animals; Apolipoprotein C-III; Apolipoproteins C; Carnitine O-Palmitoyltransferase; Chylomicrons; Cl

2001
The metabolic disorder in cholesterol gall stone disease.
    Nutrition reviews, 1978, Volume: 36, Issue:2

    Topics: Adult; Cholelithiasis; Cholesterol; Clofibrate; Diabetes Complications; Estrogens; Humans; Insulin;

1978
Hyperlipidemia in primary gout.
    Seminars in arthritis and rheumatism, 1978, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Alcohol Drinking; Cholesterol; Clofibrate; Dextrothyroxine; Diabetes

1978
Risk factors for the development of cholelithiasis in man (second of two parts).
    The New England journal of medicine, 1978, Nov-30, Volume: 299, Issue:22

    Topics: Adolescent; Adult; Age Factors; Anemia, Hemolytic; Bile; Cholelithiasis; Clofibrate; Contraceptives,

1978
The role of diet in the management of hyperlipoproteinaemias.
    The Proceedings of the Nutrition Society, 1972, Volume: 31, Issue:3

    Topics: Adolescent; Adult; Aged; Blood Protein Disorders; Cholesterol; Chylomicrons; Clofibrate; Diet Therap

1972

Trials

3 trials available for clofibrate and Obesity

ArticleYear
The direct effects of compliance on health outcome.
    Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 1984, Volume: 3, Issue:4

    Topics: Alcoholism; Chlorpromazine; Chorionic Gonadotropin; Clofibrate; Coronary Disease; Disulfiram; Drug T

1984
Long-term use of probucol in the multifactorial primary prevention of vascular disease.
    The American journal of cardiology, 1986, Jun-27, Volume: 57, Issue:16

    Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Cerebrovascular Disorders; Cholesterol, HDL; C

1986
General therapeutic and prophylactic problems in the treatment of atherosclerosis.
    Acta cardiologica, 1972

    Topics: Aged; Arteriosclerosis; Clinical Trials as Topic; Clofibrate; Coronary Disease; Diet Therapy; Dietar

1972

Other Studies

34 other studies available for clofibrate and Obesity

ArticleYear
[Effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2008, Volume: 39, Issue:6

    Topics: Animals; Cardiomyopathies; Cholesterol; Clofibrate; Fatty Acids; Female; Hypolipidemic Agents; Insul

2008
[Nutritional and medicinal factors in biliary cholesterol lithiasis].
    Revue medicale de la Suisse romande, 1984, Volume: 104, Issue:3

    Topics: Cholelithiasis; Cholesterol, Dietary; Clofibrate; Contraceptives, Oral; Dietary Carbohydrates; Dieta

1984
[Formation and modification of bile lipids].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1983, Nov-30, Volume: 59, Issue:33

    Topics: Animals; Bile; Cholelithiasis; Cholesterol; Clofibrate; Contraceptives, Oral, Hormonal; Diabetes Mel

1983
Mechanism of cholesterol gallstones formation.
    Seminars in liver disease, 1983, Volume: 3, Issue:2

    Topics: Animals; Bile; Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Cholesterol

1983
Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat.
    European journal of pharmacology, 1995, Dec-07, Volume: 293, Issue:4

    Topics: Acetone; Animals; Blood Chemical Analysis; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone

1995
Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Sep-29, Volume: 95, Issue:20

    Topics: Animals; Base Sequence; Carrier Proteins; Clofibrate; Diabetes Mellitus, Type 2; DNA Primers; DNA-Bi

1998
Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity.
    The Journal of biological chemistry, 2000, Jun-02, Volume: 275, Issue:22

    Topics: Adipose Tissue; Animals; Butyrates; Clofibrate; Fenofibrate; Hypolipidemic Agents; Insulin Resistanc

2000
[Clofibrate treatment of diabetics with hyperproteinemias (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1975, Oct-31, Volume: 117, Issue:44

    Topics: Adult; Age Factors; Aged; Chylomicrons; Clofibrate; Diabetes Complications; Drug Therapy, Combinatio

