clofibrate has been researched along with Obesity in 46 studies
angiokapsul: contains clofibrate & insoitolnicotinate
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| " To determine whether PPARalpha activators also improve insulin sensitivity, we measured the capacity of three PPARalpha-selective agonists, fenofibrate, ciprofibrate, and the new compound GW9578, in two rodent models of high fat diet-induced (C57BL/6 mice) or genetic (obese Zucker rats) IR." | 3.70 | Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. ( Berge, RK; Derudas, B; Fruchart, JC; Gervois, P; Guerre-Millo, M; Herbert, JM; Madsen, L; Poulain, P; Raspé, E; Staels, B; Willson, TM; Winegar, DA, 2000) |
| " Major risk factors associated with cholesterol gallstone formation are American Indian ancestry, female sex, obesity, and ingestion of lithogenic drugs, such as estrogen-containing preparations and clofibrate." | 3.66 | Who gets gallstones and why. ( Tangedahl, TN, 1979) |
| "Pretreatment with acetone, dexamethasone and clofibrate resulted in enhanced p-nitrophenol hydroxylase (CYP2E), erythromycin N-demethylase (CYP3A) and lauric acid hydroxylase (CYP4A) activities respectively in the liver of the lean Zucker rat but, in contrast, the obese Zucker rat was refractive to such treatment; similarly, hepatic apoprotein levels of the CYP2E and CYP4A subfamilies were increased markedly only in the lean Zucker rat." | 1.29 | Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat. ( Barnett, CR; Flatt, PR; Ioannides, C; Irizar, A, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (80.43) | 18.7374 |
| 1990's | 5 (10.87) | 18.2507 |
| 2000's | 4 (8.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Willson, TM | 2 |
| Brown, PJ | 1 |
| Sternbach, DD | 1 |
| Henke, BR | 1 |
| Yang, BX | 1 |
| Li, Y | 1 |
| Liao, R | 1 |
| Tian, Q | 1 |
| Loizeau, E | 1 |
| Epstein, LH | 1 |
| Hüdepohl, JM | 1 |
| Zielke, R | 1 |
| Grundy, SM | 2 |
| Nicoll, A | 1 |
| Miller, NE | 1 |
| Lewis, B | 2 |
| Tan, MH | 1 |
| Takikawa, H | 1 |
| Yamanaka, M | 1 |
| Irizar, A | 1 |
| Barnett, CR | 1 |
| Flatt, PR | 1 |
| Ioannides, C | 1 |
| Wang, MY | 1 |
| Koyama, K | 1 |
| Shimabukuro, M | 1 |
| Mangelsdorf, D | 1 |
| Newgard, CB | 1 |
| Unger, RH | 1 |
| Guerre-Millo, M | 1 |
| Gervois, P | 1 |
| Raspé, E | 1 |
| Madsen, L | 1 |
| Poulain, P | 1 |
| Derudas, B | 1 |
| Herbert, JM | 1 |
| Winegar, DA | 1 |
| Fruchart, JC | 1 |
| Berge, RK | 1 |
| Staels, B | 1 |
| Bremer, J | 1 |
| Jung, W | 1 |
| Kremer, GJ | 1 |
| Müller, D | 1 |
| Schwandt, P | 1 |
| Weisweiler, P | 1 |
| Neureuther, G | 1 |
| Wilkening, J | 1 |
| Yü, TF | 1 |
| Dorph, DJ | 1 |
| Smith, H | 1 |
| Bennion, LJ | 1 |
| Tangedahl, TN | 1 |
| Simonelli, C | 1 |
| Eaton, RP | 2 |
| Kuppurajan, K | 1 |
| Rajagopalan, SS | 1 |
| Rao, TK | 1 |
| Sitaraman, R | 1 |
| Pagliano, FM | 1 |
| Bombara, R | 1 |
| Giraldi, B | 1 |
| Visca, U | 1 |
| Pontiroli, AE | 1 |
| Viberti, G | 1 |
| Pozza, G | 1 |
| Schade, DS | 1 |
| Lueker, R | 1 |
| Russell, JC | 1 |
| Koeslag, DG | 1 |
| Amy, RM | 1 |
