clofibrate has been researched along with Myocardial Ischemia in 6 studies
angiokapsul: contains clofibrate & insoitolnicotinate
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clofibrate was able to decrease Angiotensin II (AngII), AngII AT1-receptor, whereas Ang-(1-7) and AngII AT2-receptor expression increased." | 5.38 | Clofibrate PPARα activation reduces oxidative stress and improves ultrastructure and ventricular hemodynamics in no-flow myocardial ischemia. ( Cervantes-Pérez, LG; Del Valle-Mondragón, L; Hong, E; Ibarra-Lara, L; Pastelín-Hernández, GS; Pérez-Severiano, F; Ramírez-Ortega, M; Sánchez-Mendoza, A; Soria-Castro, E; Torres-Narváez, JC, 2012) |
| " Male Wistar rats (weighing 300-350 g) were assigned to the following groups: (1) sham, (2) myocardial ischemia vehicle-treated (MI-V), and (3) myocardial ischemia clofibrate-treated." | 3.81 | PPARα Stimulation Modulates Myocardial Ischemia-induced Activation of Renin-Angiotensin System. ( Cervantes-Pérez, LG; del Valle-Mondragón, L; Hong, E; Ibarra-Lara, L; Pastelín-Hernández, GS; Pérez-Severiano, F; Ramírez-Ortega, M; Sánchez-Aguilar, M; Sánchez-Mendoza, A; Soria-Castro, E; Torres-Narváez, JC, 2015) |
| "Clofibrate was able to decrease Angiotensin II (AngII), AngII AT1-receptor, whereas Ang-(1-7) and AngII AT2-receptor expression increased." | 1.38 | Clofibrate PPARα activation reduces oxidative stress and improves ultrastructure and ventricular hemodynamics in no-flow myocardial ischemia. ( Cervantes-Pérez, LG; Del Valle-Mondragón, L; Hong, E; Ibarra-Lara, L; Pastelín-Hernández, GS; Pérez-Severiano, F; Ramírez-Ortega, M; Sánchez-Mendoza, A; Soria-Castro, E; Torres-Narváez, JC, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ibarra-Lara, L | 3 |
| Sánchez-Aguilar, M | 2 |
| Del Valle-Mondragón, L | 3 |
| Soria-Castro, E | 3 |
| Cervantes-Pérez, LG | 3 |
| Pastelín-Hernández, G | 1 |
| Sánchez-Mendoza, A | 3 |
| Hong, E | 2 |
| Pérez-Severiano, F | 2 |
| Torres-Narváez, JC | 2 |
| Ramírez-Ortega, M | 2 |
| Pastelín-Hernández, GS | 2 |
| Fowler, PB | 1 |
| Heady, JA | 2 |
| Morris, JN | 2 |
| Oliver, MF | 2 |
2 trials available for clofibrate and Myocardial Ischemia
| Article | Year |
|---|---|
WHO clofibrate/cholesterol trial: clarifications.
Topics: Cholesterol; Clofibrate; Female; Humans; Male; Myocardial Ischemia; Thyroid Diseases; World Health O | 1993 |
WHO clofibrate/cholesterol trial: clarifications.
Topics: Clofibrate; Humans; Hypercholesterolemia; Male; Meta-Analysis as Topic; Myocardial Ischemia; Researc | 1992 |
4 other studies available for clofibrate and Myocardial Ischemia
| Article | Year |
|---|---|
Clofibrate improves myocardial ischemia-induced damage through regulation of renin-angiotensin system and favours a pro-vasodilator profile in left ventricle.
Topics: Angiotensin II; Animals; Clofibrate; Fibrosis; Heart Ventricles; Male; Myocardial Ischemia; Myocardi | 2020 |
PPARα Stimulation Modulates Myocardial Ischemia-induced Activation of Renin-Angiotensin System.
Topics: Angiotensin-Converting Enzyme 2; Animals; Bradykinin; Clofibrate; Disease Models, Animal; Enzyme Act | 2015 |
Clofibrate PPARα activation reduces oxidative stress and improves ultrastructure and ventricular hemodynamics in no-flow myocardial ischemia.
Topics: Animals; Antioxidants; Catalase; Clofibrate; Disease Models, Animal; Hemodynamics; Lipid Peroxidatio | 2012 |
Ischaemic heart disease and cholesterol ... and mislead on adverse effects.
Topics: Clinical Trials as Topic; Clofibrate; Humans; Male; Myocardial Ischemia | 1994 |