1975
[Effect of clofibrate on glucose tolerance and insulin secretion in patients with endogenous hypertriglyceridemia (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1976, Mar-19, Volume: 118, Issue:12

    Topics: Administration, Oral; Blood Glucose; Body Weight; Cholesterol; Clofibrate; Glucose; Glucose Toleranc

1976
Who gets gallstones and why.
    Postgraduate medicine, 1979, Volume: 66, Issue:3

    Topics: Bilirubin; Cholelithiasis; Cholesterol; Clofibrate; Estrogens; Hemolysis; Indians, North American; O

1979
Effect of clofibrate on in vivo triglyceride production and clearance in genetically hyperlipemic rats.
    Atherosclerosis, 1978, Volume: 29, Issue:3

    Topics: Animals; Clofibrate; Female; Hyperlipidemias; Liver; Metabolic Clearance Rate; Obesity; Rats; Trigly

1978
Effect of guggulu (Commiphora mukul--Engl.) on serum lipids in obese, hypercholesterolemic and hyperlipemic cases.
    The Journal of the Association of Physicians of India, 1978, Volume: 26, Issue:5

    Topics: Clofibrate; Female; Humans; Hypercholesterolemia; Hyperlipidemias; Lipids; Male; Obesity; Plant Extr

1978
[Changes in lipid metabolism in a case of associated primary hypothyroidism, obesity and diabetes mellitus].
    Minerva medica, 1976, Jul-21, Volume: 67, Issue:35

    Topics: Aged; Cholesterol; Clofibrate; Diabetes Complications; Diabetes Mellitus; Female; Glyburide; Humans;

1976
Growth hormone response to arginine in normal subjects and in patients with chemical diabetes and effect of clofibrate and of metergoline.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1977, Volume: 155, Issue:2

    Topics: Adult; Aged; Arginine; Clofibrate; Diabetes Mellitus; Ergolines; Female; Glucose Tolerance Test; Gro

1977
Clofibrate-induced changes in glucagon and insulin secretion in patients with angiographically documented coronary artery disease.
    The American journal of clinical nutrition, 1977, Volume: 30, Issue:12

    Topics: Adult; Arginine; Clofibrate; Coronary Disease; Female; Glucagon; Humans; Insulin; Insulin Secretion;

1977
Independence of myocardial disease in the JCR:LA-corpulent rat on plasma cholesterol concentration.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1991, Volume: 14, Issue:4

    Topics: Animals; Apolipoproteins; Arteriosclerosis; Blood Glucose; Cardiomyopathies; Cholesterol; Clofibrate

1991
Regulation of carnitine acyltransferase synthesis in lean and obese Zucker rats by dehydroepiandrosterone and clofibrate.
    The Journal of nutrition, 1991, Volume: 121, Issue:4

    Topics: Animals; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Clofibrate; Dehydroepiandrost

1991
Comparison of dehydroepiandrosterone and clofibric acid treatments in obese Zucker rats.
    The Journal of nutrition, 1989, Volume: 119, Issue:3

    Topics: Animals; Blood Glucose; Body Weight; Clofibrate; Clofibric Acid; Dehydroepiandrosterone; Disease Mod

1989
Treatment of hyperlipidemia reduces glomerular injury in obese Zucker rats.
    Kidney international, 1988, Volume: 33, Issue:3

    Topics: Albuminuria; Animals; Cholesterol; Clofibrate; Glomerulonephritis; Glomerulosclerosis, Focal Segment

1988
Effect of long-term clofibric acid treatment on serum and tissue lipid and cholesterol levels in obese Zucker rats.
    Atherosclerosis, 1987, Volume: 66, Issue:1-2

    Topics: Adipose Tissue; Animals; Cholesterol; Clofibrate; Clofibric Acid; Lipid Metabolism; Lipids; Liver; M

1987
Xanthomas and hyperlipidemias.
    Journal of the American Academy of Dermatology, 1985, Volume: 13, Issue:1

    Topics: Apoproteins; Arteriosclerosis; Cholestasis; Cholestyramine Resin; Clofibrate; Colestipol; Dextrothyr

