Page last updated: 2024-10-25

clofibrate and Nephrotic Syndrome

clofibrate has been researched along with Nephrotic Syndrome in 15 studies

angiokapsul: contains clofibrate & insoitolnicotinate

Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.

Research Excerpts

ExcerptRelevanceReference
" As a consequence, shorter dosing intervals of these drugs seems to be advisable, rather than a reduction in the total daily dose."2.35Drug protein binding and the nephrotic syndrome. ( Azarnoff, DL; Gugler, R, 1976)
"Clofibrate has particular dangers in patients with uraemia or hypoproteinaemia, and we recommend that it be used with great caution in patients with renal disease."1.26Clofibrate-induced complications in renal disease: a case report. ( Gregory, MC; Pokroy, N; Ress, S, 1977)
" No significant differences were seen in the pharmacokinetic parameters observed for antipyrine, a drug which is less than 10% bound to plasms proteins."1.25Pharmacokinetics of drugs in patients with the nephrotic syndrome. ( Azarnoff, DL; Cohlmia, JB; Gugler, R; Huffman, DH; Shoeman, DW, 1975)
"Nephrotic syndrome was induced by a single i."1.25Efficacy and interactions of oxandrolone, halo-fenate and clofibrate in a factorial study on experimental acute nephrotic hyperlipidemia. ( Edwards, KD; Schapel, GJ, 1975)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-199014 (93.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Muroya, Y1
Ito, O1
Walther, A1
Mordasini, R1
Riesen, W1
Bruns, W1
Pokroy, N1
Ress, S1
Gregory, MC1
Gugler, R2
Azarnoff, DL2
Gibaldi, M1
Shoeman, DW1
Huffman, DH1
Cohlmia, JB1
Schapel, GJ2
Edwards, KD4
Bridgman, JF1
Rosen, SM1
Thorp, JM1
Denizot, M2
Fabre, J2
Pometta, D1
Wildi, E2
Fredrickson, DS1
Neale, FC1
Micheli, H1
Berthoud, S1
Gallt, C1
Paoletti, R1

Reviews

3 reviews available for clofibrate and Nephrotic Syndrome

ArticleYear
Drug protein binding and the nephrotic syndrome.
    Clinical pharmacokinetics, 1976, Volume: 1, Issue:1

    Topics: Antipyrine; Blood Proteins; Clofibrate; Diazepam; Half-Life; Humans; Kinetics; Nephrotic Syndrome; P

1976
A physician's guide to hyperlipidemia.
    Modern concepts of cardiovascular disease, 1972, Volume: 41, Issue:7

    Topics: Adult; Cholesterol; Chylomicrons; Clofibrate; Diabetes Complications; Diet Therapy; Female; Humans;

1972
Antilipaemic drugs and nephrotic hyperlipidaemia.
    Progress in biochemical pharmacology, 1972, Volume: 7

    Topics: Alkenes; Animals; Blood Protein Disorders; Blood Proteins; Butyrates; Clofibrate; Humans; Hyperchole

1972

Other Studies

12 other studies available for clofibrate and Nephrotic Syndrome

ArticleYear
Effect of clofibrate on fatty acid metabolism in the kidney of puromycin-induced nephrotic rats.
    Clinical and experimental nephrology, 2016, Volume: 20, Issue:6

    Topics: Animals; Clofibrate; ERRalpha Estrogen-Related Receptor; Fatty Acids; Hypolipidemic Agents; Kidney;

2016
[Changes in serum lipoproteins in kidney diseases. Therapeutic possibilities].
    Deutsche medizinische Wochenschrift (1946), 1983, Mar-11, Volume: 108, Issue:10

    Topics: Clofibrate; Dietary Fats; Energy Metabolism; Humans; Hyperlipoproteinemias; Kidney Failure, Chronic;

1983
[Secondary hyperlipoproteinemias].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1977, May-01, Volume: 32, Issue:9

    Topics: Acute Disease; Clofibrate; Female; Hepatitis; Humans; Hyperlipidemias; Hypothyroidism; Lipoproteins,

1977
Clofibrate-induced complications in renal disease: a case report.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Nov-05, Volume: 52, Issue:20

    Topics: Adult; Clofibrate; Humans; Male; Muscular Diseases; Nephrotic Syndrome; Peripheral Nervous System Di

1977
Drug distribution in renal failure.
    The American journal of medicine, 1977, Volume: 62, Issue:4

    Topics: Antipyrine; Clofibrate; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Kidney Failure, Ch

1977
Pharmacokinetics of drugs in patients with the nephrotic syndrome.
    The Journal of clinical investigation, 1975, Volume: 55, Issue:6

    Topics: Adult; Antipyrine; Blood Proteins; Body Weight; Clofibrate; Dose-Response Relationship, Drug; Female

1975
Efficacy and interactions of oxandrolone, halo-fenate and clofibrate in a factorial study on experimental acute nephrotic hyperlipidemia.
    The Journal of pharmacology and experimental therapeutics, 1975, Volume: 194, Issue:1

    Topics: Animals; Body Weight; Butyrates; Cholesterol; Clofibrate; Dose-Response Relationship, Drug; Drug Eva

1975
Complications during clofibrate treatment of nephrotic-syndrome hyperlipoproteinaemia.
    Lancet (London, England), 1972, Sep-09, Volume: 2, Issue:7776

    Topics: Adult; Binding Sites; Blood Protein Disorders; Clofibrate; Female; Fructose-Bisphosphate Aldolase; H

1972
Clofibrate, nephrotic syndrome, and histological changes in muscle.
    Lancet (London, England), 1973, Jun-09, Volume: 1, Issue:7815

    Topics: Adult; Clofibrate; Humans; Male; Muscles; Muscular Diseases; Nephrotic Syndrome

1973
Factorial study of the efficacy of cholestyramine, L-tryptophan and clofibrate in human nephrotic hyperlipidaemia.
    Progress in biochemical pharmacology, 1974, Volume: 9

    Topics: Adolescent; Adult; Alkenes; Blood Pressure; Butyrates; Cholesterol; Cholestyramine Resin; Clofibrate

1974
[Hypolipemic property and myotoxic action of clofibrate in a case of nephrotic syndrome].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1973, Jun-05, Volume: 62, Issue:23

    Topics: Adult; Arteriosclerosis; Cholesterol; Clofibrate; Glomerulonephritis; Humans; Hyperlipidemias; Male;

1973
Serum phospholipid alterations and their control by chlorophenoxyisobutyrate and betabenzalbutyrate in puromycin aminonucleoside induced nephrotic syndrome in the rat.
    Life sciences. Pt. 2: Biochemistry, general and molecular biology, 1970, May-08, Volume: 9, Issue:9

    Topics: Animals; Anticholesteremic Agents; Butyrates; Cholesterol; Cholestyramine Resin; Clofibrate; Female;

1970