| Dolphin, PJ | 1 |
| Brady, LJ | 1 |
| Ramsay, RR | 1 |
| Brady, PS | 1 |
| Mohan, PF | 1 |
| Cleary, MP | 3 |
| Miettinen, TA | 1 |
| Huttunen, JK | 1 |
| Naukkarinen, V | 1 |
| Strandberg, T | 1 |
| Vanhanen, H | 1 |
| Kasiske, BL | 1 |
| O'Donnell, MP | 2 |
| Keane, WF | 2 |
| Kasiske, B | 1 |
| Parker, F | 1 |
| Wilson, DE | 1 |
| Lees, RS | 1 |
| Stone, MC | 1 |
| Lufkin, EG | 1 |
| Stifel, FB | 1 |
| Greene, HL | 1 |
| Herman, RH | 1 |
| Taunton, OD | 1 |
| Ditschuneit, H | 1 |
| Neugebauer, A | 1 |
| Trenckmann, H | 1 |
| Duck, HJ | 1 |
| Fleischmann, HJ | 1 |
| Schauer, J | 1 |
| Bruns, W | 1 |
| Rjasanowski, I | 1 |
| Wulfert, P | 1 |
| Michael, R | 1 |
| Knospe, S | 1 |
| Hildmann, W | 1 |
| Begg, TB | 1 |
| Mirouze, J | 1 |
| Orsetti, A | 1 |
| Cartry, E | 1 |
| Borrie, P | 1 |
| Slack, J | 1 |
| Mabuchi, H | 1 |
| Mibayashi, Y | 1 |
| Ota, M | 1 |
| Miyamoto, S | 1 |
| Yamada, S | 1 |
| Bagdade, JD | 1 |
| Bierman, EL | 1 |
| Porte, D | 1 |
| Chrétien, M | 1 |
| Lewis, W | 1 |
| Bergqvist, N | 1 |
| Fanta, D | 1 |
| Formanek, I | 1 |
| Niebauer, G | 1 |
10 reviews available for clofibrate and Obesity
| Article | Year |
|---|---|
The PPARs: from orphan receptors to drug discovery.
Topics: Animals; Diabetes Mellitus; Drug Design; Humans; Hyperlipidemias; Hypertension; Inflammation; Ligand | 2000 |
The direct effects of compliance on health outcome.
Topics: Alcoholism; Chlorpromazine; Chorionic Gonadotropin; Clofibrate; Coronary Disease; Disulfiram; Drug T | 1984 |
High-density lipoprotein metabolism.
Topics: Animals; Apolipoproteins; Chemical Phenomena; Chemistry; Cholesterol; Chylomicrons; Clofibrate; Diet | 1980 |
HDL-cholesterol: the negative risk factor for coronary heart disease.
Topics: Adult; Age Factors; Alcoholism; Child; Cholesterol; Cholesterol, HDL; Cholestyramine Resin; Clofibra | 1980 |
[Diseases of the biliary system in obesity].
Topics: Cholelithiasis; Cholesterol; Clofibrate; Diet, Reducing; Female; Gastric Bypass; Humans; Male; Obesi | 1995 |
The biochemistry of hypo- and hyperlipidemic fatty acid derivatives: metabolism and metabolic effects.
Topics: Animals; Apolipoprotein C-III; Apolipoproteins C; Carnitine O-Palmitoyltransferase; Chylomicrons; Cl | 2001 |
The metabolic disorder in cholesterol gall stone disease.
Topics: Adult; Cholelithiasis; Cholesterol; Clofibrate; Diabetes Complications; Estrogens; Humans; Insulin; | 1978 |
Hyperlipidemia in primary gout.
Topics: Adolescent; Adult; Aged; Aging; Alcohol Drinking; Cholesterol; Clofibrate; Dextrothyroxine; Diabetes | 1978 |
Risk factors for the development of cholelithiasis in man (second of two parts).
Topics: Adolescent; Adult; Age Factors; Anemia, Hemolytic; Bile; Cholelithiasis; Clofibrate; Contraceptives, | 1978 |
The role of diet in the management of hyperlipoproteinaemias.
Topics: Adolescent; Adult; Aged; Blood Protein Disorders; Cholesterol; Chylomicrons; Clofibrate; Diet Therap | 1972 |
3 trials available for clofibrate and Obesity
| Article | Year |
|---|---|
The direct effects of compliance on health outcome.