1985
Metabolic relationships among the plasma lipoproteins. Reciprocal changes in the concentrations of very low and low density lipoproteins in man.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:5

    Topics: Adolescent; Adult; Angina Pectoris; Body Weight; Cholesterol; Clofibrate; Coronary Disease; Female;

1972
Suppression of activities of carbohydrate-metabolizing enzymes in adipose tissue of obese humans by clofibrate.
    The Journal of laboratory and clinical medicine, 1974, Volume: 84, Issue:5

    Topics: Adipose Tissue; Adult; Biopsy; Carbohydrate Metabolism; Clofibrate; Fructose-Bisphosphatase; Fructos

1974
The influence of drugs affecting lipids on atherosclerosis.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1974, Volume: Suppl 4

    Topics: Adult; Arteriosclerosis; Blood Protein Disorders; Clofibrate; Coronary Disease; Diabetes Complicatio

1974
[Diagnosis and treatment of risk factors in chronic ischemic heart disease].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1974, Oct-01, Volume: 29, Issue:19

    Topics: Adult; Age Factors; Arteriosclerosis; Cholestyramine Resin; Chronic Disease; Clofibrate; Coronary Di

1974
[Differential diagnosis and differential treatment of carbohydrate tolerance disorders in patients with hyperlipoproteinemia. Behavior of plasma lipids, glucose tolerance, and plasma insulin after glucose load during treatment with clofibrate].
    Endokrinologie, 1974, Volume: 64, Issue:1

    Topics: Adult; Blood Glucose; Carbohydrate Metabolism, Inborn Errors; Clofibrate; Diabetes Complications; Di

1974
[Pyridoxine para-chloro-phenoxy-isobutyrate. Analysis of hypolipidemic effects].
    La Nouvelle presse medicale, 1973, Volume: 2, Issue:46

    Topics: Clofibrate; Diabetes Mellitus; Diet; Drug Evaluation; Humans; Hyperlipidemias; Obesity; Pyridoxine;

1973
A clinical syndrome characteristic of primary Type IV-V hyperlipoproteinaemia.
    The British journal of dermatology, 1974, Volume: 90, Issue:3

    Topics: Abdomen; Adult; Cholesterol; Chylomicrons; Clofibrate; Diabetes Complications; Diet, Reducing; Elect

1974
[Metabolic anomaly of obesity: therapeutic results of combined diet and chemotherapy].
    Nihon rinsho. Japanese journal of clinical medicine, 1974, Volume: 32, Issue:3

    Topics: Adult; Clofibrate; Diet, Reducing; Female; Humans; Hyperinsulinism; Male; Middle Aged; Obesity

1974
Influence of obesity on the relationship between insulin and triglyceride levels in endogenous hypertriglyceridemia.
    Diabetes, 1971, Volume: 20, Issue:10

    Topics: Adult; Blood Glucose; Body Weight; Clofibrate; Dietary Carbohydrates; Fatty Acids, Nonesterified; Gl

1971
Classification of hyperlipidaemias.
    Proceedings of the Royal Society of Medicine, 1971, Volume: 64, Issue:9

    Topics: Carbohydrate Metabolism; Cholestyramine Resin; Chylomicrons; Clofibrate; Dextrothyroxine; Diabetes M

1971
[Antidiuretic effect of clofibrate in diabetes insipidus].
    L'union medicale du Canada, 1971, Volume: 100, Issue:10

    Topics: Adolescent; Clofibrate; Diabetes Insipidus; Diuresis; Humans; Hypogonadism; Male; Obesity

1971
Serum lipids in an ambulary diabetic clientele. Effect of therapy with Atromidin (clofibrate).
    Acta medica Scandinavica, 1970, Mar-03, Volume: 187, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Anticholesteremic Agents; Arteriosclerosis; Blood Glucose; Cho

1970
[Behavior of lipoproteins in xanthomatoses].
    Wiener klinische Wochenschrift, 1971, May-07, Volume: 83, Issue:18

    Topics: Clofibrate; Diabetes Mellitus; Diet Therapy; Humans; Hypoglycemic Agents; Lipoproteins; Obesity; Ski

1971