Topics: Alcoholism; Chlorpromazine; Chorionic Gonadotropin; Clofibrate; Coronary Disease; Disulfiram; Drug T | 1984 |
Long-term use of probucol in the multifactorial primary prevention of vascular disease.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Cerebrovascular Disorders; Cholesterol, HDL; C | 1986 |
General therapeutic and prophylactic problems in the treatment of atherosclerosis.
Topics: Aged; Arteriosclerosis; Clinical Trials as Topic; Clofibrate; Coronary Disease; Diet Therapy; Dietar | 1972 |
34 other studies available for clofibrate and Obesity
| Article | Year |
|---|---|
[Effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats].
Topics: Animals; Cardiomyopathies; Cholesterol; Clofibrate; Fatty Acids; Female; Hypolipidemic Agents; Insul | 2008 |
[Nutritional and medicinal factors in biliary cholesterol lithiasis].
Topics: Cholelithiasis; Cholesterol, Dietary; Clofibrate; Contraceptives, Oral; Dietary Carbohydrates; Dieta | 1984 |
[Formation and modification of bile lipids].
Topics: Animals; Bile; Cholelithiasis; Cholesterol; Clofibrate; Contraceptives, Oral, Hormonal; Diabetes Mel | 1983 |
Mechanism of cholesterol gallstones formation.
Topics: Animals; Bile; Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Cholesterol | 1983 |
Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat.
Topics: Acetone; Animals; Blood Chemical Analysis; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone | 1995 |
Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.
Topics: Animals; Base Sequence; Carrier Proteins; Clofibrate; Diabetes Mellitus, Type 2; DNA Primers; DNA-Bi | 1998 |
Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity.
Topics: Adipose Tissue; Animals; Butyrates; Clofibrate; Fenofibrate; Hypolipidemic Agents; Insulin Resistanc | 2000 |
[Clofibrate treatment of diabetics with hyperproteinemias (author's transl)].
Topics: Adult; Age Factors; Aged; Chylomicrons; Clofibrate; Diabetes Complications; Drug Therapy, Combinatio | 1975 |
[Effect of clofibrate on glucose tolerance and insulin secretion in patients with endogenous hypertriglyceridemia (author's transl)].
Topics: Administration, Oral; Blood Glucose; Body Weight; Cholesterol; Clofibrate; Glucose; Glucose Toleranc | 1976 |
Who gets gallstones and why.
Topics: Bilirubin; Cholelithiasis; Cholesterol; Clofibrate; Estrogens; Hemolysis; Indians, North American; O | 1979 |
Effect of clofibrate on in vivo triglyceride production and clearance in genetically hyperlipemic rats.
Topics: Animals; Clofibrate; Female; Hyperlipidemias; Liver; Metabolic Clearance Rate; Obesity; Rats; Trigly | 1978 |
Effect of guggulu (Commiphora mukul--Engl.) on serum lipids in obese, hypercholesterolemic and hyperlipemic cases.
Topics: Clofibrate; Female; Humans; Hypercholesterolemia; Hyperlipidemias; Lipids; Male; Obesity; Plant Extr | 1978 |
[Changes in lipid metabolism in a case of associated primary hypothyroidism, obesity and diabetes mellitus].
Topics: Aged; Cholesterol; Clofibrate; Diabetes Complications; Diabetes Mellitus; Female; Glyburide; Humans; | 1976 |
Growth hormone response to arginine in normal subjects and in patients with chemical diabetes and effect of clofibrate and of metergoline.
Topics: Adult; Aged; Arginine; Clofibrate; Diabetes Mellitus; Ergolines; Female; Glucose Tolerance Test; Gro | 1977 |
Clofibrate-induced changes in glucagon and insulin secretion in patients with angiographically documented coronary artery disease.
Topics: Adult; Arginine; Clofibrate; Coronary Disease; Female; Glucagon; Humans; Insulin; Insulin Secretion; | 1977 |
Independence of myocardial disease in the JCR:LA-corpulent rat on plasma cholesterol concentration.
Topics: Animals; Apolipoproteins; Arteriosclerosis; Blood Glucose; Cardiomyopathies; Cholesterol; Clofibrate | 1991 |
Regulation of carnitine acyltransferase synthesis in lean and obese Zucker rats by dehydroepiandrosterone and clofibrate.
Topics: Animals; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Clofibrate; Dehydroepiandrost | 1991 |
Comparison of dehydroepiandrosterone and clofibric acid treatments in obese Zucker rats.
Topics: Animals; Blood Glucose; Body Weight; Clofibrate; Clofibric Acid; Dehydroepiandrosterone; Disease Mod | 1989 |
Treatment of hyperlipidemia reduces glomerular injury in obese Zucker rats.
Topics: Albuminuria; Animals; Cholesterol; Clofibrate; Glomerulonephritis; Glomerulosclerosis, Focal Segment | 1988 |
Effect of long-term clofibric acid treatment on serum and tissue lipid and cholesterol levels in obese Zucker rats.
Topics: Adipose Tissue; Animals; Cholesterol; Clofibrate; Clofibric Acid; Lipid Metabolism; Lipids; Liver; M | 1987 |
Xanthomas and hyperlipidemias.
Topics: Apoproteins; Arteriosclerosis; Cholestasis; Cholestyramine Resin; Clofibrate; Colestipol; Dextrothyr | 1985 |
Metabolic relationships among the plasma lipoproteins. Reciprocal changes in the concentrations of very low and low density lipoproteins in man.
Topics: Adolescent; Adult; Angina Pectoris; Body Weight; Cholesterol; Clofibrate; Coronary Disease; Female; | 1972 |
Suppression of activities of carbohydrate-metabolizing enzymes in adipose tissue of obese humans by clofibrate.
Topics: Adipose Tissue; Adult; Biopsy; Carbohydrate Metabolism; Clofibrate; Fructose-Bisphosphatase; Fructos | 1974 |
The influence of drugs affecting lipids on atherosclerosis.
Topics: Adult; Arteriosclerosis; Blood Protein Disorders; Clofibrate; Coronary Disease; Diabetes Complicatio | 1974 |
[Diagnosis and treatment of risk factors in chronic ischemic heart disease].
Topics: Adult; Age Factors; Arteriosclerosis; Cholestyramine Resin; Chronic Disease; Clofibrate; Coronary Di | 1974 |
[Differential diagnosis and differential treatment of carbohydrate tolerance disorders in patients with hyperlipoproteinemia. Behavior of plasma lipids, glucose tolerance, and plasma insulin after glucose load during treatment with clofibrate].
Topics: Adult; Blood Glucose; Carbohydrate Metabolism, Inborn Errors; Clofibrate; Diabetes Complications; Di | 1974 |
[Pyridoxine para-chloro-phenoxy-isobutyrate. Analysis of hypolipidemic effects].
Topics: Clofibrate; Diabetes Mellitus; Diet; Drug Evaluation; Humans; Hyperlipidemias; Obesity; Pyridoxine; | 1973 |
A clinical syndrome characteristic of primary Type IV-V hyperlipoproteinaemia.
Topics: Abdomen; Adult; Cholesterol; Chylomicrons; Clofibrate; Diabetes Complications; Diet, Reducing; Elect | 1974 |
[Metabolic anomaly of obesity: therapeutic results of combined diet and chemotherapy].
Topics: Adult; Clofibrate; Diet, Reducing; Female; Humans; Hyperinsulinism; Male; Middle Aged; Obesity | 1974 |
Influence of obesity on the relationship between insulin and triglyceride levels in endogenous hypertriglyceridemia.
Topics: Adult; Blood Glucose; Body Weight; Clofibrate; Dietary Carbohydrates; Fatty Acids, Nonesterified; Gl | 1971 |
Classification of hyperlipidaemias.
Topics: Carbohydrate Metabolism; Cholestyramine Resin; Chylomicrons; Clofibrate; Dextrothyroxine; Diabetes M | 1971 |
[Antidiuretic effect of clofibrate in diabetes insipidus].
Topics: Adolescent; Clofibrate; Diabetes Insipidus; Diuresis; Humans; Hypogonadism; Male; Obesity | 1971 |
Serum lipids in an ambulary diabetic clientele. Effect of therapy with Atromidin (clofibrate).
Topics: Adolescent; Adult; Age Factors; Aged; Anticholesteremic Agents; Arteriosclerosis; Blood Glucose; Cho | 1970 |
[Behavior of lipoproteins in xanthomatoses].
Topics: Clofibrate; Diabetes Mellitus; Diet Therapy; Humans; Hypoglycemic Agents; Lipoproteins; Obesity; Ski | 1971 |